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bronchodilator agent

An agent that causes an increase in the expansion of a bronchus or bronchial tubes.

ChEBI ID: 35523

Members (35)

MemberDefinitionClass
aclidinium bromideA quaternary ammonium salt that is the bromide salt of aclidinium. A muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD).aclidinium bromide
albuterolA member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).albuterol
aminophyllineA mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.aminophylline
arformoterolAn N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have R configuration. The active enantiomer of formoterol, it is administered by inhalation (generally as the tartrate salt) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).arformoterol
azelastineA phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.azelastine
azelastine hydrochlorideThe hydrochloride salt of azelastine.azelastine hydrochloride
bambuterolA carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.bambuterol
bambuterol hydrochlorideThe hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.bambuterol hydrochloride
berotekA member of the class resorcinols that is 5-(1-hydroxyethyl)benzene-1,3-diol in which one of the methyl hydrogens is replaced by a 1-(4-hydroxyphenyl)propan-2-amino group. A beta2-adrenergic agonist, it is used (as the hydrobromide salt) as a bronchodilator in the management of reversible airway obstruction.fenoterol
bitolterolThe di-4-toluate ester of (+-)-N-tert-butylnoradrenaline (colterol). A pro-drug for colterol, a beta2-adrenergic receptor agonist, bitolterol is used as its methanesulfonate salt for relief of bronchospasm in conditions such as asthma, chronic bronchitis and emphysema.bitolterol
cilostazolA lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.cilostazol
clenbuterolA substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.clenbuterol
colterolA member of the class of ethanolamines that is catechol in which the hydrogen at position 4 is replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.colterol
diazoxideA benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.diazoxide
diphemanil methylsulfateThe alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating).diphemanil methylsulfate
doxofyllineAn oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma.doxofylline
dyphyllineAn oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.dyphylline
enprofyllineXanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.enprofylline
fenoterolThe hydrobromide salt of fenoterol. A beta2-adrenergic agonist, it is used as a bronchodilator in the management of reversible airway obstruction.fenoterol hydrobromide
fluticasone propionateA trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.fluticasone propionate
indacaterolA monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary disease.indacaterol
isoproterenolA secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.isoprenaline
khellinA furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.khellin
methoxyphenamineAn amphetamine methylated on nitrogen and with the phenyl ring methoxylated at C-2. A beta-adrenergic receptor agonist, it is used as a bronchodilator.methoxyphenamine
nab-365A hydrochloride that is the monohydrochloride salt of clenbuterol.clenbuterol hydrochloride
olodaterolA member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.olodaterol
pseudoephedrineA member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group.pseudoephedrine
pulmicortA glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.budesonide
rp 73401A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.piclamilast
s-nitrosoglutathioneA glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by a nitroso group.S-nitrosoglutathione
terbutalineA member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.terbutaline
theobromineA dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.theobromine
theophyllineA dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.theophylline
vilanterolAn dichlorobenzene derivative that is used in the form of its trifenate salt for treatment of chronic obstructive pulmonary disease.vilanterol
zardaverineA pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.zardaverine

Research

Studies (80,122)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199036,823 (45.96)18.7374
1990's16,084 (20.07)18.2507
2000's12,950 (16.16)29.6817
2010's11,060 (13.80)24.3611
