Vascular Malformations

A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.

Synonym
Vascular Malformations

Excerpt	Reference
"Treatment of vascular malformations is required in case of progression of symptoms."	( Hassler, W; Schick, U, 2009)
"Vascular malformations are the most common sources of bleeding in the small bowel."	( Ell, C; Friesing-Sosnik, T; Manner, H; May, A; Pohl, J, 2011)
"Extensive vascular malformations are often more complex than they appear and require a multidisciplinary therapeutic approach."	( Aguado, L; Martínez-Cuesta, A; Redondo, P, 2011)
"Vascular malformations are uncommon but may confer significant morbidity."	( Lidsky, ME; Shortell, CK; Spritzer, CE, 2012)
"Vascular malformations are uncommonly encountered in the hand."	( Alves, K; Bauer, A; Jupiter, J, 2014)
"Vascular malformations are difficult to treat because of poor results of treatment and recurrence of symptoms."	( Deshpande, NV; Kalyankar, R; Kothekar, S; Mardikar, HM; Mardikar, M, 2014)
"True vascular malformations are divided according to their flow."	( Bergès, O; Galatoire, O; Heran Dreyfus, F; Koskas, P; Lafitte, F; Nau, E, 2016)
"In addition, many vascular malformations are related to deregulation of TGF-β/BMP signaling."	( Cunha, SI; Dejana, E; Lampugnani, MG; Magnusson, PU, 2017)
"Vascular malformations are considered one of the most difficult vascular diseases to treat."	( Claussen, J; Eisenblätter, M; Helfen, A; Karlas, A; Markwardt, NA; Masthoff, M; Ntziachristos, V; Wildgruber, M, 2018)
"Vascular malformations are often found inside the orbit."	( Biglioli, F; Colletti, G; Cucurullo, M; Dessy, M; Petrillo, M; Poli, T; Sesenna, E; Tombris, S; Waner, M, 2019)
"Congenital vascular malformations are a heterogeneous group of lesions with the potential to cause significant lifelong morbidity in children."	( Markovic, JN; Nag, U; Shortell, CK, 2020)
"To date, vascular malformations are frequently managed by invasive techniques, after which recurrence is common."	( Geeurickx, M; Labarque, V, 2021)
"About 50% of vascular malformations are located at the head and neck region where they can usually be associated with functional and/or aesthetic limitations."	( Giraudo, C; Lupi, A; Sibillin, M; Sivolella, S; Zanette, G, 2022)
"Vascular malformations are a complex pathology with few treatment options."	( Bernabeu-Wittel, J; Conejo-Mir Sánchez, J; Domínguez-Cruz, JJ; Durán-Romero, AJ; Hernández-Rodríguez, JC; Monserrat-García, MT; Ortiz-Álvarez, J, 2022)
"Low-flow vascular malformations are rare congenital anomalies due to errors in vascular development and may be associated with known pathogenic genetic variants."	( Oo, HP; Pasricha, SR; Scardamaglia, L; Thompson, B; Winship, I, 2022)
"Low-flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs."	( Angulo-Urarte, A; Baselga, E; Castillo, SD; Celis, V; Esteve-Codina, A; Fanlo, L; Gouveia, L; Graupera, M; Javierre, BM; Kobialka, P; Lavarino, C; López-Fernández, S; Mora, J; Muixí, L; Muñoz-Aznar, O; Olaciregui, NG; Rovira, C; Sabata, H; Vilalta, O; Zanoncello, J, 2022)
"Combined vascular malformations are complex vascular anomalies that have high morbidity and therefore, therapeutic strategies are hard to establish."	( Agüero, R; Chaparro, X; Fischer, C; Hasbún, T; Reculé, F, 2022)
"Vascular malformations are rare diseases and treatment remains controversial."	( Dardik, A; Leal, BAN; Navarro, TP; Procópio, RJ, 2023)

Excerpt	Reference
"Vascular malformations have devastating cosmetic effects in addition to being associated with pain and bleeding."	( Khandpur, S; Sharma, VK, 2010)

