Any metabolite that is produced during a metabolite reaction in lichens (composite organisms consisting of a fungus and a photosynthetic partner co-existing in a symbiotic relationship).
ChEBI ID: 78361
| Member | Definition | Class |
|---|---|---|
| olivetol | A member of the class of resorcinols that is resorcinol in which the hydrogen at position 5 is replaced by a pentyl group. | olivetol |
| pannarin | A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by methyl groups at positions 1,6 and 9, chloro group at position 2, hydroxy group at position 3, formyl group at position 4, methoxy group at position 8 and an oxo group at position 11. It is a lichen metabolite isolated from several Psoroma species. | pannarin |
| usnic acid | A member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b. | usnic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (12.20) | 18.7374 |
| 1990's | 6 (14.63) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 7 (17.07) | 24.3611 |
| 2020's | 16 (39.02) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 42 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 89.3584 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 24.5442 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 50.4510 | 4 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 40.4194 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 66.1862 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 12.2468 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 49.0947 | 6 | 9 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 31.5838 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 61.1197 | 5 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0042 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 21.8087 | 2 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 46.4233 | 1 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 68.7292 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 61.9391 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 254.2190 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 43.6465 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 51.7428 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 48.5477 | 3 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 26.6032 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 47.5728 | 3 | 7 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 24.6584 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 28.9402 | 2 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 46.0086 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 43.0431 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 12.1972 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 66.4067 | 2 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 12.3013 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 60.2451 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 38.4195 | 2 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 68.7292 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Integrase | Human immunodeficiency virus 1 | IC50 | 4.0167 | 6 | 6 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 13.6300 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 17.2600 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Prenyltransferase homolog | Streptomyces coelicolor A3(2) | Km | 580.0000 | 2 | 2 |