2020's3,205 (4.00)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials10,429 (11.36%)5.53%
Reviews4,847 (5.28%)6.00%
Case Studies3,733 (4.06%)4.05%
Observational143 (0.16%)0.25%
Other72,688 (79.15%)84.16%

Protein Targets (364)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency18.480216
15-lipoxygenase, partialHomo sapiens (human)Potency0.398111
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseLeishmania major strain FriedlinPotency23.934111
67.9K proteinVaccinia virusPotency15.848911
acetylcholinesteraseHomo sapiens (human)Potency22.833335
activating transcription factor 6Homo sapiens (human)Potency13.325613
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency14.414616
alpha-galactosidaseHomo sapiens (human)Potency32.464822
Alpha-synucleinHomo sapiens (human)Potency22.387211
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency1.778311
AR proteinHomo sapiens (human)Potency7.79551038
aryl hydrocarbon receptorHomo sapiens (human)Potency3.618225
arylsulfatase AHomo sapiens (human)Potency16.918815
ATAD5 protein, partialHomo sapiens (human)Potency1.834911
Ataxin-2Homo sapiens (human)Potency6.287414
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency10.7062210
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency6.786826
beta-2 adrenergic receptorHomo sapiens (human)Potency6.467848
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.102226
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency42.204413
caspase-3Cricetulus griseus (Chinese hamster)Potency33.491511
Caspase-7Cricetulus griseus (Chinese hamster)Potency33.491511
Cellular tumor antigen p53Homo sapiens (human)Potency7.469716
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency10.000011
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency25.118911
Chain A, Beta-lactamaseEscherichia coli K-12Potency29.025326
Chain A, Ferritin light chainEquus caballus (horse)Potency0.223911
Chain A, HADH2 proteinHomo sapiens (human)Potency10.037124
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency8.912511
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency10.132314
Chain B, HADH2 proteinHomo sapiens (human)Potency10.037124
chromobox protein homolog 1Homo sapiens (human)Potency63.383929
cytochrome P450 2C19 precursorHomo sapiens (human)Potency7.481913
cytochrome P450 2C9 precursorHomo sapiens (human)Potency13.868313
cytochrome P450 2C9, partialHomo sapiens (human)Potency14.302217
cytochrome P450 2D6Homo sapiens (human)Potency16.1908111
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency10.177513
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.0378225
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency6.3578213
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.002413
D(1A) dopamine receptorHomo sapiens (human)Potency1.299511
D(1A) dopamine receptorSus scrofa (pig)Potency18.492711
DNA polymerase betaHomo sapiens (human)Potency100.000011
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency47.711713
DNA polymerase kappa isoform 1Homo sapiens (human)Potency16.833611
endonuclease IVEscherichia coliPotency12.589311
estrogen nuclear receptor alphaHomo sapiens (human)Potency22.8218829
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency44.920024
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency17.1867940
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency17.0455115
EWS/FLI fusion proteinHomo sapiens (human)Potency15.1804418
farnesoid X nuclear receptorHomo sapiens (human)Potency8.458722
flap endonuclease 1Homo sapiens (human)Potency8.436811
Fumarate hydrataseHomo sapiens (human)Potency33.173412
GVesicular stomatitis virusPotency14.302217
GABA theta subunitRattus norvegicus (Norway rat)Potency14.4123114
GALC proteinHomo sapiens (human)Potency0.631011
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.4123114
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.4123114
gemininHomo sapiens (human)Potency10.1126217
GLI family zinc finger 3Homo sapiens (human)Potency9.2969212
glp-1 receptor, partialHomo sapiens (human)Potency4.8721412
GLS proteinHomo sapiens (human)Potency10.8740213
glucocerebrosidaseHomo sapiens (human)Potency31.099012
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency3.2343314
glucokinase regulatory proteinHomo sapiens (human)Potency28.183811
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency42.932714
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency9.380513
Guanine nucleotide-binding protein GHomo sapiens (human)Potency7.770513
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1Homo sapiens (human)Potency7.943311
