Poisonous substance produced by fungi.
| Member | Definition | Class |
|---|
| 15-acetyldeoxynivalenol | A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants. | 15-acetyldeoxynivalenol |
| 3-acetyldeoxynivalenol | A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants. | 3-acetyldeoxynivalenol |
| 3-nitropropionic acid | A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group. | 3-nitropropanoic acid |
| alternariol | A benzochromenone that is 6H-benzo[c]chromen-6-one which is substituted by a methyl group at position 1 and by hydroxy groups at positions 3, 7, and 9. It is the most important mycotoxin produced by the black mould Alternaria species, which are the most common mycoflora infecting small grain cereals worldwide. | alternariol |
| alternariol monomethyl ether | A benzochromenone that is alternariol in which the hydroxy group at position 9 has been converted into the corresponding methyl ether. A natural product found in Chaetomium globosum as well as being one of the two most important compounds belonging to the group of Altenaria mycotoxins. | djalonensone |
| ascladiol | A butenolide that is furan-2(5H)-one which is substituted by a hydroxymethyl group at position 4 and a 2-hydroxyethylidene group at position 5 (the 5E isomer). A direct precursor of patulin in cell-free preparations of Penicillium urticae patulin-minus mutants J1 and S11, but not S15. | (E)-ascladiol |
| beauvericin | A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues. | beauvericin |
| botrydial | A cytotoxic fungal metabolite isolated from plant tissues infected by phytopathogen Botrytis cinerea. | botrydial |
| coprine | A non-proteinogenic L-alpha-amino acid that is L-glutamine in which one of the hydrogens attached to the amide nitrogen is replaced by a 1-hydroxycyclopropyl group. Found in the ink-cap mushroom, Coprinus atramentarius, it causes an unpleasant hypersensitivity to alcohol (the 'disulfiram effect'). | coprine |
| cytochalasin b | An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments. | cytochalasin B |
| demethoxyfumitremorgin c | An organic heteropentacyclic compound that is a mycotoxic indole alkaloid, consisting of fumitremorgin C lacking the 9-methoxy substituent. | demethoxyfumitremorgin C |
| deoxynivalenol | A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination. | deoxynivalenol |
| ergotamine | A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. | ergotamine |
| fumitremorgin a | An organic heterohexacyclic compound that is a mycotoxic indole alkaloid obtained by prenylation of the 10-hydroxy group of verruculogen. | fumitremorgin A |
| fumitremorgin b | An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi via a tryptophan-proline diketopiperazine intermediate. | fumitremorgin B |
| gliotoxin | A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi. | gliotoxin |
| helvolic acid | A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24. | helvolic acid |
| mycophenolic acid | A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. | mycophenolic acid |
| ochratoxin a | A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum. | ochratoxin A |
| ochratoxin b | A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations. | ochratoxin B |
| ochratoxin c | A phenylalanine derivative that is the ethyl ester of ochratoxin A. | ochratoxin C |
| patulin | A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic. | patulin |
| paxilline | An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. | paxilline |
| sporidesmin | An organic heteropentacyclic compound that has formula C18H20ClN3O6S2, produced by the saprophyte fungus Pithomyces chartarum. It is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants. | sporidesmin A |
| t-2 toxin | A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. | T-2 toxin |
| terphenyllin | A para-terphenyl that is 1,1':4',1''-terphenyl substituted by methoxy groups at positions 3' and 6' and hydroxy groups at positions 2', 4 and 4''. It has been isolated from Aspergillus taichungensis. | terphenyllin |
| terreic acid | | terreic acid |
| tryptoquivaline | An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi. A potent and specific inhibitor of the breast cancer resistance protein multidrug transporter. | fumitremorgin C |
| ustiloxin b | A heterodetic cyclic peptide with formula C26H39N5O12S produced by Ustilaginoidea virens fungi. It is an inhibitor of microtubule assembly. | ustiloxin B |
| verruculogen | An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species. | verruculogen |
| violaceol II | An aromatic ether in which the ether functionality links a 2,3-dihydroxy-5-methylphenyl group with a 2,6-dihydroxy-4-methylphenyl group. Fungal metabolite isolated inter alia from Aspergillus spp. | violaceol II |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 29.1570 | 1 | 5 |
| 67.9K protein | Vaccinia virus | Potency | 8.1271 | 2 | 6 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 31.9572 | 4 | 5 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.8325 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.1276 | 1 | 5 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 27.7170 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 4.4668 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 32.5833 | 7 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 44.9189 | 3 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 9.0226 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.7755 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 9.0226 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 7.5949 | 3 | 3 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 63.9051 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 4.7010 | 3 | 4 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.2663 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 24.1296 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 10.2663 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 25.1189 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.3708 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.8396 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 11.1528 | 3 | 5 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 19.0728 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.8396 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 45.8624 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.9763 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 35.4921 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 30.1601 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 49.6295 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 28.9342 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 14.1254 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.8291 | 9 | 13 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.8336 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 20.3851 | 5 | 8 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.1187 | 1 | 6 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 16.6958 | 3 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.9763 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 4.6784 | 2 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 59.6338 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 13.3001 | 1 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.8712 | 5 | 7 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 28.7388 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 39.6411 | 2 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 3.7694 | 2 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 20.9030 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 6.7508 | 1 | 3 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 1.9282 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 1.2589 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 19.7312 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.0894 | 2 | 7 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 26.7820 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0631 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.2293 | 3 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 3.8056 | 1 | 3 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 5.3959 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.3655 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.5520 | 2 | 2 |
