Compounds > 2-toluidine
Page last updated: 2024-09-21

2-toluidine

Description

2-toluidine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

o-toluidine : An aminotoluene in which the amino substituent is ortho to the methyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7242
CHEMBL ID1381
CHEBI ID66892
SCHEMBL ID15789
MeSH IDM0081065

Synonyms (115)

Synonym
2-aminotoluene (o-toluidine)
BIDD:ER0679
wln: zr b1
benzenamine, 2-methyl-
2-amino-1-methylbenzene
nsc-15348
2-methyl-1-aminobenzene
o-toluidyna
o-tolylamine
2-toluidine
2-aminotoluene
o-methylaniline
o-toluidin
1-amino-2-methylbenzene
1-methyl-2-aminobenzene
95-53-4
o-toluidine
2-methylbenzenamine
o-methylbenzenamine
nsc15348
o-aminotoluene
aniline, 2-methyl-
2-methylaniline
inchi=1/c7h9n/c1-6-4-2-3-5-7(6)8/h2-5h,8h2,1h
ortho-toluidine
NCGC00091368-01
hsdb 2042
c.i. 37077
2-methylbenzamine
rcra waste no. u328
rcra waste number u328
ai3-24383
nsc 15348
ccris 597
o-toluidin [czech]
o-toluidyna [polish]
einecs 202-429-0
o-toluidine, 98%
o-toluidine, >=99%
C90102
smr001370921
MLS002415766
CHEMBL1381
chebi:66892 ,
o-toluidine(1%)
T0299
AKOS000119109
NCGC00091368-04
NCGC00091368-03
NCGC00091368-02
HMS3039B11
NCGC00253986-01
tox21_201256
dtxcid206164
NCGC00258808-01
tox21_300179
cas-95-53-4
dtxsid1026164 ,
STL163331
o-tolyl-amine
FT-0675282
unii-b635mz0zlu
ortho toluidine
ec 202-429-0
b635mz0zlu ,
o-toluidine, liquid or solid [un1708] [poison]
o-toluidine, liquid or solid
2-methylphenylamine
benzenamine, methyl-
121536-13-8
2-toluidine-d7
68408-22-0
prilocaine impurity b [ep impurity]
ortho-toluidine [iarc]
prilocaine hydrochloride impurity b [ep impurity]
2-tolylamine
2-aminotoluene [hsdb]
o-toluidine [mi]
BP-21341
SCHEMBL15789
2-methyl aniline
2 -methylaniline
2-methyl-aniline
ortho-tolylamine
2-amino toluene
o-toluide
AM87484
51v ,
mfcd00007730
F2190-0418
o-toluidine, purum p.a., >=99.5% (gc)
o-toluidine, saj special grade, >=99.0%
o-toluidine, analytical standard
o-toluidine, liquid
o-toluidine, p.a., 99.5%
Z57127943
2-methylbenzenamine (o-toluidine)
o-toluidine 100 microg/ml in cyclohexane
o-toluidine 10 microg/ml in cyclohexane
o-toluidine 500 microg/ml in methanol
2-methyl-benzenamine
o-toluidin (czech)
o-toluidine (acd/name 4.0)
2-methylphenylamine (acd/name 4.0)
o-toluidyna (polish)
BCP17522
Q311695
STR00213
2-(methyl)aniline
o-toluidine-d3 (methyl-d3)
EN300-33459
ci 37077
prilocaine impurity b (ep impurity)
ortho-toluidine (iarc)
toluidine (ortho)

Roles (1)

RoleDescription
carcinogenic agentA role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
aminotolueneAny member of the class of toluenes carrying one or more amino groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency44.66840.000214.376460.0339AID588532
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency28.79520.003041.611522,387.1992AID1159552; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency4.42110.001530.607315,848.9004AID1224841; AID1224842; AID1259401
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.45100.000229.305416,493.5996AID743079
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency50.11870.001019.414170.9645AID588537
thyroid stimulating hormone receptorHomo sapiens (human)Potency2.81830.001628.015177.1139AID1224843; AID1224895
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID237685Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system2005Journal of medicinal chemistry, May-05, Volume: 48, Issue:9
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (168)

TimeframeStudies, This Drug (%)All Drugs %
pre-199040 (23.81)18.7374
1990's32 (19.05)18.2507
2000's43 (25.60)29.6817
2010's36 (21.43)24.3611
2020's17 (10.12)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (1.68%)5.53%
Reviews4 (2.23%)6.00%
Case Studies1 (0.56%)4.05%
Observational0 (0.00%)0.25%
Other171 (95.53%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
plant metabolite
acetic acid[no description available]medium20monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
acetone[no description available]medium10ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
benzaldehyde[no description available]medium10benzaldehydesEC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite
benzene[no description available]medium50aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
benzoic acid[no description available]medium30benzoic acidsalgal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite
benzyl alcohol[no description available]medium10benzyl alcoholsantioxidant;
fragrance;
metabolite;
solvent
1-butanol[no description available]medium10alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent
butyric acid[no description available]medium10fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
chloroacetic acid[no description available]medium10chlorocarboxylic acid;
haloacetic acid		alkylating agent;
herbicide
2-cresol[no description available]medium10cresolhuman xenobiotic metabolite
salicylic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
3-cresol[no description available]medium10cresolhuman xenobiotic metabolite
guaiacol[no description available]medium10guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
indole[no description available]medium10indole;
polycyclic heteroarene		Escherichia coli metabolite
methanol[no description available]medium10alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
acetanilide[no description available]medium10acetamides;
anilide		analgesic
n,n-dimethylaniline[no description available]medium10dimethylaniline;
tertiary amine
4-nitrophenol[no description available]medium104-nitrophenolshuman xenobiotic metabolite;
mouse metabolite
phenol[no description available]medium10phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
phenylacetic acid[no description available]medium10benzenes;
monocarboxylic acid;
phenylacetic acids		allergen;
Aspergillus metabolite;
auxin;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
Escherichia coli metabolite;
human metabolite;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite;
toxin
1-propanol[no description available]medium10propan-1-ols;
short-chain primary fatty alcohol		metabolite;
protic solvent
propionic acid[no description available]medium10saturated fatty acid;
short-chain fatty acid		antifungal drug
pyridine[no description available]medium10azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
dimethyl sulfide[no description available]medium10aliphatic sulfidealgal metabolite;
bacterial xenobiotic metabolite;
EC 3.5.1.4 (amidase) inhibitor;
Escherichia coli metabolite;
marine metabolite
thiophane[no description available]medium10saturated organic heteromonocyclic parent;
tetrahydrothiophenes
toluene[no description available]medium100methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
phenytoin[no description available]medium10imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
alprenolol[no description available]medium10secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
theophylline[no description available]medium20dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
antipyrine[no description available]medium10pyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
astemizole[no description available]medium10benzimidazoles;
piperidines		anti-allergic agent;
anticoronaviral agent;
H1-receptor antagonist
atenolol[no description available]medium10ethanolamines;
monocarboxylic acid amide;
propanolamine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic
barbital[no description available]medium10barbituratesdrug allergen
