Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire.
ChEBI ID: 79314
| Member | Definition | Class |
|---|---|---|
| belite | An inorganic calcium salt having silicate as the counterion. | calcium silicate |
| calcium silicate | An inorganic calcium salt having silicate as the counterion. | calcium silicate |
| dicyandiamido | A guanidine in which one of the amino hydrogens of guanidine itself is substituted by a cyano group. It is used in the manufacture of fertilizers, pharmaceuticals, explosives, oil well drilling muds, and dyestuffs. | cyanoguanidine |
| pentaerythritol | A tetrol that is neopentane in which one of the methyl hydrogens of all four methyl groups are replaced by hydroxy groups. It is a chemical intermediate used in the production of explosives, plastics, paints, appliances, and cosmetics. | pentaerythritol |
| potassium carbonate | A potassium salt that is the dipotassium salt of carbonic acid. | potassium carbonate |
| triphenyl phosphate | An aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol. | triphenyl phosphate |
| tris(2-butoxyethyl) phosphate | A trialkyl phosphate in which the alkyl group specified is 2-butoxyethyl. | tris(2-butoxyethyl) phosphate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 87 (10.57) | 18.7374 |
| 1990's | 55 (6.68) | 18.2507 |
| 2000's | 146 (17.74) | 29.6817 |
| 2010's | 369 (44.84) | 24.3611 |
| 2020's | 166 (20.17) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 8 (0.92%) | 5.53% |
| Reviews | 13 (1.50%) | 6.00% |
| Case Studies | 8 (0.92%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 840 (96.66%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 21.3335 | 4 | 8 |
| AR protein | Homo sapiens (human) | Potency | 38.4147 | 5 | 9 |
| Ataxin-2 | Homo sapiens (human) | Potency | 68.6594 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 68.6594 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 48.6071 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 32.4814 | 7 | 12 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 27.3474 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 34.6780 | 5 | 18 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 24.7800 | 3 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.0760 | 2 | 8 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 38.6100 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.5012 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 49.2704 | 3 | 10 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 21.7627 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 11.9446 | 3 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.4992 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 10.7890 | 2 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 17.8873 | 2 | 7 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 32.5597 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 20.4614 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 55.8118 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 33.3676 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.0066 | 3 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 33.2695 | 2 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0251 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.7104 | 4 | 9 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 42.1270 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 50.8602 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 38.6100 | 1 | 1 |