Mastocytosis, Systemic

A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.

Synonym
Mastocytosis, Systemic

Excerpt	Reference
"Systemic mastocytosis is a rare and occasionally aggressive condition that raises major diagnostic challenges."	( Bertin, P; Inaoui, R; Jaccard, A; Petit, B; Trèves, R, 2003)
"Systemic mastocytosis is a rare disease, characterized by mast cells proliferation in various organs."	( Barete, S; Bonté, I; Casassus, P; de Gennes, C; Fain, O; Hermine, O; Lortholary, O; Marrache, F; Mémain, N, 2003)
"Systemic mastocytosis is subdivided into an indolent course with good prognosis and four subgroups with poor prognosis (systemic mastocytosis with associated clonal hematologic non-mast-cell disease, aggressive systemic mastocytosis, mast cell leukemia, and mast cell sarcoma)."	( Grunewald, SM; Kolb-Mäurer, A; Kraemer, DM, 2004)
"Systemic mastocytosis is a mast cell proliferative disorder affecting many organs that is rarely associated with internal bleeding."	( Arias, M; Pereiro, I; Requena, I; Sesar, A; Vázquez-Veiga, H; Villalba, C, 2004)
"Systemic mastocytosis is characterised by proliferation of mast cells and infiltration of organs."	( Castling, B; Myers, B; Smith, AT, 2006)
"Systemic mastocytosis is characterized by abnormal mast cell proliferation in different organs."	( Barete, S; Casassus, P; Eclache, V; Fain, O; Hermine, O; Lorholary, O; Stirnemann, J, 2005)
"Systemic mastocytosis is characterized by an abnormal proliferation of tissue mast cells."	( Oates, JA; Roberts, LJ, 1991)
"Systemic mastocytosis is characterized by bone marrow involvement, which requires a bone marrow biopsy for diagnostic work-up."	( de Monchy, JG; Donker, ML; Kema, IP; Kluin, PM; Kluin-Nelemans, HC; van der Veer, E; van Doormaal, FF; van Doormaal, JJ, 2008)
"Systemic mastocytosis is regressive among children, whereas the disease is persistent among adults."	( Barete, S; Bodemer, C; Dubreuil, P; Georgin-Lavialle, S; Hermine, O; Lepelletier, Y; Lortholary, O; Suarez, F, 2009)
"Systemic mastocytosis is a rare but well-recognised cause of secondary osteoporosis, accounting for about 1."	( Dhillon, V; Mathew, R; Shepherd, P, 2009)
"Indolent systemic mastocytosis is a group of rare diseases for which reliable predictors of progression and outcome are still lacking."	( Almeida, J; Alvarez-Twose, I; Bellas, C; Escribano, L; García-Cosío, M; Garcia-Montero, A; Jara-Acevedo, M; Núñez, R; Orfao, A; Sánchez-Muñoz, L; Teodósio, C, 2009)
"Systemic mastocytosis is a rare cause of vertebral fractures in young men."	( Brendel, C; Hamann, C; Hofbauer, LC; Krüger, A; Neubauer, A; Ramaswamy, A; Schnabel, M, 2009)
"Systemic mastocytosis is a neoplastic disease of mast cells that often harbors a KIT mutation and involves the bone marrow."	( Pardanani, A; Tefferi, A, 2010)
"Systemic mastocytosis is a heterogeneous group of hematological disorders characterized by accumulation of mast cells in different organs."	( Colović, M; Colović, N; Radojković, M; Ristić, S; Terzić, T, 2011)
"Systemic mastocytosis is characterized by an excessive proliferation of mast cells and their accumulation in different organs."	( Maniu, CM; Ribi, C; Spertini, F, 2013)
"Systemic mastocytosis is characterised by abnormal proliferation of mast cells in various organs."	( Aubin, F; Daguindau, E; Deveza, E; Girardin, M; Humbert, P; Locatelli, F; Pelletier, F; Valmary-Degano, S, 2015)
"Systemic mastocytosis is defined as a clonal increase of mast cells."	( Gehlen, M; Hinz, C; Lazarescu, AD; Maier, A; Pfeifer, M; Schmidt, N; Schwarz-Eywill, M; Weidemann, HF; Werner, M, 2016)
"Systemic mastocytosis is a rare myeloproliferative disease characterized by the uncontrolled proliferation of aberrant mast cells."	( Broijl, A; Hermans, MA; van Daele, PL, 2016)
"Systemic mastocytosis is a rare disease due to mast cell accumulation in various extracutaneous sites."	( Cai, H; Jiang, X; Wang, X; Zhang, L; Zhou, D, 2020)
"Systemic mastocytosis is a rare blood disorder caused by the build-up of too many abnormal mast cells, a type of white blood cell, in the skin and organs."	( Iannazzo, S; Pilkington, H; Roskell, N; Smith, S, 2022)

Excerpt	Reference
"Systemic mastocytosis has extracutaneous organ involvement with variable symptomatology and prognosis."	( Lee, Y; Soyer, HP; Wood, P, 2013)
"Systemic Mastocytosis has been long identified as a potential cause of osteoporosis; nevertheless, data regarding longitudinal variation of bone mineral density (BMD) in patients with indolent systemic mastocytosis (ISM) are missing ."	( Artuso, A; Bonifacio, M; Caimmi, C; Gatti, D; Gavioli, I; Idolazzi, L; Rossini, M; Tripi, G; Viapiana, O; Zanotti, R, 2017)

Excerpt	Reference
"Current available treatment for systemic mastocytosis is non-curative with conventional symptom-directed therapy for all subtypes."	( Lee, Y; Soyer, HP; Wood, P, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.34)	23.3326
1990's	1 (0.34)	12.5806
2000's	111 (38.14)	18.1394
2010's	129 (44.33)	28.8240
2020's	49 (16.84)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
formaldehyde	low	1	0
histamine	medium	18	1
pteridines	low	1	0
thymine	low	1	0
uracil	low	1	0
urea	low	1	0
acetaminophen	low	1	0
alendronate	low	2	0
aspirin	low	4	0
celecoxib	low	1	0
cetirizine	low	3	0
chlorpheniramine	low	1	0
famotidine	low	1	0
fentanyl	low	1	0
fexofenadine	low	1	0
gossypol	low	1	0
hydroxyurea	low	9	0
hydroxyzine	low	1	0
ketamine	low	1	0
ketotifen	low	2	0
loratadine	low	1	0
mianserin	low	1	0
mirtazapine	low	1	0
pamidronate	low	3	0
propofol	low	1	0
sevoflurane	low	1	0
vorinostat	low	1	0
terfenadine	low	2	0
thalidomide	medium	3	1
ticlopidine	low	1	0
trimipramine	low	1	0
prednisolone	low	9	0
thymidine	low	1	0
prednisone	low	15	0
aspartic acid	low	3	0
lysine	low	1	0
galactose	low	1	0
methylene blue	low	1	0
colchicine	low	1	0
cytarabine	low	8	0
trifluridine	low	1	0
valine	low	3	0
methylprednisolone	low	1	0
pyrroles	medium	14	3
quinazolines	low	1	0
thiazoles	medium	18	3
pyrazines	low	2	0
azacitidine	low	5	0
eosine yellowish-(ys)	low	1	0
congo red	low	1	0
methylprednisolone hemisuccinate	low	1	0
fluorescein-5-isothiocyanate	low	1	0
dimethindene	low	1	0
acetylglucosamine	low	1	0
cromolyn sodium	low	2	0
daunorubicin	low	1	0
phenyl acetate	low	5	0
dexchlorpheniramine	low	1	0
idarubicin	low	5	0
nedocromil	low	1	0
clopidogrel	low	1	0
remifentanil	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	5	0
zoledronic acid	low	4	0
methylimidazoleacetic acid	medium	4	1
imatinib mesylate	medium	66	3
lenalidomide	low	3	0
bortezomib	low	2	0
oxytocin	low	1	0
pentostatin	low	1	0
rocuronium	low	5	0