benzamide[no description available]medium10benzamides
verapamil[no description available]medium10aromatic ether;
nitrile;
polyether;
tertiary amino compound
chlorpheniramine[no description available]medium10monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor
chlorpromazine[no description available]medium10organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
ciprofloxacin[no description available]medium10aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
4-cresol[no description available]medium10cresolEscherichia coli metabolite;
human metabolite;
uremic toxin
desipramine[no description available]medium10dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
nordazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
GABA modulator;
human metabolite;
sedative
amphetamine[no description available]medium10primary amine
diazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
diphenhydramine[no description available]medium10ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
epinastine[no description available]medium10benzazepine;
guanidines		anti-allergic agent;
H1-receptor antagonist;
histamine antagonist;
ophthalmology drug
flumequine[no description available]medium103-oxo monocarboxylic acid;
organofluorine compound;
pyridoquinoline;
quinolone antibiotic
fluoxetine[no description available]medium10(trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound
flurbiprofen[no description available]medium10fluorobiphenyl;
monocarboxylic acid		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
furosemide[no description available]medium10chlorobenzoic acid;
furans;
sulfonamide		environmental contaminant;
loop diuretic;
xenobiotic
haloperidol[no description available]medium10aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
hexobarbital[no description available]medium10barbiturates
hydroxyzine[no description available]medium10hydroxyether;
monochlorobenzenes;
N-alkylpiperazine		anticoronaviral agent;
antipruritic drug;
anxiolytic drug;
dermatologic drug;
H1-receptor antagonist
ibuprofen[no description available]medium10monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
lidocaine[no description available]medium70benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
lidocaine[no description available]medium71benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
imipramine[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
indomethacin[no description available]medium10aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
2-propanol[no description available]medium10secondary alcohol;
secondary fatty alcohol		protic solvent
ketoprofen[no description available]medium10benzophenones;
oxo monocarboxylic acid		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic
loratadine[no description available]medium10benzocycloheptapyridine;
ethyl ester;
N-acylpiperidine;
organochlorine compound;
tertiary carboxamide		anti-allergic agent;
cholinergic antagonist;
geroprotector;
H1-receptor antagonist
metolazone[no description available]medium10organochlorine compound;
quinazolines;
sulfonamide		antihypertensive agent;
diuretic;
ion transport inhibitor
metoprolol[no description available]medium10aromatic ether;
propanolamine;
secondary alcohol;
secondary amino compound		antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
geroprotector;
xenobiotic
oxazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anxiolytic drug;
environmental contaminant;
xenobiotic
oxprenolol[no description available]medium10aromatic ether
papaverine[no description available]medium10benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
4-chlorophenol[no description available]medium10monochlorophenol
pentobarbital[no description available]medium10barbituratesGABAA receptor agonist
phenazopyridine[no description available]medium10diaminopyridine;
monoazo compound		anticoronaviral agent;
carcinogenic agent;
local anaesthetic;
non-narcotic analgesic
phenobarbital[no description available]medium20barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
pindolol[no description available]medium10indoles;
secondary amine		antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
serotonergic antagonist;
vasodilator agent
practolol[no description available]medium10acetamides;
ethanolamines;
propanolamine;
secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
beta-adrenergic antagonist
procaine[no description available]medium10benzoate ester;
substituted aniline;
tertiary amino compound		central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug
propranolol[no description available]medium10naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
pyrilamine[no description available]medium10aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
secobarbital[no description available]medium10barbituratesanaesthesia adjuvant;
GABA modulator;
sedative
sulfasalazine[no description available]medium10
sulpiride[no description available]medium10benzamides;
N-alkylpyrrolidine;
sulfonamide		antidepressant;
antiemetic;
antipsychotic agent;
dopaminergic antagonist
terfenadine[no description available]medium10diarylmethane
tetracaine[no description available]medium10benzoate ester;
tertiary amino compound		local anaesthetic
ultram[no description available]medium10aromatic ether;
tertiary alcohol;
tertiary amino compound
tranexamic acid[no description available]medium10amino acid
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
estriol[no description available]medium1016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
estrone[no description available]medium1017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
physostigmine[no description available]medium10carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
aminopyrine[no description available]medium10pyrazolone;
tertiary amino compound		antipyretic;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
aniline[no description available]medium300anilines;
primary arylamine
desoxycorticosterone[no description available]medium1020-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
chloroform[no description available]medium20chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
mannitol[no description available]medium10mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
n-pentanol[no description available]medium10pentanol;
short-chain primary fatty alcohol		human metabolite;
plant metabolite
1,1,1-trichloroethane[no description available]medium10chloroethanespolar solvent
ethylamine[no description available]medium10primary aliphatic aminehuman metabolite
tert-butyl alcohol[no description available]medium10tertiary alcoholhuman xenobiotic metabolite
trichloroacetic acid[no description available]medium10monocarboxylic acid;
organochlorine compound		carcinogenic agent;
metabolite;
mouse metabolite
isobutyl alcohol[no description available]medium10alkyl alcohol;
primary alcohol		Saccharomyces cerevisiae metabolite
methylethyl ketone[no description available]medium10butanone;
dialkyl ketone;
methyl ketone;
volatile organic compound		bacterial metabolite;
polar aprotic solvent
methyl acetate[no description available]medium10acetate ester;
methyl ester;
volatile organic compound		EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
fragrance;
polar aprotic solvent
dichloroacetic acid[no description available]medium10monocarboxylic acid;
organochlorine compound		astringent;
marine metabolite
2,6-dichlorophenol[no description available]medium10dichlorophenol
2-tert-butylphenol[no description available]medium10alkylbenzene
