Page last updated: 2024-08-05 15:20:52
androgen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of androgens.
ChEBI ID: 35497
Members (14)
| Member | Definition | Class |
|---|---|---|
| bupirimate | A member of the class of aminopyrimidines that is 2-ethylaminopyrimidine carrying methyl, butyl and dimethylaminosulfooxy substituents at posiitons 4, 5 and 6 respectively. | bupirimate |
| cyproterone | cyproterone | |
| cyproterone acetate | A steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. | cyproterone acetate |
| epi 001 | The (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) diether of bisphenol A; a small molecule that inhibits transactivation of the AR amino-terminal domain (NTD). | bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether |
| epitestosterone | An androstanoid that is the C-17 epimer of testosterone. | epitestosterone |
| finasteride | An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia. | finasteride |
| fludioxonil | A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria. | fludioxonil |
| flutamide | flutamide | |
| germacrone | A germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities. | (E,E)-germacrone |
| mdv 3100 | A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer. | enzalutamide |
| nilutamide | nilutamide | |
| nitrogenase stabilizing-protective protein, bacteria | A N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide that is the (R)-enantiomer of bicalutamide. | (R)-bicalutamide |
| raspberry ketone | A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics. | raspberry ketone |
| spongia-13(16),14-dien-19-oic acid | A tetracyclic diterpenoid that is 3b,4,5,5a,6,7,8,9,9a,9b,10,11-dodecahydrophenanthro[1,2-c]furan substituted by methyl groups at positions 3b, 6 and 9 and a carboxy group at position 6. Isolated from Spongia, it exhibits inhibitory activity against androgen receptor. | spongia-13(16),14-dien-19-oic acid |
Research
Studies (9,510)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,667 (17.53) | 18.7374 |
| 1990's | 1,937 (20.37) | 18.2507 |
| 2000's | 2,192 (23.05) | 29.6817 |
| 2010's | 2,618 (27.53) | 24.3611 |
| 2020's | 1,096 (11.52) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,574 (13.86%) | 5.53% |
| Reviews | 1,229 (10.83%) | 6.00% |
| Case Studies | 616 (5.43%) | 4.05% |
| Observational | 46 (0.41%) | 0.25% |
| Other | 7,888 (69.48%) | 84.16% |
Protein Targets (173)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 14.5559 | 2 | 6 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.8780 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 6.1622 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 22.3872 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 18.4348 | 12 | 95 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 17.2876 | 3 | 7 |
| arylsulfatase A | Homo sapiens (human) | Potency | 1.5101 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.5750 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 27.5562 | 2 | 6 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 29.6883 | 2 | 6 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 45.8076 | 2 | 10 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 12.8750 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 26.6514 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 4.5801 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 27.2854 | 1 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.3906 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 7.3367 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 16.5587 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 38.9522 | 1 | 6 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.5343 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 0.8913 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 32.9999 | 11 | 81 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 49.1854 | 1 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.3569 | 9 | 80 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 4.8539 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 7.7614 | 4 | 9 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.4554 | 4 | 11 |
| G | Vesicular stomatitis virus | Potency | 10.3906 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 7.3367 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 7.4674 | 2 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.0799 | 2 | 23 |
| GLS protein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 18.0671 | 3 | 16 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 38.9636 | 1 | 8 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 56.5480 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 27.2854 | 1 | 12 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.3906 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 43.6412 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.3906 | 1 | 10 |
| Interferon beta | Homo sapiens (human) | Potency | 12.1600 | 2 | 6 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 7.2701 | 1 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 44.9597 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 23.0602 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 6.4950 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 20.4839 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.0795 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 56.2341 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 36.7363 | 3 | 28 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 17.0979 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 43.3679 | 1 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 30.6440 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 20.3465 | 2 | 12 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 38.0077 | 3 | 18 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 42.2090 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 15.4291 | 2 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 95.2834 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 30.6339 | 5 | 11 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.8416 | 4 | 12 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 34.0742 | 3 | 14 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 40.3708 | 1 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 18.4566 | 3 | 18 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 33.7280 | 2 | 23 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 115.8210 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 38.0947 | 3 | 20 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 23.9193 | 4 | 16 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 31.3385 | 2 | 9 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 31.3385 | 2 | 9 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 24.5825 | 1 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 17.0666 | 1 | 5 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.7565 | 2 | 27 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 39.7450 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 39.3701 | 3 | 27 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0056 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 32.3022 | 4 | 8 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 45.9919 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 10.6565 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 13.7797 | 5 | 10 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 38.9636 | 1 | 8 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | Mycobacterium tuberculosis H37Rv | IC50 | 312.0000 | 1 | 1 |
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Homo sapiens (human) | IC50 | 2.4910 | 22 | 24 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Homo sapiens (human) | Ki | 0.2580 | 2 | 2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Rattus norvegicus (Norway rat) | IC50 | 180.0078 | 5 | 7 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0595 | 3 | 4 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Homo sapiens (human) | IC50 | 24.2434 | 23 | 26 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.3286 | 5 | 7 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Rattus norvegicus (Norway rat) | Ki | 0.0770 | 2 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 17.8140 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 8.2710 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 0.0450 | 2 | 3 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 2 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 0.3360 | 1 | 3 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 0.3360 | 1 | 3 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 1.2600 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | GI50 | 0.7367 | 3 | 3 |
| Androgen receptor | Homo sapiens (human) | IC50 | 14.7564 | 46 | 54 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 10.9746 | 9 | 13 |
| Androgen receptor | Homo sapiens (human) | Ki | 1.2152 | 13 | 15 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 1.2971 | 10 | 13 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 74.9580 | 8 | 10 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 78.7000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cocaine esterase | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | GI50 | 1.8000 | 1 | 2 |
| Cytochrome P450 2B6 | Homo sapiens (human) | GI50 | 1.8000 | 1 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | GI50 | 1.8000 | 1 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 2 |
| Cytochrome P450 2C8 | Homo sapiens (human) | GI50 | 1.8000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | GI50 | 1.8000 | 1 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | GI50 | 1.8000 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 13.0750 | 3 | 3 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 7.0510 | 2 | 2 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.2250 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.1020 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.2250 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.1020 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.2250 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.1020 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.2250 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.1020 | 1 | 1 |
| Glycoprotein IIb | Oryctolagus cuniculus (rabbit) | IC50 | 0.8500 | 1 | 1 |
| Integrin beta | Oryctolagus cuniculus (rabbit) | IC50 | 0.8500 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.1830 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.8860 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 92.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.1510 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Prostate-specific antigen | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC50 | 2.6286 | 10 | 10 |
| Androgen receptor | Homo sapiens (human) | Kd | 114.0400 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | EC50 | 0.4200 | 1 | 1 |
| Olfactory receptor 51E2 | Homo sapiens (human) | EC50 | 0.0007 | 1 | 1 |
| ORF73 | Human gammaherpesvirus 8 | EC50 | 75.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | Activity | 0.0370 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Kapp | 24.0000 | 1 | 1 |
| Arylacetamide deacetylase | Homo sapiens (human) | Km | 500.0000 | 2 | 3 |
| Arylacetamide deacetylase | Mus musculus (house mouse) | Km | 4,300.0000 | 2 | 2 |
| Arylacetamide deacetylase | Rattus norvegicus (Norway rat) | Km | 5,100.0000 | 1 | 2 |
| Cocaine esterase | Homo sapiens (human) | Km | 300.0000 | 1 | 1 |
| Neuropeptide FF receptor 2 | Rattus norvegicus (Norway rat) | Activity | 0.0370 | 1 | 1 |