Page last updated: 2024-09-27

Myringosclerosis

The formation of dense connective tissue in the TYMPANIC MEMBRANE that does not necessarily cause or lead to loss of hearing.

Synonyms(2)

Synonym
Tympanosclerosis
Myringosclerosis

Research Excerpts

Overview

ExcerptReference
"Myringosclerosis is hyalinization and calcification of certain areas of the tympanic membrane, especially the fibrous lamina propria layer and appears as white sclerotic lesions."( Alabalik, U; Gul, A; Kinis, V; Ozbay, M; Ozkurt, FE; Sengul, E; Topcu, I; Yilmaz, B, 2015)

Treatment

ExcerptReference
"In the present study, the level of myringosclerosis was significantly lower in lycopene-treated groups compared to the control group (p<0."( Akyigit, A; Halil Ozercan, I; Karlıdag, T; Kaygusuz, I; Keles, E; Sahin, ED; Yalcın, S, 2015)
"While moderate and severe myringosclerosis were higher in the control group, mild myringosclerosis was found to be higher in both treatment groups."( Ağrı, A; Ağrı, İ; Bakirtaş, M; Çelebi, M; Mehel, DM; Özdemir, D; Özgür, A, 2019)

Research

Studies (23)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's20 (86.96)28.8240
2020's3 (13.04)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carnitine0low10
dalteparin0low20
ciprofloxacin0low10
gentamicin0low10
losartan0low10
prednisolone0low10
phenylethyl alcohol0low40
acetylcysteine0low10
titanium0medium21
phenyl acetate0low10
captopril0low10
fomesafen0low10
clarithromycin0low10
cobalt0low10
lycopene0low10
cobaltous chloride0low10
montelukast0low10
caffeic acid phenethyl ester0low30
rosmarinic acid0low10
hypericum0low20
ascorbic acid0low20
transforming growth factor beta0low10

