ascorbic-acid and Movement-Disorders

ascorbic-acid has been researched along with Movement-Disorders* in 7 studies

Reviews

1 review(s) available for ascorbic-acid and Movement-Disorders

ArticleYear
Scurvy: still a threat in the well-fed first world?
    Archives of disease in childhood, 2019, Volume: 104, Issue:4

    We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor.

    Topics: Anemia, Iron-Deficiency; Ascorbic Acid; Child, Preschool; Diagnosis, Differential; Dietary Supplements; Humans; Male; Movement Disorders; Musculoskeletal Pain; Scurvy; Vitamin D; Vitamin D Deficiency; Vitamins; Walking

2019

Trials

1 trial(s) available for ascorbic-acid and Movement-Disorders

ArticleYear
On-off effects in Parkinson's disease: a controlled investigation of ascorbic acid therapy.
    Advances in neurology, 1983, Volume: 37

    Patients with PD who experience on-off effects have higher erythrocyte catechol-O-methyltransferase (COMT) activities and plasma 3-O-methyldopa concentrations than do patients without these levodopa-related motor fluctuations. We therefore administered ascorbic acid, a weak competitive inhibitor of COMT, to six PD patients with on-off effects. In this double-blind crossover investigation, ascorbic acid produced a modest improvement in functional performance. However, no fundamental change was observed in the pattern of on-off effects, severity of parkinsonism/dyskinesia, or self-assessment ratings. Ascorbic acid therapy reduced plasma concentrations of levodopa and 3-O-methyldopa but did not alter erythrocyte COMT activity. These findings are discussed in the context of the pharmacokinetic and pharmacodynamic factors that contribute to the pathogenesis of levodopa-induced dyskinesias and on-off motor fluctuations.

    Topics: Aged; Ascorbic Acid; Clinical Trials as Topic; Female; Humans; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease

1983

Other Studies

5 other study(ies) available for ascorbic-acid and Movement-Disorders

ArticleYear
Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Apr-18, Volume: 32, Issue:16

    The early antecedents of cerebral palsy (CP) are unknown but are suspected to be due to hypoxia-ischemia (H-I). In our rabbit model of CP, the MRI biomarker, apparent diffusion coefficient (ADC) on diffusion-weighted imaging, predicted which fetuses will develop postnatal hypertonia. Surviving H-I fetuses experience reperfusion-reoxygenation but a subpopulation manifested a continued decline of ADC during early reperfusion-reoxygenation, which possibly represented greater brain injury (RepReOx). We hypothesized that oxidative stress in reperfusion-reoxygenation is a critical trigger for postnatal hypertonia. We investigated whether RepReOx predicted postnatal neurobehavior, indicated oxidative stress, and whether targeting antioxidants at RepReOx ameliorated motor deficits, which included testing of a new superoxide dismutase mimic (MnTnHex-2-PyP). Rabbit dams, 79% gestation (E25), were subjected to 40 min uterine ischemia. Fetal brain ADC was followed during H-I, immediate reperfusion-reoxygenation, and 4-72 h after H-I. Endpoints were postnatal neurological outcome at E32, ADC at end of H-I, ADC nadir during H-I and reperfusion-reoxygenation, and area under ADC curve during the first 20 min of reperfusion-reoxygenation. Antioxidants targeting RepReOx were administered before and/or after uterine ischemia. The new MRI-ADC biomarker for RepReOx improved prediction of postnatal hypertonia. Greater superoxide production, mitochondrial injury, and oligodendroglial loss occurred in fetal brains exhibiting RepReOx than in those without. The antioxidants, MnTnHex-2-PyP and Ascorbate and Trolox combination, significantly decreased postnatal motor deficits and extent of RepReOx. The etiological link between early injury and later motor deficits can thus be investigated by MRI, and allows us to distinguish between critical oxidative stress that causes motor deficits and noncritical oxidative stress that does not.

    Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Benzimidazoles; Blood Flow Velocity; Brain; Brain Mapping; Carbocyanines; Chromans; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Embryo, Mammalian; Female; Flow Cytometry; Hypoxia-Ischemia, Brain; Ionophores; Laser-Doppler Flowmetry; Membrane Potential, Mitochondrial; Metalloporphyrins; Microvessels; Mitochondria; Movement Disorders; Muscle Hypertonia; O Antigens; Pregnancy; Rabbits; Reperfusion Injury; Superoxides; Time Factors; Valinomycin

2012
Neuroleptic-induced striatal damage in rats: a study of antioxidant treatment using accelerometric and immunocytochemical methods.
    Psychopharmacology, 2000, Volume: 148, Issue:2

    Investigators have postulated that neuroleptic medications may affect the motor system through the creation of free radicals. Also, structural brain changes related to oxidative damage may disrupt normal striatal function.. The goals of this study were to examine whether an antioxidant diet reduced the abnormal movements caused by long-term neuroleptic exposure and to examine structural effects within specific striatal regions in rats.. Rats were given a basal diet or a diet high in antioxidants for 4 months, and treated with 10 mg/kg fluphenazine decanoate or sesame seed oil IM every 2 weeks. At baseline and after treatment, head movements were quantified by accelerometry, and immunocytochemically stained cholinergic neurons in the ventrolateral, mediodorsal, and ventromedial regions of the striatum were quantified.. Rats treated with fluphenazine had significantly lower neuron densities than those that did not receive antioxidants. Rats exposed to a diet consisting of antioxidants had significantly higher neuron densities than those that did not receive antioxidants in each of the three regions tested. Rats treated with fluphenazine had a greater increase in the number of accelerometric peaks recorded per minute compared with untreated animals. The increase in the number of accelerometric peaks recorded per minute was lower for animals exposed to antioxidant diets compared with unexposed animals. Lastly, there was a significant correlation between the accelerometric peak change score and cholinergic neuron density in all three regions.. Our results suggest that long-term neuroleptic treatment is associated with an increase in head movements and a reduction in ChAT-stained striatal cholinergic neurons and that these abnormalities are reduced by antioxidants.

    Topics: Animals; Antioxidants; Antipsychotic Agents; Ascorbic Acid; beta Carotene; Cell Count; Choline O-Acetyltransferase; Corpus Striatum; Fluphenazine; Head Movements; Immunohistochemistry; Male; Movement Disorders; Neurons; Rats; Rats, Sprague-Dawley; Vitamin E

2000
[Nigrostriatally induced motor reactions in the rat. I. Rotational behavior and posture asymetry after intracerebral injection of apomorphine and dopamine].
    Acta biologica et medica Germanica, 1976, Volume: 35, Issue:6

    Using a rotameter described by Ungrstedt, the influence of pretreatment with 6-hydroxy-dopamine and transections of the Capsula interna on the asymmetry of the animal's poise and movement following systemic and intracerebral administration of dopamine and apomorphine was studied. After lesion of the nigrostriatal tract, i.p. administered apomorphine caused the animals to rotate towards the damaged side. After injection of apomorphine in the Nucleus caudatoputamen of healthy animals, initial rotations towards the injection side with subsequent opposite rotation were observed, whereas dopamine injected into the Nucleus caudatoputamen and the Substantia nigra initiated rotations in contralateral direction only. Pretreatment with haloperidole nullified the effect of apomorphine. The results have proved the effectiveness both in the Nucleus caudatoputamen and the Substantia nigra of drugs stimulating the dopamine receptors. With intact rats, the two sides of the nigrostriatal system are functionally asymmetric, which is reflected by the quantitative differences of responses following stimulation of dopamine-sensitive receptors and the individually different preference of one rotational direction. These individual behavioural patterns are modified by experimental influences.

    Topics: Animals; Apomorphine; Ascorbic Acid; Brain; Caudate Nucleus; Dopamine; Female; Haloperidol; Hydroxydopamines; Injections; Movement Disorders; Posture; Rats; Receptors, Dopamine

1976
[Concurrence of diabetes mellitus and hypothyrosis in the diencephalic syndrome].
    Klinicheskaia meditsina, 1971, Volume: 49, Issue:9

    Topics: Adult; Ascorbic Acid; Blood Glucose; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diencephalon; Female; Goiter; Humans; Hypothyroidism; Influenza, Human; Magnesium Sulfate; Movement Disorders; Penicillins; Streptomycin; Thiamine

1971
[ON THE TREATMENT OF EXTRAPYRAMIDAL HYPERKINESIA WITH A NEW RESERPINE DERIVATIVE (RESEPINE ASCORBINATE)].
    Wiener klinische Wochenschrift, 1963, Oct-04, Volume: 75

    Topics: Ascorbic Acid; Athetosis; Chorea; Encephalitis; Extrapyramidal Tracts; Humans; Hyperkinesis; Movement Disorders; Myoclonus; Reserpine; Spasm; Tics; Torticollis

1963
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