xymedon profile

xymedon: nitrogen-containing heterocyclic compound; Russian patent; antiatherogenic; used for treatment of burns; used on varicose ulcer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	121931
CHEMBL ID	1625385
SCHEMBL ID	3114985
MeSH ID	M0190144

Synonym
1-(beta-hydroxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine
ximedon
xymedone
n-(2-hydroxyethyl)-4,6-dimethyl-2-dehydropyrimidone
ximedone
1-(2-hydroxyethyl)-4,6-dimethyl-2(1h)-pyrimidinone
2(1h)-pyrimidinone, 1-(2-hydroxyethyl)-4,6-dimethyl-
xymedon
14716-32-6
STK709192
1-(2-hydroxyethyl)-4,6-dimethylpyrimidin-2(1h)-one
CHEMDIV2_002153
HMS1375B19
1-(2-hydroxyethyl)-4,6-dimethylpyrimidin-2-one
A808941
1-(2-hydroxyethyl)-4,6-dimethyl-pyrimidin-2-one
1-(2-hydroxyethyl)-4,6-dimethyl-2-pyrimidinone
AKOS003653285
BBL009801
9prf0r9jsf ,
unii-9prf0r9jsf
SCHEMBL3114985
4,6-dimethyl-1-(2-hydroxyethyl)pyrimidin-2(1h)-one
AT-057/40905231
CHEMBL1625385
1-(2-hydroxy-ethyl)-4,6-dimethyl-1h-pyrimidin-2-one
1-(2-hydroxyethyl)-4,6-dimethyl-2(1h)-pyrimidinone #
mfcd02102216
1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidin-2-one
1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihyd-ropyrimidin-2-one
VS-02189
DTXSID20933048
1-(2-hydroxyethyl)-4,6-dimethyl-1h-pyrimidin-2-one
xymedon [who-dd]
n-(.beta.-hydroxyethyl)-4,6-dimethyl-2-pyrimidone
AT19347
EN300-6735528
CS-0064159

Excerpt	Reference	Relevance
"The Xymedone-treated patients developed fewer side effects due to basic antibacterial chemotherapy and showed more rapid culture conversion, resolution of pulmonary infiltration and closure of destructive cavities."	( [Use of systemic immunomodulator xymedone in distructive pulmonary tuberculosis]. Cherepnev, GV; Firsov, OV; Sabirova, LA; Slabnov, IuD; Vizel', AA, 2000)	1.07
"Treatment with xymedon, a regeneration stimulator, led to a 48.5% increase in the number of surviving NF200+ neurons by day 30 after ligation of the nerve and a 50.7% increase by day 90."	( Effect of stimulation of nerve regeneration on posttraumatic neuronal survival in dorsal root ganglia. Chelyshev, YA; Raginov, IS, 2002)	0.65

Excerpt	Reference	Relevance
" The results confirmed the efficiency and correctness of using allo-metrical method for extrapolation of pharmacokinetic data for tentative evaluation of drug parameters in humans by the results of preclinical trials on animals."	( Interspecies pharmacokinetics of xymedon. Garmonov, SY; Pogorel'tsev, VI; Polekhina, OV; Reznik, VS, 2005)	0.61

Excerpt	Reference	Relevance
" The positive results of experimental studies and clinical observations suggest that wound adapters have promises in practical application, transtissue device-aided vulnosynthesis in combination with topical pyrimidine derivatives, such as ximedon, shows great opportunities in soft tissue lesions."	( [Adaptation-reposition technological means in combination with a bioactive preparation Ximedon for stimulation of wound healing]. Diatlov, EE; Garaev, VN; Guryleva, AA; Izmaĭlov, GA; Izmaĭlov, SG; Kedrin, MIu; Muslinkin, AA; Pashkurov, NG; Reznik, VS, )	0.13

Excerpt	Relevance	Reference
"Effect of systemic administration of synthetic pyrimidine derivatives, xymedon and compounds 29D and 34D, was studied in rats with experimental dosed contusion spinal cord injury."	( New Xymedon Analogues for Stimulation of Posttraumatic Regeneration of the Spinal Cord in Rats. Chelyshev, YA; Galyametdinova, IV; Knni, KS; Kolesnikov, PE; Povysheva, TV; Reznik, VS; Semenov, VE, 2016)	1.23