Protein Targets (359)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
acetylcholinesterase2002
dopamine D1 receptor1001
15-lipoxygenase, partial4004
pregnane X receptor1001
phosphopantetheinyl transferase6006
RAR-related orphan receptor gamma6006
USP1 protein, partial3003
NFKB1 protein, partial1001
Microtubule-associated protein tau5005
Thrombopoietin2002
AR protein8008
regulator of G-protein signaling 43003
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor2002
estrogen nuclear receptor alpha9009
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 26006
Bloom syndrome protein isoform 14004
D(1A) dopamine receptor2002
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 24004
heat shock protein beta-11001
flap endonuclease 11001
geminin7007
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
muscarinic acetylcholine receptor M12002
Histone deacetylase 30101
Solute carrier family 22 member 60101
Histone deacetylase 40101
Guanine nucleotide-binding protein G1001
Histone deacetylase 10101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Ataxin-22002
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
ATP-dependent phosphofructokinase6006
Chain A, Hyaluronidase, phage associated0101
GLI family zinc finger 37007
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 47007
estrogen-related nuclear receptor alpha6006
IDH12002
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 22002
nuclear factor erythroid 2-related factor 2 isoform 12002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lethal factor (plasmid)1001
lamin isoform A-delta107007
Polyphenol oxidase 20202
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein2002
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, Ferritin light chain1001
endonuclease IV2002
Nrf21001
glp-1 receptor, partial1001
thioredoxin reductase2002
ATAD5 protein, partial3003
Fumarate hydratase1001
GLS protein1001
TDP1 protein6006
aldehyde dehydrogenase 1 family, member A13003
nonstructural protein 12002
polyprotein1001
67.9K protein1001
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
peripheral myelin protein 22 isoform 13003
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
importin subunit beta-1 isoform 12002
serine/threonine-protein kinase mTOR isoform 11001
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
nuclear receptor ROR-gamma isoform 11001
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 83003
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Gamma-aminobutyric acid receptor subunit pi3104
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Aldo-keto reductase family 1 member B100202
Epidermal growth factor receptor0202
Pancreatic triacylglycerol lipase0001
Transthyretin0022
Estrogen receptor0404
Receptor tyrosine-protein kinase erbB-20101
Amyloid-beta precursor protein0123
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0404
Aldo-keto reductase family 1 member B10404
Polyunsaturated fatty acid 5-lipoxygenase0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit beta-13104
Polyunsaturated fatty acid lipoxygenase ALOX150101
Aldo-keto reductase family 1 member C40101
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Prostaglandin G/H synthase 10202
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Sodium-dependent noradrenaline transporter 0404
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Mitogen-activated protein kinase 10101
Gamma-aminobutyric acid receptor subunit alpha-63104
Prostaglandin G/H synthase 20303
Alpha-synuclein1102
Aldo-keto reductase family 1 member C30101
Histamine H2 receptor2002
D(1A) dopamine receptor1001
Aldo-keto reductase family 1 member C2 0101
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Aldo-keto reductase family 1 member C10101
TAR DNA-binding protein 432002
Integrase 0303
GABA theta subunit3104
Gamma-aminobutyric acid receptor subunit epsilon3104
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
Metallo-beta-lactamase type 20112
transient receptor potential cation channel subfamily V member 11001
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Bile salt export pump0808
Prothrombin0101
Renin0101
Neprilysin0101
Neprilysin0202
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0314
Angiotensin-converting enzyme0203
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0202
Angiotensin-converting enzyme0202
Solute carrier family 15 member 10101
Beta-lactamase TEM0101
Mu-type opioid receptor0011
Beta-lactamase 0203
Canalicular multispecific organic anion transporter 10606
Beta-lactamase 0202
Angiotensin-converting enzyme 2 0101
Beta-lactamase class B VIM-2 0112
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Chain A, Cruzipain2002
EWS/FLI fusion protein3003
cytochrome P450 2C9 precursor1001
Cytochrome P450 1A20202
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Cytochrome P450 3A40202
DNA gyrase subunit B0102
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
Cytochrome P450 2D60202
DNA topoisomerase 2-alpha0104
Cytochrome P450 2C9 0303
DNA gyrase subunit A0102
Cytochrome P450 2C190101
Multidrug resistance protein MdtK0011
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Potassium voltage-gated channel subfamily H member 20304
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
mitogen-activated protein kinase 11001
GTP-binding nuclear protein Ran isoform 11001
streptokinase A precursor0011
ATP-dependent translocase ABCB10102
Solute carrier organic anion transporter family member 1B30303
Solute carrier organic anion transporter family member 1B10303
Luciferase2002
hypoxia-inducible factor 1 alpha subunit2002
progesterone receptor4004
pregnane X nuclear receptor3003
peroxisome proliferator activated receptor gamma2002
Histone H2A.x1001
G1001
histone acetyltransferase KAT2A isoform 11001
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Atrial natriuretic peptide receptor 30101
5-hydroxytryptamine receptor 1A0101
Thromboxane A2 receptor 0102
Type-1A angiotensin II receptor 0213
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Type-1B angiotensin II receptor0202
Adenosine receptor A2a0101
Type-1 angiotensin II receptor0215
Type-1 angiotensin II receptor0112
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0101
Squalene synthase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Inositol hexakisphosphate kinase 11001
Multidrug and toxin extrusion protein 10101
Platelet glycoprotein VI0113
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Type-1 angiotensin II receptor0112
cytochrome P450 2C9, partial1001
vitamin D3 receptor isoform VDRA1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
DNA polymerase kappa isoform 11001
interleukin 81001
ClpP1001
caspase 7, apoptosis-related cysteine protease1001
nuclear receptor subfamily 1, group I, member 31001
caspase-31001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
cytochrome P450 2D6 isoform 11001
ras-related protein Rab-9A1001
Cellular tumor antigen p532002
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cholinesterase0101
Cytochrome P450 2C11 0101
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase0101
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0101
Nociceptin receptor0101
Alpha-1A adrenergic receptor0303
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma1001
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
peroxisome proliferator-activated receptor delta1001
Beta-2 adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Adenosine receptor A30202
Cytochrome P450 2C80101
Muscarinic acetylcholine receptor M10202
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Substance-K receptor0202
Thromboxane-A synthase 0101
D(3) dopamine receptor0202
Delta-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Sodium-dependent dopamine transporter 0202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Mitogen-activated protein kinase 140101
Leukotriene C4 synthase0101
Cysteinyl leukotriene receptor 10101
Cysteinyl leukotriene receptor 20101
Cysteinyl leukotriene receptor 10213
cytochrome P450 2D61001
luciferase0001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
nuclear receptor subfamily 1, group I, member 21001
Voltage-dependent calcium channel gamma-2 subunit1001
Fatty acid-binding protein, liver0101
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glutamate receptor 22002
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
ATPase family AAA domain-containing protein 51001
Chain A, Beta-lactamase1001
Mcl-10101
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B1001
Replicase polyprotein 1ab0101
lysosomal alpha-glucosidase preproprotein1001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Lysine-specific histone demethylase 1A0101
Interstitial collagenase0101
Transcription factor AP-10101
Replicase polyprotein 1ab0101
Proto-oncogene tyrosine-protein kinase Src0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
17-beta-hydroxysteroid dehydrogenase type 20101
Linoleate 9S-lipoxygenase-40101
UDP-galactopyranose mutase0011
Hyaluronidase-10101
UDP-galactopyranose mutase0011
Reverse transcriptase/RNaseH 0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]