Absence of Brain, Congenital

A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)

Synonym
Hemicranial Anencephaly
Anencephalus
Incomplete Anencephaly
Anencephaly
Partial Anencephaly
Aprosencephaly
Anencephalia
Absence of Brain, Congenital
Congenital Absence of Brain

Excerpt	Reference
"A case of anencephaly is reported which was diagnosed at 32 weeks gestation by ultra-sound despite a family history: AFP, HPL and estriol were normal and the case was referred late."	( von Lengerken, W, 1979)
"Spina bifida and anencephaly are common and serious birth defects."	( , 1992)
"Anencephaly is not an uncommon defect, but because of its multifactorial inheritance pattern, twins are usually discordant for this anomaly."	( Donnenfeld, AE; Hansen, LM, 1997)
"Infants with anencephaly are born without all or most of their brain and die within a few days of life."	( Flowers, BS; Hobbs, CA; Mosley, BS; Robbins, JM; Smith, V, 2007)
"Spina bifida and anencephaly are two major neural tube defects."	( Arth, A; Johnson, Q; Kancherla, V; Oakley, GP; Pachón, H; Zimmerman, S, 2016)
"Spina bifida and anencephaly are largely preventable birth defects through mandatory folic acid fortification."	( Johnson, Q; Kancherla, V; Oakley, GP; Wagh, K, 2018)
"Exencephaly/anencephaly is one of the leading causes of neonatal mortality and the most extreme open neural tube defect with no current treatments and limited mechanistic understanding."	( Duru, S; Fernandez-Alonso, I; Fernandez-Martin, A; Figueira, RL; Marotta, M; Oria, M; Peiro, JL; Sbragia, L; Scorletti, F; Shaaban, AF; Turner, LE, 2019)
"Anencephaly is a condition in which there is an absence of skull and brain tissues."	( Koirala, S; Shrestha, HK; Shrestha, I, 2021)
"Spina bifida and anencephaly are major neural tube defects largely preventable through maternal periconceptional intake of folic acid."	( Kancherla, V; Oakley, GP; Pachón, H; Priyadarshini, P; Wagh, K, 2022)

Excerpt	Reference
"Anencephaly has been suggested to develop from exencephaly; however, there is little direct experimental evidence to support this, and the mechanism of transformation remains unclear."	( Hatta, T; Matsumoto, A; Moriyama, K; Otani, H, 2002)

Excerpt	Reference
"Head anomalies in fetuses (anencephaly, holoprosencephaly and hydrocephaly) were induced at a high frequency by the maternal administration of thalidomide on day 7, and also in a few fetuses on day 8."	( Matsubara, Y; Mikami, T, 1985)
"Exencephaly/anencephaly is one of the leading causes of neonatal mortality and the most extreme open neural tube defect with no current treatments and limited mechanistic understanding."	( Duru, S; Fernandez-Alonso, I; Fernandez-Martin, A; Figueira, RL; Marotta, M; Oria, M; Peiro, JL; Sbragia, L; Scorletti, F; Shaaban, AF; Turner, LE, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	430 (61.34)	23.3326
1990's	104 (14.84)	12.5806
2000's	69 (9.84)	18.1394
2010's	71 (10.13)	28.8240
2020's	27 (3.85)	9.53