prostaglandin d2	low	3	0
decitabine	low	3	0
isomethyleugenol	low	2	0
s 1033	medium	8	1
etomidate	low	1	0
oxazolone	low	1	0
ranitidine	low	6	0
tandutinib	low	1	0
osteoprotegerin	low	1	0
imd 0354	low	1	0
sphingosine	low	1	0
bilirubin	low	1	0
dinoprost	low	2	0
leukotriene b4	low	1	0
leukotriene c4	low	1	0
cholecalciferol	low	1	0
leukotriene e4	low	1	0
pulmicort	low	1	0
montelukast	low	5	0
rottlerin	low	1	0
sphingosine 1-phosphate	low	1	0
sirolimus	medium	5	1
pd 180970	low	1	0
lysophosphatidylcholines	low	1	0
bosutinib	low	1	0
cysteine	low	1	0
tanespimycin	low	1	0
staurosporine	medium	48	5
bi 2536	low	1	0
inno-406	low	1	0
losartan potassium	low	1	0
ants	low	1	0
oligonucleotides	low	1	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
ponatinib	low	1	0
quizartinib	low	1	0
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid	low	1	0
plx4032	low	1	0
piperidines	medium	4	2
abt-199	low	1	0
ascorbic acid	low	1	0
tetracycline	low	1	0
oblimersen	low	1	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	2	0
nintedanib	low	1	0
defibrotide	low	1	0

Protein Targets (1,665)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	15	0	0	15
chromobox protein homolog 1	24	0	0	24
geminin	36	0	0	36
Receptor-type tyrosine-protein phosphatase C	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Receptor-type tyrosine-protein phosphatase alpha	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 13	0	1	0	1
Dual specificity protein phosphatase CDC14A	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 22	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	5	0	6
Farnesyl pyrophosphate synthase	0	8	0	8
EWS/FLI fusion protein	36	0	0	36
Apoptosis regulator Bcl-2	0	4	3	7
Spike glycoprotein	20	0	2	22
Bcl-2-like protein 1	0	4	1	5
Induced myeloid leukemia cell differentiation protein Mcl-1	0	4	1	5
Aspartyl/asparaginyl beta-hydroxylase	0	4	0	4
Bcl-2-related protein A1	0	1	0	1
Bcl-2-like protein 2	0	2	0	2
Bcl2-associated agonist of cell death	0	2	0	2
RAR-related orphan receptor gamma	27	0	0	27
ATAD5 protein, partial	15	0	0	15
GLS protein	17	0	0	17
Microtubule-associated protein tau	12	0	0	12
Smad3	11	0	0	11
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
thyroid stimulating hormone receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
progesterone receptor	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	28	0	0	28
retinoid X nuclear receptor alpha	23	0	0	23
estrogen-related nuclear receptor alpha	36	0	0	36
estrogen nuclear receptor alpha	47	0	0	47
peroxisome proliferator activated receptor gamma	21	0	0	21
aryl hydrocarbon receptor	12	0	0	12
thyroid hormone receptor beta isoform 2	33	0	0	33
peripheral myelin protein 22	18	0	0	18
cytochrome P450 3A4 isoform 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	13	1	2	16
ATP-binding cassette sub-family C member 3	0	26	0	26
Multidrug resistance-associated protein 4	0	26	0	26
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	6	0	8
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	6	0	6
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Bile salt export pump	0	40	0	40
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	12	0	15
Carbonic anhydrase 2	0	13	0	18
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 3	0	5	0	7
Cytochrome P450 3A4	0	11	0	13
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	9	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	13	1	2	16
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	13	1	2	16
Gamma-aminobutyric acid receptor subunit gamma-2	13	1	2	16
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	17	0	0	17
Gamma-aminobutyric acid receptor subunit alpha-5	13	1	2	16
Gamma-aminobutyric acid receptor subunit alpha-3	13	1	2	16
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	6	0	8
Prostaglandin G/H synthase 1	0	7	0	8
Carbonic anhydrase 6	0	5	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	13	1	2	16
Gamma-aminobutyric acid receptor subunit alpha-2	13	1	2	16
Gamma-aminobutyric acid receptor subunit alpha-4	13	1	2	16
Gamma-aminobutyric acid receptor subunit gamma-3	13	1	2	16
Gamma-aminobutyric acid receptor subunit alpha-6	13	1	2	16
Carbonic anhydrase 5A, mitochondrial	0	6	0	8
Prostaglandin G/H synthase 2	0	8	10	20
Carbonic anhydrase 7	0	5	0	7
Nuclear receptor ROR-gamma	7	0	0	7
Cytochrome P450 2J2	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	13	3	2	18
Gamma-aminobutyric acid receptor subunit beta-3	13	1	2	16
Gamma-aminobutyric acid receptor subunit beta-2	13	1	2	16
Carbonic anhydrase 9	0	8	0	11
GABA theta subunit	13	1	2	16
Canalicular multispecific organic anion transporter 1	0	25	0	25
Carbonic anhydrase 15	0	5	0	7
Carbonic anhydrase 13	0	3	0	5
Gamma-aminobutyric acid receptor subunit epsilon	13	1	2	16
Carbonic anhydrase 14	0	6	0	8
Carbonic anhydrase 5B, mitochondrial	0	5	0	7
toxin B	0	0	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cannabinoid receptor 1	0	3	0	3
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	4	0	4
Farnesyl pyrophosphate synthase	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	15	0	0	15
GLI family zinc finger 3	28	0	0	28
AR protein	41	0	0	41
thioredoxin glutathione reductase	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	32	0	0	32
glucocorticoid receptor [Homo sapiens]	35	0	0	35
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
euchromatic histone-lysine N-methyltransferase 2	30	0	0	30
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	9	0	0	9
lamin isoform A-delta10	30	0	0	30
Polyphenol oxidase 2	0	2	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	11	1	12
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, Ferritin light chain	11	0	0	11
phosphopantetheinyl transferase	12	0	0	12
arylsulfatase A	13	0	0	13
Bloom syndrome protein isoform 1	16	0	0	16
cytochrome P450 2C19 precursor	8	0	0	8
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	3
Glutamate receptor ionotropic, NMDA 1	0	3	0	5
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	5
Glutamate receptor ionotropic, NMDA 2B	0	4	0	6
Glutamate receptor ionotropic, NMDA 2C	0	3	0	5
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	3	0	5
Glutamate receptor ionotropic, NMDA 3B	0	3	0	5
Carbonic anhydrase 4	0	2	0	4
Glutamate receptor ionotropic, NMDA 3A	0	3	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	4	0	0	4
thioredoxin reductase	14	0	0	14
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	19	0	0	19
glucocerebrosidase	5	0	0	5
peroxisome proliferator-activated receptor delta	17	0	0	17
Rac1 protein	0	0	2	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	17	0	0	17
DNA polymerase kappa isoform 1	13	0	0	13
