| Assay ID | Title | Year | Journal | Article |
|---|
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID353599 | Inhibition of CAMK2 assessed as level of ATP utilized by luciferase-based bioluminescence assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. |
| AID355607 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID1188619 | Anticancer activity against human LOXIMVI cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID399298 | Inhibition of aldose reductase at 0.01 uM | | | |
| AID360589 | Antiplatelet activity against washed rabbit platelet assessed as thrombin-induced platelet aggregation at 300 uM administered 3 mins before thrombin challenge | 1995 | Journal of natural products, Dec, Volume: 58, Issue:12
| Novel antiplatelet naphthalene from Rhamnus nakaharai. |
| AID1873861 | Inhibition of actin (unknown origin) polymerization | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID666769 | Inhibition of thrombin in New Zealand rabbit plasma assessed as prothrombin time at 100 uM by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID1153995 | Intracellular melanogenesis-stimulating activity in mouse B16F0 cells at 25 uM after 72 hrs by spectrophotometry relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID596753 | Cytotoxicity against human HepG2(2.2.15) cells after 8 days by MTT assay | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity. |
| AID1188616 | Anticancer activity against human 292G cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID1234562 | Neuroprotective activity against middle cerebral artery occlusion-induced focal cerebral ischemia in Sprague-Dawley rat assessed as reduction in absolute infarct total volume at 10 mg/kg, iv administered 30 mins after MCA occlusion measured after 2 hrs of | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1188609 | Anticancer activity against human H460 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID1153998 | Extracellular melanogenesis-stimulating activity in mouse B16F0 cells at 50 uM after 72 hrs by spectrophotometry relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID1188613 | Anticancer activity against human NCI-H522 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID1873856 | Binding affinity to HSP73 in mouse B16-F10 cell lysate by pull down assay | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID666770 | Inhibition of thrombin in New Zealand rabbit plasma assessed as activated partial thromboplastin time at 100 uM after 3 mins by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID235260 | Therapeutic Index measured as the ratio of CyD50(polio) / ED99(polio) values | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID611702 | Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry | 2011 | Journal of natural products, Jun-24, Volume: 74, Issue:6
| Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso. |
| AID1154014 | Induction of melanogenesis-stimulating activity in mouse B16F0 cells assessed as increase in TRP-1 protein expression at 3.1 to 12.5 uM after 72 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID404008 | Cytotoxicity against human KB cells | | | |
| AID611698 | Inhibition of Escherichia coli beta-glucuronidase assessed as inhibition of p-nitrophenyl-beta-D-glucuronide hydrolysis at 0.20 mM preincubated for 30 mins measured 30 mins after substrate addition by spectrophotometry | 2011 | Journal of natural products, Jun-24, Volume: 74, Issue:6
| Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso. |
| AID355599 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID353598 | Inhibition of CK2 assessed as level of ATP utilized by luciferase-based bioluminescence assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. |
| AID1593609 | Antioxidant activity in pH 7.4 PBS assessed as H2O2 oxidation at 50 uM incubated for 10 mins in presence of HRP and H2O2 by UV spectroscopy and HPLC analysis relative to control | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
| Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae). |
| AID1323132 | Antioxidant activity assessed as DPPH free radical scavenging activity by measuring remaining DPPH at 5 uM after 15 to 60 mins relative to trolox | 2016 | Journal of natural products, 07-22, Volume: 79, Issue:7
| Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties. |
| AID336915 | Antiviral activity against Measles virus infected in african green monkey Vero cells assessed as ratio of viral titer in absence to presence of compound at 500 ug/ml by 50% endpoint titration technique | | | |
| AID162237 | Cytotoxic dose at which 50% growth of normal cells is inhibited | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1873860 | Binding affinity to HSP73 in mouse B16-F10 cell lysate by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID1154016 | Induction of melanogenesis-stimulating activity in mouse B16F0 cells assessed as increase in p-p38 MAPK level at 3.1 to 12.5 uM after 72 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID1234559 | Aqueous solubility of the compound at room temperature by HPLC | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1873848 | Binding affinity to human MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) by SPR analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID378510 | Antiviral activity against hepatitis B virus infected in human MS-G2 cells assessed as surface antigen secretion at 25 uM | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3
| Homoflavonoids from Ophioglossum petiolatum. |
| AID1873847 | Inhibition of MMP-1 (unknown origin) using FRET substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID355887 | Antimicrobial activity against Proteus mirabilis isolates after 36 hrs under aerobic condition by microdilution method | 2003 | Journal of natural products, May, Volume: 66, Issue:5
| Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. |
| AID1873852 | Binding affinity to human 15N-labelled MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as chemical shift perturbation at E99 residue at 500 uM by 1H-15N HSQC spectra analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID355611 | Antifungal activity against Aspergillus flavus after 7 days at 27 degC by liquid dilution method | | | |
