Roles > EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor
Page last updated: 2024-08-05 15:45:15

EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor

An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of fatty acid amide hydrolase (EC 3.5.1.99).

ChEBI ID: 64033

Members (4)

MemberDefinitionClass
arachidonoylserotoninAn N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin.N-arachidonoylserotonin
biochanin aA member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.biochanin A
linoleoyl ethanolamideAn N-acylethanolamine 18:2 that is the ethanolamide of linoleic acid.linoleoyl ethanolamide
n-benzylhexadecanamideA macamide resulting from the formal condensation of the carboxy group of hexadecanoic acid with benzylamine. A moderate inhibitor of fatty acid amide hydrolase.N-benzylhexadecanamide

Research

Studies (493)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19907 (1.42)18.7374
1990's39 (7.91)18.2507
2000's146 (29.61)29.6817
2010's230 (46.65)24.3611
2020's71 (14.40)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials8 (1.56%)5.53%
Reviews21 (4.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational1 (0.19%)0.25%
Other483 (94.15%)84.16%

Protein Targets (130)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency37.646012
activating transcription factor 6Homo sapiens (human)Potency57.601222
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency7.996012
AR proteinHomo sapiens (human)Potency14.4912918
aryl hydrocarbon receptorHomo sapiens (human)Potency8.320424
ATAD5 protein, partialHomo sapiens (human)Potency10.796044
Ataxin-2Homo sapiens (human)Potency2.618412
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency3.001524
BRCA1Homo sapiens (human)Potency2.511911
Cellular tumor antigen p53Homo sapiens (human)Potency60.445623
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency11.294722
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency33.552012
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency1.258911
Chain A, Ferritin light chainEquus caballus (horse)Potency31.622811
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency48.022412
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
cytochrome P450 2C19 precursorHomo sapiens (human)Potency7.943311
cytochrome P450 2C9 precursorHomo sapiens (human)Potency0.025111
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency31.622811
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency19.952622
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.345212
estrogen nuclear receptor alphaHomo sapiens (human)Potency15.30501020
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency7.660235
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency6.5847612
EWS/FLI fusion proteinHomo sapiens (human)Potency37.221211
farnesoid X nuclear receptorHomo sapiens (human)Potency15.486411
GABA theta subunitRattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency19.952611
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency19.952611
gemininHomo sapiens (human)Potency9.812212
GLI family zinc finger 3Homo sapiens (human)Potency10.382834
glp-1 receptor, partialHomo sapiens (human)Potency0.501211
glucocerebrosidaseHomo sapiens (human)Potency2.238711
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency54.947711
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency1.640012
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency12.589311
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency0.025113
histone deacetylase 9 isoform 3Homo sapiens (human)Potency16.644424
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency52.825812
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency10.000022
Integrin alpha-IIbHomo sapiens (human)Potency12.589311
Integrin beta-3Homo sapiens (human)Potency12.589311
Interferon betaHomo sapiens (human)Potency16.538813
lamin isoform A-delta10Homo sapiens (human)Potency28.183811
LuciferasePhotinus pyralis (common eastern firefly)Potency5.804923
Microtubule-associated protein tauHomo sapiens (human)Potency15.355225
mitogen-activated protein kinase 1Homo sapiens (human)Potency15.848911
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency2.238711
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency30.083024
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency38.499812
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency24.035322
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency23.779436
P53Homo sapiens (human)Potency56.234111
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency15.848911
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency28.819623
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency21.632422
phosphopantetheinyl transferaseBacillus subtilisPotency50.118712
plasminogen precursorMus musculus (house mouse)Potency2.238711
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency15.848911
PPM1D proteinHomo sapiens (human)Potency16.538812
pregnane X nuclear receptorHomo sapiens (human)Potency30.762612
progesterone receptorHomo sapiens (human)Potency6.138012
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.333924
ras-related protein Rab-9AHomo sapiens (human)Potency2.818411
regulator of G-protein signaling 4Homo sapiens (human)Potency0.106211
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency0.618935
retinoid X nuclear receptor alphaHomo sapiens (human)Potency38.209122
SMAD family member 2Homo sapiens (human)Potency22.051811
SMAD family member 3Homo sapiens (human)Potency22.051811
survival motor neuron protein isoform dHomo sapiens (human)Potency18.867712
TAR DNA-binding protein 43Homo sapiens (human)Potency3.162311
TDP1 proteinHomo sapiens (human)Potency25.692324
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency63.259424
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency2.238711
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency2.238711
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency66.595212
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency7.761611
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency79.432811
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency1.640012

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)IC509.900022
Aldo-keto reductase family 1 member B1Homo sapiens (human)IC50127.000011
Aldo-keto reductase family 1 member B10Homo sapiens (human)IC5036.100011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC500.400011
Amine oxidase [flavin-containing] BHomo sapiens (human)IC500.400011
Androgen receptorHomo sapiens (human)IC501,600.000011
AromataseHomo sapiens (human)IC505,647,400,049.001766
AromataseHomo sapiens (human)Ki12.000044
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)IC508.000011
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC500.524011
Bifunctional epoxide hydrolase 2Mus musculus (house mouse)IC500.422011
Bifunctional epoxide hydrolase 2Rattus norvegicus (Norway rat)IC500.370011
Cannabinoid receptor 1Homo sapiens (human)Ki41.400011
Cannabinoid receptor 1Rattus norvegicus (Norway rat)Ki12.400024
Carbonic anhydrase 1Homo sapiens (human)Ki10.000011
Carbonic anhydrase 12Homo sapiens (human)Ki0.052511
Carbonic anhydrase 2Homo sapiens (human)Ki10.000011
Carbonic anhydrase 4Homo sapiens (human)Ki7.078511
Carbonic anhydrase 7Homo sapiens (human)Ki0.371511
Carbonyl reductase [NADPH] 1Homo sapiens (human)IC5012.710011
Carbonyl reductase [NADPH] 1Homo sapiens (human)Ki2.030011
Fatty-acid amide hydrolase 1Homo sapiens (human)IC50133.400044
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)IC505.745957
Lysine-specific histone demethylase 1AHomo sapiens (human)IC502.950033
Pancreatic triacylglycerol lipaseSus scrofa (pig)IC50100.000011
Prostaglandin G/H synthase 2Homo sapiens (human)IC505.000011
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)IC50100.000011
Testosterone 17-beta-dehydrogenase 3Homo sapiens (human)IC5010.800011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)IC504.635034
Transient receptor potential cation channel subfamily V member 2Rattus norvegicus (Norway rat)IC501.025022
Triosephosphate isomeraseOryctolagus cuniculus (rabbit)Ki12.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Estrogen receptorMus musculus (house mouse)EC5055.941012
Estrogen receptor betaMus musculus (house mouse)EC5055.941012
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)EC5055.941011
signal transducer and activator of transcription 1-alpha/beta isoform alphaHomo sapiens (human)EC502.060011
STAT3, partialHomo sapiens (human)EC5055.700011
transcription factor p65 isoform 1Homo sapiens (human)EC5055.941011
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)EC5025.000011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)EC500.630011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Androgen receptorHomo sapiens (human)EC1504.200011
AromataseHomo sapiens (human)Log IC500.004511
Glucocorticoid receptorHomo sapiens (human)EC1504.200011