ascorbic-acid and Cholecystitis

Hemolysis induced by high dose ascorbic acid (AA) in patients with G6PD deficiency has been reported, but is rare. To our knowledge, this is the first reported case of a male with G6PD deficiency, coexpressed with cholecystolithiasis and cholecystitis, who developed extreme hemolysis and hyperbilirubinemia after receiving pharmacological doses ascorbic acid infusion.. A 27-year-old man history with glucose-6-phosphate dehydrogenase deficiency was admitted to our hospital because of cholecystolithiasis and cholecystitis. He appeared with scleral jaundice and very deep colored urine after receiving pharmacological doses ascorbic acid infusion.. Clinical findings when combined with his medical history and various laboratory results confirmed the diagnosis as hemolysis and hyperbilirubinemia induced by ascorbic acid.. The patient was treated with steroids, hepatoprotective drugs, and folic acid in addition avoidance of agents with known hemolysis risk (such as vitamin C).. As a result, the patient's symptoms from hemolytic jaundice improved, hemoglobin remained stable, and the patient was discharged 11 days later.. Clinicians should bear in mind the possibility that vitamin C exposure may result in hemolysis in patients with G6PD deficiency, especially in those with known severe disease.

Topics: Adult; Ascorbic Acid; Cholecystitis; Cholecystolithiasis; Glucosephosphate Dehydrogenase Deficiency; Humans; Hyperbilirubinemia; Jaundice; Male

Topics: Ascorbic Acid; Cholecystitis; Cholelithiasis; Combined Modality Therapy; Humans; Postoperative Care; Sulfhydryl Compounds

Topics: Adult; Aged; Ascorbic Acid; Cholecystitis; Cholelithiasis; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Sulfhydryl Compounds

Topics: Adolescent; Adult; Ascorbic Acid; Cholecystitis; Chronic Disease; Female; Humans; Male; Middle Aged; Oxygen Inhalation Therapy; Thiamine

Topics: Adolescent; Adult; Ascorbic Acid; Cholecystitis; Chronic Disease; Female; Focal Infection; Free Radicals; Humans; Male; Middle Aged; Monosaccharides; Protein Binding; Rheumatic Diseases; Thiamine; Tonsillitis

Topics: Adolescent; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Balneology; Cholangitis; Cholecystitis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Vitamin B Complex; Vitamin B Deficiency

A study of the concentration of met- and sulfhemoglobine in patients on admission to the clinic and at the end of the preoperative management and treatment was carried out upon 35 surgical cases. The medicamentous therapy included the drugs favouring the restoration of methemoglobin (10.20% and 40% glucose solutions, ascorbic acid etc.). Therewith the concentration of non-active hemoglobine derivatives dropped at the end of the preoperative management and treatment.

Topics: Acute Disease; Ascorbic Acid; Cholecystitis; Female; Glucose; Humans; Male; Methemoglobinemia; Middle Aged; Sulfhemoglobinemia

Topics: Adult; Ascorbic Acid; Avitaminosis; Cholecystitis; Chronic Disease; Female; Health Resorts; Humans; Male; Middle Aged; Niacinamide; Thiamine; Vitamins

Topics: Adult; Aged; Ascorbic Acid; Avitaminosis; Cholecystitis; Chronic Disease; Citrates; Female; Hepatitis; Humans; Male; Methods; Middle Aged; Niacinamide; Pyruvates; Sorbitol; Thiamine

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Ascorbic Acid; Child; Cholangitis; Cholecystitis; Gastritis; Humans

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ascorbic Acid; Biomedical Research; Cholecystitis; Humans; Metabolism; Niacin; Niacinamide; Penicillins; Pharmacology; Pyridoxine; Streptomycin; Tetracycline; Urine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins