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L-alanine derivative
A proteinogenic amino acid derivative resulting from reaction of L-alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-alanine by a heteroatom.
ChEBI ID: 83943
Members (13)
| Member | Definition | Role |
|---|---|---|
| 5-fluorowillardiine | An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). | 3-(5-fluorouracil-1-yl)-L-alanine |
| anticapsin | An alanine derivative that is L-alanine bearing a 5-oxo-7-oxabicyclo[4.1.0]hept-2-yl substituent at position 3. | anticapsin zwitterion; anticapsin |
| benanomicin b | A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557). | pradimicin C |
| beta-chloro-l-alanine | A 3-chloroalanine that has R configutation at the chiral centre. | 3-chloro-L-alanine zwitterion; 3-chloro-L-alanine |
| beta-n-methylamino-l-alanine | A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a methylamino group. A non-proteinogenic amino acid produced by cyanobacteria, it is a neurotoxin that has been postulated as a possible cause of neurodegenerative disorders of aging such as Alzheimer's disease, amyotrophic lateral sclerosis, and the amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS-PDC) syndrome of Guam. | L-BMAA |
| c(alpha)-formylglycine | The L-enantiomer of 3-oxoalanine. | L-3-oxoalanine zwitterion; L-3-oxoalanine |
| gs-7340 | An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection. | tenofovir alafenamide |
| lcl161 | LCL161 | |
| n-acetylalanine | An N-acetyl-L-amino acid that is L-alanine in which one of the hydrogens attached to the nitrogen is replaced by an acetyl group. | N-acetyl-L-alanine |
| perindoprilat | A dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. | perindoprilat |
| pradimicin a | A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557). | pradimicin A |
| pradimicin b | A member of the class of prodimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557). | pradimicin B |
| willardiine | The 3-(uracil-1-yl) derivative of L-alanine. | 3-(uracil-1-yl)-L-alanine zwitterion; 3-(uracil-1-yl)-L-alanine |
Research
Studies (1,168)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 53 (4.54) | 18.7374 |
| 1990's | 158 (13.53) | 18.2507 |
| 2000's | 171 (14.64) | 29.6817 |
| 2010's | 464 (39.73) | 24.3611 |
| 2020's | 322 (27.57) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 108 (8.86%) | 5.53% |
| Reviews | 105 (8.61%) | 6.00% |
| Case Studies | 39 (3.20%) | 4.05% |
| Observational | 21 (1.72%) | 0.25% |
| Other | 946 (77.60%) | 84.16% |