Compounds > 3-amino-5-mercapto-1,2,4-triazole
Page last updated: 2024-12-09

3-amino-5-mercapto-1,2,4-triazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-amino-5-mercapto-1,2,4-triazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2723869
CHEMBL ID3187666
SCHEMBL ID94802
SCHEMBL ID11413174
MeSH IDM0470025

Synonyms (84)

Synonym
AC-16289
AKOS002350449
5-amino-4h-[1,2,4]triazole-3-thiol
nsc34807
nsc-34807
5-amino-1,2-dihydro-3h-1,2,4-triazole-3-thione
1,4-triazolidine-3-thione, 5-imino-
iminothiourazole
3-amino-5-mercapto-1,4-triazole
nsc-145149
3h-1,4-triazole-3-thione, 5-amino-1,2-dihydro-
16691-43-3
nsc145149
ent 61388
s-triazole-3-thiol, 5-amino-
3-imino-5-thiourazole
3-amino-1,2,4-triazole-5-thiol, 95%
5-amino-1,2-dihydro-3h,1,2,4-triazole-3-thione
nsc 145149
3-amino-1,2,4-triazole-5-thiol
3h-1,2,4-triazole-3-thione, 1,2-dihydro-5-amino-
1,2,4-triazolidine-3-thione, 5-imino-
3h-1,2,4-triazole-3-thione, 5-amino-1,2-dihydro-
3-amino-5-mercapto-1,2,4-triazole
1,2-triazolidine-3-thione, 5-imino-
1,2-dihydro-5-amino-3h-1,2,4-triazole-3-thione
ai3-61388
einecs 240-735-6
3-amino-4h-1,2,4-triazole-5-thiol
AKOS000276288
AKOS000813709
STK803268
3-amino-1h-1,2,4-triazole-5-thiol
AKOS001051876
5-amino-1,2-dihydro-1,2,4-triazole-3-thione
AKOS000119697
5-azanyl-1,2-dihydro-1,2,4-triazole-3-thione
A810790
unii-353f2d8l1z
353f2d8l1z ,
dtxcid5024849
dtxsid7044849 ,
cas-16691-43-3
NCGC00256233-01
tox21_301609
BBL004942
5-amino-4h-1,2,4-triazole-3-thiol
F3250-0579
BP-10581
FT-0615006
5-amino-1h-1,2,4-triazole-3-thiol
F9995-0407
SCHEMBL94802
5-amino-3-mercapto-4h-[1,2,4]triazole
3-amino-5-mercapto-1h-1,2,4-triazole
5-amino-3-mercapto-1,2,4-triazole
3-amino-5-mercapto-s-triazole
5-amino-3-mercapto-1,2,4--triazole
SCHEMBL11413174
W-107914
BS-3747
5-amino-4h-1,2,4-triazol-3-yl hydrosulfide #
3-mercapto-5-amino-1,2,4-triazole
5-amino-1h-(1,2,4)triazole-3-thiol
2-amino-5-mercapto-1,3,4-triazole
3-thio-5-amino-1,2,4-triazole
4h-3-amino-5-mercapto-1,2,4-triazole
5-mercapto-3-amino-1,2,4-triazole
CHEMBL3187666
mfcd00005231
VU0607279-1
CS-B1269
5-amino-3,4-dihydro-2h-1,2,4-triazole-3-thione
5-imino-1,2,4-triazolidine-3-thione
5-amino-1,2-dihydro-3h-1,2,4-tri-azole-3-thione
Q26841259
3-amino-5-mercapto-[1,2,4]triazole
AMY25588
mfcd00755416
amino-1,2,4-triazole-3-thiol
EN300-260497
5-amino-2,3-dihydro-1h-1,2,4-triazole-3-thione
Z56913172
PD148022

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"We concluded that long-term exposure of astrocytes to ethanol is more toxic than acute exposure."( Comparison of ethanol and acetaldehyde toxicity in rat astrocytes in primary culture.
Lipnik-Stangelj, M; Sarc, L, 2009)		0.35

Dosage Studied

ExcerptRelevanceReference
" The protein content study showed biphasic dose-response curves, after 24 hours and seven days of exposure to either ethanol or acetaldehyde."( Comparison of ethanol and acetaldehyde toxicity in rat astrocytes in primary culture.
Lipnik-Stangelj, M; Sarc, L, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
acetylcholinesteraseHomo sapiens (human)Potency89.35840.002541.796015,848.9004AID1347398
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's7 (46.67)24.3611
2020's1 (6.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.90

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.90 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.50 (4.65)
Search Engine Demand Index31.50 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.90)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetaldehyde
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.		2.0510aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
uric acid
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.. uric acid : An oxopurine that is the final oxidation product of purine metabolism.. 6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.. 7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.		2.4820uric acidEscherichia coli metabolite;
human metabolite;
mouse metabolite
amitrole
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.		7.0510aromatic amine;
triazoles		carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0210guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		2.0710amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.0710aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		2.0210aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.110copper group element atom;
elemental silver		Escherichia coli metabolite
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		2.0510inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
bathocuproine
bathocuproine: reagent for copper; RN given refers to parent cpd		2.0510
1,7-phenanthroline
[no description available]		2.0510phenanthroline
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		4.061401,2,3-triazole
fluorodeoxyglucose f18
Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)		2.03102-deoxy-2-((18)F)fluoro-D-glucose;
2-deoxy-2-fluoro-aldehydo-D-glucose
n-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide
[no description available]		2.0110sulfonamide
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0710ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
deoxyguanosine
[no description available]		2.0510purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hypoxanthine
[no description available]		2.0710nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
inosine
[no description available]		2.0710inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.		2.0510guanosinesbiomarker
ConditionIndicatedRelationship StrengthStudiesTrials
Glial Cell Tumors
[description not available]		03.5240
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		03.5240
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0810
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.		02.0810
Hypertrophy
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).		02.0810
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0810
Cancer of Liver
[description not available]		02.0510
Cancer of the Thyroid
[description not available]		02.0510
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0510
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.		02.0510
Airway Hyper-Responsiveness
[description not available]		02.0110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0210
Asthma, Bronchial
[description not available]		02.0210
Diseases, Occupational
[description not available]		02.0210
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		07.0210
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.0210
Adenoma Sebaceum
Facial ANGIOFIBROMA in tuberous sclerosis		02.0310
Tuberous Sclerosis
Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.		02.0310