cyclic hydroxamic acid

A lactam having a hydroxy substituent on the amide nitrogen.

ChEBI ID: 23445

Members (7)

Member	Definition	Role
2,4-dihydroxy-1,4-benzoxazin-3-one	A lactol that consists of 1,4-benzoxazine bearing two hydroxy substituents at positions 2 and 4 as well as a keto group at position 3.	DIBOA
2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one	A lactol that is DIBOA in which the hydrogen at position 7 is replaced by a methoxy group. It has been isolated from the maize plants.	DIMBOA
alcaligin		alcaligin
ciclopirox	A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.	ciclopirox
deferrioxamine e	A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.	desferrioxamine E
putrebactin		putrebactin
SYC-435	A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).	SYC-435