2-isopropylphenol[no description available]medium10phenols
2-nitroaniline[no description available]medium10
2-nitrophenol[no description available]medium102-nitrophenols
thymol[no description available]medium10monoterpenoid;
phenols		volatile oil component
1-naphthol[no description available]medium10naphtholgenotoxin;
human xenobiotic metabolite
quinoline[no description available]medium20azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinolines
diphenyl[no description available]medium10aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
methyl benzoate[no description available]medium10benzoate ester;
methyl ester		insect attractant;
metabolite
2-bromophenol[no description available]medium10bromophenolmarine metabolite
2-chlorophenol[no description available]medium102-halophenol;
monochlorophenol
3,4-dimethylphenol[no description available]medium10phenols
2,5-xylenol[no description available]medium10phenolsanimal metabolite;
volatile oil component
butylphen[no description available]medium10phenolsallergen
acetophenone[no description available]medium10acetophenonesanimal metabolite;
photosensitizing agent;
xenobiotic
nitrobenzene[no description available]medium40nitroarene;
nitrobenzenes
3-nitroaniline[no description available]medium10
4-nitroaniline[no description available]medium20nitroanilinebacterial xenobiotic metabolite
4-anisic acid[no description available]medium10methoxybenzoic acidplant metabolite
benzylamine[no description available]medium10aralkylamine;
primary amine		allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite
benzonitrile[no description available]medium10benzenes;
nitrile
methylaniline[no description available]medium40methylaniline;
phenylalkylamine;
secondary amine
anisole[no description available]medium10monomethoxybenzeneplant metabolite
methylphenylsulfide[no description available]medium10aryl sulfide;
benzenes
2,4-dimethylphenol[no description available]medium10aromatic fungicide;
phenols		disinfectant;
volatile oil component
4-bromophenol[no description available]medium10bromophenolhuman urinary metabolite;
human xenobiotic metabolite;
marine metabolite;
mouse metabolite;
persistent organic pollutant;
rat metabolite
4-chloroaniline[no description available]medium30chloroaniline;
monochlorobenzenes
4-toluidine[no description available]medium70aminotoluene
propylamine[no description available]medium10alkylamines
2-pentanone[no description available]medium10methyl ketone;
pentanone		plant metabolite
3-chloroaniline[no description available]medium10
3-chlorophenol[no description available]medium10monochlorophenol
3,5-xylenol[no description available]medium10phenolsxenobiotic metabolite
bromobenzene[no description available]medium10bromoarene;
bromobenzenes;
volatile organic compound		hepatotoxic agent;
mouse metabolite;
non-polar solvent
chlorobenzene[no description available]medium10monochlorobenzenessolvent
propyl acetate[no description available]medium10acetate esterfragrance;
plant metabolite
pentane[no description available]medium30alkane;
volatile organic compound		non-polar solvent;
refrigerant
n-butylamine[no description available]medium10primary aliphatic amine
1-hexanol[no description available]medium10hexanol;
primary alcohol		alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite
heptanol[no description available]medium10heptanol;
primary alcohol		flavouring agent;
fragrance;
gap junctional intercellular communication inhibitor;
plant metabolite
isoquinoline[no description available]medium10azaarene;
isoquinolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene
3-nitrobenzoic acid[no description available]medium10
2-naphthol[no description available]medium20naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
ethyl acetate[no description available]medium10acetate ester;
ethyl ester;
volatile organic compound		EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite
hexanoic acid[no description available]medium10medium-chain fatty acid;
straight-chain saturated fatty acid		human metabolite;
plant metabolite
pregnenolone[no description available]medium1020-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid		human metabolite;
mouse metabolite
3-hydroxyanisole[no description available]medium10monomethoxybenzene;
phenols
mequinol[no description available]medium10methoxybenzenes;
phenols		metabolite
ephedrine[no description available]medium10phenethylamine alkaloid;
phenylethanolamines		bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
3-fluorophenol[no description available]medium10
fluorobenzenes[no description available]medium10monofluorobenzenesNMR chemical shift reference compound
methamphetamine[no description available]medium10amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
3-nitrophenol[no description available]medium103-nitrophenols
lactulose[no description available]medium10glycosylfructosegastrointestinal drug;
laxative
2,6-xylenol[no description available]medium10hydroxytoluene
2-methoxybenzoic acid[no description available]medium10methoxybenzoic acidflavouring agent;
non-steroidal anti-inflammatory drug
3,5-dichlorophenol[no description available]medium10dichlorophenol
iodobenzene[no description available]medium10
methyl n-butyl ketone[no description available]medium10ketone
2-cyanophenol[no description available]medium10benzenes;
nitrile
4-cyanophenol[no description available]medium10phenolsEC 1.4.3.4 (monoamine oxidase) inhibitor
4-phenylpyridine[no description available]medium10phenylpyridine
diphenyl sulfoxide[no description available]medium10sulfoxide
methyl phenyl sulfoxide[no description available]medium10benzenes;
sulfoxide
azatadine[no description available]medium10benzocycloheptapyridine;
tertiary amine		anti-allergic agent;
H1-receptor antagonist
dimethindene[no description available]medium10indene
olsalazine[no description available]medium10azobenzenes;
dicarboxylic acid		non-steroidal anti-inflammatory drug;
prodrug
timolol[no description available]medium10timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
penbutolol[no description available]medium10ethanolamines
diltiazem[no description available]medium105-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
foscarnet sodium[no description available]medium10one-carbon compound;
organic sodium salt		antiviral drug
cicletanine[no description available]medium10organochlorine compound
temelastine[no description available]medium10pyrimidone
4-trifluoromethylphenol[no description available]medium10(trifluoromethyl)benzenes;
phenols		drug metabolite;
marine xenobiotic metabolite
nicotine[no description available]medium203-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
naproxen[no description available]medium10methoxynaphthalene;
monocarboxylic acid		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
cortisone[no description available]medium1011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
raffinose[no description available]medium10raffinose family oligosaccharide;
trisaccharide		mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
cortodoxone[no description available]medium10deoxycortisol;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
thiopental[no description available]medium10barbituratesanticonvulsant;
drug allergen;
environmental contaminant;
intravenous anaesthetic;
sedative;
xenobiotic
quinine[no description available]medium10cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic
diclofenac sodium[no description available]medium10organic sodium salt
guanabenz[no description available]medium10dichlorobenzene
