An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of alpha-amylase (EC 3.2.1.1).
ChEBI ID: 50627
| Member | Definition | Class |
|---|---|---|
| acarbose | A tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose. | acarbose |
| bisdemethoxycurcumin | A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. | bisdemethoxycurcumin |
| chalcone | The trans-isomer of chalcone. | trans-chalcone |
| epicatechin gallate | A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida. | (-)-epicatechin-3-O-gallate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 167 (5.99) | 18.7374 |
| 1990's | 245 (8.79) | 18.2507 |
| 2000's | 687 (24.65) | 29.6817 |
| 2010's | 1,181 (42.38) | 24.3611 |
| 2020's | 507 (18.19) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 37 (1.29%) | 5.53% |
| Reviews | 139 (4.84%) | 6.00% |
| Case Studies | 1 (0.03%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,694 (93.83%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.2550 | 2 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 17.8030 | 2 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 6.1967 | 2 | 2 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 5.0638 | 4 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.5119 | 1 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 19.9526 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.8489 | 2 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 28.1838 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 100.0000 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.9433 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 19.7929 | 5 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 4.2195 | 2 | 2 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.0000 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | IC50 | 0.2100 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 18.2700 | 1 | 1 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 109.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 5.1000 | 1 | 1 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | IC50 | 0.0600 | 1 | 1 |
| Alpha-amylase | Acarus siro | IC50 | 3.8000 | 1 | 1 |
| Alpha-amylase 1A | Homo sapiens (human) | IC50 | 0.9960 | 1 | 1 |
| Alpha-glucosidase | Blautia obeum | IC50 | 1,030.0000 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 309.9250 | 3 | 4 |
| Alpha-glucosidase MAL32 | Saccharomyces cerevisiae S288C | IC50 | 328.8700 | 3 | 3 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 1.4100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 471.7867 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 64.5654 | 1 | 1 |
| Apoptosis regulator Bcl-2 | Homo sapiens (human) | Ki | 0.2291 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.4000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 47.3000 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 95.6000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 87.0000 | 1 | 1 |
| CPG DNA methylase | Spiroplasma monobiae | IC50 | 0.0300 | 1 | 1 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | IC50 | 10.1275 | 2 | 2 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Homo sapiens (human) | IC50 | 0.5230 | 1 | 1 |
| ELAV-like protein 3 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | Escherichia coli K-12 | IC50 | 10.0000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.3500 | 2 | 2 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.1363 | 3 | 3 |
| Fatty acid synthase | Gallus gallus (chicken) | IC50 | 55.0000 | 2 | 2 |
| Genome polyprotein | Zika virus | IC50 | 89.0000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Saccharomyces cerevisiae S288C | IC50 | 0.1800 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 4 | 4 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 18.1000 | 2 | 2 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 533.1764 | 11 | 11 |
| Lysosomal alpha-glucosidase | Mus musculus (house mouse) | IC50 | 144.4700 | 1 | 2 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 423.9300 | 12 | 12 |
| Mannosyl-oligosaccharide glucosidase | Saccharomyces cerevisiae S288C | IC50 | 13.3400 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 1.4700 | 1 | 1 |
| Multidrug resistance protein CDR1 | Candida albicans | IC50 | 40.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 | 415.9700 | 9 | 10 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | IC50 | 8.7086 | 5 | 5 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | Ki | 48.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 84.4100 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 4.1940 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 4.2450 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Mus musculus (house mouse) | IC50 | 12.2000 | 1 | 1 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | IC50 | 504.7560 | 10 | 10 |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | IC50 | 22.1000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 36.3700 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 11.2000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 0.1940 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 0.7600 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 36.3700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 3.8019 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 2.0700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 4.4668 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 3.4600 | 1 | 1 |
| Sortase A | Streptococcus mutans | IC50 | 5.0000 | 1 | 1 |
| Stromal cell-derived factor 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 504.7560 | 10 | 10 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 20.2000 | 1 | 1 |
| Synaptojanin-1 | Homo sapiens (human) | IC50 | 15.9000 | 2 | 2 |
| Synaptojanin-2 | Homo sapiens (human) | IC50 | 2.8800 | 3 | 3 |
| Thioredoxin reductase 1, cytoplasmic | Rattus norvegicus (Norway rat) | IC50 | 36.5500 | 2 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 620.0000 | 1 | 1 |
| Tumor necrosis factor receptor superfamily member 1A | Homo sapiens (human) | IC50 | 23.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Delta-type opioid receptor | Homo sapiens (human) | Ke | 1.7000 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | Activity | 1.7800 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ke | 1.9000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ke | 1.5000 | 1 | 1 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | Kii | 5.8700 | 1 | 1 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | Kis | 31.6000 | 1 | 1 |
| Quinone oxidoreductase | Mus musculus (house mouse) | CD | 31.0000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | CD | 31.0000 | 1 | 1 |