Excerpt	Reference
"Sclerotherapy is effective in the treatment of vascular malformations."	( Harii, K; Kaji, N; Kurita, M; Narushima, M; Ozaki, M; Takushima, A; Wakita, S, 2009)
"This study reports our experience in treating low-flow vascular malformations by ultrasound-guided sclerosis with polidocanol foam at the Vascular Medicine Department in Grenoble, France."	( Blaise, S; Brix, M; Carpentier, PH; Charavin-Cocuzza, M; Diamand, JM; Gachet, G; Riom, H; Seinturier, C, 2011)
"Sclerotherapy was effective in the treatment of vascular malformations, and the method chosen was adequate for lesion resolution without complications."	( Costa, JR; D'Avila, OP; de Figueiredo, PJ; Hosni, ES; Torriani, MA, 2011)
"This case report describes propranolol treatment of vascular malformations such as Klippel-Trénaunay syndrome or Parkes-Weber syndrome in adults."	( Buecker, A; Janssen, E; Müller, CS; Pföhler, C; Vogt, T, 2015)
"NBCA-based embolotherapy can be used to treat vascular malformations, acute hemorrhaging, tumors, and venous disease."	( Abe, T; Fujiwara, H; Hamaguchi, S; Higashihara, H; Morishita, H; Murakami, K; Nakajima, Y; Sakamoto, N; Sato, M; Sato, Y; Sofue, K; Takeuchi, Y; Tokue, H; Yonemitsu, T, 2014)
"The current treatment for vascular malformations includes surgery, sclerotherapy, and embolization."	( Li, JL; Li, L; Zhang, Y; Zhou, P, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	11 (1.89)	23.3326
1990's	0 (0.00)	12.5806
2000's	53 (9.11)	18.1394
2010's	373 (64.09)	28.8240
2020's	145 (24.91)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	medium	6	1
salicylic acid	low	5	0
dimethyl sulfoxide	low	2	0
ethanolamine	low	2	0
dalteparin	low	2	0
dihydroxyphenylalanine	low	1	0
niacinamide	low	1	0
pyridoxine	low	1	0
urea	low	2	0
aminopropionitrile	low	1	0
phenytoin	low	2	0
acetazolamide	low	1	0
amiodarone	low	1	0
aspirin	low	3	0
carbamazepine	low	1	0
fentanyl	low	1	0
furosemide	low	1	0
hydrochlorothiazide	low	1	0
hydroxyurea	low	1	0
lidocaine	medium	4	1
iodixanol	low	1	0
iohexol	low	3	0
iopromide	low	1	0
avapro	low	1	0
2-propanol	low	2	0
ketamine	low	1	0
mepivacaine	low	1	0
metronidazole	medium	1	1
midazolam	medium	2	1
phenobarbital	low	1	0
4-phenylbutyric acid	medium	1	1
praziquantel	low	1	0
prilocaine	low	1	0
propranolol	low	11	0
ticlopidine	low	2	0
prednisolone	low	3	0
thyroxine	low	3	0
fluprednisolone	low	1	0
ethinyl estradiol	low	1	0
cycloheximide	low	1	0
tryptophan	low	1	0
arginine	low	1	0
methylprednisolone	low	1	0
quinoxalines	low	1	0
thiophenes	low	2	0
n-(2-hydroxyethyl)ethylenediamine	low	2	0
meglumine	low	2	0
quinazolines	low	1	0
thiazoles	medium	6	1
alpha-aminopyridine	low	1	0
acetylcysteine	low	1	0
deoxycytidine	low	1	0
methylprednisolone hemisuccinate	low	1	0
fluorescein-5-isothiocyanate	low	1	0
enbucrilate	medium	15	1
technetium	low	3	0
titanium	low	2	0
gadolinium	low	5	0
yttrium	low	3	0
barium sulfate	low	1	0
ammonium chloride	low	1	0
phosphotyrosine	low	1	0
carbimazole	low	1	0
phenyl acetate	low	1	0
triamcinolone	low	1	0
ursodeoxycholic acid	low	1	0
4-methoxyamphetamine	low	1	0
timolol	medium	2	1
substance p	low	1	0
propiconazole	medium	36	1
imiquimod	low	1	0
clopidogrel	low	2	0
gemcitabine	low	1	0
temoporfin	medium	2	1
atorvastatin	low	1	0
iopamidol	low	1	0
lercanidipine	low	1	0
fluorodeoxyglucose f18	low	1	0
uk 68798	low	2	0
fibrinogen	low	7	0
yttrium radioisotopes	low	1	0
bosentan anhydrous	low	2	0
tadalafil	low	1	0
methotrexate	low	1	0
potassium titanylphosphate	low	1	0
technetium tc 99m pentetate	low	1	0
angiotensin ii	low	1	0
dabigatran	low	5	0
sorafenib	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
dihydropyridines	low	1	0
carboplatin	low	1	0
fibrin	low	1	0
elastin	low	5	0
inositol 3-phosphate	low	22	0
dehydroascorbic acid	low	2	0
difluprednate	low	1	0
retinol	low	1	0
tacrolimus	low	1	0
y 27632	low	1	0
sodium benzoate	medium	1	1
picibanil	medium	5	1
polidocanol	medium	50	3
ferric ferrocyanide	low	1	0
fusidic acid	low	1	0
zinc oxide	low	1	0
nitinol	low	1	0
vitamin k semiquinone radical	low	1	0
alprostadil	low	1	0
rutin	low	1	0
montelukast	low	1	0
isotretinoin	low	1	0
misoprostol	low	1	0
fondaparinux	low	1	0
ethamolin	medium	13	1
phenylephrine hydrochloride	low	6	0
dorzolamide	low	1	0
levetiracetam	low	1	0
dexmedetomidine	medium	1	1
antimony	low	1	0
aluminum	low	2	0
everolimus	low	2	0
bifenthrin	low	1	0
gadolinium dtpa	low	3	0
rivaroxaban	low	6	0
pexacerfont	low	1	0
psd 502	low	1	0
cediranib	low	1	0
sb 525334	low	1	0
lactulose	medium	1	1
indocyanine green	medium	5	1
bleomycetin	medium	29	8
jaw	low	6	0
cellulose	low	1	0
chitosan	low	2	0
sodium tetradecyl sulfate	low	35	0
sodium pertechnetate tc 99m	low	1	0
gadofosveset trisodium	low	2	0
ponatinib	low	1	0
ethyl cellulose	low	1	0
cardiovascular agents	low	3	0
dcc-2036	low	1	0
ascorbic acid	low	2	0
oxytetracycline, anhydrous	low	1	0
warfarin	low	6	0
phenprocoumon	low	1	0
byl719	medium	7	1
epidermal growth factor	low	1	0
transforming growth factor beta	low	15	0
pyrethrins	low	1	0
caseins	low	1	0
sodium morrhuate	medium	3	1
thromboplastin	low	1	0
sildenafil citrate	low	5	0
eye	low	7	0
blz-100	low	1	0
leptin	low	1	0

