A cardiovascular drug that prevents atherogenesis, the accumulation of lipid-containing plaques on the innermost layers of the arteries. Compare with antiatherosclerotic agent.
ChEBI ID: 50855
| Member | Definition | Class |
|---|---|---|
| 9,11-linoleic acid | An octadeca-9,11-dienoic acid having 9-trans,11-trans-stereochemistry. | (9E,11E)-octadecadienoic acid |
| d-alpha tocopherol | An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils. | (R,R,R)-alpha-tocopherol |
| ochnaflavone | A biflavonoid with an ether linkage between the B-rings of the apigenin and luteolin subunits. It has been isolated from several members of the Ochnaceae plant family. | ochnaflavone |
| pd 146176 | An organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits. | PD-146176 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 7,473 (24.68) | 18.7374 |
| 1990's | 6,481 (21.40) | 18.2507 |
| 2000's | 8,285 (27.36) | 29.6817 |
| 2010's | 6,465 (21.35) | 24.3611 |
| 2020's | 1,580 (5.22) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,913 (8.99%) | 5.53% |
| Reviews | 2,777 (8.57%) | 6.00% |
| Case Studies | 441 (1.36%) | 4.05% |
| Observational | 44 (0.14%) | 0.25% |
| Other | 26,236 (80.95%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 31.1452 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 6.2333 | 5 | 6 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 14.4322 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 37.9083 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 4.9883 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 11.6886 | 2 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 1.4581 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 4.3994 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 1.4581 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 31.1452 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.2334 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 50.1187 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 43.0814 | 2 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 1.4581 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 2 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Cytosolic phospholipase A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Group 10 secretory phospholipase A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Phospholipase A2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Phospholipase A2, membrane associated | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 0.8100 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.9133 | 3 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 3.8100 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-tocopherol transfer protein | Homo sapiens (human) | Kd | 2.4200 | 1 | 1 |