Page last updated: 2024-12-08

geniposidic acid

Cross-References

ID SourceID
PubMed CID443354
CHEMBL ID460031
CHEBI ID5301
SCHEMBL ID227010
MeSH IDM0164216

Synonyms (32)

Synonym
27741-01-1
geniposidic acid ,
CHEMBL460031 ,
chebi:5301 ,
cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-d-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, (1s-(1alpha,4aalpha,7aalpha))-
cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-d-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, (1s,4as,7as)-
AKOS015896744
SCHEMBL227010
HY-N0010
Q-100352
(1s,4as,7as)-7-(hydroxymethyl)-1-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid
AB01559137_03
DTXSID40182091
AC-8846
(1s,4as,7as)-7-(hydroxymethyl)-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-4-carboxylic acid
AS-75051
bdbm50478834
premnosidic acid
geniposidic acid, >=98% (hplc)
mfcd00210294
NCGC00346663-03
geniposidinsaure
(1s,4as,7as)-7-(hydroxymethyl)-1-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid
Q5533206
S2413
BRD-K73771095-001-03-3
cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-d-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, (1s,4as,7as)-
geniposidic-acid
CCG-268347
(1r,2s,6s)-9-(hydroxymethyl)-2-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylic acid
A876868
(1s,4as,7as)-1-(beta-d-glucopyranosyloxy)-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid

Research Excerpts

Overview

Geniposidic acid (GA) is an iridoid glucoside isolated from Gardeniae jasminoides Ellis (Rubiaceae) that has long been used to treat inflammation, jaundice and hepatic disorders.

ExcerptReferenceRelevance
"Geniposidic acid (GPA) is an iridoid glucoside extracted from Gardeniae jasminoides Ellis and can treat inflammation-related diseases."( Geniposidic acid protects lipopolysaccharide-induced acute lung injury via the TLR4/MyD88 signaling pathway
Fu, H; Zhu, H, 2022
)
2.89
"Geniposidic acid (GPA) is a bioactive compound isolated from Gardenia jasminoides Ellis (Rubiaceae) that has long been used to treat arthritis, jaundice, and hypertension. "( Geniposidic acid attenuates DSS-induced colitis through inhibiting inflammation and regulating gut microbiota.
Chen, J; Jiang, P; Li, X; Zhang, Y, 2023
)
3.8
"Geniposidic acid (GPA) is an extract from Eucommia ulmoides Oliv. "( Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4/2 signaling pathway in APP/PS1 mice.
Hou, J; Hu, Y; Mo, Y; Qu, Z; Ren, M; Yang, G; Zhou, Z, 2020
)
3.44
"Geniposidic acid (GA) is an iridoid glucoside isolated from Gardeniae jasminoides Ellis (Rubiaceae) that has long been used to treat inflammation, jaundice and hepatic disorders."( Geniposidic acid protects against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.
Kim, KM; Kim, SJ; Kim, YS; Kwak, JH; Lee, SM; Park, J, 2013
)
3.28

Pharmacokinetics

The validated method was successfully applied to the pharmacokinetic study of geniposidic acid in rat plasma after oral administration of G.zhong tea extract to rats. The results indicated that this HPLC-MS/MS assay is a valuable method.

ExcerptReferenceRelevance
" Then this method was successfully applied to the pharmacokinetic study of geniposidic acid and aucubin after oral administration of Du-zhong tea extract to rats and the results indicated that this HPLC-MS/MS assay is a valuable method for the pharmacokinetic study of geniposidic acid and aucubin in rat plasma."( Development and validation of high liquid performance chromatography-tandem mass spectrometry method for simultaneous determination of geniposidic acid and aucubin in rat plasma for pharmacokinetic study after oral administration of Du-zhong tea extract.
Liu, Y; Ma, YL; Zhang, L; Zu, YG, 2014
)
0.84
" The proliferation rate of osteoblasts was taken as the pharmacodynamic index, and determined by MTT method to draw effect-time curve."( [Analysis on pharmacokinetics-pharmacodynamics correlation of effective ingredients of Qing'e wan].
Chen, ZP; Li, WD; Liu, L; Wang, H; Weng, ZB; Wu, L; Zhu, XY, 2016
)
0.43

Compound-Compound Interactions

ExcerptReferenceRelevance
"To develop a quantitative models for simultaneous determination of pinoresinol diglucoside (PDG) and geniposidic acid (GPA) in Eucommia ulmoides with near-infrared (NIR) spectroscopy combined with chemometrics."( [Rapid Determination of Pinoresinol Diglucoside and Geniposidic Acid in Eucommia ulmoides with Near Infrared Spectroscopy Combined with Chemometrics Methods].
Li, FF; Liu, R; Liu, S; Peng, YZ; Xu, XB; Zi, W, 2016
)
0.9