muscarinic acetylcholine receptor M1	10	0	0	10
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Epidermal growth factor receptor	0	13	15	28
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	5	2	0	7
Myeloperoxidase	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	5	2	0	7
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	2	0	4
Adenosine receptor A2a	0	1	0	3
Substance-P receptor	0	1	0	1
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	1	1	2
Chain A, Beta-lactamase	6	0	0	6
glp-1 receptor, partial	11	0	0	11
pregnane X receptor	5	0	0	5
Fumarate hydratase	21	0	0	21
NFKB1 protein, partial	4	0	0	4
PPM1D protein	20	0	0	20
TDP1 protein	33	0	0	33
Thrombopoietin	6	0	0	6
estrogen receptor 2 (ER beta)	19	0	0	19
farnesoid X nuclear receptor	18	0	0	18
pregnane X nuclear receptor	28	0	0	28
polyprotein	21	0	0	21
67.9K protein	11	0	0	11
Parkin	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
thyroid stimulating hormone receptor	10	0	0	10
activating transcription factor 6	14	0	0	14
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	6	0	0	6
huntingtin isoform 2	10	0	0	10
ras-related protein Rab-9A	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
histone acetyltransferase KAT2A isoform 1	11	0	0	11
Interferon beta	31	0	0	31
Cellular tumor antigen p53	29	0	0	29
Adenosine receptor A3	0	5	0	5
DNA (cytosine-5)-methyltransferase 1	0	3	0	3
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
D(1A) dopamine receptor	5	0	0	5
Multidrug and toxin extrusion protein 1	0	2	0	2
Histone-lysine N-methyltransferase EHMT2	0	3	0	3
ATPase family AAA domain-containing protein 5	18	0	0	18
Ataxin-2	27	0	0	27
ATP-dependent phosphofructokinase	18	0	0	18
Leukotriene C4 synthase	0	0	9	9
tyrosine-protein kinase Yes	10	0	0	10
Bone morphogenetic protein receptor type-1B	0	0	15	15
Membrane-associated progesterone receptor component 1	0	0	9	9
Cell division cycle 7-related protein kinase	0	0	9	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	9	10
Serine/threonine-protein kinase PLK4	0	1	15	16
Serine/threonine-protein kinase 25	0	0	9	9
ATP-dependent RNA helicase DDX3X	0	0	15	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	9	9
Pyridoxal kinase	0	0	15	15
Citron Rho-interacting kinase	0	0	15	15
Serine/threonine-protein kinase RIO3	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 7	0	0	9	9
Serine/threonine-protein kinase Chk1	0	1	15	16
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	2	9	12
Peripheral plasma membrane protein CASK	0	0	9	9
Aurora kinase A	0	3	15	18
Cyclin-G-associated kinase	0	0	15	15
Serine/threonine-protein kinase DCLK1	0	0	9	9
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	2	9	11
Muscle, skeletal receptor tyrosine-protein kinase	0	0	9	9
Ephrin type-B receptor 6	0	0	15	15
Peroxisomal acyl-coenzyme A oxidase 3	0	0	15	15
Mitogen-activated protein kinase 13	0	1	9	10
3-phosphoinositide-dependent protein kinase 1	0	1	9	10
Mitogen-activated protein kinase kinase kinase 13	0	0	9	9
Death-associated protein kinase 3	0	0	9	9
Mitogen-activated protein kinase kinase kinase 7	0	0	9	9
Receptor-interacting serine/threonine-protein kinase 2	0	3	15	18
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	14	14
NUAK family SNF1-like kinase 1	0	0	9	9
Dynamin-like 120 kDa protein, mitochondrial	0	0	15	15
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	9	9
Tyrosine-protein kinase JAK2	0	2	12	14
Eukaryotic translation initiation factor 5B	0	0	11	11
Bromodomain-containing protein 4	0	4	2	6
Rho-associated protein kinase 2	0	0	15	15
Serine/threonine-protein kinase ULK1	0	0	15	15
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	15	15
Ribosomal protein S6 kinase alpha-5	0	0	15	15
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	15	15
Ribosomal protein S6 kinase alpha-4	0	0	15	15
Serine/threonine-protein kinase 16	0	0	15	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	9	9
Serine/threonine-protein kinase PAK 3	0	0	9	9
Cyclin-dependent kinase-like 5	0	0	12	12
Serine/threonine-protein kinase 17B	0	0	9	9
Serine/threonine-protein kinase 10	0	1	15	16
Serine/threonine-protein kinase D3	0	0	15	15
Cyclin-dependent kinase 14	0	0	9	9
Structural maintenance of chromosomes protein 2	0	0	15	15
Mitogen-activated protein kinase kinase kinase 6	0	0	14	14
Serine/threonine-protein kinase OSR1	0	0	9	9
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	15	15
Serine/threonine-protein kinase LATS1	0	0	15	15
Serine/threonine-protein kinase PAK 4	0	0	15	15
Serine/threonine-protein kinase Chk2	0	0	9	9
Tyrosine-protein kinase ABL1	0	15	19	36
RAF proto-oncogene serine/threonine-protein kinase	0	3	10	14
Receptor tyrosine-protein kinase erbB-2	0	4	9	13
High affinity nerve growth factor receptor	0	2	14	16
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	10	10
ADP/ATP translocase 2	0	0	15	15
Protein kinase C beta type	0	0	15	15
Insulin receptor	0	3	15	18
Tyrosine-protein kinase Lck	0	10	15	25
Tyrosine-protein kinase Fyn	0	7	15	22
Cyclin-dependent kinase 1	0	1	15	16
Glycogen phosphorylase, liver form	0	0	15	15
Tyrosine-protein kinase Fes/Fps	0	1	15	16
Macrophage colony-stimulating factor 1 receptor	0	6	9	15
Adenine phosphoribosyltransferase	0	0	10	10
Tyrosine-protein kinase Yes	0	3	15	18
Tyrosine-protein kinase Lyn	0	6	15	21
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	15	17
Insulin-like growth factor 1 receptor	0	3	15	18
Signal recognition particle receptor subunit alpha	0	0	12	12
Hepatocyte growth factor receptor	0	1	15	16
Tyrosine-protein kinase HCK	0	5	15	20
Proto-oncogene tyrosine-protein kinase ROS	0	0	9	9
Platelet-derived growth factor receptor beta	0	7	15	22
Tyrosine-protein kinase Fgr	0	1	13	14
Wee1-like protein kinase 2	0	0	9	9
Uncharacterized serine/threonine-protein kinase SBK3	0	0	9	9
Serine/threonine-protein kinase A-Raf	0	1	15	16
Mast/stem cell growth factor receptor Kit	0	9	12	21
Glycogen phosphorylase, brain form	0	0	15	15
Breakpoint cluster region protein	0	12	18	32
Serine/threonine-protein kinase pim-1	0	1	15	16
Fibroblast growth factor receptor 1	0	5	15	21
DNA topoisomerase 2-alpha	0	0	12	13
Cyclin-dependent kinase 4	0	1	15	16
ADP/ATP translocase 3	0	0	15	15
Inosine-5'-monophosphate dehydrogenase 2	0	0	12	12
Proto-oncogene tyrosine-protein kinase Src	0	10	15	25
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	15	15
Insulin receptor-related protein	0	0	9	9
Serine/threonine-protein kinase B-raf	0	1	16	18
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	15	15
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	15	16
Platelet-derived growth factor receptor alpha	0	8	10	18
Tyrosine-protein kinase Fer	0	1	15	16
Protein kinase C alpha type	0	2	15	17