nifuroxime[no description available]medium10
warfarin[no description available]medium10benzenes;
hydroxycoumarin;
methyl ketone
laccase[no description available]medium30
methane[no description available]medium20alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
4-aminodiphenylamine[no description available]medium10aromatic amine;
secondary amino compound		allergen
2-anisidine[no description available]medium100monomethoxybenzene;
primary amino compound;
substituted aniline		genotoxin;
reagent
4,4'-diaminodiphenylmethane[no description available]medium30aromatic amineallergen;
carcinogenic agent
3-toluidine[no description available]medium80
cotinine[no description available]medium10N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid		antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite
3,4-dichloroaniline[no description available]medium10dichloroanilineepitope;
xenobiotic
melamine[no description available]medium10triamino-1,3,5-triazinexenobiotic metabolite
3-anisidine[no description available]medium10aromatic ether;
substituted aniline
tricyclazole[no description available]medium20triazolobenzothiazoleantifungal agrochemical;
melanin synthesis inhibitor
sodium dodecyl sulfate[no description available]medium30organic sodium saltdetergent;
protein denaturant
thiazoles[no description available]medium201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
lanthanum[no description available]medium10f-block element atom;
lanthanoid atom;
scandium group element atom
fluorides[no description available]medium10halide anion;
monoatomic fluorine
3-nitrotoluene[no description available]medium10mononitrotoluene
4-nitrotoluene[no description available]medium10mononitrotoluene
2-nitrotoluene[no description available]medium10mononitrotoluenecarcinogenic agent;
environmental contaminant
prilocaine[no description available]medium103amino acid amide;
monocarboxylic acid amide		anticonvulsant;
local anaesthetic
norharman[no description available]medium20beta-carbolines;
mancude organic heterotricyclic parent		fungal metabolite;
marine metabolite
2-naphthylamine[no description available]medium50naphthylaminecarcinogenic agent
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
2,6-xylidine[no description available]medium50dimethylaniline;
primary arylamine		carcinogenic agent;
drug metabolite
2,4-diaminotoluene[no description available]medium10aminotoluenemetabolite
4-phenylenediamine[no description available]medium30phenylenediamineallergen;
dye;
hapten;
reagent
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
neutral red[no description available]medium10hydrochlorideacid-base indicator;
dye;
two-colour indicator
carbon disulfide[no description available]medium10one-carbon compound;
organosulfur compound
vinyl chloride[no description available]medium10chloroethenes;
gas molecular entity;
monohaloethene		carcinogenic agent
fenton's reagent[no description available]medium30
3,4-xylidine[no description available]medium10dimethylaniline;
primary arylamine
bismuth[no description available]medium10metal atom;
pnictogen
zinc oxide[no description available]medium10zinc molecular entity
2,4-xylidine[no description available]medium30dimethylaniline;
primary arylamine
lead[no description available]medium20carbon group element atom;
elemental lead;
metal atom		neurotoxin
amoxicillin[no description available]medium10penicillin allergen;
penicillin		antibacterial drug
4-biphenylamine[no description available]medium70aminobiphenylcarcinogenic agent
1-naphthylamine[no description available]medium20naphthylaminehuman xenobiotic metabolite
isoprene[no description available]medium50alkadiene;
hemiterpene;
volatile organic compound		plant metabolite
chlorine[no description available]medium30diatomic chlorine;
gas molecular entity		bleaching agent
chloramine[no description available]medium10halide
boron[no description available]medium10boron group element atom;
metalloid atom;
nonmetal atom		micronutrient
cyclopentane[no description available]medium10cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
2-aminophenol[no description available]medium10aminophenolbacterial metabolite
2,5-diaminotoluene[no description available]medium10diamineallergen
p-chloro-o-toluidine hydrochloride[no description available]medium40
1,3-butadiene[no description available]medium20butadienecarcinogenic agent;
mutagen
pyrene[no description available]medium10ortho- and peri-fused polycyclic arenefluorescent probe;
persistent organic pollutant
4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone[no description available]medium10nitrosamine;
pyridines
carbon monoxide[no description available]medium10carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
acrolein[no description available]medium10enalherbicide;
human xenobiotic metabolite;
toxin
hydrochloric acid[no description available]medium10chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride		mouse metabolite
trinitrotoluene[no description available]medium10trinitrotolueneexplosive
1,7-dimethylxanthine[no description available]medium10dimethylxanthinecentral nervous system stimulant;
human blood serum metabolite;
human xenobiotic metabolite;
mouse metabolite
protocatechuic acid[no description available]medium10catechols;
dihydroxybenzoic acid		antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite
ellagic acid[no description available]medium10catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
theobromine[no description available]medium10dimethylxanthineadenosine receptor antagonist;
bronchodilator agent;
food component;
human blood serum metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
caffeine[no description available]medium10purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
crotamiton[no description available]medium10
sulfanilamide[no description available]medium10substituted aniline;
sulfonamide antibiotic;
sulfonamide		antibacterial agent;
drug allergen;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
phenothiazine[no description available]medium10phenothiazineferroptosis inhibitor;
plant metabolite;
radical scavenger
glycogen[no description available]medium10
2-aminodiphenyl[no description available]medium10
boric acid[no description available]medium10boric acidsastringent
furaldehyde[no description available]medium10aldehyde;
furans		Maillard reaction product;
metabolite
xylose[no description available]medium20D-xylose
galactose[no description available]medium10
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
psd 502[no description available]medium31
ascorbic acid[no description available]medium11ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
4-chloro-1,2-diaminobenzene[no description available]medium20monochlorobenzenes
kojic acid[no description available]medium104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
diethylhexyl phthalate[no description available]medium20diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
methyl methanesulfonate[no description available]medium10methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
p-dimethylaminoazobenzene[no description available]medium10azobenzenes
orcinol[no description available]medium205-alkylresorcinol;
dihydroxytoluene		Aspergillus metabolite
isoluminol[no description available]medium10
9-(4'-aminophenyl)-9h-pyrido(3,4-b)indole[no description available]medium10
sodium azide[no description available]medium10inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
cellobiose[no description available]medium10cellobioseepitope