| AID1593610 | Antioxidant activity in pH 7.4 PBS assessed as reactivity against GSH at 50 uM incubated for 10 mins in presence of HRP and H2O2 in presence of 40 uM GSH by HPLC-DAD and HPLC-MS/MS analysis relative to control | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
| Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae). |
| AID1593613 | Neuroprotective activity in Sprague-Dawley rat CGN cells assessed as protection against H2O2-induced cytotoxicity by measuring increase in cell viability at 5 to 100 uM pre-incubated for 24 hrs before H2O2 stimulation for 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
| Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae). |
| AID1234556 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 min | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1234564 | Neuroprotective activity against middle cerebral artery occlusion-induced focal cerebral ischemia in Sprague-Dawley rat assessed as reduction in edema at 10 mg/kg, iv administered 30 mins after MCA occlusion measured after 2 hrs of reperfusion by TTC stai | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1608396 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 18 hrs | 2019 | Bioorganic & medicinal chemistry, 09-01, Volume: 27, Issue:17
| Natural product derived promising anti-MRSA drug leads: A review. |
| AID1188620 | Anticancer activity against human M14 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID162249 | Minimal dose which produces titer reduction at 10 ug/mL (mD RF10e3) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1873850 | Binding affinity to human MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) in absence of Ca2+ by SPR analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID1154013 | Induction of melanogenesis-stimulating activity in mouse B16F0 cells assessed as increase in tyrosinase protein expression at 3.1 to 12.5 uM after 72 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID338975 | Inhibition of cow milk xanthine oxidase | | | |
| AID1188608 | Anticancer activity against human NCI-H157 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID1234561 | Neuroprotective activity against middle cerebral artery occlusion-induced focal cerebral ischemia in Sprague-Dawley rat assessed as reduction in absolute infarct volume in cortex at 10 mg/kg, iv administered 30 mins after MCA occlusion measured after 2 hr | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID355609 | Antibacterial activity against Staphylococcus aureus ATCC 12228 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID439062 | Antioxidant activity in rat liver homogenate assessed as inhibition of iron-ascorbic acid mix-induced lipid peroxidation by TBARS assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities. |
| AID355615 | Antifungal activity against Paecilomyces after 7 days at 27 degC by liquid dilution method | | | |
| AID293299 | Antioxidant activity in BALB/c mouse BM cells assessed as inhibition of ROS production | 2007 | Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4
| Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. |
| AID355605 | Antibacterial activity against Serratia marcescens ATCC 8100 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID1188610 | Anticancer activity against human NCI-H1792 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID360796 | Antiplatelet activity against washed rabbit platelet assessed as arachidonic acid-induced platelet aggregation at 300 uM administered 3 mins before arachidonic acid challenge | 1995 | Journal of natural products, Dec, Volume: 58, Issue:12
| Novel antiplatelet naphthalene from Rhamnus nakaharai. |
| AID1323135 | Antioxidant activity assessed as DPPH free radical scavenging activity by measuring decrease in fluorescence intensity at 0.015 mmol measured after 30 mins in presence of methyl gallate by 13C-NMR spectroscopy | 2016 | Journal of natural products, 07-22, Volume: 79, Issue:7
| Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties. |
| AID1873854 | Binding affinity to MMP-1 in mouse B16-F10 cell lysate by pull down assay | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID355604 | Antibacterial activity against Salmonella Typhimurium ATCC 14028 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID355606 | Antibacterial activity against Shigella dysenteriae after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID439061 | Antioxidant activity assessed as inhibition of xanthine/xanthine oxidase system-induced superoxide anion radical scavenging activity after 20 mins | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities. |
| AID1188607 | Anticancer activity against human A549 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID353591 | Enhancement of HSP27 Ser78 phosphorylation in human HeLa cells at 50 ug/mL treated for 1 hr | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. |
| AID336913 | Antiviral activity against Coxsackievirus infected in african green monkey Vero cells assessed as ratio of viral titer in absence to presence of compound at 5 ug/ml by 50% endpoint titration technique | | | |
| AID1188622 | Anticancer activity against human HeLa cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID293298 | Antioxidant activity assessed as inhibition of superoxide production by xanthine/xanthine oxidase method | 2007 | Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4
| Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. |
| AID611697 | Inhibition of Escherichia coli beta-glucuronidase assessed as inhibition of p-nitrophenyl-beta-D-glucuronide hydrolysis preincubated for 30 mins measured 30 mins after substrate addition by spectrophotometry | 2011 | Journal of natural products, Jun-24, Volume: 74, Issue:6
| Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso. |
| AID355602 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID1154002 | Cytotoxicity against mouse B16F0 cells assessed as cell viability at 50 uM after 72 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID314064 | Inhibition of LPS-induced NO production in mouse BV2 cells | 2008 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