hexokinase-4 isoform 1Homo sapiens (human)Potency28.183811
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency11.6350213
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency26.645913
Histone H2A.xCricetulus griseus (Chinese hamster)Potency54.285923
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency12.589311
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency14.302217
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency1.581624
IDH1Homo sapiens (human)Potency12.884812
importin subunit beta-1 isoform 1Homo sapiens (human)Potency14.941124
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency14.3022114
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency7.943311
Interferon betaHomo sapiens (human)Potency14.0067210
lamin isoform A-delta10Homo sapiens (human)Potency3.3295212
lethal factor (plasmid)Bacillus anthracis str. A2012Potency4.465413
LuciferasePhotinus pyralis (common eastern firefly)Potency39.810711
M-phase phosphoprotein 8Homo sapiens (human)Potency22.834212
Microtubule-associated protein tauHomo sapiens (human)Potency7.943312
mitogen-activated protein kinase 1Homo sapiens (human)Potency6.577226
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency44.568222
neuropeptide S receptor isoform AHomo sapiens (human)Potency13.131112
NFKB1 protein, partialHomo sapiens (human)Potency14.120024
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency34.2059210
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency20.596211
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency43.646511
Nuclear receptor ROR-gammaHomo sapiens (human)Potency42.163211
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency10.376926
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency7.087112
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency15.6027317
Ornithine decarboxylaseRattus norvegicus (Norway rat)Potency7.943311
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency34.698913
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency37.933011
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency10.861019
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency81.843013
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency57.314822
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency19.062523
phosphopantetheinyl transferaseBacillus subtilisPotency66.150714
plasminogen precursorMus musculus (house mouse)Potency11.220211
polyproteinZika virusPotency33.173412
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency3.162311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency6.610212
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency10.231013
pregnane X nuclear receptorHomo sapiens (human)Potency23.3106211
progesterone receptorHomo sapiens (human)Potency0.007126
pyruvate kinaseLeishmania mexicana mexicanaPotency10.000022
pyruvate kinase PKM isoform bHomo sapiens (human)Potency7.943322
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency11.220211
RAR-related orphan receptor gammaMus musculus (house mouse)Potency26.0126210
regulator of G-protein signaling 4Homo sapiens (human)Potency16.536919
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency28.5312315
retinoid X nuclear receptor alphaHomo sapiens (human)Potency20.6080316
RGS12Homo sapiens (human)Potency7.943311
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency15.792222
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency22.485212
SMAD family member 2Homo sapiens (human)Potency22.095027
SMAD family member 3Homo sapiens (human)Potency22.095027
Smad3Homo sapiens (human)Potency0.707911
snurportin-1Homo sapiens (human)Potency14.941124
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency27.723213
survival motor neuron protein isoform dHomo sapiens (human)Potency10.8875110
TAR DNA-binding protein 43Homo sapiens (human)Potency23.350712
TDP1 proteinHomo sapiens (human)Potency20.9908220
thioredoxin reductaseRattus norvegicus (Norway rat)Potency10.1827414
ThrombopoietinHomo sapiens (human)Potency6.340426
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency39.349439
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency6.309611
thyroid stimulating hormone receptorHomo sapiens (human)Potency8.7616734
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency20.205714
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency11.220211
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency11.220211
USP1 protein, partialHomo sapiens (human)Potency30.457027