Bioavailability

ExcerptReferenceRelevance
" The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained."( Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat.
Gao, X; Han, L; Hou, X; Huang, Y; Huo, Y; Liu, E; Wang, L, 2014
)
0.62
" AN could only be detected in the plasma and liver homogenate of normal mice, which was poorly absorbed in OVX mice and low in other measured tissues."( Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS.
An, J; Hu, F; Wang, C; Wang, Z; Yang, L; Zhang, Z, 2016
)
0.43
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51

Dosage Studied

ExcerptRelevanceReference
" This result was achieved by exerting the levels of dosage in a dose-dependent manner."( Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation.
Hsu, HY; Lin, CC; Lin, SY; Yang, JJ, 1997
)
0.65
"To investigate the effects of geniposidic acid( GPA) on hepato-enteric circulation in cholestasis rats,and to explore the mechanism based on the sirtuin 1( Sirt1)-farnesol X receptor( FXR) pathway,sixty SD rats were randomly divided into 6 groups:blank control group,ANIT model group,ursodeoxycholic acid group( 100 mg·kg~(-1)·d-1 UDCA),and GPA high,medium and low( 100,50 and 25 mg·kg~(-1)·d-1) dosage groups,10 rats in each group."( [Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway].
Chen, H; Hu, L; Li, J; Liu, HZ; Ma, ST; Yu, H; Zhao, W, 2019
)
1.19
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
terpene glycosideA terpenoid in which one or more hydroxy functions are glycosylated.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Xanthine dehydrogenase/oxidaseBos taurus (cattle)IC50 (µMol)62.16000.00303.10159.8000AID1867877
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (1)

Processvia Protein(s)Taxonomy
xanthine catabolic processXanthine dehydrogenase/oxidaseBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
xanthine dehydrogenase activityXanthine dehydrogenase/oxidaseBos taurus (cattle)
xanthine oxidase activityXanthine dehydrogenase/oxidaseBos taurus (cattle)
iron ion bindingXanthine dehydrogenase/oxidaseBos taurus (cattle)
molybdenum ion bindingXanthine dehydrogenase/oxidaseBos taurus (cattle)
protein homodimerization activityXanthine dehydrogenase/oxidaseBos taurus (cattle)
molybdopterin cofactor bindingXanthine dehydrogenase/oxidaseBos taurus (cattle)
flavin adenine dinucleotide bindingXanthine dehydrogenase/oxidaseBos taurus (cattle)
2 iron, 2 sulfur cluster bindingXanthine dehydrogenase/oxidaseBos taurus (cattle)
FAD bindingXanthine dehydrogenase/oxidaseBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
extracellular spaceXanthine dehydrogenase/oxidaseBos taurus (cattle)
peroxisomeXanthine dehydrogenase/oxidaseBos taurus (cattle)
xanthine dehydrogenase complexXanthine dehydrogenase/oxidaseBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (54)

