Roles > cholinesterase reactivator
Page last updated: 2024-08-05 15:25:08
cholinesterase reactivator
A drug used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates.
ChEBI ID: 50241
Members (5)
Research
Studies (678)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 172 (25.37) | 18.7374 |
| 1990's | 113 (16.67) | 18.2507 |
| 2000's | 175 (25.81) | 29.6817 |
| 2010's | 173 (25.52) | 24.3611 |
| 2020's | 45 (6.64) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 28 (3.77%) | 5.53% |
| Reviews | 35 (4.72%) | 6.00% |
| Case Studies | 85 (11.46%) | 4.05% |
| Observational | 1 (0.13%) | 0.25% |
| Other | 593 (79.92%) | 84.16% |
Protein Targets (30)
Potency Measurements
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 292.5000 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 771.0538 | 13 | 13 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 126.5000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 180.0000 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 346.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | IC50 | 184.7000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 878.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | Ki | 390.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | IC50 | 1,200.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 1,200.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Acetylcholinesterase | Homo sapiens (human) | Kd | 348.7181 | 16 | 16 |
Other Measurements