Drug	Relationship Strength	Studies	Trials
acetone	low	1	0
ammonium hydroxide	low	1	0
chlorine	low	1	0
salicylic acid	low	4	0
guaiacol	low	1	0
lactic acid	low	1	0
dimethyl sulfoxide	low	1	0
iodine	low	1	0
inositol	low	1	0
melatonin	low	1	0
nitrates	low	2	0
nitrites	low	4	0
pyridoxine	low	1	0
uric acid	low	1	0
urea	low	3	0
3,4-methylenedioxyamphetamine	low	5	0
phenytoin	medium	5	1
hydroxyindoleacetic acid	low	3	0
acetaminophen	low	1	0
beta-aminoethyl isothiourea	low	1	0
diatrizoic acid	low	1	0
aspirin	low	1	0
azathioprine	low	1	0
benzo(a)pyrene	low	1	0
carbamazepine	low	1	0
chlorpromazine	low	1	0
diazepam	low	2	0
valproic acid	medium	6	1
ethosuximide	low	1	0
ethoxyresorufin	low	1	0
flurbiprofen	low	1	0
haloperidol	low	1	0
ibuprofen	low	1	0
mephentermine	low	1	0
indomethacin	low	2	0
2-propanol	low	3	0
isoproterenol	low	1	0
ketamine	low	1	0
loperamide	low	1	0
meclizine	low	1	0
meperidine	low	1	0
metformin	low	1	0
methadone	low	1	0
methenamine	medium	1	1
metyrapone	low	2	0
apnea	low	3	0
octopamine	low	1	0
aminosalicylic acid	low	1	0
phenobarbital	low	2	0
potassium chloride	low	1	0
primidone	medium	4	1
promethazine	low	1	0
propranolol	low	1	0
pyrimethamine	low	1	0
sodium fluoride	low	1	0
streptonigrin	low	1	0
thalidomide	low	6	0
trimethadione	low	1	0
zonisamide	low	1	0
corticosterone	low	5	0
prednisolone	low	4	0
estriol	low	62	0
lysergic acid diethylamide	low	2	0
phentolamine	low	1	0
thyroxine	low	4	0
lynestrenol	low	1	0
prednisone	low	4	0
estrone	low	17	0
androsterone	low	3	0
etiocholanolone	low	1	0
dehydroepiandrosterone	low	43	0
pilocarpine	low	1	0
triiodothyronine	low	4	0
aspartic acid	low	1	0
glutamine	low	1	0
lysine	low	2	0
sucrose	low	2	0
ethinyl estradiol	low	2	0
apomorphine	low	1	0
carbostyril	low	1	0
tyrosine	low	4	0
methoxamine	low	2	0
leucine	low	1	0
androstenedione	low	1	0
methionine	low	2	0
phenylalanine	low	2	0
desoxycorticosterone	low	7	0
colchicine	low	1	0
norethindrone	low	2	0
medroxyprogesterone acetate	low	1	0
mestranol	low	2	0
isoleucine	low	1	0
vinyl chloride	low	1	0
cyclohexanol	low	1	0
ergotamine	low	1	0
pregnenolone	low	18	0
20-alpha-dihydroprogesterone	low	1	0
isoxazoles	low	1	0
oxazoles	low	1	0
diiodotyrosine	low	1	0
chlormadinone acetate	low	1	0
azacitidine	low	2	0
hydantoins	low	1	0
reticulin	low	1	0
medroxyprogesterone	low	1	0
erythromycin	low	1	0
dehydroepiandrosterone sulfate	low	2	0
methylnitrosourea	low	1	0
deoxyuridine	low	1	0
dronabinol	low	1	0
sulfadoxine	low	1	0
cerium	low	1	0
uranium	low	1	0
zinc sulfate	low	1	0
vasotocin	low	2	0
trolamine salicylate	low	1	0
urobilinogen	low	1	0
estetrol	low	2	0
bromocriptine	low	2	0
phenyl acetate	low	3	0
triamcinolone	low	1	0
pregnanolone	low	1	0
4-methoxyamphetamine	low	67	0
glutamic acid	low	1	0
substance p	low	1	0
propiconazole	low	3	0
colforsin	low	1	0
fomesafen	low	5	0
fenoxycarb	low	1	0
mifepristone	low	2	0
vanadates	low	1	0
venlafaxine hydrochloride	low	1	0
trazodone hydrochloride	low	6	0
efavirenz	low	1	0
n-acetylaspartic acid	low	1	0
fanasil, pyrimethamine drug combination	low	1	0
cephalosporin c	low	1	0
fibrinogen	low	1	0
17-alpha-hydroxypregnenolone	low	6	0
homocysteine	low	4	0
5-pregnene-3,20-diol	low	1	0
pregnanetriol	low	2	0
16-hydroxydehydroepiandrosterone	low	1	0
22-hydroxycholesterol	low	1	0
17-hydroxypregnenolone sulfate	low	1	0
naproxen	low	1	0
deoxycorticosterone sulfate	low	3	0
gangliotetraose	low	1	0
isospaglumic acid	low	1	0
corticosterone sulfate	low	1	0
cortisone	low	3	0
solanine	low	4	0
lithium chloride	low	1	0
s-adenosylhomocysteine	low	1	0
glycogen	low	4	0
fibrin	low	1	0
oxytocin	low	15	0
inositol 3-phosphate	low	1	0
cortodoxone	low	1	0
tretinoin	low	2	0
retinol	low	9	0
diethylstilbestrol	low	1	0
ammonium metavanadate	low	1	0
bromochloroacetic acid	low	2	0
glycosides	low	1	0
isomethyleugenol	low	1	0
arginine vasopressin	low	4	0
enclomiphene	low	13	0
D-fructopyranose	low	2	0
nadp	low	1	0
thiopental	low	1	0
estrone sulfate	low	1	0
lithium	low	1	0
quinine	low	1	0
freedom	low	7	0
17-ketosteroids	low	15	0
bilirubin	low	3	0
dinoprostone	low	3	0
dinoprost	low	3	0
carboprost	low	2	0
humulene	low	1	0
misoprostol	low	2	0
phenylephrine hydrochloride	low	4	0
morphine	low	4	0
cytochalasin b	low	2	0
lead	low	3	0
barium	low	1	0
aluminum	low	1	0
strontium	low	1	0
arsenic	low	2	0
methylazoxymethanol acetate	low	1	0
urobilin	low	1	0
selenium	low	1	0
pregnanediol	low	11	0
nitrofurantoin	low	1	0
mocetinostat	low	1	0
g(m1) ganglioside	low	1	0
pituitrin	low	4	0
enerbol	low	21	0
acid phosphatase	low	1	0
nad	low	2	0
beta-endorphin	low	2	0
phosphatidylcholines	low	9	0
menotropins	low	3	0
sodium ethylxanthate	low	3	0
s-adenosylmethionine	low	1	0
cardiovascular agents	low	1	0
triiodothyronine, reverse	low	1	0
glycolipids	low	7	0
ascorbic acid	low	1	0
salicylates	low	2	0
vitamin b 12	low	6	0
lysergic acid	low	1	0
thromboplastin	low	1	0
muramidase	low	1	0
exudates	low	1	0
levoleucovorin	low	1	0
folic acid	medium	135	7
olanzapine	low	1	0
trypan blue	low	3	0
5-methyltetrahydrofolate	low	1	0
eye	low	10	0
concanavalin a	low	3	0
gq1b ganglioside	low	1	0

