EC 1.21.3.3 (reticuline oxidase) inhibitor

An EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor that interferes with the action of reticuline oxidase (EC 1.21.3.3, previously EC 1.5.3.9).

ChEBI ID: 77110

Members (1)

Member	Definition	Class
berberine		berberine

Research

Studies (4,018)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	219 (5.45)	18.7374
1990's	262 (6.52)	18.2507
2000's	617 (15.36)	29.6817
2010's	1,874 (46.64)	24.3611
2020's	1,046 (26.03)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	102 (2.48%)	5.53%
Reviews	297 (7.23%)	6.00%
Case Studies	7 (0.17%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3,700 (90.11%)	84.16%

Protein Targets (45)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	44.6684	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	6.5656	1	2
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	2.5119	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	12.5893	2	2
EWS/FLI fusion protein	Homo sapiens (human)	Potency	8.3572	4	4
Fumarate hydratase	Homo sapiens (human)	Potency	33.1734	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	12.5893	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	2.5119	2	2
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	10.4304	2	2
Interferon beta	Homo sapiens (human)	Potency	10.4353	1	3
Microtubule-associated protein tau	Homo sapiens (human)	Potency	12.5893	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	6.2426	2	2
polyprotein	Zika virus	Potency	33.1734	1	1
PPM1D protein	Homo sapiens (human)	Potency	10.4353	1	2
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	7.0795	1	1
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	12.5893	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	0.7827	3	3
Acetylcholinesterase	Homo sapiens (human)	IC50	0.4000	2	2
Aldo-keto reductase family 1 member C2	Homo sapiens (human)	IC50	6.7100	1	1
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	IC50	4.9900	2	2
Cholinesterase	Equus caballus (horse)	IC50	15.2667	3	3
Cholinesterase	Homo sapiens (human)	IC50	15.8950	2	2
Cytochrome P450 1B1	Homo sapiens (human)	IC50	0.9747	3	3
Cytochrome P450 1B1	Homo sapiens (human)	Ki	0.0440	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	6.9700	1	1
Neuraminidase	Influenza A virus (A/USSR/90/1977(H1N1))	IC50	35.3500	2	2
Neuraminidase	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Ki	14.3000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	66.0693	1	1
Prolyl endopeptidase	Homo sapiens (human)	IC50	143.5000	2	2
Telomerase reverse transcriptase	Homo sapiens (human)	IC50	37.0000	1	1
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50	67.0000	1	1

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