edetic acid[no description available]medium20ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
carbon tetrachloride[no description available]medium10chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
ozone[no description available]medium10elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen		antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer
chromium[no description available]medium10chromium group element atom;
metal allergen		micronutrient
1-amino-2-naphthol[no description available]medium10
sudan iii[no description available]medium10azobenzenes;
bis(azo) compound;
naphthols		carcinogenic agent;
fluorochrome;
histological dye
sudan red[no description available]medium10
1-phenylazo-2-naphthol[no description available]medium10
gold[no description available]medium10copper group element atom;
elemental gold
palladium[no description available]medium10metal allergen;
nickel group element atom;
platinum group metal atom
azobenzene[no description available]medium10azobenzenes
dapsone[no description available]medium10substituted aniline;
sulfone		anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug
d.c. red no. 9[no description available]medium10
2-nitrosotoluene[no description available]medium30
2-chloro-4-acetotoluidine[no description available]medium10
4,4'-methylene bis(2-methylaniline)[no description available]medium10diarylmethane
hempa[no description available]medium10phosphoramideinsect sterilant;
mutagen
diethylstilbestrol[no description available]medium20olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
acrylonitrile[no description available]medium10aliphatic nitrile;
volatile organic compound		antifungal agent;
carcinogenic agent;
fungal metabolite;
mutagen;
polar aprotic solvent
safrole[no description available]medium20benzodioxolesflavouring agent;
insecticide;
metabolite;
plant metabolite
1,2-diaminobenzene[no description available]medium10phenylenediaminehydrogen donor
3,3',5,5'-tetramethylbenzidine[no description available]medium10
thiourea[no description available]medium10one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
4-nitroquinoline-1-oxide[no description available]medium10C-nitro compound;
quinoline N-oxide		carcinogenic agent
benzo(a)pyrene[no description available]medium10ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
propyleneimine[no description available]medium10aziridines
acetamide[no description available]medium10acetamides;
carboximidic acid;
monocarboxylic acid amide;
N-acylammonia
acrylamide[no description available]medium10acrylamides;
N-acylammonia;
primary carboxamide		alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin
deoxyguanosine[no description available]medium20purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine[no description available]medium10guanosinesbiomarker
phenmedipham[no description available]medium10carbamate esterenvironmental contaminant;
herbicide;
xenobiotic
carbamates[no description available]medium10amino-acid anion
harmine[no description available]medium10harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
diphenylamine[no description available]medium10aromatic amine;
bridged diphenyl fungicide;
secondary amino compound		antifungal agrochemical;
antioxidant;
carotogenesis inhibitor;
EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor;
ferroptosis inhibitor;
radical scavenger
4-bromoaniline[no description available]medium10
3-chloro-2-methylaniline[no description available]medium10
1,2-diamino-4-nitrobenzene[no description available]medium10C-nitro compound;
primary amino compound
chlorphenamidine[no description available]medium10
aminoglutethimide[no description available]medium10dicarboximide;
piperidones;
substituted aniline		adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
vanillic acid[no description available]medium10methoxybenzoic acid;
monohydroxybenzoic acid		plant metabolite
acetaldehyde[no description available]low00aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
2-nitropropane[no description available]low00secondary nitroalkanecarcinogenic agent;
hepatotoxic agent;
polar aprotic solvent;
xenobiotic
formaldehyde[no description available]low00aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydroquinone[no description available]low00benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
naphthalene[no description available]low00naphthalenes;
ortho-fused bicyclic arene		apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component
1,2-dimethylhydrazine[no description available]low00hydrazinesalkylating agent;
carcinogenic agent
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine[no description available]low00imidazopyridine;
primary amino compound		carcinogenic agent;
mutagen
3-methylcholanthrene[no description available]low00ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
aristolochic acid i[no description available]low00aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin
azathioprine[no description available]low00aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug
busulfan[no description available]low00methanesulfonate esteralkylating agent;
antineoplastic agent;
carcinogenic agent;
insect sterilant;
teratogenic agent
chlorambucil[no description available]low00aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
dacarbazine[no description available]low00imidazoles;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
carcinogenic agent;
prodrug
ddt[no description available]low00benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
methapyrilene[no description available]low00ethylenediamine derivativeanti-allergic agent;
carcinogenic agent;
H1-receptor antagonist;
sedative
patulin[no description available]low00furopyran;
gamma-lactone;
lactol		antimicrobial agent;
Aspergillus metabolite;
carcinogenic agent;
mutagen;
mycotoxin;
Penicillium metabolite
semustine[no description available]low00N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent
sulfamethazine[no description available]low00pyrimidines;
sulfonamide antibiotic;
sulfonamide		antibacterial drug;
antiinfective agent;
antimicrobial agent;
carcinogenic agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
ligand;
xenobiotic
2-acetylaminofluorene[no description available]low002-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
diethylnitrosamine[no description available]low00nitrosaminecarcinogenic agent;
hepatotoxic agent;
mutagen
dimazine[no description available]low00hydrazinescarcinogenic agent;
fuel;
teratogenic agent
9,10-dimethyl-1,2-benzanthracene[no description available]low00ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
n-nitrosomorpholine[no description available]low00nitrosaminecarcinogenic agent;
mutagen
ethyl methanesulfonate[no description available]low00methanesulfonate esteralkylating agent;
antineoplastic agent;
carcinogenic agent;
genotoxin;
mutagen;
teratogenic agent
diethyl sulfate[no description available]low00alkyl sulfatealkylating agent;
apoptosis inducer;
carcinogenic agent;
mutagen
hexachloroethane[no description available]low00chlorocarbon;
chloroethanes		carcinogenic agent;
refrigerant
bromoethane[no description available]low00bromoalkane;
bromohydrocarbon;
volatile organic compound		alkylating agent;
carcinogenic agent;
local anaesthetic;
refrigerant;
solvent
methylene chloride[no description available]low00chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
vinylidene chloride[no description available]low00chloroethenescarcinogenic agent;
mouse metabolite;
mutagen
acriflavine chloride[no description available]low00organic chloride saltantibacterial agent;