Protein Targets (1,405)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Glucose-6-phosphate 1-dehydrogenase	0	7	0	7
Chain A, Cruzipain	10	0	0	10
IDH1	22	0	0	22
DNA polymerase iota isoform a (long)	22	0	0	22
geminin	64	0	0	64
Sex hormone-binding globulin	0	0	16	16
acetylcholinesterase	24	0	0	24
pregnane X receptor	18	0	0	18
SMAD family member 2	23	0	0	23
SMAD family member 3	23	0	0	23
TDP1 protein	70	0	0	70
GLI family zinc finger 3	65	0	0	65
Microtubule-associated protein tau	24	0	0	24
AR protein	74	0	0	74
progesterone receptor	45	0	0	45
glucocorticoid receptor [Homo sapiens]	57	0	0	57
retinoic acid nuclear receptor alpha variant 1	57	0	0	57
retinoid X nuclear receptor alpha	51	0	0	51
estrogen-related nuclear receptor alpha	68	0	0	68
farnesoid X nuclear receptor	36	0	0	36
pregnane X nuclear receptor	56	0	0	56
estrogen nuclear receptor alpha	88	0	0	88
G	29	0	0	29
vitamin D (1,25- dihydroxyvitamin D3) receptor	39	0	0	39
arylsulfatase A	24	0	0	24
euchromatic histone-lysine N-methyltransferase 2	52	0	0	52
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	44	0	0	44
activating transcription factor 6	22	0	0	22
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
chromobox protein homolog 1	43	0	0	43
nuclear factor erythroid 2-related factor 2 isoform 1	59	0	0	59
survival motor neuron protein isoform d	20	0	0	20
histone acetyltransferase KAT2A isoform 1	17	0	0	17
lamin isoform A-delta10	54	0	0	54
Voltage-dependent calcium channel gamma-2 subunit	30	0	0	30
Interferon beta	37	0	0	37
HLA class I histocompatibility antigen, B alpha chain	29	0	0	29
Glucocorticoid receptor	1	26	5	39
Glycine receptor subunit alpha-1	0	26	0	26
Corticosteroid-binding globulin	0	13	0	13
Adenosine receptor A3	0	12	1	13
Replicase polyprotein 1ab	0	4	3	7
Androgen receptor	0	26	0	26
Alpha-1B adrenergic receptor	0	21	3	24
Glutamate receptor 2	30	2	2	34
Glycine receptor subunit beta	0	26	0	26
Glycine receptor subunit alpha-2	0	26	0	26
Glycine receptor subunit alpha-3	0	26	0	26
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	22	3	25
Sodium-dependent dopamine transporter	0	14	0	14
TAR DNA-binding protein 43	18	0	0	18
Inositol hexakisphosphate kinase 1	29	0	0	29
cytochrome P450 2C9, partial	29	0	0	29
ATP-dependent phosphofructokinase	20	0	0	20
hypoxia-inducible factor 1 alpha subunit	20	0	0	20
RAR-related orphan receptor gamma	53	0	0	53
aldehyde dehydrogenase 1 family, member A1	34	0	0	34
peroxisome proliferator-activated receptor delta	35	0	0	35
v-jun sarcoma virus 17 oncogene homolog (avian)	29	0	0	29
Histone H2A.x	17	0	0	17
thyroid hormone receptor beta isoform a	16	0	0	16
heat shock protein beta-1	19	0	0	19
Chain A, Beta-lactamase	14	0	0	14
Chain A, 2-oxoglutarate Oxygenase	17	0	0	17
Skn7p	0	0	0	1
ATAD5 protein, partial	24	0	0	24
nonstructural protein 1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	24	0	0	24
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	8	0	0	8
muscleblind-like protein 1 isoform 1	10	0	0	10
Rap guanine nucleotide exchange factor 3	8	0	0	8
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
5-hydroxytryptamine receptor 2C	0	10	2	13
5-hydroxytryptamine receptor 2A	0	10	3	13
5-hydroxytryptamine receptor 1A	0	23	4	29
Sodium-dependent noradrenaline transporter	0	18	0	18
Sodium-dependent dopamine transporter	0	8	1	9
5-hydroxytryptamine receptor 1B	0	16	2	18
5-hydroxytryptamine receptor 1D	0	3	2	5
5-hydroxytryptamine receptor 1F	0	3	2	5
5-hydroxytryptamine receptor 2B	0	9	2	11
5-hydroxytryptamine receptor 6	0	1	2	3
Sodium-dependent serotonin transporter	0	29	2	31
Sodium-dependent serotonin transporter	0	5	1	6
5-hydroxytryptamine receptor 7	0	5	2	7
5-hydroxytryptamine receptor 5A	0	1	2	3
5-hydroxytryptamine receptor 5B	0	1	2	3
5-hydroxytryptamine receptor 3A	0	1	2	3
5-hydroxytryptamine receptor 4	0	1	2	3
5-hydroxytryptamine receptor 3B	0	1	2	3
GLS protein	27	0	0	27
Smad3	15	0	0	15
thyroid stimulating hormone receptor	19	0	0	19
nuclear receptor subfamily 1, group I, member 3	47	0	0	47
EWS/FLI fusion protein	22	0	0	22
peroxisome proliferator activated receptor gamma	47	0	0	47
aryl hydrocarbon receptor	24	0	0	24
thyroid hormone receptor beta isoform 2	56	0	0	56
peripheral myelin protein 22	29	0	0	29
cytochrome P450 3A4 isoform 1	23	0	0	23
Gamma-aminobutyric acid receptor subunit pi	23	7	3	33
ATP-binding cassette sub-family C member 3	0	33	0	33
Multidrug resistance-associated protein 4	0	35	0	39
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	6	0	9
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	12	0	12
Bile salt export pump	0	57	0	57