Assay IDTitleYearJournalArticle
AID579999Antiobesity activity against high-fat diet fed ICR mouse assessed as change in initial body weight after 4 weeks (high fat diet fed group = 25.9 +/- 0.38 g)2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID1850979Displacement of thiazole orange from human telomeric IKF1 G4 quadruplex DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID375988Antioxidant activity assessed as DPPH free radical scavenging activity relative to control2006Journal of natural products, Apr, Volume: 69, Issue:4
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID735999Antiviral activity against EV71 infected in human RD cells assessed as cell survival rate at 1 to 2 mg/ml after 24 hrs by WST-1 assay2013European journal of medicinal chemistry, Apr, Volume: 62Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide.
AID1850990Displacement of thiazole orange from human 1BNA double stranded DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1251037Inhibition of COX1 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID334195Inhibition of classical complement pathway activation at 4 uM in presence of beta glucosidase by complement modulation test2003Journal of natural products, Jan, Volume: 66, Issue:1
Complement-inhibiting iridoids from Morinda morindoides.
AID375991Antioxidant activity assessed as inhibition of 2,2'-azobis(2-amidinopropane)dihydrochloride-induced lipid peroxidation at 3.125 ug/ml by ferric thiocyanate system relative to control2006Journal of natural products, Apr, Volume: 69, Issue:4
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID1850977Binding affinity to human 1BNA double stranded DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID375992Inhibition of HIV1 recombinant integrase expressed in Escherichia coli2006Journal of natural products, Apr, Volume: 69, Issue:4
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID580002Antiobesity activity against high-fat diet fed ICR mouse assessed as change in food intake per day after 4 weeks (high fat diet fed group = 5.51 +/- 0.20 g/day)2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID358155Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 molar ratio after 48 hrs relative to TPA
AID358156Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio after 48 hrs by trypan blue assay
AID1251039Inhibition of COX2 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID357036Antioxidant activity assessed as radical scavenging activity in FMLP-stimulated human PMNC up to 30 uM by chemiluminescence assay2001Journal of natural products, Jul, Volume: 64, Issue:7
Flavonoid, iridoid, and lignan glycosides from Putoria calabrica.
AID375989Antioxidant activity assessed as superoxide anion scavenging activity by xanthine oxidase oxidation system relative to control2006Journal of natural products, Apr, Volume: 69, Issue:4
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
AID580121Antiobesity activity against high-fat diet fed ICR mouse assessed as decrease in respiratory quotients at 0.1 % after 4 weeks relative to high-fat diet fed group2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID1850972Binding affinity to human telomeric 1ELN i-motif DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID580004Antiobesity activity against high-fat diet fed ICR mouse assessed as decrease in plasma triglyceride level after 4 weeks relative to high-fat diet fed group2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID1251036Inhibition of COX1 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1251040Inhibition of COX2 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID580001Antiobesity activity against high-fat diet fed ICR mouse assessed as change in body weight after 4 weeks (high fat diet fed group = 9.50 +/- 0.68 g)2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID580003Antiobesity activity against high-fat diet fed ICR mouse assessed as decrease in weight adipose tissue weight after 4 weeks relative to high-fat diet fed group2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID1850984Displacement of thiazole orange from human ILPR G4 quadruplex DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850980Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850981Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850983Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 100 equiv. at pH 5.5 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850976Binding affinity to human ILPR i-motif DNA assessed as change in melting temperature at 20 uM at pH 5.5 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850971Binding affinity to human telomeric IKF1 G4 quadruplex DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850975Binding affinity to human ILPR i-motif DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850974Binding affinity to human ILPR G4 quadruplex DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1251038Inhibition of COX1 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1850978Displacement of thiazole orange from human telomeric IKF1 G4 quadruplex DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850985Displacement of thiazole orange from human ILPR G4 quadruplex DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850988Displacement of thiazole orange from human ILPR i-motif DNA at 10 equiv. at pH 5.5 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1867877Inhibition of bovine XOD assessed as inhibition of uric acid formation using xanthine as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured for 30 mins by microplate reader analysis2022European journal of medicinal chemistry, Jul-05, Volume: 237Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.
AID1850987Displacement of thiazole orange from human ILPR i-motif DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID334194Inhibition of classical complement pathway activation at 4 uM assessed as complement modulation test2003Journal of natural products, Jan, Volume: 66, Issue:1
Complement-inhibiting iridoids from Morinda morindoides.
AID358153Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 molar ratio after 48 hrs relative to TPA
AID1850986Displacement of thiazole orange from human ILPR i-motif DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1251041Inhibition of COX2 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID358152Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 molar ratio after 48 hrs relative to TPA
AID1850973Binding affinity to human telomeric 1ELN i-motif DNA assessed as change in melting temperature at 20 uM at pH 5.5 by FRET assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID580000Antiobesity activity against high-fat diet fed ICR mouse assessed as change in final body weight after 4 weeks (high fat diet fed group = 35.5 +/- 0.68 g)2011Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
Anti-obesity compounds in green leaves of Eucommia ulmoides.
AID358154Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 molar ratio after 48 hrs relative to TPA
AID1850991Displacement of thiazole orange from human 1BNA double stranded DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850989Displacement of thiazole orange from human ILPR i-motif DNA at 100 equiv. at pH 5.5 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1850982Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 10 equiv. at pH 5.5 by fluorescent intercalator displacement assay2022Bioorganic & medicinal chemistry letters, 10-01, Volume: 73Identification of sugar-containing natural products that interact with i-motif DNA.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (65)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (1.54)18.7374
1990's8 (12.31)18.2507
2000's15 (23.08)29.6817
2010's26 (40.00)24.3611
2020's15 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.53 (24.57)
Research Supply Index4.22 (2.92)
Research Growth Index5.56 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.99%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other65 (97.01%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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