Protein Targets (1,598)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	21	0	0	21
USP1 protein, partial	24	0	0	24
TDP1 protein	36	0	0	36
vitamin D3 receptor isoform VDRA	15	0	0	15
importin subunit beta-1 isoform 1	7	0	0	7
flap endonuclease 1	12	0	0	12
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
DNA polymerase eta isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	14	0	0	14
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
geminin	43	0	0	43
DNA polymerase kappa isoform 1	13	0	0	13
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	2	3
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	3
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	2	9	11
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	2	3
Guanine nucleotide-binding protein G	7	0	0	7
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	6	7
Mitogen-activated protein kinase 14	0	6	7	13
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
RAR-related orphan receptor gamma	32	0	0	32
GLI family zinc finger 3	31	0	0	31
AR protein	50	0	0	50
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	39	0	0	39
retinoid X nuclear receptor alpha	26	0	0	26
estrogen nuclear receptor alpha	58	0	0	58
peroxisome proliferator-activated receptor delta	17	0	0	17
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	27	0	0	27
activating transcription factor 6	13	0	0	13
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
Histone H2A.x	14	0	0	14
thyroid hormone receptor beta isoform a	19	0	0	19
heat shock protein beta-1	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
lamin isoform A-delta10	27	0	0	27
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Glutamate receptor 2	17	0	0	17
5-hydroxytryptamine receptor 2C	0	4	1	6
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	6	3	10
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	8	1	9
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	20	0	0	20
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	12	0	0	12
survival motor neuron protein isoform d	10	0	0	10
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	3	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	10	0	0	10
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	3	0	3
GALC protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	31	0	0	31
glucocorticoid receptor [Homo sapiens]	39	0	0	39
estrogen-related nuclear receptor alpha	40	0	0	40
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	2	0	2
arylsulfatase A	14	0	0	14
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	36	0	0	36
Bloom syndrome protein isoform 1	15	0	0	15
peripheral myelin protein 22	18	0	0	18
muscleblind-like protein 1 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	13	5	3	21
ATP-binding cassette sub-family C member 3	0	31	0	31
Multidrug resistance-associated protein 4	0	31	0	33
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	6	1	13
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	43	0	43
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	13	1	22
Carbonic anhydrase 2	0	15	3	26
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Carbonic anhydrase 3	0	6	1	12
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	11	0	12
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	6	0	6
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	11	0	11
Androgen receptor	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	13	5	3	21
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	13	5	3	21
Gamma-aminobutyric acid receptor subunit gamma-2	13	5	3	21
Gamma-aminobutyric acid receptor subunit alpha-5	13	5	3	21
Gamma-aminobutyric acid receptor subunit alpha-3	13	5	3	21
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	5	1	6
Carbonic anhydrase 4	0	9	1	15
Carbonic anhydrase 6	0	6	1	12
Gamma-aminobutyric acid receptor subunit gamma-1	13	5	3	21
Gamma-aminobutyric acid receptor subunit alpha-2	13	5	3	21
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	3	0	3
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	13	5	3	21
Gamma-aminobutyric acid receptor subunit gamma-3	13	5	3	21
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	13	5	3	21
Adenosine receptor A2a	0	2	0	2
Delta-type opioid receptor	0	6	1	7
Cytochrome P450 2C19	0	6	0	6
Delta-type opioid receptor	0	6	0	6
Mu-type opioid receptor	0	6	1	7
Carbonic anhydrase 5A, mitochondrial	0	8	1	15
Carbonic anhydrase	0	2	0	3
Kappa-type opioid receptor	0	3	1	4
Carbonic anhydrase 7	0	7	1	13
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	2	0	3
D(2) dopamine receptor	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	13	6	3	22
Gamma-aminobutyric acid receptor subunit beta-3	13	5	3	21
Gamma-aminobutyric acid receptor subunit beta-2	13	5	3	21
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	5	1	6
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	3	0	4
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	10	1	18
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
GABA theta subunit	13	5	3	21
Canalicular multispecific organic anion transporter 1	0	29	0	29
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	6	0	11
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	13	5	3	21
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	6	1	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	6	1	13
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	16	0	0	16
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	4	0	0	4
pregnane X receptor	5	0	0	5
phosphopantetheinyl transferase	13	0	0	13
NFKB1 protein, partial	6	0	0	6
Microtubule-associated protein tau	13	0	0	13
Thrombopoietin	2	0	0	2
regulator of G-protein signaling 4	7	0	0	7
farnesoid X nuclear receptor	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
D(1A) dopamine receptor	4	0	0	4
thyroid hormone receptor beta isoform 2	26	0	0	26
muscarinic acetylcholine receptor M1	9	0	0	9
Ataxin-2	18	0	0	18
ATP-dependent phosphofructokinase	17	0	0	17
thyroid stimulating hormone receptor	15	0	0	15
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	2	3
