A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound.
| Member | Definition | Class |
|---|
| 1,2-benzisothiazoline-3-one | An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. | benzo[d]isothiazol-3-one |
| 1,2-dibromo-2,4-dicyanobutane | An organobromine compound that consists of pentanedinitrile bearing bromo and bromomethyl substituents at position 2. | 2-bromo-2-(bromomethyl)pentanedinitrile |
| 4-nitrobenzyl bromide | A C-nitro compound that consists of nitrobenzene bearing a bromomethyl substituent at the para-position. | 4-nitrobenzyl bromide |
| benzocaine | A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. | benzocaine |
| cinnamaldehyde | The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes. | (E)-cinnamaldehyde |
| cobaltous chloride | A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants. | cobalt dichloride |
| copper sulfate | A metal sulfate compound having copper(2+) as the metal ion. | copper(II) sulfate |
| dinitrochlorobenzene | A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions. | 1-chloro-2,4-dinitrobenzene |
| mercuric chloride | A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed. | mercury dichloride |
| potassium dichromate | A potassium salt that is the dipotassium salt of dichromic acid. | potassium dichromate |
| resorcinol | A benzenediol that is benzene dihydroxylated at positions 1 and 3. | resorcinol |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 25.2855 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 54.0236 | 4 | 9 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 33.4202 | 2 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 18.0897 | 1 | 4 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 39.8107 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 29.4854 | 11 | 53 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 46.1467 | 2 | 7 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 22.7136 | 2 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 42.2706 | 1 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 22.3991 | 3 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 39.7616 | 2 | 7 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 31.2618 | 1 | 4 |
| caspase-3 | Homo sapiens (human) | Potency | 31.2618 | 1 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 32.9184 | 3 | 14 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.6234 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 55.5278 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 12.7585 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 21.8865 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.9640 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 21.0073 | 1 | 10 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.3440 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 37.9491 | 11 | 54 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 33.5640 | 2 | 8 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 33.3866 | 6 | 42 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.7783 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.8533 | 5 | 15 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 27.5404 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 21.8865 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 11.1834 | 2 | 8 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.7224 | 3 | 17 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 18.2995 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 31.7757 | 5 | 18 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 36.8985 | 1 | 7 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 37.4245 | 2 | 9 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 41.0623 | 2 | 8 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 28.2644 | 2 | 10 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 17.8753 | 1 | 4 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 27.5404 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 72.2601 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.1986 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 29.8649 | 2 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.1696 | 2 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 38.1062 | 4 | 21 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 46.3629 | 2 | 7 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 43.1138 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.8193 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 34.0169 | 3 | 22 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 58.3344 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.1056 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 44.5389 | 4 | 13 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 37.4316 | 4 | 16 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 5.0119 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.2589 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 37.3384 | 2 | 10 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 62.0859 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 37.6365 | 2 | 6 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.4166 | 2 | 15 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.5239 | 3 | 25 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 16.6075 | 4 | 15 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 5.3233 | 1 | 1 |
| shiga toxin 1 B subunit | Escherichia coli O157:H7 | Potency | 10.0238 | 2 | 2 |
| shiga toxin 1 variant A subunit | Escherichia coli O157:H7 | Potency | 10.0238 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 25.7421 | 2 | 5 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 25.7421 | 2 | 5 |
| Smad3 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 27.3943 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.4254 | 2 | 8 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 45.6819 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 11.2735 | 1 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 5.5343 | 3 | 13 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 36.6017 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.8864 | 6 | 14 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 37.9534 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.2589 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.2589 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 27.3012 | 2 | 6 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 38.8561 | 5 | 10 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 36.8985 | 1 | 7 |
| Vpr | Human immunodeficiency virus 1 | Potency | 29.9033 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |