Compounds > pancratistatin
Page last updated: 2024-11-06

pancratistatin

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Description

pancratistatin: an isocarbostyril from Amaryllidaceae [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AmaryllidaceaefamilyA family of herbaceous plants with bulbs or rhizomes in the order Asparagales.[MeSH]AmaryllidaceaeA family of herbaceous plants with bulbs or rhizomes in the order Asparagales.[MeSH]

Cross-References

ID SourceID
PubMed CID441597
CHEMBL ID419335
CHEBI ID7906
SCHEMBL ID93612
MeSH IDM0131072

Synonyms (28)

Synonym
(+)-pancratistatin
CHEMBL419335
chebi:7906 ,
NCI60_003105
nsc-349156
[1,5-j]phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-,
b844009k070
SMP1_000217
pancratistatin
C08535
96203-70-2
(1r,2s,3s,4s,4ar,11br)-1,2,3,4,7-pentahydroxy-2,3,4,4a,5,11b-hexahydro-1h-[1,3]dioxolo[4,5-j]phenanthridin-6-one
nsc 349156
SCHEMBL93612
VREZDOWOLGNDPW-ALTGWBOUSA-N
Q7130395
DTXSID501315881
CS-0022453
HY-102010
pancratistatine
unii-4gum4b7k5b
(1,3)dioxolo(4,5-j)phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1r-(1alpha,2beta,3alpha,4alpha,4aalpha,11bbeta))-
(1,3)dioxolo(4,5-j)phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1r,2s,3s,4s,4ar,11br)-
(1r,2s,3s,4s,4ar,11br)-1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy(1,3)dioxolo(4,5-j)phenanthridin-6(2h)-one
4gum4b7k5b ,
[1,3]dioxolo[4,5-j]phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1r,2s,3s,4s,4ar,11br)-
(1r,2s,3s,4s,4ar,11br)-1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy[1,3]dioxolo[4,5-j]phenanthridin-6(2h)-one
[1,3]dioxolo[4,5-j]phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, [1r-(1alpha,2beta,3alpha,4alpha,4aalpha,11bbeta)]-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
citraconoyl group
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (104)

Assay IDTitleYearJournalArticle
AID399640In vivo cytotoxicity against mouse P388 cells at 0.78 to 3.1 mg/kg relative to control
AID336625Antiviral activity against Sandfly fever sicilian virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID663224Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID420064Inhibition of human CYP3A4 assessed as biotransformation of 7-benzyloxyquinoline2009Bioorganic & medicinal chemistry letters, Jun-15, Volume: 19, Issue:12
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.
AID143046Tested for growth inhibition activity against lung NCI-H460 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID403385Cytotoxicity against human DU145 cells after 48 hrs by SRB assay2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID336007Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed inhibition of virus-induced mortality at 4 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336004Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as average day of death at 4 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID399929Cytotoxicity against human NCI-H460 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID399928Cytotoxicity against human SF268 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID336002Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as average day of death at 6 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336613Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Japanese encephalitis virus Nakayama1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID1283343Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells at 10 uM treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis relative to contro2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID378663Growth inhibition of human MCF7 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID336621Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336003Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as average day of death at 5 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID332888In vivo cytotoxicity against mouse P388 cells at 12.5 mg/kg relative to control
AID335995Toxicity in C57BL/6 mouse assessed as change in body weight at 4 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post infection1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID332892In vivo antitumor activity against mouse M5076 cells assessed as life extension at 0.38 to 3 mg/kg
AID336001Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as average day of death at 8 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336628Toxicity in C57BL/6 mouse assessed as mortality at 4 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID257543Induction of apoptosis in human Jurkat B lymphoma cell line2005Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
A synthesis of 3-deoxydihydrolycoricidine: refinement of a structurally minimum pancratistatin pharmacophore.
AID336624Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Rift valley fever virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID281098Growth inhibition of human BXPC3 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID332887Cytotoxicity against mouse 9PS cells
AID399925Cytotoxicity against mouse P388 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID332547In vivo cytotoxicity against mouse P388 cells1995Journal of natural products, Jan, Volume: 58, Issue:1
Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis.
AID663226Cytotoxicity against human DU145 cells after 48 hrs by SRB assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID335991Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as survival rate at 6 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post in1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335992Toxicity in C57BL/6 mouse assessed as change in body weight at 8 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post infection1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID332889In vivo cytotoxicity against mouse P388 cells at 0.75 to 6 mg/kg relative to control
AID688343Cytotoxicity against human MCF7 cells2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae.
AID336633Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as average day of death at 6 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days po1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID281099Growth inhibition of human MCF7 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID403379Cytotoxicity against mouse P388 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID663223Cytotoxicity against human SF268 cells after 48 hrs by SRB assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID663225Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID94881Tested for growth inhibition activity against colon KM20L2 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID336617Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Dengue type 4 virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID1283345Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in virus yield at 10 uM treated at 2 hrs post infection measured 48 hrs post infection by flow cytometric analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID1283350Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as viral DNA replication at 10 uM measured 24 hrs post infection by FISH analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID378664Growth inhibition of human SF269 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID1283347Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in EGFP-positive cells at 10 uM treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID663222Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID336009Toxicity in C57BL/6 mouse assessed as mortality at 6 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID154171Tested for growth inhibition activity against murine P388 lymphocytic leukemia2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID335990Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as survival rate at 6 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days post infe1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336005Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as average day of death at 3 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID378661Growth inhibition of mouse P388 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID101762Tested for growth inhibition activity against breast MCF-7 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID335999Toxicity in C57BL/6 mouse assessed as mortality at 3 mg/kg/day, ip twice daily for 9 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID378662Growth inhibition of human BXPC3 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID336008Toxicity in C57BL/6 mouse assessed as mortality at 2 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336614Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336623Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID663220Cytotoxicity against mouse P388 cells after 48 hrs by cell counting2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID200949Tested for growth inhibition activity against CNS SF-268 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID399641Cytotoxicity against mouse P388 cells
AID378667Growth inhibition of human DU145 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID335760Growth inhibition of mouse P388 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID378666Growth inhibition of human KM20L2 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID336612Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID399643In vivo cytotoxicity against mouse P388 cells at 12.5 mg/kg relative to control
AID335997Toxicity in C57BL/6 mouse assessed as change in body weight at 2 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post infection1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID281104Growth inhibition of murine P388 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID403381Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID403380Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID332890In vivo cytotoxicity against mouse M5076 cells at 0.38 to 3 mg/kg relative to control
AID335984Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as inhibition of virus-induced mortality at 4 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335998Toxicity in C57BL/6 mouse assessed as mortality at 4 mg/kg/day, ip twice daily for 9 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335996Toxicity in C57BL/6 mouse assessed as change in body weight at 3 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post infection1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID403383Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID336627Toxicity in C57BL/6 mouse assessed as average day of death at 6 mg/kg/day, sc once daily for 7 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID399926Cytotoxicity against human BxPC3 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID663221Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
AID399927Cytotoxicity against human MCF7 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID378665Growth inhibition of human NCI-H460 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID332548In vivo cytotoxicity against mouse M5076 cells1995Journal of natural products, Jan, Volume: 58, Issue:1
Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis.
AID281102Growth inhibition of human KM20L2 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID403382Cytotoxicity against human SF268 cells after 48 hrs by SRB assay2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID399931Cytotoxicity against human DU145 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID336616Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID40033Tested for growth inhibition activity against pancreas BXPC-3 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID332891In vivo antitumor activity against mouse P388 cells assessed as life extension at 0.75 to 12.5 mg/kg
AID281103Growth inhibition of human DU145 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID336006Antiviral activity against Japanese encephalitis virus Beijing infected in high viral dose challenge C57BL/6 mouse model assessed as average day of death at 2 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days 1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID399932Solubility in water2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID335989Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as survival rate at 4 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days post infe1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID257542Induction of apoptosis in human breast carcinoma MCF7 cell line2005Bioorganic & medicinal chemistry letters, Dec-01, Volume: 15, Issue:23
A synthesis of 3-deoxydihydrolycoricidine: refinement of a structurally minimum pancratistatin pharmacophore.
AID1283349Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in virus yield at 10 uM treated at 2 hrs post infection measured 48 hrs post infection by flow cytometric analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335993Toxicity in C57BL/6 mouse assessed as change in body weight at 6 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post infection1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID399930Cytotoxicity against human KM20L2 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin.
AID281101Growth inhibition of human NCI-H460 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID336615Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Yellow fever virus Ashibi1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336000Toxicity in C57BL/6 mouse assessed as mortality at 2 mg/kg/day, ip twice daily for 9 days1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335994Toxicity in C57BL/6 mouse assessed as change in body weight at 5 mg/kg/day, ip twice daily for 9 days administered 1 day before infection measured after 28 days post infection1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID328905Cytotoxicity against mouse P388 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
synthesis and biological evaluation of fully functionalized seco-pancratistatin analogues.
AID335979Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as average day of death at 4 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days po1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID399642In vivo cytotoxicity against mouse P388 cells at 0.75 to 6 mg/kg relative to control
AID403384Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 553. The Texas grasshopper Brachystola magna.
AID57889Tested for growth inhibition activity against prostate DU-145 human cancer cell2004Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
Synthesis and biological activity of some structural modifications of pancratistatin.
AID281100Growth inhibition of human SF268 cells after 48 hrs2007Journal of natural products, Mar, Volume: 70, Issue:3
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
AID335980Antiviral activity against Japanese encephalitis virus Beijing infected in low viral dose challenge C57BL/6 mouse model assessed as average day of death at 2 mg/kg/day, sc once daily for 7 days administered 1 day before infection measured after 28 days po1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335761Growth inhibition of mouse M5076 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (67)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (11.94)18.2507
2000's35 (52.24)29.6817
2010's19 (28.36)24.3611
2020's5 (7.46)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews5 (7.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other64 (92.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		7.1510aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
inositol
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.		2.4520cyclitol;
hexol
phenanthridone
phenanthridone: coal tar derivative; structure given in first source. phenanthridone : A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.		8.5420lactam;
phenanthridines		EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
immunosuppressive agent;
mutagen
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0510dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
ethylene oxide
Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794). oxirane : A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.		2.0210gas molecular entity;
oxacycle;
saturated organic heteromonocyclic parent		allergen;
mouse metabolite;
mutagen
quinic acid
(-)-quinic acid : The (-)-enantiomer of quinic acid.		2.0110
styrene
Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.		7.0610styrenes;
vinylarene;
volatile organic compound		mouse metabolite;
mutagen;
plant metabolite
bromobenzene
[no description available]		2.0610bromoarene;
bromobenzenes;
volatile organic compound		hepatotoxic agent;
mouse metabolite;
non-polar solvent
cyclohexanol
Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.		2.0510cyclohexanols;
secondary alcohol		solvent
aziridine
[no description available]		7.0210azacycloalkane;
aziridines;
saturated organic heteromonocyclic parent		alkylating agent
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		2.4620benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.		2.1510cobalt group element atom
ammonium chloride
Ammonium Chloride: An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.. ammonium chloride : An inorganic chloride having ammonium as the counterion.		1.9710ammonium salt;
inorganic chloride		ferroptosis inhibitor
alkenes
[no description available]		2.1510
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		2.0510pseudohalide anionmitochondrial respiratory-chain inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		3.8530taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
etoposide
[no description available]		2.4320beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
staurosporine
[no description available]		2.0710indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.4320D-glucopyranoseepitope;
mouse metabolite
lissamine rhodamine b
lissamine rhodamine B: RN given refers to parent cpd; Lissamine Rhodamine B refers to Na salt		2.0310
betulin
betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.		3.3510diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species		5.73150phenanthridinesmetabolite
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		4.5470indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
lycoricidine
lycoricidine: antineoplastic from daffodil (Narcissus) bulbs; structure in first source		3.8130phenanthridines
cb 10375
trimelamol: structure given in first source		1.9810
trans-dihydronarciclasine
[no description available]		2.3820
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.0210cobalt group element atom;
metal allergen		micronutrient
xylose
xylopyranose: structure in first source		2.0210D-xylose
ungeremine
ungeremine: RN given refers to parent cpd; structure		2.0210
homolycorine
homolycorine: irritant isolated from daffodils (Narcissus pseudonarcissus L., Amaryllidaceae); structure given in first source		2.0710
carmethizole
carmethizole: RN & structure given in first source; RN given refers to HCl; RN for parent cpd not available 2/89		1.9810
dihydronarciclasine
dihydronarciclasine: isolated from Zephyranthes candida; structure given in first source; RN given refers to (2S-(2alpha,3beta,4beta,4abeta,11balpha))-isomer		2.0710
valienamine
valienamine: intermediate formed by microbial degradation of validamycins; structure given in first source		7.0510
1-O-Acetyllycorine
1-acetyllycorine: has antiviral activity; structure in first source		2.0510alkaloid
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source		2.4420phenanthridines
7-deoxypancratistatin
7-deoxypancratistatin: a phytogenic antineoplastic agent; structure in first source		4.3760phenanthridines
7-deoxy-trans-dihydronarciclasine
7-deoxy-trans-dihydronarciclasine: structure in first source		2.9240
glycosides
[no description available]		2.2510
piplartine
piplartine: Antineoplastic Agent, Phytogenic; alkaloid from Piper; structure in first source		2.1710cinnamamides;
dicarboximide
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.3510aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
tamoxifen
[no description available]		2.7430stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ungeremine
[no description available]		2.0210organic molecular entitymetabolite
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		2.0610carbon group element atom;
metalloid atom;
nonmetal atom
rhizoxin
rhizoxin: from Rhizopus chinensis; causal agent of rice seedling blight; structure given in first source. rhizoxin : An macrolide antibiotic isolated from the pathogenic plant fungus Rhizopus microsporus. It also exhibits antitumour and antimitotic activity.		1.98101,3-oxazoles;
epoxide;
macrolide antibiotic		antimitotic;
antineoplastic agent;
metabolite
nsc 262266
NSC 262266: structure given in first source		1.9810
3,5-dibromo-2-pyrone
3,5-dibromo-2-pyrone: structure in first source		2.4820
crinamine
crinamine: RN given for (3alpha,5alpha,11R,13beta,19alpha)-isomer; structure in first source		2.0710
tannins
Tannins: Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.		3.3510
hoe 33342
bisbenzimide ethoxide trihydrochloride: benzimidazole fluorescent dye		2.0410
bryostatin 1
bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S*-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.		1.9810
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		3.3510ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0110benzenes;
hydroxycoumarin;
methyl ketone
7-deoxynarciclasine
7-deoxynarciclasine: structure in first source		8.8130
nifedipine
hemanthamine: crinine-like alkaloid from AMARYLLIDACEAE; RN given for (3beta,5alpha,11R,13beta,19alpha)-isomer; structure in first source		2.2510
digitonin
Digitonin: A glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Digitonin solubilizes lipids, especially in membranes and is used as a tool in cellular biochemistry, and reagent for precipitating cholesterol. It has no cardiac effects.. digitonin : A spirostanyl glycoside that is digitogenin in which the 3-hydroxy group is substituted by a beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranosyl group. It is a steroidal saponin isolated from the foxglove plant, Digitalis purpurea. It is used extensively as a mild non-ionic detergent for extracting proteins from membranes for structure and function studies.		1.9710
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.13102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		3.5420
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Japanese B
[description not available]		01.9810
Encephalitis, Japanese
A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)		01.9810
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.9440
Benign Neoplasms
[description not available]		04.0850
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		04.0850
2019 Novel Coronavirus Disease
[description not available]		02.610
Cancer of Colon
[description not available]		02.7730
Colorectal Cancer
[description not available]		07.2110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.7730
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.2110
Behavior Disorders
[description not available]		0310
Mental Disorders
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.		0310
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.1510
Malignant Melanoma
[description not available]		02.0610
Cancer of Skin
[description not available]		02.0610
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.0610
Skin Neoplasms
Tumors or cancer of the SKIN.		02.0610
Metastase
[description not available]		02.0610
Cancer of Prostate
[description not available]		02.0610
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.0610
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0610
Germinoblastoma
[description not available]		02.0210
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		07.0210
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.0210
Breast Cancer
[description not available]		02.4420
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4420
Encephalitozoonosis
Infection with FUNGI of the genus ENCEPHALITOZOON. Lesions commonly occur in the BRAIN and KIDNEY tubules. Other sites of infection in MAMMALS are the LIVER; ADRENAL GLANDS; OPTIC NERVES; RETINA; and MYOCARDIUM.		0210