antiseptic drug;
carcinogenic agent;
histological dye;
intercalator
2,4,6-trichlorophenol[no description available]low00trichlorophenolcarcinogenic agent
1-methylnaphthalene[no description available]low00methylnaphthalenecarcinogenic agent;
plant metabolite
2-nitroanisole[no description available]low002-nitroanisolescarcinogenic agent
proflavine[no description available]low00aminoacridinesantibacterial agent;
antiseptic drug;
carcinogenic agent;
chromophore;
intercalator
benzidine[no description available]low00biphenyls;
substituted aniline		carcinogenic agent
benzotrichloride[no description available]low00benzenes;
organochlorine compound;
volatile organic compound		carcinogenic agent
benzoyl chloride[no description available]low00acyl chloride;
benzenes		carcinogenic agent
n-nitrosopiperidine[no description available]low00nitrosamine;
piperidine		apoptosis inducer;
carcinogenic agent;
environmental contaminant;
mutagen
4-vinyl-1-cyclohexene dioxide[no description available]low00epoxidecarcinogenic agent
ethylene dibromide[no description available]low00bromoalkane;
bromohydrocarbon		algal metabolite;
carcinogenic agent;
fumigant;
marine metabolite;
mouse metabolite;
mutagen
furan[no description available]low00furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		carcinogenic agent;
hepatotoxic agent;
Maillard reaction product
chlorendic acid[no description available]low00bridged compound;
dicarboxylic acid;
organochlorine compound		carcinogenic agent
hexachlorobenzene[no description available]low00aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
methapyrilene hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
carcinogenic agent;
H1-receptor antagonist;
sedative
phenazopyridine hydrochloride[no description available]low00hydrochloridecarcinogenic agent;
local anaesthetic;
non-narcotic analgesic
nitrilotriacetic acid[no description available]low00NTA;
tricarboxylic acid		carcinogenic agent;
nephrotoxic agent
estragole[no description available]low00alkenylbenzene;
monomethoxybenzene;
phenylpropanoid		carcinogenic agent;
flavouring agent;
genotoxin;
insect attractant;
plant metabolite
benzo(e)pyrene[no description available]low00ortho- and peri-fused polycyclic arenecarcinogenic agent;
mutagen
diazomethane[no description available]low00diazo compoundalkylating agent;
antineoplastic agent;
carcinogenic agent;
poison
perfluorooctanoic acid[no description available]low00fluoroalkanoic acidcarcinogenic agent;
endocrine disruptor;
environmental contaminant;
surfactant;
xenobiotic
4-methylcatechol[no description available]low00methylcatecholantioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite
mustard gas[no description available]low00ethyl sulfide;
organochlorine compound		alkylating agent;
carcinogenic agent;
vesicant
1,2-naphthoquinone[no description available]low001,2-naphthoquinonesaryl hydrocarbon receptor agonist;
carcinogenic agent
bis(chloromethyl) ether[no description available]low00ether;
organochlorine compound		alkylating agent;
carcinogenic agent
malachite green[no description available]low00organic chloride saltantibacterial agent;
antifungal drug;
carcinogenic agent;
environmental contaminant;
fluorochrome;
histological dye;
teratogenic agent
2-nitrofluorene[no description available]low00nitroarenecarcinogenic agent;
mutagen
methylnitrosourea[no description available]low00N-nitrosoureasalkylating agent;
carcinogenic agent;
mutagen;
teratogenic agent
2,6-dichlorobenzoquinone[no description available]low001,4-benzoquinones;
organochlorine compound		carcinogenic agent;
poison
ethylnitrosourea[no description available]low00N-nitrosoureasalkylating agent;
carcinogenic agent;
genotoxin;
mutagen
4-methylimidazole[no description available]low00imidazolescarcinogenic agent;
reaction intermediate
beryllium oxide[no description available]low00beryllium molecular entity;
metal oxide		carcinogenic agent
1,5-naphthalenediamine[no description available]low00naphthalenediaminecarcinogenic agent
5-methoxyindoleacetic acid[no description available]low00aromatic ether;
indole-3-acetic acids		antibacterial agent;
Brassica napus metabolite;
carcinogenic agent;
human urinary metabolite;
marine xenobiotic metabolite;
rat metabolite
butylhydroxybutylnitrosamine[no description available]low00nitrosamine;
primary alcohol		carcinogenic agent
1-nitropyrene[no description available]low00nitroarenecarcinogenic agent
cyclophosphamide[no description available]low00hydratealkylating agent;
antineoplastic agent;
carcinogenic agent;
immunosuppressive agent
acetoxyacetylaminofluorene[no description available]low002-acetamidofluorenescarcinogenic agent;
mutagen
nitrosocarbaryl[no description available]low00carbamate ester;
naphthalenes;
nitroso compound		carcinogenic agent;
mutagen
phosphine[no description available]low00mononuclear parent hydride;
phosphanes;
phosphine		carcinogenic agent;
fumigant insecticide
lead chromate[no description available]low00chromium coordination entity;
lead coordination entity		carcinogenic agent;
nephrotoxin;
neurotoxin
sodium chromate(vi)[no description available]low00inorganic sodium saltcarcinogenic agent;
diagnostic agent;
oxidising agent;
poison
beryllium chloride[no description available]low00beryllium molecular entity;
inorganic chloride		carcinogenic agent;
genotoxin
potassium chromate(vi)[no description available]low00potassium saltcarcinogenic agent;
oxidising agent
cadmium nitrate[no description available]low00cadmium salt;
inorganic nitrate salt		carcinogenic agent;
genotoxin;
hepatotoxic agent
ethionine[no description available]low00S-ethylhomocysteineantimetabolite;
carcinogenic agent
n-ethyl-n-hydroxyethylnitrosamine[no description available]low00nitrosamine;
primary alcohol		carcinogenic agent
n-amyl-n-methylnitrosamine[no description available]low00nitrosaminecarcinogenic agent
n-nitrososarcosine[no description available]low00nitrosamine;
non-proteinogenic amino acid derivative		carcinogenic agent
ferric nitrilotriacetate[no description available]low00iron chelatecarcinogenic agent;
mutagen
tetradecanoylphorbol acetate[no description available]low00acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
1,4-dioxane[no description available]low00dioxane;
volatile organic compound		carcinogenic agent;
metabolite;
NMR chemical shift reference compound;
non-polar solvent
butyl(3-carboxypropyl)nitrosamine[no description available]low00monocarboxylic acid;
nitrosamine		carcinogenic agent
diisopropanolnitrosamine[no description available]low00diol;
nitrosamine;
secondary alcohol		carcinogenic agent
nitrosobis(2-oxopropyl)amine[no description available]low00ketone;
nitrosamine		carcinogenic agent
2-amino-3-methylimidazo(4,5-f)quinoline[no description available]low00imidazoquinolinecarcinogenic agent
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline[no description available]low00aromatic amine;
imidazoquinoxaline		carcinogenic agent;
genotoxin;
Maillard reaction product;
mutagen
musk xylene[no description available]low00C-nitro compoundcarcinogenic agent;
explosive;
fragrance
scarlet red[no description available]low00azobenzenes;
bis(azo) compound;
naphthols		carcinogenic agent;
fluorochrome;
histological dye
xanthurenic acid 8-methyl ether[no description available]low00aromatic ether;
monohydroxyquinoline;
quinolinemonocarboxylic acid		carcinogenic agent;
metabolite;
mouse metabolite
n-hydroxy-4-aminobiphenyl[no description available]low00aminobiphenyl;
N-substituted amine		carcinogenic agent;
