ascorbic-acid and Stomatitis

Topics: Aged; Ascorbic Acid; Capillary Fragility; Clinical Trials as Topic; Glossitis, Benign Migratory; Humans; Niacinamide; Nutrition Disorders; Oral Manifestations; Placebos; Purpura; Pyridoxine; Riboflavin; Stomatitis; Thiamine; Tongue; Vitamins

Oral mucositis (OM) is known to be a significant complication of chemotherapy preceding haematopoietic cell transplantation (HCT). Antioxidants (AOX) scavenge free radicals, which play a major role in the initiation of OM and may reduce the OM risk.. The primary objective of this prospective study was to investigate the association between the incidence and severity of OM (WHO oral toxicity scale) and the AOX status in buccal mucosa cells (BMC) and plasma. The α-tocopherol, ascorbic acid and ß-carotene concentrations in BMC and plasma were assessed at admission in 70 patients with a median age of 58 years before undergoing allogeneic HCT.. Severe OM (III-IV), ulcerative OM (II-IV) and no or mild OM (0-I) were documented in 14 (20.0%), 32 (45.7%) and 38 (54.3%) patients, respectively. We observed no significant differences in baseline AOX concentrations in plasma or BMC among the OM groups. However, between patients with at least one plasma AOX beneath the normal range (39/70) and those with all plasma AOX in the normal range (31/70), we noted a trend towards longer duration of parenteral nutrition (PN) during the study period (10 vs. 8 days; p = 0.066).. No single AOX, either in plasma or BMC (α-tocopherol, ascorbic acid and ß-carotene), revealed predictive value for the incidence or severity of OM. However, patients with an overall good plasma AOX status tended to require less PN, a common clinical marker for OM, which may be more relevant than any one AOX at reducing the risk of OM.

Topics: Adult; Aged; alpha-Tocopherol; Ascorbic Acid; beta Carotene; Female; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Male; Middle Aged; Mouth Mucosa; Neoplasms; Prospective Studies; Severity of Illness Index; Stomatitis; Transplantation Conditioning; Transplantation, Homologous

To test the hypothesis that there is a link between plasma glutathione (GSH) or other antioxidants (uric acid, ascorbate) and the severity of radiation mucositis following radiation treatment of tumors of the head and neck.. Patients with carcinomas of the head-and-neck region were treated with the continuous hyperfractionated accelerated radiotherapy (CHART) regimen (54 Gy in 36 fractions over 12 days). Samples of blood plasma were analyzed for GSH, cysteine, urate, and ascorbate by high-pressure liquid chromatography. Patients were graded for dysphagia and requirement for analgesics. The areas under the curves of scores over 2-6 weeks following treatment were computed, and Spearman's rank-correlation coefficient was used to test for an association between plasma GSH levels (or those of other antioxidants) and mucositis.. The pretreatment plasma GSH level in 18 patients scored in the study was 1.0 +/- 0.7 M. Analysis of these and the dysphagia scores produced a correlation coefficient of 0.22 (confidence interval -0.28, 0.61; p = 0.39). No correlation was seen between mucositis severity and other measures of plasma antioxidants: cysteine (7.6 +/- 1.7 M), cysteine + GSH (8.6 +/- 1.9 M), uric acid (317 +/- 86 M), ascorbate (29 +/- 20 M), or whole-blood GSH concentrations (1,010 +/- 239 M).. The measurements of approximately micromolar levels of plasma GSH, or about 10 M cysteine + GSH (almost all of the total nonprotein thiols), are consistent with most other published data for either healthy adults or cancer patients; however, the values reported in an earlier study, suggesting a link between GSH and mucositis, are much higher. The hypothesis of a possible link between radiation mucositis and plasma-free (nonprotein) thiols was not supported.

Topics: Ascorbic Acid; Carcinoma, Squamous Cell; Cysteine; Dose Fractionation, Radiation; Glutathione; Humans; Linear Models; Mouth Mucosa; Mouth Neoplasms; Sensitivity and Specificity; Stomatitis; Uric Acid

Topics: Anti-Infective Agents, Local; Ascorbic Acid; Clioquinol; Humans; Stomatitis

Topics: Adolescent; Ascorbic Acid; Ascorbic Acid Deficiency; Aspartate Aminotransferases; Child; Child Nutritional Physiological Phenomena; Clinical Enzyme Tests; Gingival Diseases; Glutathione Reductase; Humans; Nutrition Surveys; Oral Hemorrhage; Riboflavin; Riboflavin Deficiency; Seasons; Stomatitis

Topics: Ascorbic Acid; Gingivitis, Necrotizing Ulcerative; Humans; Rabbits; Research; Stomatitis; Stomatitis, Aphthous; Vitamins

Topics: Ascorbic Acid; Balanitis; Candidiasis, Oral; Carbonates; Female; Gastritis; Gingivitis; Herpes Simplex; Humans; Leukoplakia; Male; Mycoses; Osteomyelitis; Pressure Ulcer; Stomatitis; Tonsillitis; Vulvitis

Topics: Ascorbic Acid; Bacteriology; Dehydroascorbic Acid; Dentistry; Gingivitis; Humans; Mouth; Oxidation-Reduction; Saliva; Stomatitis

Topics: Ascorbic Acid; Stomatitis; Vitamins