ascorbic-acid and Contusions

Topics: Aged; Anemia; Ascorbic Acid; Avitaminosis; Cognition Disorders; Contusions; Diagnosis, Differential; Diet; Dizziness; Hemoglobins; Humans; Male; Melena; Scurvy

Topics: 5-Methylcytosine; Animals; Ascorbic Acid; Axons; Contusions; Dioxygenases; Epigenesis, Genetic; Female; Motor Cortex; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries

Scurvy is a rare entity in developed countries and the diagnosis may often be delayed resulting in unnecessary investigations and/or potentially severe complications. A recent increase in the number of patients diagnosed with scurvy in our hematology clinics indicated the need to review the literature on the diagnosis and optimal management of similar patients.. We conducted a retrospective chart review of patients referred to hematology at our tertiary care centre between 2010 and 2018, who were ultimately diagnosed with scurvy. Data collected from electronic medical records included baseline characteristics, clinical features on presentation, bloodwork results from initial consultation, treatment plan as well as response to treatment.. Twenty-two adults patient had a diagnosis of scurvy with a mean vitamin C level of 6 μmol/L. Iron deficiency anemia (54%) and gastrointestinal disorders (54%) were the most common comorbidities noted in our cohort. Proton-pump inhibitors use was noted in 54% of patients. Bleeding (45%) and bruising (45%) were the most commonly reported clinical features. Eleven patients received oral supplementation, five had intravenous (IV) vitamin C and six were not treated. Two patients required a transition from oral to IV supplementation. Vitamin C dosing ranged between 250 and 2000 mg and the frequency varied from daily for oral therapy to every few weeks or months for IV.. Awareness of scurvy and its associated risk factors and clinical presentation is important in the evaluation of a patient with bleeding tendency. Treatment plan should be individualized, and a careful review of patients' diet, medial history and medications is warranted.

Topics: Adult; Ascorbic Acid; Contusions; Diet; Hemorrhage; Humans; Medical History Taking; Precision Medicine; Proton Pump Inhibitors; Retrospective Studies; Scurvy

Topics: Aged; Ascorbic Acid; Contusions; Diagnosis, Differential; Dietary Supplements; Female; Humans; Scurvy

This patient was a liver transplant recipient and had a history of malnutrition. One tell-tale sign on the physical exam, however, left no doubt as to the diagnosis.

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Contusions; Female; Humans; Middle Aged; Purpura; Treatment Outcome

To analyze the protective activity of vitamin C on the lungs by assessing biochemical and histopathological analysi after performing an experimental isolated lung contusion model.. Fifty-four male Sprague-Dawley male rats were used. The rats were randomly separated into 4 groups Vitamin C (200 mg/kg) was injected intraperitoneally 30 min after trauma. Blood samples were obtained for myeloperoxidase (MPO) glutirthione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities and malondialdehyde (MDA) levels Blood gas analysis and bronchoalveolar lavage was performed. The lung tissue was also extracted for histopathological examination.. The lung contusion enhanced MDA, SOD, CAT, and MPO and diminished GSH-Px. Vitamin C administration after th pulmonary contusion was found to diminish the level of MDA and the activities of SOD, CAT, and MPO and to enhance the level of GSH-Px (P < 0.05). Contusion-induced disrupted gas analysis and leukocyte infiltration were both resolved by the vitamin C.. The present results indicate that vitamin C administration attenuated the oxidative damage and morphological change induced by pulmonary contusion in an experimental rat study.

Topics: Animals; Antioxidants; Ascorbic Acid; Bronchoalveolar Lavage; Catalase; Contusions; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxidation; Lung Injury; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley

Topics: Adult; Ascorbic Acid; Contusions; Female; Humans; Leg; Scurvy; Skin Diseases

A 53-year-old woman was referred because of progressive haematomas of the lower extremities and fatigue. Her medical history included hyperplastic gums and tooth loss. Scurvy was diagnosed; this was the result of an insufficient diet due to a paranoid psychosis. There was a dramatic improvement within a few days after addition of vitamin C and starting highly nutritious food. Scurvy is easily treated, but is not a disease of the past.

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Contusions; Diet; Fatigue; Female; Humans; Middle Aged; Schizophrenia; Schizophrenic Psychology; Tooth Loss; Treatment Outcome

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Contusions; Fatigue; Humans; Schizophrenia; Tooth Loss

A case of scurvy occurred in an apparently well-nourished 5-year-old boy with normal growth parameters. Only after the diagnosis of scurvy was raised on clinical grounds did we discover the peculiar dietary habits that were responsible for his deficiency of ascorbic acid. His case is a reminder to the clinician that nutritionally based disease may occur in any socioeconomic setting and that nutritional screening remains an important part of every child's general health care.

Topics: Ascorbic Acid; Child, Preschool; Contusions; Diagnosis, Differential; Feeding Behavior; Gait; Humans; Male; Scurvy

Topics: Ascorbic Acid; Capillaries; Cardiovascular System; Contusions; Hemorrhage; Humans; Iron; Vascular Diseases

Topics: Animals; Ascorbic Acid; Contusions; Humans; Poultry; Skin; Skin Diseases; Vitamins; Wound Healing