Page last updated: 2024-08-05 15:25:08

cholinesterase reactivator

A drug used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates.

ChEBI ID: 50241

Members (5)

MemberDefinitionClass
duodoteA pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.pralidoxime
pralidoximeA pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.pralidoxime
pralidoxime chloridepralidoxime chloride
pralidoxime iodideAn organic iodide salt that has pralidoxime as the cation.pralidoxime iodide
pralidoxime iodideAn organic iodide salt that has pralidoxime as the cation.pralidoxime iodide

Research

Studies (678)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990172 (25.37)18.7374
1990's113 (16.67)18.2507
2000's175 (25.81)29.6817
2010's173 (25.52)24.3611
2020's45 (6.64)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials28 (3.77%)5.53%
Reviews35 (4.72%)6.00%
Case Studies85 (11.46%)4.05%
Observational1 (0.13%)0.25%
Other593 (79.92%)84.16%

Protein Targets (30)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency17.782811
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency35.481311
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.079411
chromobox protein homolog 1Homo sapiens (human)Potency100.000011
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency39.810711
gemininHomo sapiens (human)Potency0.707911
GLS proteinHomo sapiens (human)Potency11.220211
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency0.115811
importin subunit beta-1 isoform 1Homo sapiens (human)Potency0.115811
snurportin-1Homo sapiens (human)Potency0.115811
survival motor neuron protein isoform dHomo sapiens (human)Potency1.412511
USP1 protein, partialHomo sapiens (human)Potency79.432811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50292.500022
AcetylcholinesteraseHomo sapiens (human)IC50771.05381313
AcetylcholinesteraseElectrophorus electricus (electric eel)Ki126.500011
AcetylcholinesteraseHomo sapiens (human)Ki180.000011
Acetylcholinesterase Bos taurus (cattle)IC50346.000011
Bile salt export pumpHomo sapiens (human)IC501,000.000011
Choline O-acetyltransferase Rattus norvegicus (Norway rat)IC50184.700011
CholinesteraseHomo sapiens (human)IC50878.000011
CholinesteraseHomo sapiens (human)Ki390.000011
Neuronal acetylcholine receptor subunit alpha-2Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit alpha-3Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit alpha-4Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit alpha-5Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit alpha-6Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit alpha-7Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit beta-2Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit beta-3Mus musculus (house mouse)IC501,200.000011
Neuronal acetylcholine receptor subunit beta-4Mus musculus (house mouse)IC501,200.000011
TransporterRattus norvegicus (Norway rat)IC501,200.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)Kd348.71811616

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)K449.500088
AcetylcholinesteraseRattus norvegicus (Norway rat)K diss210.000012
AcetylcholinesteraseHomo sapiens (human)kaKr/kr75,000,000.000011
AcetylcholinesteraseHomo sapiens (human)Kdiss5.000011
AcetylcholinesteraseHomo sapiens (human)Kr1,100,000,000.000011
AcetylcholinesteraseRattus norvegicus (Norway rat)KR575.000011
CholinesteraseHomo sapiens (human)K58.333333
CholinesteraseHomo sapiens (human)Kdiss1,887.500044
Thyroid hormone receptor betaRattus norvegicus (Norway rat)Kr1,100,000,000.000011