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	18	0	24
Carbonic anhydrase 2	0	19	4	29
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	5	2	8
Prostaglandin G/H synthase 1	0	11	0	12
Carbonic anhydrase 3	0	5	0	7
Cytochrome P450 3A4	0	15	3	19
Cytochrome P450 2D6	0	11	2	13
Cytochrome P450 2C9	0	15	1	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	23	7	3	33
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	23	7	3	33
Gamma-aminobutyric acid receptor subunit gamma-2	23	7	3	33
UDP-glucuronosyltransferase 1-6	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	23	7	3	33
Gamma-aminobutyric acid receptor subunit alpha-3	23	7	3	33
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	5
Carbonic anhydrase 4	0	10	0	13
Prostaglandin G/H synthase 1	0	12	0	12
Carbonic anhydrase 6	0	6	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	23	7	3	33
Gamma-aminobutyric acid receptor subunit alpha-2	23	7	3	33
Gamma-aminobutyric acid receptor subunit alpha-4	23	7	3	33
Gamma-aminobutyric acid receptor subunit gamma-3	23	7	3	33
Gamma-aminobutyric acid receptor subunit alpha-6	23	7	3	33
Carbonic anhydrase 5A, mitochondrial	0	6	1	10
Prostaglandin G/H synthase 2	0	10	1	12
Carbonic anhydrase 7	0	5	0	8
Nuclear receptor ROR-gamma	19	1	1	21
Cytochrome P450 2J2	0	11	0	11
Gamma-aminobutyric acid receptor subunit alpha-1	23	8	3	34
Gamma-aminobutyric acid receptor subunit beta-3	23	7	3	33
Gamma-aminobutyric acid receptor subunit beta-2	23	7	3	33
Carbonic anhydrase 9	0	8	1	12
GABA theta subunit	23	7	3	33
Canalicular multispecific organic anion transporter 1	0	31	0	31
Carbonic anhydrase 15	0	6	0	8
Carbonic anhydrase 13	0	2	0	4
Gamma-aminobutyric acid receptor subunit epsilon	23	7	3	33
Carbonic anhydrase 14	0	5	0	8
Carbonic anhydrase 5B, mitochondrial	0	5	0	8
toxin B	0	0	0	1
thioredoxin glutathione reductase	10	0	0	10
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	1	6
Chain A, HADH2 protein	17	0	0	17
Chain B, HADH2 protein	17	0	0	17
interleukin 8	11	0	0	11
estrogen receptor 2 (ER beta)	36	0	0	36
regulator of G-protein signaling 4	21	0	0	21
cytochrome P450 family 3 subfamily A polypeptide 4	44	0	0	44
Caspase-7	4	0	0	4
Bloom syndrome protein isoform 1	17	0	0	17
peripheral myelin protein 22 isoform 1	13	0	0	13
potassium voltage-gated channel subfamily H member 2 isoform d	18	0	0	18
caspase-3	4	0	0	4
importin subunit beta-1 isoform 1	7	0	0	7
mitogen-activated protein kinase 1	14	0	0	14
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	21	0	0	21
neuropeptide S receptor isoform A	13	0	0	13
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	3	0	3
Aromatase	0	5	0	7
Gastrin/cholecystokinin type B receptor	1	1	0	3
Testosterone 17-beta-dehydrogenase 3	0	3	0	3
Alpha-synuclein	5	6	0	11
Chain A, retinol dehydratase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	8	0	10
G-protein coupled bile acid receptor 1	0	0	4	4
thioredoxin reductase	38	0	0	38
D(1A) dopamine receptor	10	0	0	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	20	0	0	20
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
Luciferase	16	0	0	16
phosphopantetheinyl transferase	22	0	0	22
cytochrome P450 2D6	26	0	0	26
thyroid stimulating hormone receptor	27	0	0	27
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	23	0	0	23
cytochrome P450 2D6 isoform 1	10	0	0	10
cellular tumor antigen p53 isoform a	11	0	0	11
cytochrome P450 2C19 precursor	5	0	0	5
cytochrome P450 2C9 precursor	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	11	0	0	11
vitamin D3 receptor isoform VDRA	23	0	0	23
lethal factor (plasmid)	12	0	0	12
Solute carrier family 22 member 1	0	14	0	16
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Cellular tumor antigen p53	52	0	0	52
Integrin beta-3	8	1	1	10
Integrin alpha-IIb	8	1	1	10
5-hydroxytryptamine receptor 1A	0	9	1	10
Tryptophan 5-hydroxylase 1	0	1	0	1
D(2) dopamine receptor	0	23	5	33
D	0	8	0	8
D(3) dopamine receptor	0	8	0	8
Alpha-2B adrenergic receptor	0	10	3	13
D(2) dopamine receptor	0	5	0	5
D(1A) dopamine receptor	0	20	3	27
D(4) dopamine receptor	0	12	2	18
D(1B) dopamine receptor	0	6	0	9
Alpha-2C adrenergic receptor	0	10	3	13
Alpha-2A adrenergic receptor	0	10	3	13
Alpha-1D adrenergic receptor	0	12	3	16
D(1B) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	24	3	27
D(4) dopamine receptor	0	7	1	8
D(3) dopamine receptor	0	25	3	32
Histamine H2 receptor	12	0	1	15
5-hydroxytryptamine receptor 7	0	8	0	8
Spike glycoprotein	20	2	3	25
D(2) dopamine receptor	0	10	4	15
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	2	0	2
D	0	4	0	4
ATPase family AAA domain-containing protein 5	22	0	0	22
Ataxin-2	26	0	0	26
Sigma non-opioid intracellular receptor 1	0	19	1	20
Translocator protein	0	2	3	6
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	3	3	6
Vasopressin V1a receptor	0	1	3	4
Vasopressin V1a receptor	0	6	3	9
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	1	0	2
Oxytocin receptor	0	2	1	3
Vasopressin V2 receptor	0	2	1	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	2	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	22	3	27
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	25	0	0	25
Chain A, Ferritin light chain	16	0	0	16
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	7	2	11
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	7	2	11
Glutamate receptor ionotropic, NMDA 2B	0	7	2	11
Glutamate receptor ionotropic, NMDA 2C	0	7	2	11
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	7	2	11
Glutamate receptor ionotropic, NMDA 3B	0	7	2	11
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	7	2	11
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	9	0	0	9
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase kappa isoform 1	15	0	0	15
muscarinic acetylcholine receptor M1	13	0	0	13
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	5	0	6
Prostaglandin G/H synthase 2	0	4	0	5
Epidermal growth factor receptor	0	5	0	5
Fatty acid-binding protein, liver	0	5	0	5
Myeloperoxidase	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	1	6	1	10
Adenosine receptor A2a	0	4	2	8
Substance-P receptor	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	7	0	7
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	7	0	7
Solute carrier family 22 member 6	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	2	1	3
glp-1 receptor, partial	18	0	0	18
Fumarate hydratase	13	0	0	13
NFKB1 protein, partial	8	0	0	8
PPM1D protein	7	0	0	7
Thrombopoietin	6	0	0	6
polyprotein	13	0	0	13
67.9K protein	13	0	0	13
Parkin	6	0	0	6
hemoglobin subunit beta	2	0	0	2
huntingtin isoform 2	4	0	0	4
ras-related protein Rab-9A	8	0	0	8
serine/threonine-protein kinase mTOR isoform 1	10	0	0	10
urokinase-type plasminogen activator precursor	11	0	0	11
plasminogen precursor	11	0	0	11
urokinase plasminogen activator surface receptor precursor	11	0	0	11
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Adenosine receptor A2a	0	6	1	7
Adenosine receptor A1	0	5	0	5
D(1A) dopamine receptor	7	1	0	8
Multidrug and toxin extrusion protein 1	0	6	0	6
Histone-lysine N-methyltransferase EHMT2	0	3	0	3
P53	1	0	0	1
M-phase phosphoprotein 8	11	0	0	11
Protein-arginine deiminase type-4	0	5	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
acid sphingomyelinase	5	0	0	5
apical membrane antigen 1, AMA1	5	0	0	5
caspase 7, apoptosis-related cysteine protease	10	0	0	10
caspase-3	10	0	0	10
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	9	0	0	9
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Tyrosine-protein kinase Fyn	0	6	0	6
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	5	0	5
Aryl hydrocarbon receptor	0	0	1	1
Nitric oxide synthase, brain	0	1	0	1
USP1 protein, partial	22	0	0	22
caspase-1 isoform alpha precursor	4	0	0	4
Caspase-7	4	0	0	4
Inositol monophosphatase 1	8	0	0	8
Solute carrier organic anion transporter family member 1B3	0	4	0	8
Solute carrier organic anion transporter family member 1B1	0	5	0	10
Genome polyprotein	0	1	1	2
dopamine D1 receptor	8	0	0	8
5-hydroxytryptamine receptor 4	0	22	0	22
ATP-dependent translocase ABCB1	0	6	0	6
ATP-dependent translocase ABCB1	0	17	0	24
Beta-1 adrenergic receptor	0	11	2	13
Alpha-2A adrenergic receptor	0	21	4	27
Alpha-2C adrenergic receptor	0	19	3	24
ATP-dependent translocase ABCB1	0	6	1	7
Alpha-1D adrenergic receptor	0	16	3	21
5-hydroxytryptamine receptor 2C	0	23	2	25
5-hydroxytryptamine receptor 2B	0	29	1	30
5-hydroxytryptamine receptor 6	0	20	1	21
Vpr	3	0	0	3
Albumin	0	0	5	5
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	8
Cytochrome P450 2B6	0	2	1	4
Sodium channel protein type 4 subunit alpha	0	5	0	7
Potassium voltage-gated channel subfamily H member 2	0	20	0	20
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase	0	4	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
transcriptional regulator ERG isoform 3	7	0	0	7
Cytochrome P450 2C19	0	5	1	6
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	3	0	3
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
histone deacetylase 9 isoform 3	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	2	3	5
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Potassium channel subfamily K member 2	0	3	0	3
Albumin	0	4	8	13
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Major prion protein	0	0	1	1
Procathepsin L	0	3	3	6
Aldo-keto reductase family 1 member B1	0	16	0	16
Muscarinic acetylcholine receptor M2	0	10	2	12
Muscarinic acetylcholine receptor M4	0	9	0	9
Muscarinic acetylcholine receptor M1	0	6	0	7
Muscarinic acetylcholine receptor M3	0	6	0	7
Muscarinic acetylcholine receptor M4	0	6	0	7
Muscarinic acetylcholine receptor M5	0	6	0	7
Muscarinic acetylcholine receptor M5	0	11	0	11
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Muscarinic acetylcholine receptor M2	0	6	0	7
Muscarinic acetylcholine receptor M1	0	13	4	17
Angiotensin-converting enzyme	0	6	0	6
Sphingomyelin phosphodiesterase	0	1	0	1
Muscarinic acetylcholine receptor M3	0	12	1	13
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	8	0	8
Adenylate cyclase type 3	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	0	0	3
Histamine H2 receptor	0	10	0	10
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	1	4
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	4	0	4
Histamine H1 receptor	0	2	1	3
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	5	1	6
Histamine H1 receptor	0	10	1	11
Mu-type opioid receptor	0	18	4	23
Sodium channel protein type 1 subunit alpha	0	4	0	4
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	11	3	15
Kappa-type opioid receptor	0	15	2	18
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	2	0	2
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	2	3	5
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Aldehyde oxidase	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	5	0	5
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	5	0	5
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	3	5
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
endonuclease IV	7	0	0	7
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	2	0	2
flap endonuclease 1	10	0	0	10
steroidogenic factor 1	0	2	0	2
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	3
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	1	3	4
Solute carrier family 2, facilitated glucose transporter member 1	0	1	1	2
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
GALC protein	8	0	0	8
Solute carrier family 22 member 2	0	4	0	7
Solute carrier family 22 member 3	0	2	0	2
Mineralocorticoid receptor	1	5	3	10
C-8 sterol isomerase	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	0	3
Solute carrier family 22 member 1	0	4	0	6
Solute carrier family 22 member 2	0	5	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
PINK1	3	0	0	3
neutrophil cytosol factor 1	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	3	0	7
Solute carrier organic anion transporter family member 1A5	0	0	0	5
Steryl-sulfatase	0	3	0	5
Multidrug resistance-associated protein 1	0	2	0	5
Solute carrier organic anion transporter family member 1A2	0	0	0	4
Solute carrier organic anion transporter family member 1A3	0	2	0	6
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier family 22 member 11	0	0	0	5
Solute carrier organic anion transporter family member 1A1	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	3
Chain A, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Gamma-aminobutyric acid	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	4
Neuronal acetylcholine receptor subunit alpha-4	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	4
Neuronal acetylcholine receptor subunit beta-2	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
15-lipoxygenase, partial	6	0	0	6
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
serine/threonine-protein kinase PLK1	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
Estrogen receptor	1	19	5	26
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Thromboxane-A synthase	0	3	0	3
Estrogen-related receptor gamma	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	4	1	0	5
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Estrogen receptor beta	1	9	5	16
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	5
Cysteinyl leukotriene receptor 1	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
RGS12	1	0	0	1
WRN	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
C-terminal-binding protein 1	1	0	0	1
Cereblon isoform 4	0	4	0	4
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	6	1	8
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	5	0	9
Solute carrier family 22 member 7	0	0	0	4
Solute carrier family 22 member 8	0	4	0	8
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	0	2	2	4
Glutamate receptor 3	0	2	2	4
Glutamate receptor 4	0	2	2	4
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	4	1	6
Glycine receptor subunit alpha-1	0	0	1	1