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (21.88)	18.2507
2000's	14 (43.75)	29.6817
2010's	8 (25.00)	24.3611
2020's	3 (9.38)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	4 (8.16%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	45 (91.84%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
phytic acid Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.. myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.	2.1	1	0	inositol phosphate
succinic acid Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.	7.31	1	0	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	4.07	3	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
pyridinolcarbamate Pyridinolcarbamate: A drug that has been given by mouth in the treatment of atherosclerosis and other vascular disorders, hyperlipidemias, and thrombo-embolic disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1408)	1.98	1	0	pyridines
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	7.8	3	0	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.1	1	0	dialdehyde	biomarker
6-methyluracil 6-methyluracil: RN given refers to unlabeled cpd; structure. 6-methyluracil : A pyrimidone that is uracil with a methyl group at position 6.	3.78	2	1	pyrimidone	metabolite
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	3.41	1	1	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	3.41	1	1	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
diucifon diucifon: contains 6-methyluracil & p,p-2,4-dihydroxy-6-methylpyrimidinyl-5-sulfonaminodiphenylsulfone	1.99	1	0
emoxypine succinate emoxypine succinate: has antihypoxic effects	2.31	1	0
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	2.15	1	0	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
n-acetylneuraminic acid N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518). N-acetylneuraminic acid : An N-acylneuraminic acid where the N-acyl group is specified as acetyl.	3.37	1	1	N-acetylneuraminic acids	antioxidant; bacterial metabolite; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; human metabolite; mouse metabolite
lysophosphatidylcholines lysophosphatidylcholine : An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.	2.03	1	0	1-O-acyl-sn-glycero-3-phosphocholine
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.15	1	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
lysophosphatidylethanolamine lysophosphatidylethanolamine : A glycerophosphoethanolamine resulting from partial hydrolysis of a phosphatidylethanolamine, which removes one of the fatty acid groups. The structure is depicted in the image where R(1) = acyl, R(2) = H or where R(1) = H, R(2) = acyl.	2.03	1	0

Condition	Relationship Strength	Studies	Trials
Carcinoma 256, Walker A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)	2.93	3	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.08	1	0
Acute Liver Injury, Drug-Induced [description not available]	2.8	3	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.8	3	0
Chronic Illness [description not available]	2.73	3	0
Autoimmune Disease [description not available]	2.13	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.42	2	0
Innate Inflammatory Response [description not available]	2.13	1	0
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	2.13	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.73	3	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.13	1	0
Injuries, Spinal Cord [description not available]	2.13	1	0
Spinal Cord Injuries Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).	2.13	1	0
Cyst [description not available]	2.04	1	0
Sinus Infections [description not available]	2.04	1	0
Paranasal Sinus Diseases Diseases affecting or involving the PARANASAL SINUSES and generally manifesting as inflammation, abscesses, cysts, or tumors.	2.04	1	0
Sinusitis Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.	2.04	1	0
Burns Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.	4.07	3	1
Chronic Kidney Failure [description not available]	3.41	1	1
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	3.41	1	1
Elevated Cholesterol [description not available]	1.98	1	0
Arteriosclerosis Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	1.98	1	0
Hypercholesterolemia A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.	1.98	1	0
Delayed Hypersensitivity [description not available]	2	1	0
Complication, Postoperative [description not available]	2.39	2	0
Infection, Postoperative Wound [description not available]	2	1	0
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	2.39	2	0
Pulmonary Consumption [description not available]	2	1	0
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	2	1	0
Recrudescence [description not available]	2	1	0
Osteomyelitis INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.	7	1	0
Perforated Appendicitis [description not available]	1.97	1	0
Cicatrization The formation of fibrous tissue in the place of normal tissue during the process of WOUND HEALING. It includes scar tissue formation occurring in healing internal organs as well as in the skin after surface injuries.	1.97	1	0
Appendicitis Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.	1.97	1	0
Cicatrix The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.	1.97	1	0

xymedon

Description

Cross-References

Synonyms (38)

Research Excerpts

Treatment

Pharmacokinetics

Compound-Compound Interactions

Dosage Studied

Research

Studies (32)

Market Indicators

Research Demand Index: 15.76

Study Types