human xenobiotic metabolite
aflatoxin q1[no description available]low00aflatoxin;
aromatic ether;
aromatic ketone		carcinogenic agent;
human xenobiotic metabolite
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol[no description available]low00nitrosamine;
pyridines;
secondary alcohol		biomarker;
carcinogenic agent;
human urinary metabolite
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine[no description available]low00hydroxylamine;
imidazopyridine		carcinogenic agent;
genotoxin;
human xenobiotic metabolite;
mouse metabolite;
mutagen;
neurotoxin;
rat metabolite
thiamethoxam[no description available]low001,3-thiazoles;
2-nitroguanidine derivative;
organochlorine compound;
oxadiazane		antifeedant;
carcinogenic agent;
environmental contaminant;
neonicotinoid insectide;
xenobiotic
aristolochic acid ii[no description available]low00aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin
ponceau mx[no description available]low00azobenzenes;
naphthalenesulfonic acid;
naphthols		carcinogenic agent;
cardiotoxic agent
aristolochic acid D[no description available]low00aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
nephrotoxin;
toxin
methanearsonous acid[no description available]low00arsonous acids;
one-carbon compound		carcinogenic agent;
human xenobiotic metabolite;
poison
aristolochic acid c[no description available]low00aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin
aflatoxin b1[no description available]low00aflatoxin;
aromatic ether;
aromatic ketone		carcinogenic agent;
human metabolite
2-hydroxyestradiol[no description available]low0017beta-hydroxy steroid;
2-hydroxy steroid		carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug
ochratoxin a[no description available]low00isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent
sodium arsenite[no description available]low00arsenic molecular entity;
inorganic sodium salt		antibacterial agent;
antifungal agent;
antineoplastic agent;
carcinogenic agent;
herbicide;
insecticide;
rodenticide
melphalan[no description available]low00L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
versicolorin a[no description available]low00cyclic acetal;
organic heteropentacyclic compound;
p-quinones;
polyphenol		Aspergillus metabolite;
carcinogenic agent
propylthiouracil[no description available]low00pyrimidinethioneantidote to paracetamol poisoning;
antimetabolite;
antioxidant;
antithyroid drug;
carcinogenic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
hormone antagonist
captax[no description available]low00aryl thiol;
benzothiazoles		carcinogenic agent;
metabolite
dieldrin[no description available]low00epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic
fumonisin b1[no description available]low00diester;
fumonisin;
primary amino compound;
triol		carcinogenic agent;
metabolite
fumonisin b2[no description available]low00diester;
diol;
fumonisin;
primary amino compound		Aspergillus metabolite;
carcinogenic agent
riddelliine[no description available]low00macrodiolide;
olefinic compound;
organic heterotricyclic compound;
pyrrolizine alkaloid		carcinogenic agent;
genotoxin;
mutagen
cyclosporine[no description available]low00homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
beryllium[no description available]low00alkaline earth metal atom;
elemental beryllium;
metal allergen		adjuvant;
carcinogenic agent;
epitope
riddelliine n-oxide[no description available]low00diol;
macrocyclic lactone;
olefinic compound;
organic heterotricyclic compound;
primary alcohol;
pyrrolizine alkaloid;
tertiary alcohol;
tertiary amine oxide		carcinogenic agent;
genotoxin;
human xenobiotic metabolite;
Jacobaea metabolite;
mutagen;
rat metabolite
gw 501516[no description available]low001,3-thiazoles;
aromatic ether;
aryl sulfide;
monocarboxylic acid;
organofluorine compound		carcinogenic agent;
PPARbeta/delta agonist
4-hydroxyestrone[no description available]low0017-oxo steroid;
3-hydroxy steroid;
4-hydroxy steroid;
catechols;
phenolic steroid		carcinogenic agent;
estrogen;
human urinary metabolite
3,6-diamino-10-methylacridinium chloride hydrochloride[no description available]low00hydrochlorideantibacterial agent;
antiseptic drug;
carcinogenic agent;
intercalator
debromoaplysiatoxin[no description available]low00aplysiatoxins;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
phenols;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist
aplysiatoxin[no description available]low00aplysiatoxins;
bromophenol;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
secondary alcohol;
spiroketal		algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist
colibactin[no description available]low001,3-thiazoles;
azaspiro compound;
polyketide;
pyrroline;
secondary carboxamide		alkylating agent;
carcinogenic agent;
Escherichia coli metabolite;
genotoxin
N,N'-bis(3-methylphenyl)ethane-1,2-diamine[no description available]low00aminotoluene
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione[no description available]low00aminotoluene
4-methyl-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)aniline[no description available]low00aminotoluene
N2-(4-methylphenyl)benzene-1,2-diamine[no description available]low00aminotoluene
N-(4-Methylphenyl)-2,3-dihydro-3-thiophenamine 1,1-dioxide[no description available]low00aminotoluene
ly3009120[no description available]low00aminotoluene;
aromatic amine;
biaryl;
monofluorobenzenes;
phenylureas;
pyridopyrimidine;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
B-Raf inhibitor;
necroptosis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Abdominal Neoplasms0low10
Abnormalities, Autosome0low10
Abnormalities, Chromosomal0low10
Abnormalities, Chromosome0low10
Adenocarcinoma0low10
Adenocarcinoma, Alveolar0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Bronchiolo-Alveolar0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma0low10
Adenoma, Basal Cell0low10
Adenoma, Follicular0low10
Adenoma, Malignant0low10
Adenoma, Microcystic0low10
Adenoma, Monomorphic0low10
Adenoma, Papillary0low10
Adenoma, Trabecular0low10
Airflow Obstruction, Chronic0low10
Alcohol Abuse0low10
Alcohol Addiction0low10
Alcohol Dependence0low10
Alcohol Use Disorder0low10
Alcoholic Intoxication0low10
Alcoholic Intoxication, Chronic0low10
Alcoholism0low10
Alveolar Cell Carcinoma0low10
Arteriosclerosis, Coronary0low10
Ascariasis0low10
Ascaris Infection0low10
Atherosclerosis, Coronary0low10
Autosome Abnormalities0low10
Benign Neoplasms0low40
Biliary Tract Cancer0low10
Biliary Tract Neoplasms0low10
Bladder Cancer0low270
Bladder Neoplasms0low270
Bladder Tumors0low270
Cancer0low40
Cancer of Biliary Tract0low10
Cancer of Bladder0low270
Cancer of Colon0low10
Cancer of Digestive System0low10
Cancer of Liver0low10
Cancer of Lung0low20
Cancer of Rectum0low10
Cancer of Spleen0low10
Cancer of the Biliary Tract0low10
Cancer of the Bladder0low270
Cancer of the Colon0low10
Cancer of the Digestive System0low10
Cancer of the Liver0low10
Cancer of the Lung0low20
Cancer of the Rectum0low10
Cancer of the Spleen0low10
Cancer, Hepatocellular0low10
Canine Diseases0low10
Carcinogenesis0low10
Carcinoma, Alveolar0low10
Carcinoma, Bronchiolar0low10
Carcinoma, Bronchiolo-Alveolar0low10
Carcinoma, Bronchioloalveolar0low10
Carcinoma, Cribriform0low10
Carcinoma, Granular Cell0low10
Carcinoma, Hepatocellular0low10
Carcinoma, Transitional Cell0low10
Carcinoma, Tubular0low10
Cell Transformation, Neoplastic0low10
Chemical Dependence0low10
Chromosomal Aberrations0low10
Chromosome Aberrations0low10
Chromosome Abnormalities0low10
Chromosome Deletion0low10
