Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16).
| Member | Definition | Class |
|---|
| cantharidin | A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A. | cantharidin |
| cyanoginosin lr | A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. | microcystin-LR |
| cyclosporine | A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. | cyclosporin A |
| decamethrin | A cyclopropanecarboxylate ester obtained by formal condensation between 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol. It is the active insecticide of the proinsecticide tralomethrin. | deltamethrin |
| dinophysistoxin 1 | A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models. | dinophysistoxin 1 |
| dinophysistoxin 2 | A ketal that is a rare marine toxin structurally related to okadaic acid. Found yearly along with okadaic acid in Portuguese shellfish, its presence has been correlated with the occurrence of Dinophysis acta. | dinophysistoxin 2 |
| fostriecin | A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines. | fostriecin |
| leflunomide | A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. | leflunomide |
| okadaic acid | A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. | okadaic acid |
| vanadates | A vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms. | vanadate(3-) |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 1.6194 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 48.5088 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 44.3071 | 2 | 5 |
| AR protein | Homo sapiens (human) | Potency | 13.9498 | 11 | 30 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 7.6097 | 2 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 8.5663 | 4 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 3.9022 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 3.9022 | 2 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 1.8058 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 1.8058 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 48.2086 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.0000 | 2 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 2.8184 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 12.7082 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 2.8214 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 3.4671 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.5906 | 1 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 57.1220 | 1 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.3238 | 10 | 28 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 11.5646 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 16.7626 | 10 | 37 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 16.1362 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.2118 | 3 | 8 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 11.7704 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 13.8029 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 2.8214 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 1.3193 | 3 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.6655 | 3 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 8.3186 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 30.3164 | 5 | 10 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 13.5613 | 1 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 49.0009 | 2 | 6 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 27.8298 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 1.7561 | 2 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 2.9698 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 46.6354 | 1 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.8029 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 13.5107 | 3 | 8 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.0835 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 22.3670 | 3 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 10.4304 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 17.0157 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.0794 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 18.0448 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.2882 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.3323 | 3 | 10 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 8.3109 | 2 | 3 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 48.6557 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 20.2466 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 10.4965 | 3 | 11 |
| P53 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 1.6360 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 1.6896 | 2 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 25.8009 | 5 | 10 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.0172 | 3 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 39.8107 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 5.7122 | 1 | 2 |
| polyprotein | Zika virus | Potency | 11.7704 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 12.2126 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 8.0098 | 3 | 8 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 34.5631 | 1 | 3 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 17.7828 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.9728 | 2 | 10 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.0716 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 8.8588 | 3 | 11 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 21.6588 | 4 | 9 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.4681 | 2 | 7 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.2825 | 2 | 8 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 23.2573 | 2 | 9 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 22.3392 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 17.2289 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.7122 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.7122 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 193.2179 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 43.2863 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 13.8034 | 4 | 6 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 13.5613 | 1 | 3 |