cAMP-dependent protein kinase catalytic subunit alpha	0	1	15	16
Vascular endothelial growth factor receptor 1	0	3	9	12
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	15	15
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	9	9
Casein kinase II subunit alpha'	0	0	15	15
Ras-related protein Rab-6A	0	0	14	14
Serine/threonine-protein kinase MAK	0	0	9	9
Cyclin-dependent kinase 11B	0	0	9	9
Transcription initiation factor TFIID subunit 1	0	1	1	2
Ephrin type-A receptor 1	0	1	15	16
Fibroblast growth factor receptor 2	0	3	9	12
Receptor tyrosine-protein kinase erbB-3	0	0	9	9
Multifunctional protein ADE2	0	0	15	15
Fibroblast growth factor receptor 4	0	3	9	12
Fibroblast growth factor receptor 3	0	3	9	12
cAMP-dependent protein kinase catalytic subunit gamma	0	0	13	13
cAMP-dependent protein kinase catalytic subunit beta	0	0	15	15
Ferrochelatase, mitochondrial	0	0	16	16
Ribosomal protein S6 kinase beta-1	0	0	14	14
Tyrosine-protein kinase JAK1	0	1	15	16
Protein kinase C eta type	0	0	9	9
Cyclin-dependent kinase 2	0	3	15	18
Beta-adrenergic receptor kinase 1	0	0	15	15
Probable ATP-dependent RNA helicase DDX6	0	0	15	15
Activin receptor type-2A	0	0	9	9
Mitogen-activated protein kinase 3	0	0	15	15
MAP/microtubule affinity-regulating kinase 3	0	0	15	15
Deoxycytidine kinase	0	0	15	17
Mitogen-activated protein kinase 1	0	0	15	15
Ephrin type-A receptor 2	0	4	15	19
Ephrin type-A receptor 3	0	0	9	9
Ephrin type-A receptor 8	0	0	9	9
Ephrin type-B receptor 2	0	2	15	17
Leukocyte tyrosine kinase receptor	0	1	9	10
Non-receptor tyrosine-protein kinase TYK2	0	0	15	15
UMP-CMP kinase	0	0	9	9
Wee1-like protein kinase	0	0	15	15
Heme oxygenase 2	0	0	14	14
Tyrosine-protein kinase receptor UFO	0	1	9	10
Mitogen-activated protein kinase 4	0	0	9	9
S-adenosylmethionine synthase isoform type-2	0	0	14	14
DnaJ homolog subfamily A member 1	0	0	15	15
RAC-alpha serine/threonine-protein kinase	0	1	15	16
RAC-beta serine/threonine-protein kinase	0	1	15	16
G protein-coupled receptor kinase 4	0	0	9	9
Dual specificity protein kinase TTK	0	0	14	14
DNA replication licensing factor MCM4	0	0	15	15
Myosin-10	0	0	13	13
Tyrosine-protein kinase receptor Tie-1	0	0	9	9
Vascular endothelial growth factor receptor 3	0	2	9	11
Vascular endothelial growth factor receptor 2	0	8	9	18
Dual specificity mitogen-activated protein kinase kinase 2	0	2	15	17
Receptor-type tyrosine-protein kinase FLT3	0	10	15	25
Bone morphogenetic protein receptor type-1A	0	0	15	15
Activin receptor type-1B	0	0	15	15
TGF-beta receptor type-1	0	0	15	15
Serine/threonine-protein kinase receptor R3	0	0	11	11
TGF-beta receptor type-2	0	0	15	15
Electron transfer flavoprotein subunit beta	0	0	11	11
Tyrosine-protein kinase CSK	0	3	15	18
Glycine--tRNA ligase	0	0	15	15
Protein kinase C iota type	0	0	15	15
Exosome RNA helicase MTR4	0	0	15	15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	9	11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	9	10
Serine/threonine-protein kinase mTOR	0	3	11	14
Megakaryocyte-associated tyrosine-protein kinase	0	0	9	9
Tyrosine-protein kinase Tec	0	2	15	17
Tyrosine-protein kinase TXK	0	2	9	11
Tyrosine-protein kinase ABL2	0	1	15	16
Tyrosine-protein kinase FRK	0	2	15	17
G protein-coupled receptor kinase 6	0	0	11	11
Tyrosine-protein kinase ZAP-70	0	0	9	9
Tyrosine-protein kinase SYK	0	2	15	17
26S proteasome regulatory subunit 6B	0	1	15	16
Mitogen-activated protein kinase 8	0	0	15	15
Mitogen-activated protein kinase 9	0	0	15	15
Dual specificity mitogen-activated protein kinase kinase 4	0	0	11	11
Dual specificity mitogen-activated protein kinase kinase 3	0	0	15	15
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	11	11
Casein kinase I isoform alpha	0	1	15	16
Casein kinase I isoform delta	0	0	15	15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	9	10
MAP kinase-activated protein kinase 2	0	2	15	17
Cyclin-dependent kinase 8	0	0	9	9
Elongation factor Tu, mitochondrial	0	0	15	15
Choline-phosphate cytidylyltransferase A	0	0	8	8
Cysteine--tRNA ligase, cytoplasmic	0	0	12	12
Casein kinase I isoform epsilon	0	0	15	15
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	15	15
Dual specificity protein kinase CLK1	0	0	15	15
Dual specificity protein kinase CLK2	0	0	15	15
Dual specificity protein kinase CLK3	0	0	13	13
Glycogen synthase kinase-3 alpha	0	0	15	15
Glycogen synthase kinase-3 beta	0	1	15	16
Cyclin-dependent kinase 7	0	0	15	15
Cyclin-dependent kinase 9	0	0	15	15
Ras-related protein Rab-27A	0	0	14	14
Tyrosine-protein kinase Blk	0	2	9	11
Interleukin-1 receptor-associated kinase 1	0	0	15	15
Ribosomal protein S6 kinase alpha-3	0	1	15	16
Cytoplasmic tyrosine-protein kinase BMX	0	1	9	10
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	9	9
Serine/threonine-protein kinase Nek2	0	0	15	15
Serine/threonine-protein kinase Nek3	0	0	15	15
Serine/threonine-protein kinase Nek4	0	0	9	9
Tyrosine-protein kinase JAK3	0	1	9	10
Dual specificity mitogen-activated protein kinase kinase 6	0	0	15	15
Serine/threonine-protein kinase PLK1	0	3	16	20
Death-associated protein kinase 1	0	0	9	9
LIM domain kinase 1	0	1	15	16
LIM domain kinase 2	0	1	15	16
Mitogen-activated protein kinase 12	0	1	9	10
Mitogen-activated protein kinase 10	0	0	15	15
Tyrosine--tRNA ligase, cytoplasmic	0	0	14	14
5'-AMP-activated protein kinase subunit gamma-1	0	0	15	16
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	9	10
Ephrin type-B receptor 3	0	0	15	15
Ephrin type-A receptor 5	0	0	15	15
Ephrin type-B receptor 4	0	2	15	17
Ephrin type-B receptor 1	0	0	9	9
Ephrin type-A receptor 4	0	0	15	15
Adenylate kinase 2, mitochondrial	0	0	15	15
Adenosine kinase	0	0	15	15
Hormonally up-regulated neu tumor-associated kinase	0	0	9	9
Serine/threonine-protein kinase SIK1	0	2	9	11
Receptor-interacting serine/threonine-protein kinase 4	0	0	9	9
Ras-related protein Rab-10	0	0	13	13
Cell division control protein 2 homolog	0	0	9	9
Actin-related protein 3	0	0	15	15
Actin-related protein 2	0	0	15	15
Calcium-dependent protein kinase 1	0	0	9	9
GTP-binding nuclear protein Ran	0	0	15	15
Casein kinase II subunit alpha	0	0	9	9
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	9	9
SRSF protein kinase 2	0	0	9	9
Casein kinase I isoform gamma-2	0	0	15	15
Mitogen-activated protein kinase kinase kinase 9	0	0	9	9
Serine/threonine-protein kinase PknB	0	0	9	9
Cyclin-dependent kinase 3	0	0	14	14
Cyclin-dependent kinase-like 1	0	0	9	9
Cyclin-dependent kinase 6	0	0	15	15
Cyclin-dependent-like kinase 5	0	0	15	15
Cyclin-dependent kinase 16	0	0	15	15
Cyclin-dependent kinase 17	0	0	15	15
ATP-dependent 6-phosphofructokinase, platelet type	0	0	12	12
Protein kinase C epsilon type	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 1	0	3	15	18
