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branched-chain keto acid

An oxo carboxylic acid in which the parent hydrocarbon chain has one or more alkyl substituents. Derivatives formed from the first step in the metabolism of branched-chain amino acids and can provide important information on animal health and disease.

ChEBI ID: 191197

Members (3)

MemberDefinitionRole
2-keto-4-methylvalerateA 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.4-methyl-2-oxopentanoic acid
2-oxo-3-methylvalerateA 2-oxo monocarboxylic acid that is valeric acid carrying oxo- and methyl substituents at C-2 and C-3, respectively. An alpha-keto acid analogue and metabolite of isoleucine in man, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).3-methyl-2-oxovaleric acid
alpha-ketoisovalerateA 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid.3-methyl-2-oxobutanoic acid

Research

Studies (821)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990302 (36.78)18.7374
1990's255 (31.06)18.2507
2000's151 (18.39)29.6817
2010's99 (12.06)24.3611
2020's14 (1.71)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials55 (5.48%)5.53%
Reviews30 (2.99%)6.00%
Case Studies3 (0.30%)4.05%
Observational0 (0.00%)0.25%
Other915 (91.23%)84.16%