A compound which can carry specific ions through membranes of cells or organelles.
| Member | Definition | Class |
|---|
| alborixin | A polyether antibiotic that is isolated from cultures of a strain of Streptomyces albus. | alborixin |
| beauvericin | A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues. | beauvericin |
| carbonyl cyanide m-chlorophenyl hydrazone | A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death. | CCCP |
| carbonyl cyanide p-trifluoromethoxyphenylhydrazone | A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group. | carbonyl cyanide p-trifluoromethoxyphenylhydrazone |
| lasalocid | A polyether antibiotic used for prevention and treatment of coccidiosis in poultry. | lasalocid |
| lasalocid sodium | The sodium salt of lasalocid. It is a veterinary ionophore antibiotic used for prevention and treatment of coccidiosis in poultry. | lasalocid sodium |
| monensin | A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle. | monensin A |
| pyrithione | A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent. | pyrithione |
| zincophorin | | griseochelin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 11.6208 | 2 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 70.9799 | 3 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 10.9622 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 6.4092 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 28.1838 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 4.8478 | 9 | 16 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.7528 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 15.1410 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 28.2981 | 2 | 4 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 0.7308 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 13.7255 | 2 | 4 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.0119 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 13.8768 | 3 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 43.9284 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 23.1194 | 1 | 3 |
| Chain A, PAPAIN | Carica papaya (papaya) | Potency | 28.1838 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 35.3973 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 31.4651 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| ClpP | Bacillus subtilis | Potency | 3.9811 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 3.1354 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 3.0398 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 17.3926 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 4.4906 | 8 | 12 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 0.9689 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.9041 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.5610 | 1 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 6.9167 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 3.1354 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 9.1585 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 1.4387 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 8.9716 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.4414 | 3 | 5 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 1.0871 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 2.2017 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 17.9008 | 1 | 4 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 21.3882 | 1 | 3 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 25.8212 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 100.7150 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 25.1189 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 5.8986 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 0.8385 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 3.7646 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 1.5065 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 22.0332 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.4560 | 2 | 5 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 12.5893 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 21.4175 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.8848 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 7.7606 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 5.2690 | 2 | 8 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 13.5073 | 3 | 3 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 48.5342 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 1.4642 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 1.7374 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 72.6796 | 1 | 2 |
| PINK1 | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 17.9008 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 13.6854 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.4951 | 2 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 2.8395 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 10.7806 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 17.9538 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 8.5634 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 8.5634 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 5.1409 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 17.7828 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 5.7538 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.6167 | 2 | 8 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 1.0981 | 3 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 0.6310 | 2 | 4 |
| TSHR protein | Homo sapiens (human) | Potency | 4.7755 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 13.6272 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 6.6427 | 3 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 8.4246 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 1.0871 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 4.4668 | 1 | 1 |