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency20.081229
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency14.439423
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency79.432811
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency42.932714

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
10 kDa chaperonin Escherichia coliIC50175.000022
10 kDa heat shock protein, mitochondrialHomo sapiens (human)IC50100.000011
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)IC500.001011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC502.652011
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki86.000011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki1.515011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC502.652011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Ki1.515011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki0.020011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki0.501211
60 kDa chaperoninEscherichia coli K-12IC50250.000011
60 kDa chaperonin Escherichia coliIC50175.000022
60 kDa heat shock protein, mitochondrialHomo sapiens (human)IC50100.000011
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50100.000011
AcetylcholinesteraseHomo sapiens (human)IC5025.000044
AcetylcholinesteraseRattus norvegicus (Norway rat)IC5030.000011
Adenosine receptor A1Bos taurus (cattle)IC501,006,650,005.043333
Adenosine receptor A1Homo sapiens (human)IC5017.104011
Adenosine receptor A1Rattus norvegicus (Norway rat)IC5019.000022
Adenosine receptor A1Bos taurus (cattle)Ki4.114377
Adenosine receptor A1Cavia porcellus (domestic guinea pig)Ki21.333366
Adenosine receptor A1Gallus gallus (chicken)Ki6.000011
Adenosine receptor A1Homo sapiens (human)Ki10.27591820
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki18.05593141
Adenosine receptor A2aHomo sapiens (human)IC5012.007011
Adenosine receptor A2aCavia porcellus (domestic guinea pig)Ki14.000022
Adenosine receptor A2aHomo sapiens (human)Ki17.79502732
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki47.49802440
Adenosine receptor A2bHomo sapiens (human)Ki16.86922026
Adenosine receptor A2bRattus norvegicus (Norway rat)Ki54.44841832
Adenosine receptor A3Homo sapiens (human)Ki61.26882022
Adenosine receptor A3Rattus norvegicus (Norway rat)Ki47.3650810
Alkaline phosphatase, tissue-nonspecific isozymeHomo sapiens (human)IC5052.500022
Alkaline phosphatase, tissue-nonspecific isozymeHomo sapiens (human)Ki82.000011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC50100.000011
Alpha-1A adrenergic receptorHomo sapiens (human)Ki0.050133
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki17.775122
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC50100.000011
Alpha-1B adrenergic receptorHomo sapiens (human)Ki0.050133
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki35.500011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)IC50100.000011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Ki35.500011
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)IC50100.000011
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)Ki21.000011
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)IC50100.000011
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Ki21.000011
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)IC50100.000011
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)Ki21.000011
Androgen receptorRattus norvegicus (Norway rat)IC504.115023
Androgen receptorRattus norvegicus (Norway rat)Ki1.090011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50123.187518
ATP-binding cassette sub-family C member 8Homo sapiens (human)IC50470.500044
ATP-dependent translocase ABCB1Homo sapiens (human)IC5023.000022
ATP-sensitive inward rectifier potassium channel 11Homo sapiens (human)IC50470.500044
Beta-1 adrenergic receptorHomo sapiens (human)IC500.256423
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)IC500.212522
Beta-1 adrenergic receptorHomo sapiens (human)Ki0.405945
Beta-1 adrenergic receptorMus musculus (house mouse)Ki0.220011
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)Ki0.375022
Beta-2 adrenergic receptorCanis lupus familiaris (dog)IC500.666723
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)IC500.034022
Beta-2 adrenergic receptorHomo sapiens (human)IC500.895436
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)IC500.212522
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)Ki0.952012
Beta-2 adrenergic receptorHomo sapiens (human)Ki0.35521217
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)Ki0.676111
