AID579999 | Antiobesity activity against high-fat diet fed ICR mouse assessed as change in initial body weight after 4 weeks (high fat diet fed group = 25.9 +/- 0.38 g) | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID1850979 | Displacement of thiazole orange from human telomeric IKF1 G4 quadruplex DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID375988 | Antioxidant activity assessed as DPPH free radical scavenging activity relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
AID735999 | Antiviral activity against EV71 infected in human RD cells assessed as cell survival rate at 1 to 2 mg/ml after 24 hrs by WST-1 assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide. |
AID1850990 | Displacement of thiazole orange from human 1BNA double stranded DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1251037 | Inhibition of COX1 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis. |
AID334195 | Inhibition of classical complement pathway activation at 4 uM in presence of beta glucosidase by complement modulation test | 2003 | Journal of natural products, Jan, Volume: 66, Issue:1
| Complement-inhibiting iridoids from Morinda morindoides. |
AID375991 | Antioxidant activity assessed as inhibition of 2,2'-azobis(2-amidinopropane)dihydrochloride-induced lipid peroxidation at 3.125 ug/ml by ferric thiocyanate system relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
AID1850977 | Binding affinity to human 1BNA double stranded DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID375992 | Inhibition of HIV1 recombinant integrase expressed in Escherichia coli | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
AID580002 | Antiobesity activity against high-fat diet fed ICR mouse assessed as change in food intake per day after 4 weeks (high fat diet fed group = 5.51 +/- 0.20 g/day) | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID358155 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 molar ratio after 48 hrs relative to TPA | | | |
AID358156 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio after 48 hrs by trypan blue assay | | | |
AID1251039 | Inhibition of COX2 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis. |
AID357036 | Antioxidant activity assessed as radical scavenging activity in FMLP-stimulated human PMNC up to 30 uM by chemiluminescence assay | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7
| Flavonoid, iridoid, and lignan glycosides from Putoria calabrica. |
AID375989 | Antioxidant activity assessed as superoxide anion scavenging activity by xanthine oxidase oxidation system relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. |
AID580121 | Antiobesity activity against high-fat diet fed ICR mouse assessed as decrease in respiratory quotients at 0.1 % after 4 weeks relative to high-fat diet fed group | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID1850972 | Binding affinity to human telomeric 1ELN i-motif DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID580004 | Antiobesity activity against high-fat diet fed ICR mouse assessed as decrease in plasma triglyceride level after 4 weeks relative to high-fat diet fed group | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID1251036 | Inhibition of COX1 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis. |
AID1251040 | Inhibition of COX2 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis. |
AID580001 | Antiobesity activity against high-fat diet fed ICR mouse assessed as change in body weight after 4 weeks (high fat diet fed group = 9.50 +/- 0.68 g) | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID580003 | Antiobesity activity against high-fat diet fed ICR mouse assessed as decrease in weight adipose tissue weight after 4 weeks relative to high-fat diet fed group | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID1850984 | Displacement of thiazole orange from human ILPR G4 quadruplex DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850980 | Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850981 | Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850983 | Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 100 equiv. at pH 5.5 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850976 | Binding affinity to human ILPR i-motif DNA assessed as change in melting temperature at 20 uM at pH 5.5 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850971 | Binding affinity to human telomeric IKF1 G4 quadruplex DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850975 | Binding affinity to human ILPR i-motif DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850974 | Binding affinity to human ILPR G4 quadruplex DNA assessed as change in melting temperature at 20 uM at pH 7.4 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1251038 | Inhibition of COX1 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis. |
AID1850978 | Displacement of thiazole orange from human telomeric IKF1 G4 quadruplex DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850985 | Displacement of thiazole orange from human ILPR G4 quadruplex DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850988 | Displacement of thiazole orange from human ILPR i-motif DNA at 10 equiv. at pH 5.5 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1867877 | Inhibition of bovine XOD assessed as inhibition of uric acid formation using xanthine as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured for 30 mins by microplate reader analysis | 2022 | European journal of medicinal chemistry, Jul-05, Volume: 237 | Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis. |
AID1850987 | Displacement of thiazole orange from human ILPR i-motif DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID334194 | Inhibition of classical complement pathway activation at 4 uM assessed as complement modulation test | 2003 | Journal of natural products, Jan, Volume: 66, Issue:1
| Complement-inhibiting iridoids from Morinda morindoides. |
AID358153 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 molar ratio after 48 hrs relative to TPA | | | |
AID1850986 | Displacement of thiazole orange from human ILPR i-motif DNA at 10 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1251041 | Inhibition of COX2 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay | 2015 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
| In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis. |
AID358152 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 molar ratio after 48 hrs relative to TPA | | | |
AID1850973 | Binding affinity to human telomeric 1ELN i-motif DNA assessed as change in melting temperature at 20 uM at pH 5.5 by FRET assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID580000 | Antiobesity activity against high-fat diet fed ICR mouse assessed as change in final body weight after 4 weeks (high fat diet fed group = 35.5 +/- 0.68 g) | 2011 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 21, Issue:6
| Anti-obesity compounds in green leaves of Eucommia ulmoides. |
AID358154 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 molar ratio after 48 hrs relative to TPA | | | |
AID1850991 | Displacement of thiazole orange from human 1BNA double stranded DNA at 100 equiv. at pH 7.4 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850989 | Displacement of thiazole orange from human ILPR i-motif DNA at 100 equiv. at pH 5.5 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1850982 | Displacement of thiazole orange from human telomeric 1ELN i-motif DNA at 10 equiv. at pH 5.5 by fluorescent intercalator displacement assay | 2022 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 73 | Identification of sugar-containing natural products that interact with i-motif DNA. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |