An EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor that interferes with the action of reticuline oxidase (EC 1.21.3.3, previously EC 1.5.3.9).
ChEBI ID: 77110
Member | Definition | Class |
---|---|---|
berberine | berberine |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 219 (5.45) | 18.7374 |
1990's | 262 (6.52) | 18.2507 |
2000's | 617 (15.36) | 29.6817 |
2010's | 1,874 (46.64) | 24.3611 |
2020's | 1,046 (26.03) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 102 (2.48%) | 5.53% |
Reviews | 297 (7.23%) | 6.00% |
Case Studies | 7 (0.17%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 3,700 (90.11%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 6.5656 | 1 | 2 |
cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
EWS/FLI fusion protein | Homo sapiens (human) | Potency | 8.3572 | 4 | 4 |
Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 2 | 2 |
Interferon beta | Homo sapiens (human) | Potency | 10.4353 | 1 | 3 |
Microtubule-associated protein tau | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.2426 | 2 | 2 |
polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
PPM1D protein | Homo sapiens (human) | Potency | 10.4353 | 1 | 2 |
survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 0.7827 | 3 | 3 |
Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.4000 | 2 | 2 |
Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 6.7100 | 1 | 1 |
Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
Cholinesterase | Equus caballus (horse) | IC50 | 15.2667 | 3 | 3 |
Cholinesterase | Homo sapiens (human) | IC50 | 15.8950 | 2 | 2 |
Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.9747 | 3 | 3 |
Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0440 | 1 | 1 |
Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 6.9700 | 1 | 1 |
Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 35.3500 | 2 | 2 |
Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Ki | 14.3000 | 1 | 1 |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 66.0693 | 1 | 1 |
Prolyl endopeptidase | Homo sapiens (human) | IC50 | 143.5000 | 2 | 2 |
Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |