1,3'-diethyl-4,2'-quinolylthiacyanine iodide profile

1,3'-diethyl-4,2'-quinolylthiacyanine iodide, often abbreviated as **DQTI**, is a **cyanine dye** used in various research applications. Let's break down its significance:

**What is it?**

* **Cyanine Dyes:** These are organic compounds characterized by a polymethine bridge (a chain of carbon atoms with alternating single and double bonds) linking two nitrogen-containing heterocycles. They exhibit strong absorption and fluorescence properties, making them useful in various fields.
* **DQTI Structure:** DQTI is a specific cyanine dye with two quinoline rings connected by a sulfur atom and a polymethine chain. The diethyl part refers to two ethyl groups attached to the quinoline rings, which modify its properties.

**Why is it Important in Research?**

DQTI's importance stems from its unique characteristics and applications:

1. **Fluorescence Properties:** DQTI exhibits strong fluorescence, making it valuable for:
* **Fluorescence Microscopy:** It can be used as a fluorescent probe to visualize and study biological structures and processes.
* **Fluorescence Spectroscopy:** Its fluorescence properties are used to measure and analyze various biochemical and physical phenomena.

2. **Antimicrobial Activity:** DQTI has shown antimicrobial activity against certain bacteria and fungi. Research explores its potential as a new antibiotic or antifungal agent.

3. **Photodynamic Therapy (PDT):** This involves using light to activate a photosensitizer, like DQTI, to generate reactive oxygen species that kill cancer cells. Its photophysical properties make it a potential candidate for PDT.

4. **Optical Materials:** DQTI's optical properties, including its ability to absorb and emit light, make it potentially useful in:
* **Solar cells:** As a sensitizer to improve the efficiency of solar energy conversion.
* **Lasers:** As a gain medium for dye lasers.

**Research Areas:**

* **Biological and Biomedical Research:** To study cell processes, develop new diagnostic tools, and explore potential therapies.
* **Material Science:** To create new materials with improved optical and electronic properties.
* **Pharmacology:** To develop novel antimicrobial and anticancer agents.

**Overall, 1,3'-diethyl-4,2'-quinolylthiacyanine iodide is a versatile compound with applications in a variety of research fields. Its fluorescence, antimicrobial activity, and photodynamic properties make it a valuable tool for scientists across disciplines.**

cyanine dye 7: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6440951
SCHEMBL ID	1807089
MeSH ID	M0057313

Synonym
cyanine dye 7
einecs 240-075-9
l-lysine, n2-(n2-(n2-l-lysyl-l-lysyl)-l-lysyl)-, hydrochloride
1-ethyl-4-((3-ethyl-2(3h)-benzothiazolylidene)methyl)quinolinium iodide
1,3'-diethyl-4,2'-quinolylthiacyanine iodide
1-ethyl-4-((3-ethyl-3h-benzothiazol-2-ylidene)methyl)quinolinium iodide
15941-82-9
AKOS015911912
SCHEMBL1807089
(2z)-3-ethyl-2-[(1-ethylquinolin-1-ium-4-yl)methylidene]-1,3-benzothiazole;iodide
DTXSID40936096
3-ethyl-2-[(1-ethylquinolin-4(1h)-ylidene)methyl]-1,3-benzothiazol-3-ium iodide
1-ethyl-4-((3-ethylbenzo[d]thiazol-2(3h)-ylidene)methyl)quinolin-1-iumiodide
1-ethyl-4-((3-ethylbenzo[d]thiazol-2(3h)-ylidene)methyl)quinolin-1-ium iodide
1,3-diethyl-4,2-quinolylthiacyanineiodide

Excerpt	Reference	Relevance
"4 kDa) moiety in order to increase its solubility and bioavailability to circulating neutrophils."	( Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging. Liu, Z; Pan, D; Pu, L; Xiao, L; Yang, M; Zhang, Y, 2010)	0.36

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (3.85)	18.7374
1990's	3 (11.54)	18.2507
2000's	2 (7.69)	29.6817
2010's	14 (53.85)	24.3611
2020's	6 (23.08)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.70%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (96.30%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.21	1	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.	2.25	1	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	2.25	1	alkanethiol; primary alcohol	geroprotector
trifluridine Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557). trifluridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.	2.31	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor
mannose mannopyranose : The pyranose form of mannose.	2.25	1	D-aldohexose; D-mannose; mannopyranose	metabolite
gadolinium Gadolinium: An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.	2.17	1	f-block element atom; lanthanoid atom
hypochlorous acid Hypochlorous Acid: An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.. hypochlorous acid : A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water.	2.08	1	chlorine oxoacid; reactive oxygen species	EC 2.5.1.18 (glutathione transferase) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; human metabolite
sodium azide Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).	2.05	1	inorganic sodium salt	antibacterial agent; explosive; mitochondrial respiratory-chain inhibitor; mutagen
cathinone cathinone: alkaloid from khat shrub, Catha edulis; RN given refers to parent cpd without isomeric designation. cathinone : The S stereoisomer of 2-aminopropiophenone.	2.25	1	2-aminopropiophenone; monoamine alkaloid	central nervous system stimulant; psychotropic drug
homocysteine Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE.. homocysteine : A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.. L-homocysteine : A homocysteine that has L configuration.	2.08	1	amino acid zwitterion; homocysteine; serine family amino acid	fundamental metabolite; mouse metabolite
arginyl-glycyl-aspartic acid arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system	2.17	1	oligopeptide
technetium tc 99m pentetate Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.	2.1	1
nitrogen dioxide Nitrogen Dioxide: Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.	2.08	1	nitrogen oxide
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.08	1	cysteinium	fundamental metabolite
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	5.77	26	cyanine dye; organic iodide salt	fluorochrome
indocyanine green Indocyanine Green: A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.	2.06	1	1,1-diunsubstituted alkanesulfonate; benzoindole; cyanine dye
mannans [no description available]	2.1	1
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.05	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
cyanine dye 3 cyanine dye 3: structures of Cy3 derivatives given in first source	1.99	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	4.17	5
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.17	5
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.31	1
Cancer of Lung [description not available]	2.31	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.31	1
Margins of Excision The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.	2.17	1
Cancer of Pancreas [description not available]	2.17	1
Carcinoma, Ductal, Pancreatic [description not available]	2.17	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.17	1
Carcinoma, Pancreatic Ductal Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.	2.17	1
B16 Melanoma [description not available]	2.1	1
Experimental Mammary Neoplasms [description not available]	2.1	1
Anoxemia [description not available]	2.11	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	2.11	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.11	1
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Teratocarcinoma A malignant neoplasm consisting of elements of teratoma with those of embryonal carcinoma or choriocarcinoma, or both. It occurs most often in the testis. (Dorland, 27th ed)	1.99	1
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	1.98	1

1,3'-diethyl-4,2'-quinolylthiacyanine iodide

Description

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Synonyms (15)

Research Excerpts

Bioavailability

Research

Studies (26)

Market Indicators

Research Demand Index: 12.09

Study Types