Cannabinoid receptor 2	0	2	1	4
Cannabinoid receptor 1	0	2	0	2
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Acetylcholinesterase	0	0	0	1
Kappa-type opioid receptor	0	4	0	4
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Reverse transcriptase/RNaseH	0	2	1	8
Protease	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	0	0	1
Reverse transcriptase	0	1	1	2
Cholesterol 24-hydroxylase	0	0	1	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Beta-3 adrenergic receptor	0	5	2	7
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Beta-2 adrenergic receptor	0	9	3	13
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 5A	0	2	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	2	0	2
streptokinase A precursor	0	0	3	3
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
60 kDa chaperonin	0	2	0	2
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	2	0	2
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	3	0	3
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
50S ribosomal protein L36 2	0	1	1	2
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	2	2
UDP-glucuronosyltransferase 1A10	0	0	0	1
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	8	2	13
Mu-type opioid receptor	0	5	2	7
Ghrelin O-acyltransferase	0	1	0	1
Estrogen receptor beta	0	0	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Estrogen receptor	0	0	0	2
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	2	0	2
Solute carrier family 22 member 8	0	1	0	2
lysosomal alpha-glucosidase preproprotein	5	0	0	5
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
ClpP	4	0	0	4
Guanine nucleotide-binding protein G	7	0	0	7
Acid-sensing ion channel 3	0	2	0	2
Amyloid-beta precursor protein	0	4	0	4
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member C4	0	3	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	3
Aldo-keto reductase family 1 member C3	0	6	0	6
Aldo-keto reductase family 1 member C2	0	4	0	4
Acid-sensing ion channel 1	0	2	0	2
Aldo-keto reductase family 1 member C1	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Prostaglandin G/H synthase 1	0	4	0	6
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	5	0	0	5
DNA polymerase beta	6	0	0	6
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	4	4	9
Aldo-keto reductase family 1 member B1	0	4	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	2
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Integrin beta-1	0	2	0	2
Beta-2 adrenergic receptor	0	6	1	8
Integrin alpha-4	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	5	2	9
5-hydroxytryptamine receptor 3A	0	1	0	1
Beta-3 adrenergic receptor	0	4	1	5
Histamine H1 receptor	0	2	0	2
Delta-type opioid receptor	0	6	1	8
5-hydroxytryptamine receptor 2C	0	1	0	1
Kappa-type opioid receptor	0	4	1	6
Alpha-1A adrenergic receptor	0	5	4	11
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	4	3	9
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	2	1	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Acetylcholinesterase	0	3	0	3
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Genome polyprotein	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Cholinesterase	0	2	0	2
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Dihydrofolate reductase	0	7	0	8
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	7
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	2	0	3
Prostaglandin G/H synthase 2	0	3	0	5
Caspase-3	0	2	0	2
Caspase-4	0	2	0	2
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	1	7	4	12
Aldo-keto reductase family 1 member B1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Sodium- and chloride-dependent betaine transporter	0	3	0	3
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	6
Proton-coupled amino acid transporter 1	0	2	0	3
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	1	2	5
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	2	3	6
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	3
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
inositol monophosphatase 1	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Menin	0	1	0	1
Nociceptin receptor	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Catechol O-methyltransferase	0	1	0	2
5-hydroxytryptamine receptor 1E	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Progesterone receptor	0	8	4	15
Androgen receptor	0	0	1	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Delta-type opioid receptor	0	3	0	4
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	3	1	6
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Dipeptidyl peptidase 4	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	3	3
Aldehyde oxidase 1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Proton-coupled folate transporter	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	2	2	5
Glucocorticoid receptor	0	1	1	2
Coagulation factor VII	0	1	0	1
Thyroid hormone receptor alpha	0	3	3	6
Thyroid hormone receptor beta	0	3	3	6
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tissue factor	0	2	0	2
Progesterone receptor	0	0	1	1
Glucocorticoid receptor	0	1	0	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Histone deacetylase 3	0	4	0	4
Nuclear receptor corepressor 1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 5	0	3	0	3
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Hormone-sensitive lipase	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Estrogen receptor	0	0	3	3
Estrogen receptor beta	0	0	3	3
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
5-hydroxytryptamine receptor 3A	0	1	1	2
Trace amine-associated receptor 1	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Transporter	0	1	0	1
Oxytocin receptor	0	0	1	1
Hsf1 protein	0	0	1	1
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase	0	1	0	3
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	1	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	1	0	3
Monocarboxylate transporter 10	0	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Cytochrome P450 2A6	0	2	1	3
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	2	1	3
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Adenine-n6-dna-methyltransferase Taqi	0	0	1	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Ermc' Methyltransferase	0	1	0	1
Chain A, Ermc' Rrna Methyltransferase	0	1	0	1
Chain A, Uroporphyrin-III C-methyltransferase	0	1	0	1
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
tRNA (cytosine(38)-C(5))-methyltransferase	0	1	1	2
Protein arginine N-methyltransferase 5	0	1	0	1
Histone-lysine N-methyltransferase SUV39H1	0	2	0	2
Adenosylhomocysteinase	0	0	0	1
Protein arginine N-methyltransferase 3	0	1	0	1
Indolethylamine N-methyltransferase	0	1	0	1
Histone-lysine N-methyltransferase NSD2	0	1	0	1
Adenosylhomocysteinase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
rRNA adenine N-6-methyltransferase	0	1	0	1
Nicotinamide N-methyltransferase	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Histone-lysine N-methyltransferase SETDB1	0	1	0	1
Retinoblastoma-binding protein 5	0	1	0	1
Histone-lysine N-methyltransferase EZH2	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N6-adenosine-methyltransferase catalytic subunit	0	1	0	1
Histone-arginine methyltransferase CARM1	0	1	0	1
Histone-lysine N-methyltransferase KMT5C	0	1	0	1
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	2	1	3
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Histone-lysine N-methyltransferase EZH1	0	1	0	1
Protein arginine N-methyltransferase 1	0	2	0	2
Methylosome protein 50	0	1	0	1
Protein dpy-30 homolog	0	1	0	1
Histamine N-methyltransferase	0	0	0	1
Histone-lysine N-methyltransferase SUV39H2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N-lysine methyltransferase SMYD2	0	1	0	1
Protein arginine N-methyltransferase 7	0	1	0	1
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
Set1/Ash2 histone methyltransferase complex subunit ASH2	0	1	0	1
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Non-structural protein 1	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	2	0	2
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
MPI protein	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
galactokinase	1	0	0	1
protein-arginine deiminase type-4	0	1	0	1
Vif	0	1	0	1
Tat	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
DNA repair and recombination protein RAD54-like	0	0	1	1
Sentrin-specific protease 6	0	1	0	1
Sentrin-specific protease 2	0	1	0	1
Sentrin-specific protease 1	0	1	0	1
Protein-arginine deiminase type-1	0	1	0	1
Protein-arginine deiminase type-3	0	1	0	1
Protein-arginine deiminase type-2	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Transthyretin	0	1	0	3
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	4	6
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Polyamine deacetylase HDAC10	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 9	0	2	0	2
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Absence of Brain, Congenital

Synonyms(9)

Research Excerpts

Overview

Context

Treatment

Research

Studies (701)

Protein Targets (1,405)

Absence of Brain, Congenital

Synonyms(9)

Research Excerpts

Overview

Context

Treatment

Research

Studies (701)

Drugs Studied (264)

Protein Targets (1,405)