| In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. |
| AID1234560 | Neuroprotective activity against middle cerebral artery occlusion-induced focal cerebral ischemia in Sprague-Dawley rat assessed as reduction in absolute infarct volume in striatum at 10 mg/kg, iv administered 30 mins after MCA occlusion measured after 2 | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1188612 | Anticancer activity against human H266 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID355614 | Antifungal activity against Microsporum canis after 7 days at 27 degC by liquid dilution method | | | |
| AID293297 | Antioxidant activity assessed as DPPH radical scavenging activity after 20 min | 2007 | Bioorganic & medicinal chemistry, Feb-15, Volume: 15, Issue:4
| Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. |
| AID1154015 | Induction of melanogenesis-stimulating activity in mouse B16F0 cells assessed as increase in MITF protein expression at 3.1 to 12.5 uM after 72 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID355610 | Antibacterial activity against Streptococcus pyogenes ATCC 19651 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID439060 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities. |
| AID355885 | Antimicrobial activity against Helicobacter pylori isolates after 36 hrs under aerobic condition by microdilution method | 2003 | Journal of natural products, May, Volume: 66, Issue:5
| Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. |
| AID314066 | Peroxynitrite scavenging activity assessed as inhibition of DHR 123 oxidation | 2008 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
| In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. |
| AID353590 | Inhibition of heat-induced HSP70 expression in human Jurkat cells at 50 ug/mL treated for 1 hr before heat induction by Western blot | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives. |
| AID596755 | Antiviral activity against HBV transfected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg secretion at nontoxic concentration by ELISA | 2011 | Journal of natural products, Apr-25, Volume: 74, Issue:4
| Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity. |
| AID1188618 | Anticancer activity against human M4E cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID336914 | Antiviral activity against Herpes simplex virus type 1 infected in african green monkey Vero cells assessed as ratio of viral titer in absence to presence of compound at 500 ug/ml by 50% endpoint titration technique | | | |
| AID1873857 | Binding affinity to MLK3 in mouse B16-F10 cell lysate by pull down assay | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID1154004 | Cytotoxicity against mouse B16F0 cells assessed as cell viability at 12.5 uM after 72 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID1873855 | Binding affinity to beta-actin in mouse B16-F10 cell lysate by pull down assay | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID355888 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 36 hrs under aerobic condition by microdilution method | 2003 | Journal of natural products, May, Volume: 66, Issue:5
| Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. |
| AID399301 | Inhibition of aldose reductase at 10 uM | | | |
| AID1153999 | Extracellular melanogenesis-stimulating activity in mouse B16F0 cells at 25 uM after 72 hrs by spectrophotometry relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID1239713 | Anti-platelet activity in rat platelet rich plasma assessed as inhibition of ADP and calcium-induced platelet aggregation at 100 uM pre-incubated at 37 degC for 10 mins and measured 30 mins after ADP and calcium addition | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
| Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men). |
| AID1234557 | Antioxidant activity assessed as superoxide anion radical scavenging activity after 20 mins by xanthine/xanthine oxidase method | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1873851 | Binding affinity to human 15N-labelled MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as chemical shift perturbation at F97 residue at 500 uM by 1H-15N HSQC spectra analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID399299 | Inhibition of aldose reductase at 0.1 uM | | | |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | | | |
| AID162238 | Minimum drug concentration at which 99% of the polio virus is inhibited | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1188615 | Anticancer activity against human H1299 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID1323133 | Antioxidant activity assessed as DPPH free radical scavenging activity at 5 uM after 15 to 60 mins in presence of CuSO4.5H2O | 2016 | Journal of natural products, 07-22, Volume: 79, Issue:7
| Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties. |
| AID355886 | Antimicrobial activity against Escherichia coli ATCC 35218 after 36 hrs under aerobic condition by microdilution method | 2003 | Journal of natural products, May, Volume: 66, Issue:5
| Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. |
| AID1188617 | Anticancer activity against human Calu1 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID360802 | Antiplatelet activity against washed rabbit platelet assessed as PAF-induced platelet aggregation at 300 uM administered 3 mins before PAF challenge | 1995 | Journal of natural products, Dec, Volume: 58, Issue:12
| Novel antiplatelet naphthalene from Rhamnus nakaharai. |
| AID1188611 | Anticancer activity against human NCI-H1944 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID1873859 | Binding affinity to beta-actin in mouse B16-F10 cell lysate by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID1873849 | Binding affinity to human MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) in absence of Zn2+ by SPR analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID355601 | Antibacterial activity against Proteus vulgaris ATCC 27853 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID336917 | Antiviral activity against Poliovirus infected in african green monkey Vero cells assessed as ratio of viral titer in absence to presence of compound at 5 ug/ml by 50% endpoint titration technique | | | |
| AID360799 | Antiplatelet activity against washed rabbit platelet assessed as collagen-induced platelet aggregation at 300 uM administered 3 mins before collagen challenge | 1995 | Journal of natural products, Dec, Volume: 58, Issue:12
| Novel antiplatelet naphthalene from Rhamnus nakaharai. |
| AID1607883 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent based assay | 2019 | European journal of medicinal chemistry, Oct-01, Volume: 179 | Human disorders associated with inflammation and the evolving role of natural products to overcome. |
| AID1188621 | Anticancer activity against human SKBR cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID355608 | Antibacterial activity against Mycobacterium smegmatis ATCC 607 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID355603 | Antibacterial activity against Pseudomonas solanacearum after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID355600 | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID1153994 | Intracellular melanogenesis-stimulating activity in mouse B16F0 cells at 50 uM after 72 hrs by spectrophotometry relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID162244 | The ratio of the poliovirus viral titer of the virus control (reduction factor) to the viral titer in the presence of the maximal non-toxic dose (RF MNTD) | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID1873858 | Binding affinity to MMP-1 in mouse B16-F10 cell lysate by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives. |
| AID1188614 | Anticancer activity against human HOP62 cells by HTS assay | 2014 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
| Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. |
| AID355613 | Antifungal activity against Epidermophyton floccosum after 7 days at 27 degC by liquid dilution method | | | |
| AID1593607 | Antioxidant activity in pH 7.4 PBS assessed as ABTS+ radical scavenger activity incubated under absence of light for 16 hrs | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
| Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae). |
| AID379054 | Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA | 1999 | Journal of natural products, Mar, Volume: 62, Issue:3
| Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes. |
| AID355612 | Antifungal activity against Candida albicans CBS 562 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| AID611778 | Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate at 0.1 mM peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry | 2011 | Journal of natural products, Jun-24, Volume: 74, Issue:6
| Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso. |
| AID399300 | Inhibition of aldose reductase at 1 uM | | | |
| AID336918 | Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as ratio of viral titer in absence to presence of compound at 500 ug/ml by 50% endpoint titration technique | | | |
| AID314065 | Decrease in iNOS protein expression in LPS-activated mouse BV2 cells at 20 uM | 2008 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
| In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. |
| AID439063 | Neuroprotective activity against H2O2-induced neuronal damage in Sprague-Dawley rat cerebral cortical cells after 20 to 24 hrs by MTT assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities. |
| AID1234563 | Neuroprotective activity against middle cerebral artery occlusion-induced focal cerebral ischemia in Sprague-Dawley rat assessed as reduction in corrected total infarct volume at 10 mg/kg, iv administered 30 mins after MCA occlusion measured after 2 hrs o | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID1154000 | Extracellular melanogenesis-stimulating activity in mouse B16F0 cells at 12.5 uM after 72 hrs by spectrophotometry relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID1153996 | Intracellular melanogenesis-stimulating activity in mouse B16F0 cells at 12.5 uM after 72 hrs by spectrophotometry relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID1154026 | Induction of melanogenesis-stimulating activity in mouse B16F0 cells assessed as increase in TRP-2 protein expression at 3.1 to 12.5 uM after 72 hrs by Western blotting analysis | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID162242 | Maximal non-toxic dose (MNTD) that shows antiviral activity. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. |
| AID666771 | Inhibition of thrombin in New Zealand rabbit plasma assessed as fibrinogen level at 100 uM by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID1593608 | Antioxidant activity in Sprague-Dawley rat brain homogenates assessed as inhibition of lipoperoxidation incubated for 40 mins by fluorescence based assay | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
| Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae). |
| AID379055 | Cytotoxicity against human monocytes assessed as depletion of cellular LDH activity | 1999 | Journal of natural products, Mar, Volume: 62, Issue:3
| Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes. |
| AID1154003 | Cytotoxicity against mouse B16F0 cells assessed as cell viability at 25 uM after 72 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. |
| AID666768 | Inhibition of thrombin in New Zealand rabbit plasma assessed as thrombin time at 100 uM after 3 mins by coagulometry | 2012 | European journal of medicinal chemistry, Aug, Volume: 54 | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. |
| AID1234558 | Antioxidant activity in rat liver microsomes assessed as reduction in iron-ascorbic acid-induced lipid peroxidase activity after 30 mins by TBARS assay | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
| Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. |
| AID355598 | Antibacterial activity against Enterobacter cloacae ATCC 23355 after 24 to 48 hrs at 37 degC by liquid dilution method | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |