ascorbic-acid and Stomatitis--Aphthous

Topics: Anti-Infective Agents, Local; Ascorbic Acid; Behcet Syndrome; Colchicine; Diagnosis, Differential; Humans; Inosine Pranobex; Mouthwashes; Prednisone; Stomatitis, Aphthous; Stomatitis, Herpetic; Thalidomide

Recurrent aphthous stomatitis (RAS) is a painful condition of unknown etiology, affecting more than 2.5 billion people worldwide. Vitamin deficiencies have been implicated as a possible cause.. The authors conducted a single-center, randomized, parallel-arm, double-masked, placebo-controlled study to examine the effect of daily multivitamin supplementation on the number and duration of RAS episodes. The authors randomly assigned 160 adults who had a validated history of at least three episodes of idiopathic minor RAS within the previous 12 months to one of two groups: the first group (n = 83) received a once-daily multivitamin containing 100 percent of the U.S. reference daily intake (RDI) of essential vitamins, and the second group (n = 77) received once-daily placebo for up to 365 days.. The results showed no significant difference in the mean number of new RAS episodes between the multivitamin (4.19 episodes) and placebo (4.60 episodes) arms during the study period (P = .69). The mean duration of new RAS episodes also was similar for the multivitamin (8.66 days) and placebo (8.99 days) arms (P = .60). Furthermore, the authors found no differences between the two arms with regard to mouth pain, normalcy of diet or compliance with the study medication regimen.. Daily multivitamin supplementation, with the RDI of essential vitamins, did not result in a reduction in the number or duration of RAS episodes.. Clinicians should not recommend multi-vitamin supplementation routinely as prophylaxis for RAS.

Topics: Adolescent; Adult; Aged; Antioxidants; Ascorbic Acid; Diet; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Humans; Male; Middle Aged; Nutrition Policy; Patient Compliance; Placebos; Prospective Studies; Recurrence; Stomatitis, Aphthous; Treatment Outcome; Vitamin A; Vitamin B 12; Vitamin B Complex; Vitamin D; Vitamin E; Vitamins; Young Adult

Minor recurrent aphthous stomatitis (MRAS) is a common, painful and inflammatory ailment of the oral cavity with juvenile onset and unknown aetiology. The purpose of this study was to evaluate the potential of ascorbate (vitamin C) to reduce the frequency of MRAS and severity of pain.. Sixteen MRAS patients (9 boys and 7 girls: mean age, 12.0 +/- 2.4 years old) were assigned to take an oral dosage of 2000 mg/m(2)/day ascorbate.. Their baseline frequency of outbreaks and the level of pains were compared during the treatment; in addition, a crossover clinical trial was performed. Polymorphonuclear leucocytes play a role in the pathogenesis, and then superoxide anion production was evaluated in prior to ascorbate treatment.. The data indicated a statistically significant 50% reduction in oral ulcer outbreaks and a decline of pain level. Neutrophils were primed for superoxide anion production in the patients with MRAS.. Ascorbate may modulate the generation of reactive oxygen species and augment neutrophil apoptosis, which could prevent neutrophil-mediated inflammation. Ascorbate seems to be effective, but the findings of our study were preliminary and it should be re-evaluated with a larger randomized controlled clinical trials.

Topics: Administration, Oral; Adolescent; Antioxidants; Ascorbic Acid; Child; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Male; Neutrophils; Pain; Secondary Prevention; Severity of Illness Index; Stomatitis, Aphthous; Superoxides; Treatment Outcome

Recurrent aphthous stomatitis (RAS) is recognized as one of the most common oral mucosal diseases worldwide. The aim of this study was to determine the oxidant/antioxidant status in erythrocyte and plasma samples from patients with RAS in comparison with healthy controls. Twenty-two patients with RAS and 23 healthy controls were recruited. Superoxide dismutase, glutathione peroxidase (GSHPx) and catalase (CAT) activities, and malondialdehyde (MDA) and antioxidant potential (AOP) levels were measured in plasma and erythrocytes from patient with RAS and controls. We found decreased CAT and GSHPx activities and AOP levels in the erythrocytes, and decreased AOP and increased MDA plasma levels in patients with RAS in comparison with control subjects. In summary, this study demonstrated that enzymatic and nonenzymatic antioxidant defence systems are impaired in patients with RAS.