Angiopoietin-1 receptor	0	1	10	11
Mitogen-activated protein kinase kinase kinase 10	0	0	9	9
DNA topoisomerase 2-beta	0	0	15	15
Protein kinase C theta type	0	0	14	14
Activin receptor type-1	0	1	15	16
Macrophage-stimulating protein receptor	0	0	15	15
Focal adhesion kinase 1	0	2	15	17
Protein kinase C delta type	0	2	15	17
Tyrosine-protein kinase BTK	0	3	15	18
Tyrosine-protein kinase receptor TYRO3	0	0	9	9
Cyclin-dependent kinase 18	0	0	10	10
Activated CDC42 kinase 1	0	2	15	17
Epithelial discoidin domain-containing receptor 1	0	6	15	21
Tyrosine-protein kinase ITK/TSK	0	1	9	10
Myotonin-protein kinase	0	0	9	9
Nucleosome-remodeling factor subunit BPTF	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	1	15	16
Mitogen-activated protein kinase kinase kinase 12	0	0	9	9
Tyrosine-protein kinase Mer	0	0	12	12
Serine/threonine-protein kinase 4	0	1	15	16
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	15	16
Serine/threonine-protein kinase PAK 1	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 5	0	0	15	15
Mitogen-activated protein kinase 7	0	0	15	15
Serine/threonine-protein kinase PAK 2	0	0	15	15
Serine/threonine-protein kinase 3	0	0	15	15
Mitogen-activated protein kinase kinase kinase 1	0	0	15	15
cGMP-dependent protein kinase 2	0	0	9	9
Integrin-linked protein kinase	0	0	15	15
Rho-associated protein kinase 1	0	0	15	15
Non-receptor tyrosine-protein kinase TNK1	0	0	15	15
Serine/threonine-protein kinase PRP4 homolog	0	0	9	9
Receptor-interacting serine/threonine-protein kinase 1	0	1	9	10
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	9	9
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	1	15	16
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	15	15
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	15	15
Activin receptor type-2B	0	0	15	15
Bone morphogenetic protein receptor type-2	0	0	15	15
Protein-tyrosine kinase 6	0	1	15	16
cGMP-dependent protein kinase 1	0	0	14	14
Cyclin-dependent kinase 13	0	0	15	15
Calcium/calmodulin-dependent protein kinase type 1	0	0	9	9
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	1	15	16
Protein-tyrosine kinase 2-beta	0	1	15	16
Maternal embryonic leucine zipper kinase	0	2	15	17
Structural maintenance of chromosomes protein 1A	0	0	14	14
Chromodomain-helicase-DNA-binding protein 4	0	0	14	14
Peroxisomal acyl-coenzyme A oxidase 1	0	0	12	12
Cyclin-dependent kinase 10	0	0	5	5
Serine/threonine-protein kinase D1	0	0	9	9
Serine/threonine-protein kinase 38	0	0	9	9
Receptor tyrosine-protein kinase erbB-4	0	0	9	9
Ribosomal protein S6 kinase alpha-2	0	0	9	9
Ephrin type-A receptor 7	0	0	12	12
Delta(24)-sterol reductase	0	0	15	15
Ribosomal protein S6 kinase alpha-1	0	1	15	16
Dual specificity testis-specific protein kinase 1	0	0	14	14
Myosin light chain kinase, smooth muscle	0	0	15	15
Mitogen-activated protein kinase 11	0	1	15	16
Serine/threonine-protein kinase STK11	0	0	15	15
Rhodopsin kinase GRK1	0	0	9	9
NT-3 growth factor receptor	0	0	9	9
Serine/threonine-protein kinase N1	0	0	15	15
Serine/threonine-protein kinase N2	0	0	15	15
Mitogen-activated protein kinase 14	0	4	17	21
Calcium/calmodulin-dependent protein kinase type IV	0	0	15	15
Mitogen-activated protein kinase kinase kinase 11	0	0	15	15
BDNF/NT-3 growth factors receptor	0	1	9	10
MAP kinase-activated protein kinase 3	0	0	3	3
Mitogen-activated protein kinase 6	0	0	9	9
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	9	9
Discoidin domain-containing receptor 2	0	4	15	19
AP2-associated protein kinase 1	0	1	15	16
Myosin light chain kinase 3	0	0	14	14
Uncharacterized aarF domain-containing protein kinase 5	0	0	10	10
Serine/threonine-protein kinase SBK1	0	0	9	9
Mitogen-activated protein kinase kinase kinase 19	0	0	9	9
Bromodomain testis-specific protein	0	1	1	2
Putative heat shock protein HSP 90-beta 2	0	0	15	15
Serine/threonine-protein kinase TNNI3K	0	0	9	9
Rab-like protein 3	0	0	10	10
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	9	10
Serine/threonine-protein kinase MRCK alpha	0	0	15	15
Serine/threonine-protein kinase MRCK gamma	0	0	15	15
Acyl-CoA dehydrogenase family member 10	0	0	13	13
Serine/threonine-protein kinase Nek5	0	0	9	9
Serine/threonine-protein kinase ULK3	0	0	15	15
Dual serine/threonine and tyrosine protein kinase	0	0	9	9
Mitogen-activated protein kinase kinase kinase 15	0	0	9	9
Uncharacterized protein FLJ45252	0	0	15	15
Acyl-CoA dehydrogenase family member 11	0	0	14	14
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	15	15
Serine/threonine-protein kinase MARK2	0	0	15	15
ATP-dependent RNA helicase DHX30	0	0	7	7
Serine/threonine-protein kinase TAO1	0	0	15	15
STE20-related kinase adapter protein alpha	0	0	15	15
Myosin-14	0	0	15	15
AarF domain-containing protein kinase 1	0	0	15	15
Serine/threonine-protein kinase tousled-like 2	0	0	9	9
Serine/threonine-protein kinase 32C	0	0	9	9
Serine/threonine-protein kinase pim-3	0	0	9	9
ATP-dependent RNA helicase DDX42	0	0	10	10
Serine/threonine-protein kinase VRK2	0	0	9	9
Myosin light chain kinase family member 4	0	0	9	9
Homeodomain-interacting protein kinase 1	0	0	9	9
Calcium/calmodulin-dependent protein kinase type 1D	0	1	9	10
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	15	15
Cyclin-dependent kinase-like 3	0	0	9	9
MAP kinase-activated protein kinase 5	0	1	14	15
Serine/threonine-protein kinase BRSK2	0	0	9	9
Serine/threonine-protein kinase NIM1	0	0	9	9
Serine/threonine-protein kinase ULK2	0	0	9	9
Misshapen-like kinase 1	0	1	11	12
Serine/threonine-protein kinase DCLK2	0	0	9	9
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	9	9
Casein kinase I isoform alpha-like	0	0	9	9
Homeodomain-interacting protein kinase 4	0	0	9	9
Myosin-IIIa	0	0	9	9
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	9	9
Serine/threonine-protein kinase Nek11	0	0	9	9
Atypical kinase COQ8A, mitochondrial	0	0	15	15
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	15	15
Mitogen-activated protein kinase 15	0	0	15	15
Serine/threonine-protein kinase Nek9	0	0	15	15
Serine/threonine-protein kinase BRSK1	0	0	9	9
Serine/threonine-protein kinase 35	0	0	9	9
Serine/threonine-protein kinase Nek7	0	0	13	13
Rhodopsin kinase GRK7	0	0	9	9
Serine/threonine-protein kinase 32A	0	0	9	9
Myosin-IIIb	0	0	9	9
ATP-dependent RNA helicase DDX1	0	0	15	15
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	9	9
Cyclin-dependent kinase-like 2	0	0	9	9
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	15	15
Serine/threonine-protein kinase Sgk3	0	0	9	9
Atypical kinase COQ8B, mitochondrial	0	0	9	9
Aurora kinase B	0	1	15	16
MAP/microtubule affinity-regulating kinase 4	0	0	14	14
