Roles > lichen metabolite
Page last updated: 2024-08-05 15:32:28

lichen metabolite

Any metabolite that is produced during a metabolite reaction in lichens (composite organisms consisting of a fungus and a photosynthetic partner co-existing in a symbiotic relationship).

ChEBI ID: 78361

Members (3)

MemberDefinitionClass
olivetolA member of the class of resorcinols that is resorcinol in which the hydrogen at position 5 is replaced by a pentyl group.olivetol
pannarinA member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by methyl groups at positions 1,6 and 9, chloro group at position 2, hydroxy group at position 3, formyl group at position 4, methoxy group at position 8 and an oxo group at position 11. It is a lichen metabolite isolated from several Psoroma species.pannarin
usnic acidA member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.usnic acid

Research

Studies (41)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19905 (12.20)18.7374
1990's6 (14.63)18.2507
2000's7 (17.07)29.6817
2010's7 (17.07)24.3611
2020's16 (39.02)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other42 (100.00%)84.16%

Protein Targets (54)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency89.358411
activating transcription factor 6Homo sapiens (human)Potency24.544211
AR proteinHomo sapiens (human)Potency50.451048
aryl hydrocarbon receptorHomo sapiens (human)Potency40.419424
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency61.130611
caspase-3Homo sapiens (human)Potency61.130611
Cellular tumor antigen p53Homo sapiens (human)Potency66.186223
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency7.079511
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency12.589322
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency12.246811
estrogen nuclear receptor alphaHomo sapiens (human)Potency49.094769
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency31.583823
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency61.119757
EWS/FLI fusion proteinHomo sapiens (human)Potency0.004211
GABA theta subunitRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency12.589311
GLI family zinc finger 3Homo sapiens (human)Potency21.808724
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency46.423312
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency68.729212
heat shock protein beta-1Homo sapiens (human)Potency61.939111
Histone H2A.xCricetulus griseus (Chinese hamster)Potency254.219011
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency43.646511
LuciferasePhotinus pyralis (common eastern firefly)Potency51.742812
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency48.547735
Nuclear receptor ROR-gammaHomo sapiens (human)Potency26.603212
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency47.572837
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency24.658411
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency28.940222
pregnane X nuclear receptorHomo sapiens (human)Potency46.008612
progesterone receptorHomo sapiens (human)Potency43.043123
RAR-related orphan receptor gammaMus musculus (house mouse)Potency12.197222
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency66.406723
retinoid X nuclear receptor alphaHomo sapiens (human)Potency12.301311
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency60.245123
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency38.419524
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency68.729212

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Integrase Human immunodeficiency virus 1IC504.016766
Prostaglandin G/H synthase 1Ovis aries (sheep)IC5013.630011
Prostaglandin G/H synthase 2Homo sapiens (human)IC5017.260011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Prenyltransferase homologStreptomyces coelicolor A3(2)Km580.000022
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