peroxisome proliferator activated receptor gamma	25	0	0	25
Cellular tumor antigen p53	30	1	0	31
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
ATAD5 protein, partial	15	0	0	15
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
SMAD family member 2	9	0	0	9
Fumarate hydratase	10	0	0	10
PPM1D protein	12	0	0	12
SMAD family member 3	9	0	0	9
caspase 7, apoptosis-related cysteine protease	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
thyroid stimulating hormone receptor	13	0	0	13
estrogen receptor 2 (ER beta)	18	0	0	18
progesterone receptor	20	0	0	20
EWS/FLI fusion protein	23	0	0	23
pregnane X nuclear receptor	33	0	0	33
G	22	0	0	22
cytochrome P450 2D6	20	0	0	20
polyprotein	10	0	0	10
caspase-3	7	0	0	7
cytochrome P450 2D6 isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	6	0	0	6
cytochrome P450 2C9 precursor	4	0	0	4
chromobox protein homolog 1	24	0	0	24
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	13	0	0	13
cytochrome P450 3A4 isoform 1	13	0	0	13
lethal factor (plasmid)	6	0	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	6	0	6
Lysine-specific demethylase PHF2	0	1	0	1
Interferon beta	29	0	0	29
HLA class I histocompatibility antigen, B alpha chain	22	0	0	22
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	2	4
Integrin beta-3	3	1	0	4
Tyrosine-protein kinase Fyn	0	3	7	10
ATP-dependent translocase ABCB1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	9	0	9
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	8	1	9
Integrin alpha-IIb	3	1	0	4
Beta-1 adrenergic receptor	0	6	1	7
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	9	3	13
Adenosine receptor A3	0	9	1	10
Thyroid hormone receptor alpha	0	1	1	2
Thyroid hormone receptor beta	0	1	1	2
Muscarinic acetylcholine receptor M1	0	5	1	6
Beta-3 adrenergic receptor	0	8	1	9
D(2) dopamine receptor	0	4	1	5
Alpha-1B adrenergic receptor	0	11	1	12
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	6	2	9
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M3	0	5	1	6
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	7	0	7
D(1A) dopamine receptor	0	3	1	4
D(4) dopamine receptor	0	3	0	3
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	8	1	9
Histamine H2 receptor	0	4	0	4
Endothelin-1 receptor	0	7	1	8
5-hydroxytryptamine receptor 2A	0	5	1	6
5-hydroxytryptamine receptor 2C	0	7	1	8
Lysine-specific demethylase 5A	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	7	2	9
D(3) dopamine receptor	0	5	0	5
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	6	0	8
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	7	1	8
5-hydroxytryptamine receptor 2B	0	11	1	12
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	11	1	12
Histamine H2 receptor	5	0	0	5
5-hydroxytryptamine receptor 6	0	5	1	6
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	17	0	2	19
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	6	0	6
Potassium voltage-gated channel subfamily H member 2	0	15	0	16
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	7	0	7
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	6	0	6
Lysine-specific demethylase 7A	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	22	0	0	22
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	8	1	9
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	2	0	2
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
cytochrome P450 2C9, partial	22	0	0	22
glucocerebrosidase	2	0	0	2
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	3	0	3
Type-1 angiotensin II receptor	0	5	3	9
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	3	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
GLS protein	10	0	0	10
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	9	0	0	9
IDH1	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Polyphenol oxidase 2	0	3	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	3
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
hypothetical protein, conserved	2	0	0	2
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	6	7	13
Fatty acid-binding protein, liver	0	2	0	2
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Substance-P receptor	0	4	0	4
Prostaglandin G/H synthase 2	0	5	2	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
Chain A, Cruzipain	6	0	0	6
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	7	0	8
Solute carrier organic anion transporter family member 1B1	0	3	0	5
Luciferase	9	0	0	9
lysosomal alpha-glucosidase preproprotein	5	0	0	5
Neuronal acetylcholine receptor subunit alpha-4	4	0	0	4
Neuronal acetylcholine receptor subunit beta-2	4	0	0	4
Thromboxane A2 receptor	0	0	0	1
Sodium/bile acid cotransporter	0	7	0	7
Multidrug and toxin extrusion protein 1	0	5	0	5
Leukotriene B4 receptor 2	0	0	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
Bile salt export pump	0	12	0	12
Nuclear receptor subfamily 1 group I member 2	0	0	6	6
Endothelin receptor type B	0	2	0	2
Endothelin receptor type B	0	3	1	4
Endothelin-1 receptor	0	2	1	3
Endothelin receptor type B	0	0	1	1
Deoxyhypusine synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	7	7
Membrane-associated progesterone receptor component 1	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	2	4
Serine/threonine-protein kinase PLK4	0	1	7	8
ATP-dependent RNA helicase DDX3X	0	0	7	7
Pyridoxal kinase	0	0	7	8
Citron Rho-interacting kinase	0	0	7	7
Serine/threonine-protein kinase Chk1	0	0	7	7
Aurora kinase A	0	1	7	8
Cyclin-G-associated kinase	0	0	7	7
Ephrin type-B receptor 6	0	0	7	7
Peroxisomal acyl-coenzyme A oxidase 3	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 2	0	2	7	9
Dynamin-like 120 kDa protein, mitochondrial	0	0	7	7
Eukaryotic translation initiation factor 5B	0	0	5	5
Rho-associated protein kinase 2	0	2	7	9
Serine/threonine-protein kinase ULK1	0	0	7	7
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	7	7
Ribosomal protein S6 kinase alpha-5	0	1	7	8
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	7	7
Ribosomal protein S6 kinase alpha-4	0	0	7	7
Serine/threonine-protein kinase 16	0	0	7	7
