Page last updated: 2024-11-05

heneicosanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Heneicosanoic acid, also known as heneicosylic acid, is a saturated fatty acid with the chemical formula CH3(CH2)19COOH. It is a long-chain fatty acid, meaning it has a relatively long hydrocarbon chain. Heneicosanoic acid is found in small amounts in various natural sources, including animal fats, plant oils, and beeswax. Its synthesis can occur through various methods, including the hydrogenation of unsaturated fatty acids, the esterification of long-chain alcohols with carboxylic acids, and the microbial production of fatty acids. While not as well-studied as other fatty acids, research suggests it may possess anti-inflammatory and anti-tumor properties. This has led to investigations into its potential therapeutic applications. Due to its unique structure and potential biological activities, heneicosanoic acid continues to be a subject of ongoing research in fields such as food science, cosmetics, and medicine. Further studies are needed to fully understand its biological effects and potential applications.'

henicosanoic acid : A long-chain fatty acid that is henicosane in which one of the methyl groups has been oxidised to give the corresponding carboxylic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID16898
CHEMBL ID1172909
CHEBI ID39248
SCHEMBL ID63618
MeSH IDM0507677

Synonyms (40)

Synonym
n-heneicosanoic acid
heneicosanoic acid
n-henicosanoic acid
CHEBI:39248 ,
n-heneicosylic acid
2363-71-5
heneicosylic acid
LMFA01010021
henicosanoic acid
c21:0
BA927389-7F05-42E2-ADA5-59C0A171ABB2
H0010
CHEMBL1172909
fa 21:0
einecs 219-113-3
unii-nry04fuk8h
nry04fuk8h ,
A816817
FT-0634223
AKOS015893024
SCHEMBL63618
heneicosanoate
CKDDRHZIAZRDBW-UHFFFAOYSA-N
henicosanoic acid #
mfcd00002805
DTXSID0021595
heneicosanoic acid, analytical standard
n-heneicosanoate
heneicosanate
heneicosanic acid
J-015173
HY-121447
Q911218
henicosanoicacid
CS-0082055
T72126
AS-56877
fa 21:0a
CAA36371
87k ,

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The calculated LD50 by ip route and dermal route was more than 5 g/kg in mouse and rats of both the sexes."( Acute and sub-acute toxicity of an insect pheromone, N-heneicosane and combination with insect growth regulator, diflubenzuron, for establishing no observed adverse effect level (NOAEL).
Ahmed, F; Bhutia, YD; Gautam, A; Jain, N; Kumar, P; Kumar, S; Mendki, MJ; Sharma, M; Singh, R; Vijayaraghavan, R, 2010
)
0.36

Compound-Compound Interactions

ExcerptReferenceRelevance
" This study was planned to assess the safety of C21 alone and the combination with DB."( Acute and sub-acute toxicity of an insect pheromone, N-heneicosane and combination with insect growth regulator, diflubenzuron, for establishing no observed adverse effect level (NOAEL).
Ahmed, F; Bhutia, YD; Gautam, A; Jain, N; Kumar, P; Kumar, S; Mendki, MJ; Sharma, M; Singh, R; Vijayaraghavan, R, 2010
)
0.36

Dosage Studied

ExcerptRelevanceReference
" In the sub-acute toxicity studies even 500 mg/kg dose was not able to produce toxic response in rats when they were dosed daily for 90 days."( Acute and sub-acute toxicity of an insect pheromone, N-heneicosane and combination with insect growth regulator, diflubenzuron, for establishing no observed adverse effect level (NOAEL).
Ahmed, F; Bhutia, YD; Gautam, A; Jain, N; Kumar, P; Kumar, S; Mendki, MJ; Sharma, M; Singh, R; Vijayaraghavan, R, 2010
)
0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
straight-chain saturated fatty acidAny saturated fatty acid lacking a side-chain.
long-chain fatty acidA fatty acid with a chain length ranging from C13 to C22.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID492140Antioxidant activity assessed as formazan formation induced absorbance changes at 25 ppm at 570 nm at 37 degC for 6 hrs by MTT assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.04 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index47.77 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]