Topics: Adult; Antioxidants; Ascorbic Acid; Catalase; Erythrocytes; Female; Glutathione Peroxidase; Humans; Male; Malondialdehyde; Middle Aged; Oxidants; Prospective Studies; Recurrence; Selenium; Stomatitis, Aphthous; Superoxide Dismutase

To investigate the relationship between peripheral blood micronutrient levels and 4 kinds of oral mucosal diseases (minor recurrent aphthous ulcer, angular cheilitis, cheilitis and geographic tongue) in children aged 0~14 years.. One hundred and fifty-two children with oral mucosal lesions (COML) and 65 healthy children (health control group, HC) were included. The clinical data of each group were recorded separately to compare whether there existed differences in the levels of serum water-soluble vitamins (vitamins B1, B2, B3, B5, B6, B7, B9, B12, C), serum fat-soluble vitamins [vitamins A, E, K, 25(OH)D2, 25(OH)D3], zinc and serum calcium. Whether peripheral blood micronutrients were risk factors associated with the onset of COML was analyzed through disorder multiclass logistic regression with SPSS 23.0 software package.. Peripheral blood micronutrients differed in children with minor recurrent aphthous ulcers, cheilitis, and geographic tongue (P＜0.05). Compared with HC group, children in minor recurrent aphthous ulcer group had significantly lower levels of vitamin B1, B6, B7, C, A, and 25(OH)D3 (P＜0.05), and relatively higher rates of vitamin B6 (50.00% vs 13.85%), vitamin B7 (36.76% vs 9.23%), 25(OH)D3 (64.71% vs 36.92%) deficiency and vitamin K excess (8.82% vs 0.00%)(P＜0.005). Multiclass logistic regression analysis showed that vitamin B1, vitamin C, vitamin A deficiency, vitamin B5, and vitamin K excess were risk factors for incidence in children with minor recurrent aphthous ulcer, and each element was independent for each other. Compared with HC group, the levels of vitamin B7 and 25(OH)D3 in children with cheilitis were significantly lower(P＜0.05), and the rate of vitamin B7 deficiency was significantly higher (P＜0.005). Multiclass logistic regression analysis showed that vitamin B7 and vitamin A deficiency were risk factors for cheilitis in children, and the two were independent for each other. Compared with the HC group, vitamin K excess rate was significantly higher in children with geographic tongue (7.14% vs 0.00%) (P＜0.005). Multiclass logistic regression analysis showed that vitamin C deficiency and vitamin K excess were risk factors for the incidence of geographic tongue, and the two were independent for each other. Compared with other groups, peripheral blood micronutrients had no correlation with the pathogenesis of angular cheilitis (P＞0.05).. The occurrence of COML is closely related to peripheral blood micronutrient levels, which suggests that children with COML need to monitor vitamin and mineral levels and supplement treatment when necessary.

Topics: Ascorbic Acid; Calcium; Cheilitis; Child; Glossitis, Benign Migratory; Humans; Micronutrients; Minerals; Pantothenic Acid; Stomatitis, Aphthous; Thiamine; Vitamin A Deficiency; Vitamin B 6; Vitamin K; Vitamins; Water; Zinc

Recurrent aphthous ulceration (RAU) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae. Although the exact cause of RAU is not known, local trauma, microorganisms, nutritional deficiencies, hormonal changes, genetics, and immunological factors have been suggested to contribute to its pathogenesis. The aim of this study was to assess the level of lipid peroxidation and status of antioxidant vitamins in patients with RAU. Thirty patients with RAU and 20 healthy controls were recruited. Vitamins A, E, and C and malondialdehyde (MDA) levels were measured in both serum and saliva of patients with RAU and control subjects by high performance liquid chromatography. Levels of vitamins A, E and C in both fluids were significantly lower (p < 0.05 for vitamins A and E, and p < 0.005 for vitamin C, respectively) in patients with RAU than in healthy control subjects. Conversely, the levels of MDA in serum and saliva were significantly higher (p < 0.005) in patients with RAU than in the control group. Furthermore, strong and highly significant correlation was found between serum and salivary levels of vitamins A, E and C, and MDA in patients with RAU (r > or = 0.90, p < 0.0001). The present study demonstrates that the serum and saliva levels of selected antioxidant vitamins are lower, while the degree of lipid peroxidation, as judged by the MDA levels, is higher in patients with RAU than in the control subjects. This is the first to measure specific antioxidant levels in both saliva and blood in the same patients, and indicates that the non-enzymatic anti-oxidant ability is impaired in patients with RAU.