Serine/threonine-protein kinase 10	0	0	7	7
Serine/threonine-protein kinase D3	0	0	7	7
Structural maintenance of chromosomes protein 2	0	0	7	7
Mitogen-activated protein kinase kinase kinase 6	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	7	7
Serine/threonine-protein kinase LATS1	0	0	7	7
Serine/threonine-protein kinase PAK 4	0	0	7	7
Tyrosine-protein kinase ABL1	0	5	9	14
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	3	3
ADP/ATP translocase 2	0	0	7	7
Protein kinase C beta type	0	0	7	7
Insulin receptor	0	1	7	8
Tyrosine-protein kinase Lck	0	2	7	10
Cyclin-dependent kinase 1	0	0	7	7
Glycogen phosphorylase, liver form	0	0	7	7
Tyrosine-protein kinase Fes/Fps	0	0	7	7
Adenine phosphoribosyltransferase	0	0	6	6
Tyrosine-protein kinase Yes	0	2	7	9
Tyrosine-protein kinase Lyn	0	1	7	8
Proto-oncogene tyrosine-protein kinase receptor Ret	0	3	7	10
Insulin-like growth factor 1 receptor	0	1	7	8
Signal recognition particle receptor subunit alpha	0	0	6	6
Cytochrome c1, heme protein, mitochondrial	0	0	7	7
Hepatocyte growth factor receptor	0	2	7	9
Tyrosine-protein kinase HCK	0	2	7	9
Platelet-derived growth factor receptor beta	0	3	7	10
Serine/threonine-protein kinase A-Raf	0	1	7	8
Glycogen phosphorylase, brain form	0	0	7	7
Breakpoint cluster region protein	0	3	8	11
Serine/threonine-protein kinase pim-1	0	0	7	7
Fibroblast growth factor receptor 1	0	3	7	11
DNA topoisomerase 2-alpha	0	0	7	7
Cyclin-dependent kinase 4	0	1	7	8
ADP/ATP translocase 3	0	0	7	7
Inosine-5'-monophosphate dehydrogenase 2	0	0	7	7
Proto-oncogene tyrosine-protein kinase Src	0	2	7	10
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	7	7
Serine/threonine-protein kinase B-raf	0	3	8	11
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	7	7
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	7	9
Tyrosine-protein kinase Fer	0	0	7	7
Protein kinase C alpha type	0	0	7	7
cAMP-dependent protein kinase catalytic subunit alpha	0	2	7	9
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	7	7
Casein kinase II subunit alpha'	0	0	7	7
Ras-related protein Rab-6A	0	0	7	7
Ephrin type-A receptor 1	0	1	7	8
Multifunctional protein ADE2	0	0	7	7
cAMP-dependent protein kinase catalytic subunit gamma	0	1	5	6
cAMP-dependent protein kinase catalytic subunit beta	0	1	7	8
Ferrochelatase, mitochondrial	0	0	7	7
Ribosomal protein S6 kinase beta-1	0	0	7	7
Tyrosine-protein kinase JAK1	0	1	7	8
Beta-adrenergic receptor kinase 1	0	0	7	7
Probable ATP-dependent RNA helicase DDX6	0	0	7	7
Mitogen-activated protein kinase 3	0	1	7	8
MAP/microtubule affinity-regulating kinase 3	0	0	7	7
Deoxycytidine kinase	0	0	7	9
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Mitogen-activated protein kinase 1	0	2	7	9
Ephrin type-A receptor 2	0	1	7	8
Ephrin type-B receptor 2	0	0	7	7
Non-receptor tyrosine-protein kinase TYK2	0	0	7	7
UMP-CMP kinase	0	0	4	4
Phosphatidylethanolamine-binding protein 1	0	0	5	5
Wee1-like protein kinase	0	0	7	7
Heme oxygenase 2	0	0	7	7
S-adenosylmethionine synthase isoform type-2	0	0	6	6
DnaJ homolog subfamily A member 1	0	0	7	7
RAC-alpha serine/threonine-protein kinase	0	0	7	7
RAC-beta serine/threonine-protein kinase	0	0	7	7
DNA replication licensing factor MCM4	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 2	0	0	7	7
Receptor-type tyrosine-protein kinase FLT3	0	4	7	11
Bone morphogenetic protein receptor type-1A	0	0	7	7
Activin receptor type-1B	0	0	7	7
TGF-beta receptor type-1	0	1	7	8
Electron transfer flavoprotein subunit beta	0	0	6	6
Tyrosine-protein kinase CSK	0	1	7	8
Glycine--tRNA ligase	0	0	7	7
Protein kinase C iota type	0	0	7	7
Exosome RNA helicase MTR4	0	0	7	7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	2	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	2	4
Serine/threonine-protein kinase mTOR	0	5	4	9
Tyrosine-protein kinase Tec	0	0	7	7
Tyrosine-protein kinase ABL2	0	0	7	7
Tyrosine-protein kinase FRK	0	1	7	8
Tyrosine-protein kinase SYK	0	0	7	7
26S proteasome regulatory subunit 6B	0	0	7	7
Mitogen-activated protein kinase 8	0	0	7	7
Mitogen-activated protein kinase 9	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 3	0	0	7	7
Casein kinase I isoform alpha	0	1	7	8
Casein kinase I isoform delta	0	0	7	7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	2	4
MAP kinase-activated protein kinase 2	0	0	7	7
Elongation factor Tu, mitochondrial	0	0	7	7
Cysteine--tRNA ligase, cytoplasmic	0	0	6	6
Casein kinase I isoform epsilon	0	0	7	7
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	7	7
Dual specificity protein kinase CLK1	0	0	7	7
Dual specificity protein kinase CLK2	0	0	7	7
Glycogen synthase kinase-3 alpha	0	0	7	7
Glycogen synthase kinase-3 beta	0	2	7	9
Cyclin-dependent kinase 7	0	0	7	7
Cyclin-dependent kinase 9	0	0	7	7
Interleukin-1 receptor-associated kinase 1	0	0	7	7
Ribosomal protein S6 kinase alpha-3	0	0	7	7
Serine/threonine-protein kinase Nek2	0	0	7	7
Serine/threonine-protein kinase Nek3	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 6	0	0	7	7
LIM domain kinase 1	0	0	7	7
LIM domain kinase 2	0	0	7	7
Mitogen-activated protein kinase 10	0	1	7	8
Tyrosine--tRNA ligase, cytoplasmic	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-1	0	0	7	8
Ephrin type-B receptor 3	0	0	7	7
Ephrin type-A receptor 5	0	0	7	7
Ephrin type-B receptor 4	0	1	7	8
Ephrin type-A receptor 4	0	0	7	7
Adenylate kinase 2, mitochondrial	0	0	7	7
Adenosine kinase	0	0	7	7
Ras-related protein Rab-10	0	0	7	7
Actin-related protein 3	0	0	7	7
Actin-related protein 2	0	0	7	7
GTP-binding nuclear protein Ran	0	0	7	7
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Cyclin-dependent kinase 3	0	0	6	6
Cyclin-dependent kinase 6	0	1	7	8
Cyclin-dependent-like kinase 5	0	0	7	7
Cyclin-dependent kinase 16	0	0	7	7
ATP-dependent 6-phosphofructokinase, platelet type	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 1	0	1	7	8
DNA topoisomerase 2-beta	0	0	7	7
Protein kinase C theta type	0	0	6	6
Activin receptor type-1	0	0	7	7
Macrophage-stimulating protein receptor	0	0	7	7
Focal adhesion kinase 1	0	0	7	7
Protein kinase C delta type	0	0	7	7
Tyrosine-protein kinase BTK	0	0	7	7
Activated CDC42 kinase 1	0	0	7	7
Epithelial discoidin domain-containing receptor 1	0	1	7	8
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	7	7
Serine/threonine-protein kinase 4	0	0	7	7
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	7	8
Dual specificity mitogen-activated protein kinase kinase 5	0	0	7	7
Mitogen-activated protein kinase 7	0	0	7	7
Serine/threonine-protein kinase PAK 2	0	0	7	7
Serine/threonine-protein kinase 3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 1	0	0	7	7
Serine-protein kinase ATM	0	1	0	1
Rho-associated protein kinase 1	0	2	7	9
Non-receptor tyrosine-protein kinase TNK1	0	0	7	7
Serine/threonine-protein kinase ATR	0	1	3	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	7	7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	7	7
Bone morphogenetic protein receptor type-2	0	0	7	7
Protein-tyrosine kinase 6	0	0	7	7
cGMP-dependent protein kinase 1	0	0	6	6
Cyclin-dependent kinase 13	0	0	7	7
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	7	7
Protein-tyrosine kinase 2-beta	0	0	7	7
Maternal embryonic leucine zipper kinase	0	0	7	7
Structural maintenance of chromosomes protein 1A	0	0	7	7
Chromodomain-helicase-DNA-binding protein 4	0	0	7	7
Peroxisomal acyl-coenzyme A oxidase 1	0	0	7	7
Ephrin type-A receptor 7	0	0	4	4
Delta(24)-sterol reductase	0	0	7	7
Ribosomal protein S6 kinase alpha-1	0	0	7	7
Dual specificity testis-specific protein kinase 1	0	0	7	7
Myosin light chain kinase, smooth muscle	0	0	7	7
Serine/threonine-protein kinase STK11	0	0	7	7
Serine/threonine-protein kinase N1	0	0	7	7
Serine/threonine-protein kinase N2	0	1	7	8
Mitogen-activated protein kinase kinase kinase 11	0	0	7	7
Discoidin domain-containing receptor 2	0	1	7	8
AP2-associated protein kinase 1	0	0	7	7
Myosin light chain kinase 3	0	0	6	6
Putative heat shock protein HSP 90-beta 2	0	0	7	7
Serine/threonine-protein kinase MRCK alpha	0	0	7	7
Serine/threonine-protein kinase MRCK gamma	0	0	7	7
Acyl-CoA dehydrogenase family member 10	0	0	7	7
Serine/threonine-protein kinase ULK3	0	0	7	7
Uncharacterized protein FLJ45252	0	0	7	7
Acyl-CoA dehydrogenase family member 11	0	0	7	7
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	6	6
Serine/threonine-protein kinase MARK2	0	0	7	7
Serine/threonine-protein kinase TAO1	0	0	7	7
STE20-related kinase adapter protein alpha	0	0	7	7
Myosin-14	0	0	7	7
AarF domain-containing protein kinase 1	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	7	7
MAP kinase-activated protein kinase 5	0	0	6	6
Misshapen-like kinase 1	0	0	5	5
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	1	0	1
Atypical kinase COQ8A, mitochondrial	0	0	7	7
Mitogen-activated protein kinase 15	0	0	7	7
Serine/threonine-protein kinase Nek9	0	0	7	7
ATP-dependent RNA helicase DDX1	0	0	7	7
Aurora kinase B	0	0	7	7
Serine/threonine-protein kinase Nek1	0	0	7	7
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	7	7
EKC/KEOPS complex subunit TP53RK	0	0	7	7
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	7	7
Mitogen-activated protein kinase kinase kinase 5	0	0	7	7
Mitogen-activated protein kinase kinase kinase 3	0	0	7	7
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	7	7
Nucleolar GTP-binding protein 1	0	0	6	6
Serine/threonine-protein kinase D2	0	0	7	7
NUAK family SNF1-like kinase 2	0	0	6	6
RNA cytidine acetyltransferase	0	0	7	7
Serine/threonine-protein kinase SIK2	0	0	7	7
STE20-like serine/threonine-protein kinase	0	0	7	7
Serine/threonine-protein kinase TAO3	0	0	7	7
dCTP pyrophosphatase 1	0	0	7	7
Dual specificity protein kinase CLK4	0	0	6	6
Casein kinase I isoform gamma-1	0	0	7	7
Phenylalanine--tRNA ligase beta subunit	0	0	7	7
Isoleucine--tRNA ligase, mitochondrial	0	0	4	4
BMP-2-inducible protein kinase	0	0	7	7
Obg-like ATPase 1	0	0	7	7
Midasin	0	0	7	7
Interleukin-1 receptor-associated kinase 4	0	0	7	7
Mitogen-activated protein kinase kinase kinase 20	0	0	7	7
Cyclin-dependent kinase 12	0	0	7	7
Serine/threonine-protein kinase 26	0	0	7	7
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-2	0	0	7	8
Serine/threonine-protein kinase TBK1	0	0	7	7
Septin-9	0	0	7	7
Ribosomal protein S6 kinase alpha-6	0	0	7	7
TRAF2 and NCK-interacting protein kinase	0	0	7	7
Serine/threonine-protein kinase TAO2	0	0	7	7
Serine/threonine-protein kinase ICK	0	0	6	6
RAC-gamma serine/threonine-protein kinase	0	0	7	7
Serine/threonine-protein kinase SIK3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 2	0	0	7	7
Thyroid hormone receptor-associated protein 3	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 3	0	2	7	9
Serine/threonine-protein kinase MRCK beta	0	0	7	7
Interleukin-1 receptor-associated kinase 3	0	0	7	7
Casein kinase I isoform gamma-3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 4	0	0	7	7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	1
Vpr	4	0	0	4
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Cytochrome P450 2J2	0	7	0	7
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Lactoperoxidase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Leukotriene C4 synthase	0	0	2	2
tyrosine-protein kinase Yes	5	0	0	5
Cell division cycle 7-related protein kinase	0	0	4	4
Serine/threonine-protein kinase 25	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 7	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	3
Peripheral plasma membrane protein CASK	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	2	2
3-phosphoinositide-dependent protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	6	6
NUAK family SNF1-like kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Tyrosine-protein kinase JAK2	0	1	4	5
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	2	2
Cyclin-dependent kinase-like 5	0	0	3	3
Serine/threonine-protein kinase 17B	0	0	2	2
Cyclin-dependent kinase 14	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	2	2
RAF proto-oncogene serine/threonine-protein kinase	0	2	2	4
High affinity nerve growth factor receptor	0	2	5	7
