Page last updated: 2024-08-05 14:48:55

hematologic agent

Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.

ChEBI ID: 50248

Members (6)

MemberDefinitionClass
1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholineA 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has octadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine
1-hexadecyl-2-acetyl-glycero-3-phosphocholineA 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
aminocaproic acidAn epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.6-aminohexanoic acid zwitterion; 6-aminohexanoic acid
arginine vasopressinThe predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.argipressin
s-nitrosocysteineAn L-cysteine derivative in which the sulfur atom carries a nitroso substituent. A cell-permeable low-molecular-weight nitrosothiol and nitric oxide donor.S-nitroso-L-cysteine
ticlopidineA thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.ticlopidine

Research

Studies (32,235)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19908,159 (25.31)18.7374
1990's9,327 (28.93)18.2507
2000's6,953 (21.57)29.6817
2010's7,136 (22.14)24.3611
2020's660 (2.05)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,635 (7.78%)5.53%
Reviews3,655 (10.79%)6.00%
Case Studies1,599 (4.72%)4.05%
Observational200 (0.59%)0.25%
Other25,799 (76.13%)84.16%

Protein Targets (104)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency0.005011
acetylcholinesteraseHomo sapiens (human)Potency5.128822
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency11.966912
AR proteinHomo sapiens (human)Potency15.446733
arylsulfatase AHomo sapiens (human)Potency0.338111
ATAD5 protein, partialHomo sapiens (human)Potency15.836422
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency6.309611
Chain A, CruzipainTrypanosoma cruziPotency39.810711
Chain A, Ferritin light chainEquus caballus (horse)Potency22.369623
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency50.118711
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency8.892314
chromobox protein homolog 1Homo sapiens (human)Potency81.786423
cytochrome P450 2C19 precursorHomo sapiens (human)Potency0.039811
cytochrome P450 2C9, partialHomo sapiens (human)Potency4.897511
cytochrome P450 2D6Homo sapiens (human)Potency0.549511
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency0.398111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.848922
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency12.341712
D(1A) dopamine receptorHomo sapiens (human)Potency0.129911
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency10.000011
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency19.952611
DNA polymerase kappa isoform 1Homo sapiens (human)Potency8.436811
estrogen nuclear receptor alphaHomo sapiens (human)Potency19.022433
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency7.326013
EWS/FLI fusion proteinHomo sapiens (human)Potency13.656634
GVesicular stomatitis virusPotency4.897511
GABA theta subunitRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency15.848911
gemininHomo sapiens (human)Potency0.206011
glp-1 receptor, partialHomo sapiens (human)Potency7.943311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency4.066422
heat shock protein beta-1Homo sapiens (human)Potency21.130011
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency4.897511
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency4.897512
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency2.238711
Interferon betaHomo sapiens (human)Potency4.897511
lamin isoform A-delta10Homo sapiens (human)Potency5.629412
LuciferasePhotinus pyralis (common eastern firefly)Potency8.709011
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency10.000011
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency26.832511
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency18.138233
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency19.011511
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency0.064211
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency14.125411
pregnane X nuclear receptorHomo sapiens (human)Potency33.491511
progesterone receptorHomo sapiens (human)Potency18.833611
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency125.892011
regulator of G-protein signaling 4Homo sapiens (human)Potency0.258612
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency29.849311
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency19.952611
TDP1 proteinHomo sapiens (human)Potency29.474212
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency29.849322
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.398111
thyroid stimulating hormone receptorHomo sapiens (human)Potency19.270433
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency10.000011
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency25.373522
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency89.125111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.382011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.143011
Alpha-2B adrenergic receptorHomo sapiens (human)IC500.304011
Alpha-2B adrenergic receptorHomo sapiens (human)Ki0.139011
Alpha-2C adrenergic receptorHomo sapiens (human)IC501.175011
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.171011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC5077.983333
Bile salt export pumpRattus norvegicus (Norway rat)IC5049.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Cytochrome P450 2B6Homo sapiens (human)IC500.405022
Cytochrome P450 2B6Homo sapiens (human)Ki0.800012
Cytochrome P450 2C19Homo sapiens (human)IC500.667811
Cytochrome P450 2C19Homo sapiens (human)Ki45.150022
Cytochrome P450 2C8Homo sapiens (human)Ki30.366733
Cytochrome P450 2C9 Homo sapiens (human)IC5021.800011
Cytochrome P450 2D6Homo sapiens (human)IC506.292811
Cytochrome P450 2J2Homo sapiens (human)IC5021.800011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Oxytocin receptorHomo sapiens (human)Ki0.004755
Oxytocin receptorRattus norvegicus (Norway rat)Ki0.001211
PlasminogenHomo sapiens (human)IC50105.000011
PlasminogenHomo sapiens (human)Ki53,000.000011
Platelet-activating factor receptorHomo sapiens (human)IC500.000311
Platelet-activating factor receptorHomo sapiens (human)Ki0.000111
Proton-coupled amino acid transporter 1Homo sapiens (human)Ki35,000.000011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC500.426011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki0.179011
Translocator proteinMus musculus (house mouse)Ki0.000412
Vasopressin V1a receptorHomo sapiens (human)Ki0.00131111
Vasopressin V1b receptorHomo sapiens (human)Ki0.001133
Vasopressin V1b receptorRattus norvegicus (Norway rat)Ki0.000311
Vasopressin V2 receptorHomo sapiens (human)IC500.242011
Vasopressin V2 receptorHomo sapiens (human)Ki0.009044
Vasopressin V2 receptor Rattus norvegicus (Norway rat)Ki0.000411

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, ApolipoproteinHomo sapiens (human)Kd20.000011
Chain A, PLASMINOGENHomo sapiens (human)Kd11.000012
Oxytocin receptorHomo sapiens (human)EC500.016956
PlasminogenHomo sapiens (human)Kd9.000011
Translocator proteinRattus norvegicus (Norway rat)EC500.000112
Vasopressin V1a receptorHomo sapiens (human)EC500.000234
Vasopressin V1a receptorRattus norvegicus (Norway rat)EC500.000112
Vasopressin V1a receptorRattus norvegicus (Norway rat)Kd0.000644
Vasopressin V1b receptorHomo sapiens (human)EC500.003045
Vasopressin V1b receptorRattus norvegicus (Norway rat)Kd0.000622
Vasopressin V2 receptorHomo sapiens (human)EC500.000134
Vasopressin V2 receptorBos taurus (cattle)Kd0.001511
Vasopressin V2 receptor Rattus norvegicus (Norway rat)Kd0.001512

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Translocator proteinMus musculus (house mouse)Kact0.002311
Vasopressin V1b receptorRattus norvegicus (Norway rat)Kact0.002311
Vasopressin V2 receptorHomo sapiens (human)Kact0.000311