| Parkin | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 3.4887 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 5.7458 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.4369 | 3 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 21.2526 | 1 | 3 |
| PINK1 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 4.6352 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 35.4454 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 35.4481 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.9713 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 23.0265 | 4 | 6 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 6.7400 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 6.7400 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 24.0282 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.4677 | 2 | 9 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 19.4769 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.6993 | 2 | 21 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 32.5455 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 42.9350 | 1 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.5074 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 19.3492 | 2 | 3 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 30.1475 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 4.6352 | 1 | 3 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 4.6352 | 1 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 61.2757 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 30.2744 | 5 | 7 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 5.8975 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 36.0454 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 23.6829 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0008 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.0008 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0027 | 2 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0032 | 4 | 5 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0065 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0019 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0022 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0560 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0290 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0560 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0290 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 0.0215 | 4 | 5 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0009 | 1 | 1 |
| Acetolactate synthase catalytic subunit, mitochondrial | Saccharomyces cerevisiae S288C | IC50 | 0.2000 | 1 | 1 |
| Adenylate cyclase | Arthrospira platensis | IC50 | 70.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0490 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0240 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0021 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0038 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0018 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.0120 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0018 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 1.7100 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 1.8080 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 56.5750 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 103.4000 | 2 | 2 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 4.1420 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 2.3920 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 2.7610 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 1.8980 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 1.5899 | 12 | 12 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Ki | 1.3000 | 1 | 1 |
| BZLF2 | Human herpesvirus 4 type 2 (Epstein-Barr virus type 2) | IC50 | 2.0300 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 58.0000 | 1 | 1 |
| Chain A, Inosine-5'-Monophosphate Dehydrogenase 2 | Cricetulus griseus (Chinese hamster) | Ki | 0.0060 | 1 | 1 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 1.7280 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.8640 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0043 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0014 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0043 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0015 | 1 | 1 |
| Delta-aminolevulinic acid dehydratase | Escherichia coli K-12 | Ki | 44,900.0000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 13.7700 | 1 | 1 |
| E3 ubiquitin-protein ligase RNF31 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Genome polyprotein | | IC50 | 3.8000 | 1 | 1 |
| Geranylgeranyl transferase type-1 subunit beta | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0140 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0140 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 0.0140 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 0.0140 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 3.4650 | 2 | 2 |
| Histone-lysine N-methyltransferase SUV39H1 | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase | Cryptococcus neoformans var. neoformans JEC21 | IC50 | 0.1200 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase 1 | Homo sapiens (human) | IC50 | 3.3977 | 6 | 6 |
| Inosine-5'-monophosphate dehydrogenase 1 | Homo sapiens (human) | Ki | 0.0365 | 8 | 8 |
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | IC50 | 1.1421 | 20 | 20 |
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | Ki | 0.0084 | 8 | 8 |
| Isocitrate lyase | Candida albicans | IC50 | 32.6164 | 11 | 11 |
| Isocitrate lyase | Mycobacterium tuberculosis H37Rv | IC50 | 116.0000 | 1 | 1 |
| Isocitrate lyase 1 | Mycobacterium tuberculosis CDC1551 | IC50 | 14.7000 | 1 | 1 |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | Mycobacterium tuberculosis H37Rv | IC50 | 2,500.0000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 4.7900 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 4.7900 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| MPI protein | Homo sapiens (human) | IC50 | 39.4790 | 1 | 1 |
| Mycothiol S-conjugate amidase | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | IC50 | 4.7900 | 1 | 1 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | IC50 | 40.5500 | 2 | 2 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | IC50 | 32.7000 | 3 | 3 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 22.6400 | 1 | 1 |
| RanBP-type and C3HC4-type zinc finger-containing protein 1 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 5.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Sharpin | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 4.1000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 3 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 4 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 48.9890 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 6.2548 | 1 | 2 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 4.7900 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Tat | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 3.0640 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 33.5500 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 3.1600 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 6.4990 | 1 | 1 |
| Vif | Human immunodeficiency virus 1 | IC50 | 13.7700 | 1 | 1 |