Beta-2 adrenergic receptor Bos taurus (cattle)Ki0.110022
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)IC500.212522
Beta-3 adrenergic receptorHomo sapiens (human)Ki18.620911
Bile salt export pumpHomo sapiens (human)IC50493.0632519
Bile salt export pumpRattus norvegicus (Norway rat)IC501,000.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)IC50660.000022
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)IC50285.333366
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)IC50242.400055
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)IC50122.0782322
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)IC50660.000022
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)IC5068.2860120
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)IC5095.76932224
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)IC500.210011
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)Ki75.715277
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)Ki265.013022
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)IC5069.59192950
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)IC500.210011
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)Ki75.715277
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)Ki265.013022
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)IC5083.15112123
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)IC500.210011
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)Ki75.715277
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)Ki265.013022
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)IC5060.41633056
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)Ki75.715277
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)IC500.210011
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)Ki265.013022
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)IC5068.2860120
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000018
Carboxylic ester hydrolase Rattus norvegicus (Norway rat)IC500.003011
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC5069.8633324
cGMP-dependent 3',5'-cyclic phosphodiesteraseRattus norvegicus (Norway rat)IC5010.000011
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)IC5054.17391113
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)IC5067.89581029
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC5061.5300324
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)IC500.1300121
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)IC500.1300112
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC500.130016
Chain A, Phosphodiesterase 4DHomo sapiens (human)IC500.160011
Chain A, Pyridoxal kinaseHomo sapiens (human)Ki50.000012
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)IC500.130013
Chitotriosidase-1Homo sapiens (human)IC501,000.000012
CholinesteraseEquus caballus (horse)IC500.119311
CholinesteraseHomo sapiens (human)IC500.003344
Coagulation factor VIIHomo sapiens (human)IC50740.000011
Cytochrome P450 1A1Homo sapiens (human)IC504.020011
Cytochrome P450 1A1Homo sapiens (human)Ki3.800011
Cytochrome P450 1A2Homo sapiens (human)IC500.040011
Cytochrome P450 1A2Homo sapiens (human)Ki0.031011
Cytochrome P450 1B1Homo sapiens (human)IC5046.900022
Cytochrome P450 2C19Homo sapiens (human)IC5010.000011
Cytochrome P450 2C9 Homo sapiens (human)IC5010.000022
Cytochrome P450 2D6Homo sapiens (human)IC504.333333
Cytochrome P450 2D6Homo sapiens (human)Ki0.050111
Cytochrome P450 3A4Homo sapiens (human)IC5010.000011
Cytochrome P450 3A4Homo sapiens (human)Ki0.020011
D(1A) dopamine receptorHomo sapiens (human)Ki50.000011
D(2) dopamine receptorHomo sapiens (human)Ki30.000022
D(3) dopamine receptorHomo sapiens (human)Ki2.874022
D(3) dopamine receptorRattus norvegicus (Norway rat)Ki0.000611
D(4) dopamine receptorHomo sapiens (human)Ki2.900011
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)IC5068.2860120
Endochitinase B1Aspergillus fumigatusIC501,000.000012
Endothelin-1 receptorSus scrofa (pig)IC500.001011
Estrogen receptorHomo sapiens (human)IC5010.000012
Estrogen receptor betaHomo sapiens (human)IC5010.000012
Glucocorticoid receptorHomo sapiens (human)IC500.001369
Glucocorticoid receptorRattus norvegicus (Norway rat)IC500.002723
Glucocorticoid receptorHomo sapiens (human)Ki0.001722
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)IC500.004511
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki0.002011
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)IC500.004511
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki0.002011
