Any compound that interferes with bacterial communication (quorum sensing, QS).
ChEBI ID: 138977
| Member | Definition | Class |
|---|---|---|
| 2,3,4-trihydroxbenzophenone | A benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator. | 2,3,4-trihydroxbenzophenone |
| equisetin | A member of the class of tetramic acids that is trichosetin in which the hydrogen attached to the lactam nitrogen has been replaced by a methyl group. It is produced by the filamentous fungus Fusarium heterosporum. | equisetin |
| iberin | An isothiocyanate that is 1-isothiocyanatopropane in which a hydrogen at position 3 has been replaced by a methylsulfinyl group. A glucosinolate hydrolysis product found in many members of the Brassicaceae family, it is a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa. | iberin |
| n-acetyltyramine | A member of the class of tyramines that is tyramine in which one of the hydrogens of the amino group is replaced by an acetyl group. | N-acetyltyramine |
| resveratrol | A resveratrol in which the double bond has E configuration. | trans-resveratrol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 7 (0.07) | 18.7374 |
| 1990's | 137 (1.27) | 18.2507 |
| 2000's | 2,110 (19.60) | 29.6817 |
| 2010's | 6,180 (57.39) | 24.3611 |
| 2020's | 2,334 (21.68) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 242 (2.19%) | 5.53% |
| Reviews | 1,363 (12.36%) | 6.00% |
| Case Studies | 11 (0.10%) | 4.05% |
| Observational | 8 (0.07%) | 0.25% |
| Other | 9,402 (85.27%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 21.1972 | 1 | 5 |
| 67.9K protein | Vaccinia virus | Potency | 28.1838 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 33.8225 | 1 | 5 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 12.5893 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 14.7481 | 11 | 32 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 21.8561 | 3 | 9 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.3793 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 7.0272 | 4 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 24.1085 | 2 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 9.5283 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 18.5162 | 2 | 8 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 20.7491 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 2 | 2 |
| BRCA1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 3.0560 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 3.0560 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 49.9749 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 8.7699 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.7501 | 1 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 44.6684 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 34.3521 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 34.3521 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 12.5595 | 2 | 2 |
| ClpP | Bacillus subtilis | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.7717 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.9811 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 9.5114 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 3.3297 | 1 | 4 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 3.6898 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 36.4261 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 18.2563 | 1 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.6620 | 12 | 38 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 12.5571 | 3 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 5.9983 | 10 | 23 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 21.9547 | 1 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 9.7717 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 23.5304 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 33.3628 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 7.5060 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 16.0784 | 2 | 5 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 31.0994 | 1 | 3 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 0.6488 | 2 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 19.9526 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 2.0396 | 2 | 6 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 53.2986 | 2 | 8 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.7717 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 32.6427 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.7717 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 9.7717 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 16.0252 | 2 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 13.6707 | 3 | 7 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 39.5068 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.1585 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.2664 | 2 | 7 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 11.9899 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 27.2567 | 4 | 14 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 2.3710 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.3026 | 4 | 10 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 28.2258 | 3 | 15 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 1.1582 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 42.5615 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.9505 | 3 | 7 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.1966 | 4 | 6 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 9.9621 | 2 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 13.5294 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 33.8211 | 3 | 8 |
| progesterone receptor | Homo sapiens (human) | Potency | 22.5543 | 2 | 4 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 17.7828 | 2 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 2.1208 | 2 | 6 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 16.5370 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 44.2490 | 3 | 13 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 47.3021 | 2 | 3 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 11.0912 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 17.7771 | 1 | 4 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.2735 | 2 | 11 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 20.5178 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 49.3299 | 2 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 69.2658 | 1 | 3 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 13.5294 | 2 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 13.5294 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 3.0899 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 31.0994 | 1 | 3 |
| WRN | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 1,000.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 13.6560 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 160.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.2930 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | Ki | 21.5000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 9.8297 | 4 | 4 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 22.2367 | 3 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 11.5375 | 12 | 12 |
| Aromatase | Homo sapiens (human) | IC50 | 30.2267 | 6 | 6 |
| Aromatase | Homo sapiens (human) | Ki | 41.6700 | 1 | 1 |
| Aryl hydrocarbon receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.3743 | 2 | 3 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| Autoinducer 2-binding periplasmic protein LuxP | Vibrio harveyi | IC50 | 4.0000 | 1 | 1 |
| Bcl-2-like protein 1 | Homo sapiens (human) | IC50 | 190.0000 | 1 | 1 |
| Breakpoint cluster region protein | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | IC50 | 1,000.0000 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 2.2100 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.9500 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.0900 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 0.8300 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 9.3600 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 2.7700 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 9.0900 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 4.4700 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 4.7500 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 4.6400 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.0700 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.3500 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| Cathepsin D | Homo sapiens (human) | IC50 | 138.0000 | 1 | 1 |
| cathepsin L1 | Homo sapiens (human) | IC50 | 59.6420 | 1 | 1 |
| Chain A, Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 212.0000 | 1 | 17 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 57.6600 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 400.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 22.6667 | 3 | 3 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 28.2000 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 3.2318 | 4 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 8.1500 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 0.0006 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 25.3100 | 1 | 1 |
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.5797 | 2 | 3 |
| Kelch-like ECH-associated protein 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 26.2000 | 1 | 1 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 289.0000 | 2 | 2 |
| Luciferin 4-monooxygenase | Photinus pyralis (common eastern firefly) | IC50 | 0.0589 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 12.6000 | 2 | 2 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| M18 aspartyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 2.2420 | 1 | 1 |
| Myc proto-oncogene protein | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| N1L | Vaccinia virus | IC50 | 21.9000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.6850 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.6850 | 2 | 2 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 20.4667 | 3 | 3 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| Ornithine decarboxylase | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| Polyphenol oxidase 1 | Agaricus bisporus | IC50 | 10.5000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 45.9500 | 3 | 3 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 49.5138 | 4 | 4 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 2.0250 | 4 | 4 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 6.0046 | 7 | 7 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 3.4900 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | IC50 | 1.3972 | 12 | 12 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | Ki | 0.0880 | 1 | 1 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 40.0000 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.3120 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.2930 | 1 | 1 |
| Squalene synthase | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 400.0000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | IC50 | 15.3750 | 2 | 2 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | IC50 | 6.1975 | 4 | 4 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 40.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 985.1750 | 4 | 4 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 10.7800 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 2,900.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 112.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 525.0000 | 2 | 2 |
| Vif | Human immunodeficiency virus 1 | IC50 | 25.3100 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | Kd | 38.5000 | 1 | 1 |
| Chain A, Troponin C, slow skeletal and cardiac muscles | Homo sapiens (human) | Kd | 243.0000 | 1 | 1 |
| Estrogen receptor | Mus musculus (house mouse) | EC50 | 5.2030 | 1 | 2 |
| Estrogen receptor beta | Mus musculus (house mouse) | EC50 | 5.2030 | 1 | 2 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | EC50 | 52.3333 | 3 | 3 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-3, mitochondrial | Homo sapiens (human) | EC50 | 177.5950 | 2 | 2 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | EC50 | 5.4000 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | EC50 | 5.2030 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 300.0000 | 1 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Kd | 11.7000 | 1 | 1 |
| Protein kinase C alpha type | Homo sapiens (human) | EC50 | 5,780.0000 | 1 | 1 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | Kd | 0.0540 | 1 | 1 |
| serine/threonine-protein kinase 33 isoform a | Homo sapiens (human) | EC50 | 12.3300 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 163.1310 | 1 | 1 |
| transcription factor p65 isoform 1 | Homo sapiens (human) | EC50 | 5.2030 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | Kd | 0.4700 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 163.1310 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | AC50 | 100.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | AC50 | 100.0000 | 1 | 1 |
| Breakpoint cluster region protein | Homo sapiens (human) | AC50 | 100.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | AC50 | 100.0000 | 1 | 1 |
| FAD-linked sulfhydryl oxidase ALR | Homo sapiens (human) | AC50 | 4.0210 | 1 | 1 |
| Myc proto-oncogene protein | Homo sapiens (human) | MED | 55.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | Activity | 48.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | EC1.5 | 46.1333 | 3 | 3 |
| NAD(P)H dehydrogenase [quinone] 1 | Mus musculus (house mouse) | Activity | 20.0000 | 1 | 1 |
| NAD(P)H dehydrogenase [quinone] 1 | Mus musculus (house mouse) | CD | 29.2857 | 7 | 7 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | CD | 21.0000 | 1 | 1 |
| Prenyltransferase homolog | Streptomyces coelicolor A3(2) | Km | 440.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | AC50 | 100.0000 | 1 | 1 |