EC 1.1.1.25 (shikimate dehydrogenase) inhibitor

An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of shikimate dehydrogenase (EC 1.1.1.25).

ChEBI ID: 77484

Members (4)

Member	Definition	Class
2,4-dichlorophenoxyacetic acid	A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.	2,4-D
curcumin	A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	curcumin
guaiacol	A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.	guaiacol
protocatechuic acid	A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.	3,4-dihydroxybenzoic acid

Research

Studies (21,363)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	1,282 (6.00)	18.7374
1990's	1,008 (4.72)	18.2507
2000's	3,638 (17.03)	29.6817
2010's	10,275 (48.10)	24.3611
2020's	5,160 (24.15)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	632 (2.85%)	5.53%
Reviews	1,874 (8.45%)	6.00%
Case Studies	131 (0.59%)	4.05%
Observational	7 (0.03%)	0.25%
Other	19,531 (88.08%)	84.16%

Protein Targets (252)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	26.9680	1	2
15-lipoxygenase, partial	Homo sapiens (human)	Potency	14.2191	1	2
acetylcholinesterase	Homo sapiens (human)	Potency	63.6740	3	4
activating transcription factor 6	Homo sapiens (human)	Potency	18.7837	2	4
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	18.5482	1	2
Alpha-synuclein	Homo sapiens (human)	Potency	18.8541	1	2
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	7.0795	1	1
AR protein	Homo sapiens (human)	Potency	26.9044	9	22
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	31.5724	3	6
ATAD5 protein, partial	Homo sapiens (human)	Potency	14.8366	1	2
Ataxin-2	Homo sapiens (human)	Potency	44.1534	1	2
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	48.3696	2	4
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	39.8107	1	1
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	27.4727	1	1
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	23.7358	1	2
caspase-3	Homo sapiens (human)	Potency	27.4727	1	1
Caspase-7	Homo sapiens (human)	Potency	12.5893	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	16.5446	3	8
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	26.5447	2	3
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	35.4813	1	3
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	5.6234	1	1
Chain A, Breast cancer type 1 susceptibility protein	Homo sapiens (human)	Potency	5.0119	1	3
Chain A, Cruzipain	Trypanosoma cruzi	Potency	31.6228	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	7.0795	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	17.8020	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	79.4328	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	17.7407	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	15.8540	1	4
Chain B, HADH2 protein	Homo sapiens (human)	Potency	17.8020	2	2
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	14.2191	2	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	34.4925	1	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	22.3872	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	27.2454	2	3
DNA polymerase beta	Homo sapiens (human)	Potency	34.8936	1	2
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	68.0131	1	3
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	57.9023	1	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	40.2251	8	21
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	27.4912	2	3
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	28.0321	6	11
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	17.4882	1	2
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	41.5055	4	5
flap endonuclease 1	Homo sapiens (human)	Potency	60.4566	1	2
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	14.2191	1	2
geminin	Homo sapiens (human)	Potency	11.9725	2	5
GLI family zinc finger 3	Homo sapiens (human)	Potency	17.1307	3	5
GLS protein	Homo sapiens (human)	Potency	16.0825	1	2
glucocerebrosidase	Homo sapiens (human)	Potency	32.4648	1	2
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	47.0383	3	5
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	77.4286	1	1
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	35.4813	1	1
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	28.9342	2	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	17.7828	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	27.3162	2	2
hemoglobin subunit beta	Homo sapiens (human)	Potency	39.8107	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	7.9433	1	4
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	107.1630	1	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	14.1254	1	1
huntingtin isoform 2	Homo sapiens (human)	Potency	3.5481	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	52.2970	2	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	6.3096	2	2
IDH1	Homo sapiens (human)	Potency	16.3601	1	1
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	25.6651	2	2
Integrin alpha-IIb	Homo sapiens (human)	Potency	19.9116	1	2
Integrin beta-3	Homo sapiens (human)	Potency	19.9116	1	2
interleukin 8	Homo sapiens (human)	Potency	84.1267	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	18.6298	1	2
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	0.5397	1	2
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	39.8107	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	50.2069	3	5
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	22.2593	1	2
Microtubule-associated protein tau	Homo sapiens (human)	Potency	3.3049	1	3
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	35.7168	1	2
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	0.3162	1	1
Nrf2	Homo sapiens (human)	Potency	22.3872	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	38.1712	4	7
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	7.3078	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	50.1187	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	3.4895	1	1
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	16.8206	1	2
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	24.3888	2	8
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	64.0169	3	4
Parkin	Homo sapiens (human)	Potency	22.3872	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	19.9526	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	20.3148	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	27.0962	5	8
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	34.0393	5	7
phosphopantetheinyl transferase	Bacillus subtilis	Potency	46.4623	1	3
PINK1	Homo sapiens (human)	Potency	22.3872	1	1
plasminogen precursor	Mus musculus (house mouse)	Potency	3.9811	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	19.9526	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	7.9433	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	3.8146	1	2
pregnane X nuclear receptor	Homo sapiens (human)	Potency	31.3510	2	3
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	79.4328	1	2
progesterone receptor	Homo sapiens (human)	Potency	26.6408	2	3
pyruvate kinase PKM isoform a	Homo sapiens (human)	Potency	28.1838	2	2
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	125.8920	1	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	58.8778	2	3
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	41.2181	2	4
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	27.0848	4	8
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	29.9349	1	1
SMAD family member 2	Homo sapiens (human)	Potency	38.7796	2	5
SMAD family member 3	Homo sapiens (human)	Potency	38.7796	2	5
Smad3	Homo sapiens (human)	Potency	28.9342	1	2
snurportin-1	Homo sapiens (human)	Potency	25.6651	2	2
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	35.4813	1	1
TDP1 protein	Homo sapiens (human)	Potency	15.9634	2	10
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	39.8107	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	25.6203	1	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	20.4439	3	11
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	52.1315	3	3
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	19.6182	5	7
thyrotropin-releasing hormone receptor	Homo sapiens (human)	Potency	27.7247	1	1
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	15.8489	1	1
tumor susceptibility gene 101 protein	Homo sapiens (human)	Potency	19.9526	1	1
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	3.9811	1	1
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	3.9811	1	1
USP1 protein, partial	Homo sapiens (human)	Potency	7.5506	2	2
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	9.3233	2	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	42.7771	5	7
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	44.6684	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	77.4286	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	IC50	9.6995	2	2
10 kDa chaperonin	Escherichia coli	IC50	3.0000	2	2
10 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	8.3000	1	1
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens (human)	IC50	1.7300	1	1
3-dehydroquinate synthase	Escherichia coli K-12	Ki	54.5000	2	2
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	Homo sapiens (human)	IC50	137.0000	1	1
60 kDa chaperonin	Escherichia coli K-12	IC50	250.0000	1	1
60 kDa chaperonin	Escherichia coli	IC50	3.0000	2	2
60 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	8.3000	1	1
72 kDa type IV collagenase	Homo sapiens (human)	IC50	137.0000	1	1
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	132.1300	2	2
Acetylcholinesterase	Homo sapiens (human)	IC50	5.0000	1	1
alkaline phosphatase, germ cell type preproprotein	Homo sapiens (human)	IC50	100.0000	1	1
alkaline phosphatase, intestinal	Homo sapiens (human)	IC50	100.0000	1	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	Homo sapiens (human)	IC50	100.0000	1	1
Alpha-(1,3)-fucosyltransferase 7	Homo sapiens (human)	IC50	137.0000	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	5.4000	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	5.4000	1	1
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	5.4000	1	1
Alpha-glucosidase MAL12	Saccharomyces cerevisiae S288C	IC50	192.5500	2	2
Alpha-synuclein	Homo sapiens (human)	IC50	81.0100	2	2
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	3.5000	3	3
Amine oxidase [flavin-containing] A	Homo sapiens (human)	Ki	0.7100	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	2.5733	3	3
Amine oxidase [flavin-containing] B	Homo sapiens (human)	Ki	21.5000	1	1
Aminopeptidase N	Homo sapiens (human)	IC50	15.5000	1	1
Aminopeptidase N	Sus scrofa (pig)	IC50	15.5000	1	1
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	9.8541	30	30
Anthrax toxin receptor 2	Homo sapiens (human)	IC50	300.0000	1	1
Beta lactamase (plasmid)	Pseudomonas aeruginosa	IC50	7.7510	1	1
Beta-secretase 1	Homo sapiens (human)	IC50	343.0000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	1,000.0000	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	1.6300	1	1
Carbonic anhydrase	Dicentrarchus labrax (European seabass)	Ki	3.2100	1	1
Carbonic anhydrase 1	Homo sapiens (human)	Ki	80.2929	3	7
Carbonic anhydrase 12	Homo sapiens (human)	Ki	4.0900	1	1
Carbonic anhydrase 14	Homo sapiens (human)	Ki	0.6900	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	72.0257	3	7
Carbonic anhydrase 4	Homo sapiens (human)	Ki	83.8700	2	6
Carbonic anhydrase 6	Homo sapiens (human)	Ki	72.8871	3	7
Carbonic anhydrase 7	Homo sapiens (human)	Ki	7.8700	1	1
Carbonic anhydrase 9	Homo sapiens (human)	Ki	4.4500	1	1
cathepsin L1	Homo sapiens (human)	IC50	59.6420	1	1
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	IC50	2.3600	1	1
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	Ki	0.1010	1	1
Cholinesterase	Equus caballus (horse)	IC50	300.0000	1	1
Cholinesterase	Homo sapiens (human)	IC50	5.0000	1	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	Homo sapiens (human)	IC50	137.0000	1	1
CREB-binding protein	Homo sapiens (human)	IC50	25.0000	4	4
Cysteine protease	Trypanosoma brucei rhodesiense	IC50	7.7500	1	1
D-amino-acid oxidase	Sus scrofa (pig)	IC50	1.0700	2	2
Dihydroorotate dehydrogenase	Leishmania major	IC50	961.0000	1	2
Glutathione S-transferase P	Homo sapiens (human)	IC50	69.0000	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	17.9500	1	1
Glycogen synthase kinase-3 beta	Rattus norvegicus (Norway rat)	IC50	0.0660	1	1
Heme oxygenase 1	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
Heme oxygenase 2	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
Histone acetyltransferase p300	Homo sapiens (human)	IC50	21.9167	6	6
Histone deacetylase 1	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 1	Homo sapiens (human)	Ki	50.7900	1	1
Histone deacetylase 11	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	Ki	97.6700	1	1
Histone deacetylase 3	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 4	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 5	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 7	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	Ki	64.9800	1	1
Histone deacetylase 9	Homo sapiens (human)	IC50	187.0000	1	1
hypothetical protein SA1422	Staphylococcus aureus subsp. aureus N315	IC50	42.9000	2	2
intestinal alkaline phosphatase precursor	Mus musculus (house mouse)	IC50	18.7000	1	1
Lactoylglutathione lyase	Homo sapiens (human)	Ki	0.0050	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	9.6000	1	1
M18 aspartyl aminopeptidase	Plasmodium falciparum 3D7	IC50	0.4794	1	1
Matrilysin	Homo sapiens (human)	IC50	137.0000	1	1
Microtubule-associated protein tau	Homo sapiens (human)	IC50	54.8750	4	4
NACHT, LRR and PYD domains-containing protein 3	Homo sapiens (human)	IC50	24.2000	1	1
Neuronal proto-oncogene tyrosine-protein kinase Src	Mus musculus (house mouse)	IC50	2.2000	1	1
perilipin-1	Homo sapiens (human)	IC50	9.1670	1	1
perilipin-5	Homo sapiens (human)	IC50	10.2320	1	1
Phospholipase A2	Homo sapiens (human)	IC50	11.1000	1	1
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	187.0000	1	1
Polyphenol oxidase 2	Agaricus bisporus	IC50	100.0000	1	1
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	30.0000	1	1
Prolyl 4-hydroxylase subunit alpha-1	Gallus gallus (chicken)	Ki	5.0000	1	1
Prostaglandin E synthase	Homo sapiens (human)	IC50	1.8000	3	3
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	63.8350	1	2
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	63.8350	1	2
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	10.0000	2	2
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	Pisum sativum (garden pea)	IC50	4,530.0000	2	2
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	Pisum sativum (garden pea)	IC50	4,530.0000	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	31.7500	1	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	31.7500	1	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	3.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	Ki	5.8000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Homo sapiens (human)	IC50	7.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Homo sapiens (human)	Ki	53.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Rattus norvegicus (Norway rat)	Ki	5.8000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	Homo sapiens (human)	IC50	7.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	Homo sapiens (human)	Ki	8.6000	1	1
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	IC50	16.0000	1	1
Sortase A	Streptococcus mutans	IC50	10.2000	1	1
Thioredoxin reductase 1, cytoplasmic	Homo sapiens (human)	IC50	40.4667	3	3
Thioredoxin reductase 2, mitochondrial	Homo sapiens (human)	IC50	40.4667	3	3
Thioredoxin reductase 3	Homo sapiens (human)	IC50	40.4667	3	3
Thiosulfate sulfurtransferase	Homo sapiens (human)	IC50	56.0000	1	1
Tissue factor	Homo sapiens (human)	IC50	0.0132	1	1
toll-like receptor 9	Homo sapiens (human)	IC50	8.3620	1	1
TPA: protein transporter TIM10	Saccharomyces cerevisiae S288C	IC50	19.7000	1	1
Tyrosinase	Homo sapiens (human)	IC50	5.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	IC50	5.8000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 4	Homo sapiens (human)	EC50	10.0000	1	1
Alpha-synuclein	Homo sapiens (human)	Kd	3.5000	4	4
Chain A, Protocatechuate 3,4-dioxygenase alpha chain	Pseudomonas putida	Kd	1,100.0000	1	1
Chain B, Protocatechuate 3,4-dioxygenase beta chain	Pseudomonas putida	Kd	1,100.0000	1	1
Lymphocyte antigen 96	Homo sapiens (human)	Kd	379.0000	1	1
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	EC50	21.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	10.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	10.0000	1	1
Sodium/bile acid cotransporter	Homo sapiens (human)	Kd	64.3000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Amyloid-beta precursor protein	Homo sapiens (human)	DC50	0.7550	2	2
EWS/FLI fusion protein	Homo sapiens (human)	AbsAC35_uM	40.2500	1	1
Microtubule-associated protein tau	Homo sapiens (human)	DC50	200.0000	1	1