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC500.004511
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.002011
Glycine receptor subunit betaRattus norvegicus (Norway rat)IC500.004511
Glycine receptor subunit betaRattus norvegicus (Norway rat)Ki0.002011
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)IC50200.000011
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)IC5063.7704223
high affinity choline transporter 1 isoform aHomo sapiens (human)IC500.007824
Histamine H1 receptorHomo sapiens (human)Ki0.001233
Histamine H3 receptorHomo sapiens (human)Ki0.151433
Interleukin-5Homo sapiens (human)IC5026.800011
Interleukin-5Mus musculus (house mouse)IC5026.537588
Interleukin-5 receptor subunit alphaMus musculus (house mouse)IC5026.200011
Intestinal-type alkaline phosphataseHomo sapiens (human)IC505.000011
Matrix metalloproteinase-9Homo sapiens (human)IC501.989011
Mineralocorticoid receptor Homo sapiens (human)IC500.081512
Multidrug resistance-associated protein 4Homo sapiens (human)IC50106.200018
Muscarinic acetylcholine receptor M1Homo sapiens (human)IC502.103333
Muscarinic acetylcholine receptor M1Homo sapiens (human)Ki0.000111
Muscarinic acetylcholine receptor M2Homo sapiens (human)IC500.000133
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki0.000322
Muscarinic acetylcholine receptor M3Homo sapiens (human)IC500.000144
Muscarinic acetylcholine receptor M3Homo sapiens (human)Ki0.000322
Muscarinic acetylcholine receptor M4Homo sapiens (human)IC500.000211
Muscarinic acetylcholine receptor M5Homo sapiens (human)IC500.000211
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)IC502,904.000011
Phosphodiesterase Bos taurus (cattle)IC50250.333366
Phosphodiesterase Bos taurus (cattle)Ki77.000011
Phospholipase A-2-activating proteinHomo sapiens (human)IC505.000011
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)IC501.770011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC500.100044
Progesterone receptorHomo sapiens (human)IC500.024512
ReninHomo sapiens (human)Ki2.325012
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC50100.000011
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC50100.000011
Serine/arginine-rich splicing factor 6Homo sapiens (human)IC5019.010011
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)Ki7.900011
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)IC5027.100011
Testosterone 17-beta-dehydrogenase 3Rattus norvegicus (Norway rat)IC500.000111
Thiosulfate sulfurtransferaseHomo sapiens (human)IC50100.000011
Thyroid hormone receptor betaRattus norvegicus (Norway rat)Ki14.000011
Tissue factorHomo sapiens (human)IC50740.000011
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC5091.200011
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)IC5091.200011
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)IC5091.200011
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)IC5091.200011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A1Homo sapiens (human)Kd12.000011
Adenosine receptor A2aHomo sapiens (human)EC5017.700012
Adenosine receptor A2aHomo sapiens (human)Kd2.811533
Alpha-1A adrenergic receptorHomo sapiens (human)EC500.001511
Alpha-1B adrenergic receptorHomo sapiens (human)EC500.001511
Alpha-1D adrenergic receptorHomo sapiens (human)EC500.001511
ATP-binding cassette sub-family C member 8Homo sapiens (human)EC5023.016766
ATP-sensitive inward rectifier potassium channel 11Homo sapiens (human)EC5023.016766
Beta-1 adrenergic receptorHomo sapiens (human)EC500.13862326
Beta-1 adrenergic receptorMus musculus (house mouse)EC500.980011
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)EC500.007011
Beta-1 adrenergic receptorHomo sapiens (human)Kd67.850317
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)EC500.022926
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)EC500.6486813
Beta-2 adrenergic receptorHomo sapiens (human)EC500.12683542
Beta-2 adrenergic receptorMus musculus (house mouse)EC500.980011
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)EC500.007011
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)Kd0.431623
Beta-2 adrenergic receptorHomo sapiens (human)Kd26.8344618
Beta-2 adrenergic receptor Bos taurus (cattle)Kd1.093215
Beta-3 adrenergic receptorHomo sapiens (human)EC500.07302525
Beta-3 adrenergic receptorMus musculus (house mouse)EC500.980011
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)EC500.047022
Beta-3 adrenergic receptorHomo sapiens (human)Kd67.850317
Beta-adrenergic receptor kinase 1Homo sapiens (human)Kd3.800012