Calcium/calmodulin-dependent protein kinase type 1G	0	0	10	10
Serine/threonine-protein kinase Nek1	0	0	15	15
Cyclin-dependent kinase 15	0	0	9	9
PAS domain-containing serine/threonine-protein kinase	0	0	12	12
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	15	15
EKC/KEOPS complex subunit TP53RK	0	0	15	15
Dual specificity testis-specific protein kinase 2	0	0	11	11
SRSF protein kinase 1	0	0	9	9
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	6	15	21
Mitogen-activated protein kinase kinase kinase 5	0	0	15	15
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	9	9
Mitogen-activated protein kinase kinase kinase 3	0	0	15	15
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	15	15
Serine/threonine-protein kinase RIO1	0	0	9	9
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	9	9
Serine/threonine-protein kinase RIO2	0	0	9	9
Cyclin-dependent kinase 19	0	0	9	9
Transient receptor potential cation channel subfamily M member 6	0	0	9	9
Testis-specific serine/threonine-protein kinase 1	0	0	9	9
Serine/threonine-protein kinase 33	0	0	9	9
Nucleolar GTP-binding protein 1	0	0	13	13
Serine/threonine-protein kinase D2	0	0	15	15
Serine/threonine-protein kinase DCLK3	0	0	9	9
NUAK family SNF1-like kinase 2	0	0	14	14
RNA cytidine acetyltransferase	0	0	15	15
Serine/threonine-protein kinase SIK2	0	1	15	16
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	9	9
STE20-like serine/threonine-protein kinase	0	0	15	15
Serine/threonine-protein kinase TAO3	0	0	15	15
Homeodomain-interacting protein kinase 2	0	0	9	9
Tyrosine-protein kinase Srms	0	0	9	9
Homeodomain-interacting protein kinase 3	0	0	9	9
Serine/threonine-protein kinase PLK3	0	2	9	11
dCTP pyrophosphatase 1	0	0	15	15
Dual specificity protein kinase CLK4	0	0	13	13
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	9	9
Serine/threonine-protein kinase Nek6	0	0	9	9
Casein kinase I isoform gamma-1	0	0	15	15
Serine/threonine-protein kinase PAK 6	0	0	11	11
SNF-related serine/threonine-protein kinase	0	0	9	9
Serine/threonine-protein kinase LATS2	0	0	9	9
Serine/threonine-protein kinase 36	0	0	9	9
Phenylalanine--tRNA ligase beta subunit	0	0	15	15
BMP-2-inducible protein kinase	0	0	15	15
Obg-like ATPase 1	0	0	13	13
Midasin	0	0	15	15
Interleukin-1 receptor-associated kinase 4	0	1	15	16
Serine/threonine-protein kinase 32B	0	0	9	9
Mitogen-activated protein kinase kinase kinase 20	0	1	15	16
Cyclin-dependent kinase 12	0	0	15	15
Serine/threonine-protein kinase PLK2	0	2	9	11
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	14	14
Serine/threonine-protein kinase MARK1	0	0	9	9
Serine/threonine-protein kinase pim-2	0	0	12	12
Serine/threonine-protein kinase PAK 5	0	0	9	9
Serine/threonine-protein kinase 26	0	0	15	15
eIF-2-alpha kinase GCN2	0	0	9	9
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	13	13
Serine/threonine-protein kinase NLK	0	0	15	15
Phosphatidylinositol 4-kinase beta	0	0	9	9
Serine/threonine-protein kinase 17A	0	0	9	9
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	9	9
Ephrin type-A receptor 6	0	0	9	9
5'-AMP-activated protein kinase subunit gamma-2	0	0	15	16
Serine/threonine-protein kinase TBK1	0	1	15	16
Septin-9	0	0	15	15
Death-associated protein kinase 2	0	0	9	9
Ribosomal protein S6 kinase alpha-6	0	0	15	15
TRAF2 and NCK-interacting protein kinase	0	0	15	15
Serine/threonine-protein kinase tousled-like 1	0	0	9	9
Serine/threonine-protein kinase TAO2	0	0	15	15
Long-chain-fatty-acid--CoA ligase 5	0	0	10	10
ALK tyrosine kinase receptor	0	2	10	12
SRSF protein kinase 3	0	0	9	9
Serine/threonine-protein kinase ICK	0	0	14	14
Cyclin-dependent kinase 11A	0	0	9	9
Aurora kinase C	0	0	9	9
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	9	9
RAC-gamma serine/threonine-protein kinase	0	1	15	16
Serine/threonine-protein kinase 38-like	0	0	12	12
Microtubule-associated serine/threonine-protein kinase 1	0	0	9	9
Serine/threonine-protein kinase SIK3	0	1	15	16
Mitogen-activated protein kinase kinase kinase 2	0	0	15	15
Thyroid hormone receptor-associated protein 3	0	0	13	13
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	12	12
Mitogen-activated protein kinase kinase kinase kinase 5	0	1	15	16
Receptor-interacting serine/threonine-protein kinase 3	0	1	15	16
Serine/threonine-protein kinase MRCK beta	0	0	15	15
Interleukin-1 receptor-associated kinase 3	0	0	15	15
Serine/threonine-protein kinase 24	0	1	11	12
Casein kinase I isoform gamma-3	0	0	15	15
Mitogen-activated protein kinase kinase kinase 4	0	0	15	15
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, Cruzipain	7	0	0	7
USP1 protein, partial	20	0	0	20
vitamin D3 receptor isoform VDRA	16	0	0	16
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	2	0	0	2
Inositol monophosphatase 1	9	0	0	9
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
caspase 7, apoptosis-related cysteine protease	10	0	0	10
caspase-3	10	0	0	10
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Histone H2A.x	18	0	0	18
Caspase-7	6	0	0	6
caspase-3	6	0	0	6
heat shock protein beta-1	11	0	0	11
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	5	1	9
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Prothrombin	0	1	0	1
Chymotrypsinogen A	0	2	0	3
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	2	0	2
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	3	0	4
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	2	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	6	2	11
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	2	0	3
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	5	2	10
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Histone deacetylase 8	0	6	2	11
Histone deacetylase 6	0	6	2	11
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
G	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
nuclear receptor ROR-gamma isoform 1	13	0	0	13
Nuclear receptor subfamily 1 group I member 2	0	0	6	6
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Endothelin receptor type B	0	2	0	2
Endothelin receptor type B	0	3	1	4
Endothelin-1 receptor	0	3	0	3
Endothelin-1 receptor	0	2	1	3
Endothelin receptor type B	0	0	1	1
Deoxyhypusine synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Inositol hexakisphosphate kinase 1	14	0	0	14
cytochrome P450 2C9, partial	14	0	0	14
Nucleophosmin	0	1	0	1
Cytochrome c1, heme protein, mitochondrial	0	0	14	14
Glycogen phosphorylase, muscle form	0	1	0	1
Tyrosine-protein kinase Blk	0	2	0	2
Platelet-derived growth factor receptor alpha	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Phosphatidylethanolamine-binding protein 1	0	0	12	12
Synaptic vesicular amine transporter	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Protein kinase C zeta type	0	1	8	9
Serine/threonine-protein kinase ATR	0	0	6	6
Isoleucine--tRNA ligase, mitochondrial	0	0	6	6
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
thyroid hormone receptor beta isoform a	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	14	0	0	14
Prostaglandin E synthase	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	14	0	14
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	4
Quinolone resistance protein NorA	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Beta-3 adrenergic receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	13	1	14
Calpain-2 catalytic subunit	0	1	0	1
5-hydroxytryptamine receptor 1A	0	8	0	8
D(1A) dopamine receptor	0	8	0	8
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	14	1	15
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	9	1	10
Sodium-dependent serotonin transporter	0	3	1	4
Delta-type opioid receptor	0	3	0	3
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	1	5
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	1	0	3
Alpha-1A adrenergic receptor	0	13	1	14
Carbonic anhydrase	0	1	0	4
Histone deacetylase 4	0	4	1	8
D(2) dopamine receptor	0	4	0	4
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	8	0	8
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	4	2	9
Rap guanine nucleotide exchange factor 4	3	0	0	3
Polyamine deacetylase HDAC10	0	4	1	8
Histone deacetylase 11	0	4	1	8
P2Y purinoceptor 12	0	1	0	1
Histone deacetylase 9	0	4	1	8
Histone deacetylase 5	0	4	1	8
atrial natriuretic peptide receptor 2 precursor	8	0	0	8
Histamine H1 receptor	0	23	3	26
Potassium voltage-gated channel subfamily H member 2	0	18	0	18
Histamine H4 receptor	0	7	2	9
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
flap endonuclease 1	7	0	0	7
MBT domain-containing protein 1	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Luciferase	14	0	0	14
15-lipoxygenase, partial	4	0	0	4
survival motor neuron protein isoform d	11	0	0	11
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Vitamin D3 receptor	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
muscleblind-like protein 1 isoform 1	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Adenosine receptor A3	0	1	0	1
nonstructural protein 1	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Cytochrome P450 2C8	0	4	0	5
Cytochrome P450 2B6	0	4	0	4
Liver carboxylesterase 1	0	0	0	1
Cytochrome P450 2C19	0	7	0	7
P2Y purinoceptor 12	0	2	1	3
endonuclease IV	5	0	0	5
PAX8	0	0	0	2
cytochrome P450 2D6 isoform 1	7	0	0	7
nuclear receptor subfamily 0 group B member 1	0	2	0	2
cytochrome P450 2C9 precursor	4	0	0	4
steroidogenic factor 1	0	2	0	2
neuropeptide S receptor isoform A	6	0	0	6
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	3	1	4
Plasma kallikrein	0	0	0	3
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	6	1	9
Tubulin alpha-3C chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Histamine H2 receptor	6	2	1	12
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
B2 bradykinin receptor	0	2	0	2
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Beta-lactamase	0	3	0	3
Amyloid-beta precursor protein	1	4	0	5
Beta-lactamase	0	1	0	2
5-hydroxytryptamine receptor 2A	0	3	0	4
Beta-galactosidase	0	2	0	3
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	0	0	3
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	3	0	3
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
GALC protein	2	0	0	2
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Tyrosine-protein kinase ABL1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	3	5
Transthyretin	0	1	1	2
Neuronal proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Proto-oncogene tyrosine-protein kinase LCK	0	2	0	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Cytochrome P450 2A6	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	3	3
Angiotensin-converting enzyme	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	3	0	3
Potassium voltage-gated channel subfamily KQT member 1	0	3	0	3
Tubulin alpha-1A chain	0	0	3	3
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Myelin transcription factor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	5	0	5
Serine/threonine-protein kinase N3	0	0	8	8
Breakpoint cluster region protein	0	1	0	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	5	5
Protein cereblon	0	6	4	14
Angiotensin-converting enzyme 2	0	0	2	2
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
NF-kappa-B essential modulator	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
mitogen-activated protein kinase 1	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	3	0	3
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Platelet-activating factor receptor	1	1	0	2
Multidrug resistance-associated protein 1	0	2	0	3
Reverse transcriptase/RNaseH	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	2	0	2
exodeoxyribonuclease V subunit RecB	0	2	0	2
exodeoxyribonuclease V subunit RecC	0	2	0	2
5-hydroxytryptamine receptor 4	0	12	0	12
Muscarinic acetylcholine receptor M2	0	10	0	10
Muscarinic acetylcholine receptor M4	0	9	0	9
Muscarinic acetylcholine receptor M5	0	9	0	9
Alpha-2A adrenergic receptor	0	12	0	12
Muscarinic acetylcholine receptor M1	0	12	0	12
Muscarinic acetylcholine receptor M3	0	11	0	11
Histamine H2 receptor	0	7	2	9
Alpha-1D adrenergic receptor	0	7	0	7
5-hydroxytryptamine receptor 2A	0	12	0	12
5-hydroxytryptamine receptor 2C	0	13	0	13
Histamine H1 receptor	0	2	3	7
Histamine H3 receptor	0	1	0	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Histamine H1 receptor	0	4	1	5
Histamine H1 receptor	0	1	0	1
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	2	0	4
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	2	3
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	2	0	4
Prostaglandin D2 receptor	0	1	1	2
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	2
Solute carrier family 22 member 8	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	2	0	4
Solute carrier organic anion transporter family member 2A1	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Solute carrier family 22 member 7	0	0	0	2
regulator of G-protein signaling 4	9	0	0	9
Angiotensin-converting enzyme	0	4	0	4
5-hydroxytryptamine receptor 2B	0	14	0	14
Histamine N-methyltransferase	0	0	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	2	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	2	4
Transporter	0	5	0	5
Regulatory-associated protein of mTOR	0	2	0	2
Target of rapamycin complex subunit LST8	0	2	0	2
D(2) dopamine receptor	0	7	0	7
Amine oxidase [flavin-containing] A	0	3	0	3
D(4) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	10	0	10
Delta-type opioid receptor	0	5	0	5