Chromosome-Defective Micronuclei0low20
Chronic Airflow Obstruction0low10
Chronic Obstructive Airway Disease0low10
Chronic Obstructive Lung Disease0low10
Chronic Obstructive Pulmonary Disease0low10
Chronic Obstructive Pulmonary Diseases0low10
COAD0low10
Colon Cancer0low10
Colon Neoplasms0low10
Colonic Cancer0low10
Colonic Neoplasms0low10
COPD0low10
Coronary Arteriosclerosis0low10
Coronary Artery Disease0low10
Coronary Atherosclerosis0low10
Cytogenetic Aberrations0low10
Cytogenetic Abnormalities0low10
Death, Sudden0low10
Dermatoses0low10
Dermatosis0low10
Diabetes Mellitus0low20
Diffuse Mixed Small and Large Cell Lymphoma0low10
Diffuse Mixed-Cell Lymphoma0low10
Diffuse Small Cleaved-Cell Lymphoma0low10
Diffuse Undifferentiated Lymphoma0low10
Digestive System Cancer0low10
Digestive System Neoplasms0low10
Disease0low10
Disease Models, Animal0low20
Diseases, Occupational0low120
Dog Diseases0low10
Drug Abuse0low10
Drug Addiction0low10
Drug Dependence0low10
Drug Habituation0low10
Drug Use Disorders0low10
Drunkenness0low10
EHS Tumor0low10
Equine Diseases0low10
Ethanol Abuse0low10
Experimental Hepatoma0low10
Experimental Hepatomas0low10
Experimental Liver Neoplasms0low10
Experimental Neoplasms0low40
Experimental Sarcoma0low10
Experimental Sarcomas0low10
Gastrointestinal Hemorrhage0low20
Genotoxicant-Induced Micronuclei0low20
Glycosuria0low10
Hematochezia0low20
Hematuria0low30
Hemorrhage, Gastrointestinal0low20
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
Hepatoma, Experimental0low10
Hepatoma, Morris0low10
Hepatoma, Novikoff0low10
Hepatomas, Experimental0low10
Horse Diseases0low10
Hyperlipemia0low10
Hyperlipidemia0low10
Hyperlipidemias0low10
Inflammation0low10
Innate Inflammatory Response0low10
Intestinal Diseases0low10
Intestinal Polyps0low10
Intoxication, Alcoholic0low10
Itching0low30
Left Main Coronary Artery Disease0low10
Left Main Coronary Disease0low10
Left Main Disease0low10
Lipemia0low10
Lipidemia0low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Neoplasms0low10
Liver Neoplasms, Experimental0low10
Lung Cancer0low20
Lung Neoplasms0low20
Lymphatic Sarcoma0low10
Lymphoma, Atypical Diffuse Small Lymphoid0low10
Lymphoma, Diffuse0low10
Lymphoma, Diffuse, Mixed Lymphocytic-Histiocytic0low10
Lymphoma, High-Grade0low10
Lymphoma, Intermediate-Grade0low10
Lymphoma, Low-Grade0low10
Lymphoma, Mixed0low10
Lymphoma, Mixed Cell, Diffuse0low10
Lymphoma, Mixed Lymphocytic-Histiocytic0low10
Lymphoma, Mixed Small and Large Cell, Diffuse0low10
Lymphoma, Mixed-Cell0low10
Lymphoma, Mixed-Cell, Diffuse0low10
Lymphoma, Non-Hodgkin0low10
Lymphoma, Non-Hodgkin, Familial0low10
Lymphoma, Non-Hodgkin's0low10
Lymphoma, Non-Hodgkins0low10
Lymphoma, Nonhodgkin's0low10
Lymphoma, Nonhodgkins0low10
Lymphoma, Pleomorphic0low10
Lymphoma, Small and Large Cleaved-Cell, Diffuse0low10
Lymphoma, Small Cleaved Cell, Diffuse0low10
Lymphoma, Small Cleaved-Cell, Diffuse0low10
Lymphoma, Small Non-Cleaved-Cell0low10
Lymphoma, Small Noncleaved-Cell0low10
Lymphoma, Undifferentiated0low10
Lymphoma, Undifferentiated, Diffuse0low10
Lymphosarcoma0low10
Malignancy0low40
Malignant Neoplasms0low40
Malignant Tumor of Urinary Bladder0low270
Mange, Sarcoptic0low20
Melena0low20
Mesothelioma0low10
Methemoglobinemia0medium31
Micronuclei, Chromosome-Defective0low20
Micronuclei, Genotoxicant-Induced0low20
Micronucleus, Chromosome-Defective0low20
Mixed Small and Large Cell Lymphoma, Diffuse0low10
Mixed-Cell Lymphoma0low10
Mixed-Cell Lymphoma, Diffuse0low10
Monosomy, Partial0low10
Muscle Disorders0low10
Muscular Diseases0low10
Myopathic Conditions0low10
Myopathies0low10
Neoplasia0low40
Neoplasm0low40
Neoplasms0low40
Neoplasms, Benign0low40
Neoplasms, Biliary Tract0low10
Neoplasms, Bladder0low270
Neoplasms, Colonic0low10
Neoplasms, Digestive System0low10
Neoplasms, Experimental0low40
Neoplasms, Experimental Liver0low10
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Neoplasms, Lung0low20
Neoplasms, Pulmonary0low20
Neoplasms, Rectal0low10
Neoplasms, Splenic0low10
Neoplastic Cell Transformation0low10
Neoplastic Transformation, Cell0low10
Non-Hodgkin Lymphoma0low10
Non-Hodgkin's Lymphoma0low10
Occupational Diseases0low120
Occupational Illnesses0low120
Oncogenesis0low10
Organic Mental Disorders, Substance-Induced0low10
Partial Monosomy0low10
Pericementitis0low10
Periodontal Pocket0medium21
Periodontitis0low10
Peripheral Nerve Diseases0low10
Peripheral Nervous System Disease0low10
Peripheral Nervous System Diseases0low10
Peripheral Nervous System Disorders0low10
Peripheral Neuropathies0low10
PNS (Peripheral Nervous System) Diseases0low10
PNS Diseases0low10
Pocket, Periodontal0medium21
Poisoning0low10
Pregnancy0low20
Prescription Drug Abuse0low10
Prurigo0low10
Pruritis0low30
Pruritus0low30
Pruritus Vulvae0low10
Pulmonary Cancer0low20
Pulmonary Disease, Chronic Obstructive0low10
Pulmonary Neoplasms0low20
Rectal Cancer0low10
Rectal Neoplasms0low10
Rectal Tumors0low10
Rectum Cancer0low10
Rectum Neoplasms0low10
Respiratory Tract Neoplasms0low10
Reticulosarcoma0low10
Reticulum Cell Sarcoma0low10
Reticulum-Cell Sarcoma0low10
Sarcoma, Engelbreth-Holm-Swarm0low10
Sarcoma, Experimental0low10
Sarcoma, Jensen0low10
Sarcoma, Lymphatic0low10
Sarcoma, Reticulum-Cell0low10
Sarcomas, Experimental0low10
Scabies0low20
Sensitivity and Specificity0low30
Skin and Subcutaneous Tissue Disorders0low10
Skin Diseases0low10
Small Cleaved-Cell Lymphoma, Diffuse0low10
Small Non-Cleaved-Cell Lymphoma0low10
Small Noncleaved-Cell Lymphoma0low10
Spleen Cancer0low10
Spleen Neoplasms0low10
Splenic Cancer0low10
Splenic Neoplasms0low10
Substance Abuse0low10
Substance Addiction0low10
Substance Dependence0low10
Substance Use0low10
Substance Use Disorders0low10
Substance-Related Disorders0low10
Sudden Death0low10
Transformation, Neoplastic Cell0low10
Tumorigenesis0low10
Tumorigenic Transformation0low10
Tumors0low40
Undifferentiated Lymphoma0low10
Urinary Bladder Cancer0low270
Urinary Bladder Neoplasms0low270
Vulvar Diseases0low10

Research Highlights

Safety/Toxicity (4)

ArticleYear
Miniaturization of cytotoxicity tests for concentration range-finding studies prior to conducting the pH 6.7 Syrian hamster embryo cell-transformation assay.
Mutation research, Aug-15, Volume: 755, Issue: 2		2013
Toxicity identification and reduction of wastewaters from a pigment manufacturing factory.
Chemosphere, Volume: 70, Issue: 6		2008
Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens.
Mutation research, Volume: 320, Issue: 4		1994
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Penile absorption of EMLA cream in piglets: implications for use of EMLA in neonatal circumcision.
Biology of the neonate, Volume: 68, Issue: 5		1995
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

ArticleYear
Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 36, Issue: 8		2008
Hepatic macromolecular binding and tissue distribution of ortho- and para-toluidine in rats.
Toxicology letters, Volume: 54, Issue: 2-3		1990
ortho-toluidine blood protein adducts: HPLC analysis with fluorescence detection after a single dose in the adult male rat.
Fundamental and applied toxicology : official journal of the Society of Toxicology, Volume: 18, Issue: 4		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Rapid determination of six carcinogenic primary aromatic amines in mainstream cigarette smoke by two-dimensional online solid phase extraction combined with liquid chromatography tandem mass spectrometry.
Journal of chromatography. A, Jan-27, Volume: 1482		2017
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]