Macrophage colony-stimulating factor 1 receptor	0	2	2	4
Proto-oncogene tyrosine-protein kinase ROS	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	6	6
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	3	3	6
Insulin receptor-related protein	0	0	2	2
Platelet-derived growth factor receptor alpha	0	3	2	5
Vascular endothelial growth factor receptor 1	0	3	2	5
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	2	2
Fibroblast growth factor receptor 2	0	1	2	3
Receptor tyrosine-protein kinase erbB-3	0	0	2	2
Fibroblast growth factor receptor 4	0	1	2	3
Fibroblast growth factor receptor 3	0	1	2	3
Protein kinase C eta type	0	0	2	2
Activin receptor type-2A	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	2	2
Leukocyte tyrosine kinase receptor	0	1	2	3
Tyrosine-protein kinase receptor UFO	0	0	2	2
Mitogen-activated protein kinase 4	0	0	2	2
G protein-coupled receptor kinase 4	0	0	2	2
Dual specificity protein kinase TTK	0	0	6	6
Myosin-10	0	0	6	6
Tyrosine-protein kinase receptor Tie-1	0	0	2	2
Vascular endothelial growth factor receptor 3	0	2	2	4
Vascular endothelial growth factor receptor 2	0	4	3	9
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	6	6
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase TXK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	5	5
Tyrosine-protein kinase ZAP-70	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	5	5
Cyclin-dependent kinase 8	0	1	2	3
Choline-phosphate cytidylyltransferase A	0	0	4	4
Dual specificity protein kinase CLK3	0	0	5	5
Ras-related protein Rab-27A	0	0	6	6
Tyrosine-protein kinase Blk	0	0	2	2
Cytoplasmic tyrosine-protein kinase BMX	0	0	2	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	2	2
Tyrosine-protein kinase JAK3	0	0	2	2
Serine/threonine-protein kinase PLK1	0	1	6	7
Death-associated protein kinase 1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	2	3
Ephrin type-B receptor 1	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Cell division control protein 2 homolog	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
Casein kinase II subunit alpha	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	2	2
SRSF protein kinase 2	0	0	2	2
Casein kinase I isoform gamma-2	0	0	5	5
Mitogen-activated protein kinase kinase kinase 9	0	0	2	2
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	2	2
Cyclin-dependent kinase 17	0	0	6	6
Protein kinase C epsilon type	0	0	2	2
Angiopoietin-1 receptor	0	1	2	3
Mitogen-activated protein kinase kinase kinase 10	0	0	2	2
Protein kinase C zeta type	0	0	4	4
Tyrosine-protein kinase receptor TYRO3	0	0	2	2
Cyclin-dependent kinase 18	0	0	3	3
Tyrosine-protein kinase ITK/TSK	0	0	2	2
Myotonin-protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	1	4	5
Serine/threonine-protein kinase PAK 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	2	2
Integrin-linked protein kinase	0	0	6	6
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	2	2	4
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	2	2
Activin receptor type-2B	0	0	6	6
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Serine/threonine-protein kinase D1	0	0	2	2
Serine/threonine-protein kinase 38	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	0	2	2
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	2	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	6	6
BDNF/NT-3 growth factors receptor	0	0	2	2
Mitogen-activated protein kinase 6	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	2	2
Uncharacterized aarF domain-containing protein kinase 5	0	0	4	4
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	1	2	3
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	2	3
Serine/threonine-protein kinase Nek5	0	0	2	2
Serine/threonine-protein kinase N3	0	0	5	5
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	5	5
Serine/threonine-protein kinase tousled-like 2	0	0	2	2
Serine/threonine-protein kinase 32C	0	0	2	2
Serine/threonine-protein kinase pim-3	0	0	2	2
ATP-dependent RNA helicase DDX42	0	0	3	3
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	2	2
Homeodomain-interacting protein kinase 1	0	1	2	3
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	2	2
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	2	2
Casein kinase I isoform alpha-like	0	0	2	2
Homeodomain-interacting protein kinase 4	0	1	2	3
Myosin-IIIa	0	0	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	2	2
Serine/threonine-protein kinase Nek11	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	6	6
Serine/threonine-protein kinase BRSK1	0	0	2	2
Serine/threonine-protein kinase 35	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	4	4
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	6	6
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	6	6
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Cyclin-dependent kinase 15	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	6	6
Dual specificity testis-specific protein kinase 2	0	0	6	6
SRSF protein kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	1	2	3
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase 33	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	2	2
Homeodomain-interacting protein kinase 2	0	1	2	3
Tyrosine-protein kinase Srms	0	0	2	2
Homeodomain-interacting protein kinase 3	0	1	2	3
Serine/threonine-protein kinase PLK3	0	1	2	3
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	2	3
Serine/threonine-protein kinase Nek6	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	0	3	3
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	2	2
Serine/threonine-protein kinase 36	0	0	2	2
Serine/threonine-protein kinase 32B	0	0	2	2
Serine/threonine-protein kinase PLK2	0	1	2	3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	5	5
Serine/threonine-protein kinase MARK1	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	4	4
Serine/threonine-protein kinase PAK 5	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	6	6
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	4	4
ALK tyrosine kinase receptor	0	0	2	2
SRSF protein kinase 3	0	0	2	2
