A lactam having a hydroxy substituent on the amide nitrogen.
| Member | Definition | Role |
|---|
| 2,4-dihydroxy-1,4-benzoxazin-3-one | A lactol that consists of 1,4-benzoxazine bearing two hydroxy substituents at positions 2 and 4 as well as a keto group at position 3. | DIBOA |
| 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one | A lactol that is DIBOA in which the hydrogen at position 7 is replaced by a methoxy group. It has been isolated from the maize plants. | DIMBOA |
| alcaligin | | alcaligin |
| ciclopirox | A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections. | ciclopirox |
| deferrioxamine e | A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity. | desferrioxamine E |
| putrebactin | | putrebactin |
| SYC-435 | A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant). | SYC-435 |