Topics: Adolescent; Adult; Antioxidants; Ascorbic Acid; Female; Humans; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Retrospective Studies; Saliva; Statistics as Topic; Stomatitis, Aphthous; Vitamin A; Vitamin E; Vitamins

This study describes the relationship between varying ascorbate intake, periodontal status, and subgingival microflora as part of a multidisciplinary investigation of ascorbic acid (AA) metabolism in young men housed for 13 weeks in a nutrition suite that provided controlled periods of ascorbic acid depletion and repletion. Twelve medically healthy non-smoking men, aged 25 to 43 years, ate a rotating four-day diet adequate in all nutrients except ascorbic acid. Following an initial baseline period during which the subjects received 250 mg AA/day, the subjects received 5 mg AA/day for a 32-day depletion period. Eight of the 12 subjects participated in a subsequent 56-day repletion period designed to replace the reduced body AA pool slowly. Plasma and leukocyte ascorbate levels, Plaque Index, Gingival Index, probing depths, and attachment level were monitored at the beginning and end of the depletion and repletion periods. Subgingival plaque samples were obtained and examined for selected organisms by indirect immunofluorescence microscopy. A uniform oral hygiene program was reinforced after each examination. Ascorbate concentrations in plasma and leukocytes responded rapidly to changes in vitamin C intake. There were no significant changes in plaque accumulation, probing pocket depth, or attachment level during the study. In contrast, gingival bleeding increased significantly after the period of AA depletion and returned to baseline values after the period of AA repletion. However, no relationship could be demonstrated between either the presence or proportion of target periodontal micro-organisms and measures of bleeding or ascorbate levels.

Topics: Actinomyces viscosus; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Bacteria; Bacteroides; Dental Plaque; Gingival Hemorrhage; Gingival Pocket; Humans; Leukocytes; Male; Porphyromonas gingivalis; Stomatitis, Aphthous

Topics: Ascorbic Acid; Female; Humans; Immunity, Cellular; Male; Mouth Diseases; Mouth Mucosa; Neutrophils; Periodontitis; Recurrence; Stomatitis, Aphthous; Ulcer

Topics: Adolescent; Adrenal Glands; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Catecholamines; Chronic Disease; Humans; Middle Aged; Recurrence; Stomatitis, Aphthous; Sympathetic Nervous System

New results concerning the etiology of recurrent aphthae are reported. According to own experiments of the authors, adenoviruses persisting in the epithelial cells of the oral mucosa may sensitize the aphthous patient. Adenovirus antigen was demonstrable in the oral mucosa cells in more than 50% of the patients and in the lymphocytes in approx. 1% of the patients. Lymphoblast transformation in the circulating lymphocytes could be demonstrated in vitro with heat-inactivated type 1 adenovirus, in 75% of the patients. This virus type has been isolated from 2 patients. Köbner's isomorphous phenomenon could be demonstrated in aphthous patients. The use of a disinfectant for mouth rinsing, the removal of foci as well as vitamin treatment are recommended for preventing recurrent aphthae.

Topics: Adenoviridae Infections; Antigens, Viral; Ascorbic Acid; Focal Infection, Dental; Herpesviridae Infections; Humans; Hypochlorous Acid; Lymphocyte Activation; Mouthwashes; Recurrence; Stomatitis, Aphthous

Topics: Adult; Ascorbic Acid; Crohn Disease; Humans; Hydrocortisone; Male; Mouth Diseases; Mouth Mucosa; Stomatitis, Aphthous; Vitamin B Complex

Topics: Adult; Anemia; Ascorbic Acid; Blood Transfusion; Carcinoma, Squamous Cell; Citrus; Diet; Epistaxis; Female; Gastrointestinal Diseases; Hemoglobins; Humans; Intestinal Absorption; Iron; Leukocytes; Male; Middle Aged; Peptic Ulcer; Pharyngeal Neoplasms; Scurvy; Smoking; Stomatitis, Aphthous

Topics: Ascorbic Acid; Gingivitis, Necrotizing Ulcerative; Humans; Rabbits; Research; Stomatitis; Stomatitis, Aphthous; Vitamins

Topics: Ascorbic Acid; Gingivitis, Necrotizing Ulcerative; Humans; Penicillins; Stomatitis, Aphthous; Sulfanilamide; Sulfanilamides; Sulfonamides; Vitamins