Cyclin-dependent kinase 11A	0	0	2	2
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	2	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	3	3
Serine/threonine-protein kinase 24	0	0	4	4
nonstructural protein 1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
Liver carboxylesterase 1	0	0	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
glp-1 receptor, partial	6	0	0	6
Smad3	6	0	0	6
67.9K protein	7	0	0	7
P53	1	0	0	1
RPL19A	0	0	1	1
aryl hydrocarbon receptor	15	0	0	15
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	2	2
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Alpha-synuclein	5	1	0	6
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	6	2	8
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
ATPase family AAA domain-containing protein 5	13	0	0	13
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	2
Solute carrier family 22 member 2	0	2	0	2
Prothrombin	0	3	0	3
Coagulation factor X	0	4	0	4
Plasminogen	0	1	0	1
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Trypsin-3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Chain A, Tyrosine-protein kinase ABL1	0	1	0	1
Chain A, Tyrosine-protein kinase ABL1	0	1	0	1
Chain A, Tyrosine-protein kinase ABL1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	2	3
MAP kinase-activated protein kinase 3	0	0	2	2
Rab-like protein 3	0	0	2	2
Thymidine kinase 2	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	7	3	11
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	3	1	5
Chain A, Ferritin light chain	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
neuropeptide S receptor isoform A	4	0	0	4
endonuclease IV	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Caspase-7	2	0	0	2
Cereblon isoform 4	0	4	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	4	2	7
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Androgen receptor	0	3	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Estrogen receptor	0	4	1	5
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
UDP-glucuronosyltransferase 1A1	0	3	0	4
Glycine receptor subunit alpha-2	0	8	0	8
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	8	0	8
Adenosine receptor A2a	0	5	1	6
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	3	1	4
Potassium voltage-gated channel subfamily E member 1	0	3	0	3
Potassium voltage-gated channel subfamily KQT member 1	0	3	0	3
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	2	0	2
Target of rapamycin complex subunit LST8	0	2	0	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Solute carrier family 22 member 1	0	3	0	3
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Albumin	0	3	3	6
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
streptokinase A precursor	0	0	1	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	2	0	3
large T antigen	0	1	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
Hsf1 protein	0	0	1	1
peripheral myelin protein 22 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Stromelysin-1	0	1	2	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Inositol monophosphatase 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
DNA polymerase beta	6	0	0	6
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
Parkin	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Olfactory receptor 51E2	0	1	1	2
Chymotrypsinogen A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	5	0	0	5
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
M-phase phosphoprotein 8	4	0	0	4
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
Synaptic vesicle glycoprotein 2A	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Amyloid-beta precursor protein	0	2	0	2
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Beta-2 adrenergic receptor	0	6	1	7
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Leukotriene C4 synthase	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Cysteinyl leukotriene receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 1	0	2	1	3
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Corticotropin-releasing factor-binding protein	0	1	0	1
Corticotropin-releasing factor receptor 1	0	1	0	1
Corticotropin-releasing factor receptor 1	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
Coiled-coil domain-containing protein 6	0	1	0	1
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b	0	0	1	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	1	2	4
5-hydroxytryptamine receptor 1A	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	3
Beta-1 adrenergic receptor	0	3	1	5
D(3) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	2	4
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Genome polyprotein	0	1	0	1
Neuraminidase	0	2	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Neuraminidase	0	1	0	1
Beta-lactamase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	2	2
Acetylcholinesterase	0	2	0	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Transforming growth factor beta-1 proprotein	0	1	0	1
Mothers against decapentaplegic homolog 3	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	1	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Aromatase	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-C	0	1	1	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
Protein delta homolog 1	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	1	1
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	1	2
Solute carrier organic anion transporter family member 1C1	0	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
M1-family alanyl aminopeptidase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor, alpha form	0	1	0	1
Chain B, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
C-C motif chemokine 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

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Overview

Context

Treatment

Research

Studies (582)

Protein Targets (1,598)

Vascular Malformations

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (582)

Drugs Studied (184)

Protein Targets (1,598)