D(2) dopamine receptorHomo sapiens (human)EC5010.000011
Delta-type opioid receptorRattus norvegicus (Norway rat)EC500.011112
Glucocorticoid receptorHomo sapiens (human)EC500.003656
Glucocorticoid receptorRattus norvegicus (Norway rat)EC500.000811
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)EC500.003011
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)EC500.003011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)EC500.003011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)EC500.003011
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)EC500.003011
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)EC500.003011
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)EC500.003011
Histamine H1 receptorHomo sapiens (human)Kd0.000244
Histamine H2 receptorCavia porcellus (domestic guinea pig)EC500.039811
Mineralocorticoid receptor Homo sapiens (human)EC500.004811
Nicotinamide phosphoribosyltransferaseHomo sapiens (human)Kd230.000011
NPYLR7BAedes aegypti (yellow fever mosquito)EC5013.346313
ORF73Human gammaherpesvirus 8EC5075.000011
Oxytocin receptorRattus norvegicus (Norway rat)EC500.003011
Palmitoleoyl-protein carboxylesterase NOTUMHomo sapiens (human)Kd6,800.000011
Potassium channel subfamily K member 2Homo sapiens (human)EC50486.000011
Taste receptor type 2 member 1Homo sapiens (human)EC500.004911
Taste receptor type 2 member 10Homo sapiens (human)EC500.004911
Taste receptor type 2 member 13Homo sapiens (human)EC500.004911
Taste receptor type 2 member 14Homo sapiens (human)EC500.004911
Taste receptor type 2 member 16Homo sapiens (human)EC500.004911
Taste receptor type 2 member 19Homo sapiens (human)EC500.004911
Taste receptor type 2 member 20Homo sapiens (human)EC500.004911
Taste receptor type 2 member 3Homo sapiens (human)EC500.004911
Taste receptor type 2 member 30Homo sapiens (human)EC500.004911
Taste receptor type 2 member 31Homo sapiens (human)EC500.004911
Taste receptor type 2 member 38Homo sapiens (human)EC500.004911
Taste receptor type 2 member 39Homo sapiens (human)EC500.004911
Taste receptor type 2 member 4Homo sapiens (human)EC500.004911
Taste receptor type 2 member 40Homo sapiens (human)EC500.004911
Taste receptor type 2 member 41Homo sapiens (human)EC500.004911
Taste receptor type 2 member 42Homo sapiens (human)EC500.004911
Taste receptor type 2 member 43Homo sapiens (human)EC500.004911
Taste receptor type 2 member 45Homo sapiens (human)EC500.004911
Taste receptor type 2 member 46Homo sapiens (human)EC500.004911
Taste receptor type 2 member 5Homo sapiens (human)EC500.004911
Taste receptor type 2 member 50Homo sapiens (human)EC500.004911
Taste receptor type 2 member 60Homo sapiens (human)EC500.004911
Taste receptor type 2 member 7Homo sapiens (human)EC500.004911
Taste receptor type 2 member 8Homo sapiens (human)EC500.004911
Taste receptor type 2 member 9Homo sapiens (human)EC500.004911
Vasopressin V1a receptorRattus norvegicus (Norway rat)EC501.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A1Homo sapiens (human)Affinity constant10.000011
Adenosine receptor A1Rattus norvegicus (Norway rat)Kb20.350012
Adenosine receptor A1Homo sapiens (human)KD hydro2,500.000011
Adenosine receptor A2aHomo sapiens (human)Affinity constant10.000011
Adenosine receptor A2aRattus norvegicus (Norway rat)Kb66.850012
Adenosine receptor A2aRattus norvegicus (Norway rat)Ratio25.000012
Adenosine receptor A2bHomo sapiens (human)Affinity constant10.000011
Adenosine receptor A2bMus musculus (house mouse)Kb17.000012
Adenosine receptor A2bRattus norvegicus (Norway rat)Ratio25.000012
Adenylate cyclase type 1Homo sapiens (human)Kb14.000011
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)EC200.000111
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)ED250.005212
Beta-2 adrenergic receptorHomo sapiens (human)Km0.050011
Beta-2 adrenergic receptor Bos taurus (cattle)Concentration1,000,007.750014
Beta-2 adrenergic receptor Bos taurus (cattle)KD app1.439314
Glutamate receptor 1Rattus norvegicus (Norway rat)EC2x448.000011
Glutamate receptor 1Rattus norvegicus (Norway rat)EC5X1,000.000012
Glutamate receptor 2Rattus norvegicus (Norway rat)EC2x448.000011
Glutamate receptor 2Rattus norvegicus (Norway rat)EC5X1,000.000012
Glutamate receptor 3Rattus norvegicus (Norway rat)EC2x448.000011
Glutamate receptor 3Rattus norvegicus (Norway rat)EC5X1,000.000012
Glutamate receptor 4Rattus norvegicus (Norway rat)EC2x448.000011
Glutamate receptor 4Rattus norvegicus (Norway rat)EC5X1,000.000012
Vasopressin V2 receptorSus scrofa (pig)Kb14.000011