Kappa-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Solute carrier organic anion transporter family member 1A4	0	0	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Mcl-1	0	1	0	1
Estrogen receptor 1	0	1	0	1
DNA polymerase III, partial	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
PINK1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
galactokinase	1	0	0	1
hexokinase-4 isoform 1	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
D(1A) dopamine receptor	7	0	0	7
glucokinase regulatory protein	3	0	0	3
DNA polymerase beta	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
M-phase phosphoprotein 8	6	0	0	6
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase	1	0	0	1
Prolyl endopeptidase	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
L-lactate dehydrogenase B chain	0	1	0	1
DNA-3-methyladenine glycosylase	0	1	0	1
Caspase-1	1	1	0	2
Alpha-synuclein	3	1	0	4
DNA repair protein RAD52 homolog	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Kinesin-like protein KIF11	0	1	0	1
BH3-interacting domain death agonist	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Type 1 InsP3 receptor isoform S2	1	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Histamine H3 receptor	1	0	0	1
phosphoglycerate kinase	3	0	0	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	1	2	3
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Alpha-1D adrenergic receptor	0	9	1	10
NPYLR7B	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	6	0	0	6
Single-stranded DNA cytosine deaminase	1	0	0	1
Prostacyclin receptor	0	1	1	2
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Cytochrome P450 3A5	0	0	0	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 3	0	1	0	1
Mitogen-activated protein kinase kinase kinase 14	0	1	0	1
P2X purinoceptor 4	0	1	0	1
P2X purinoceptor 7	0	1	0	1
Transmembrane protease serine 4	0	1	0	1
P2X purinoceptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	5
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
5-hydroxytryptamine receptor 1B	0	4	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 6	0	6	0	7
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Cereblon isoform 4	0	3	0	3
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Zinc finger protein Aiolos	0	0	1	1
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 2	0	1	2	3
Cysteinyl leukotriene receptor 1	0	2	3	5
Canalicular multispecific organic anion transporter 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
dopamine D1 receptor	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
pyruvate kinase	1	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
isocitrate dehydrogenase 1, partial	2	0	0	2
alpha-galactosidase	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Bile acid receptor	0	1	0	1
Sodium-dependent neutral amino acid transporter B(0)AT2	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	3	0	0	3
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
TAR DNA-binding protein 43	3	0	0	3
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Glucocorticoid receptor	0	8	3	16
Glycine receptor subunit alpha-1	0	8	0	8
Androgen receptor	0	6	0	6
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	2	5
5-hydroxytryptamine receptor 2C	0	3	0	3
Alpha-2C adrenergic receptor	0	10	0	10
D	0	3	0	3
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Alpha-1A adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Protein delta homolog 1	0	0	3	3
Poly [ADP-ribose] polymerase tankyrase-2	0	0	3	3
Sodium-dependent dopamine transporter	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Substance-K receptor	0	4	0	4
Thromboxane-A synthase	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Leukotriene C4 synthase	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase ABL1	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase ABL1	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase ABL1	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase ABL1	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase ABL1	0	1	0	1
Adenosine deaminase	0	1	0	1
Adenosine deaminase	0	1	0	1
Adenosine deaminase	0	1	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Pirin	0	1	0	1
GTPase KRas	0	1	0	1
Serine/threonine-protein kinase B-raf	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Heat shock factor protein 1	0	1	0	1
Coiled-coil domain-containing protein 6	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	3	0	3
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	5
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	0	3
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Interleukin-5 receptor subunit alpha	0	1	0	1
Cyclin-A1	0	1	0	1
Eukaryotic elongation factor 2 kinase	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Malate dehydrogenase	0	1	0	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Receptor protein-tyrosine kinase	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
RuvB-like 1	0	1	0	1
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Multidrug resistance-associated protein 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	2	0	2
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
acid sphingomyelinase	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Corticotropin releasing hormone receptor 2	0	1	0	1
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4B	0	1	0	1
ATP-dependent molecular chaperone HSP82	0	1	0	1
Heat shock protein HSP 90-alpha	0	4	2	6
Heat shock protein HSP 90-beta	0	2	2	6
Cholesteryl ester transfer protein	0	0	1	1
ATP-dependent molecular chaperone HSC82	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Endoplasmin	0	1	1	2
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
Heat-shock protein	0	1	0	1
Putative heat shock protein HSP 90-alpha A4	0	1	0	1
Lysine-specific demethylase 4C	0	1	0	1
XBP1	0	1	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
C-C chemokine receptor type 5	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Thymidine kinase	0	2	0	3
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Arginase 1	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Histone deacetylase 8	0	1	0	1
Nrf2	1	0	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
protein Wnt-3a precursor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Protein Tat	0	0	1	1
Leukotriene A-4 hydrolase	0	1	0	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Carboxypeptidase B2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
REST corepressor 3	0	1	0	1
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (291)

Protein Targets (1,665)

Mastocytosis, Systemic

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (291)

Drugs Studied (142)

Protein Targets (1,665)