An antiviral agent that destroys or inhibits the replication of the hepatitis B virus.
ChEBI ID: 64951
| Member | Definition | Class |
|---|---|---|
| helioxanthin | A furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses. | helioxanthin |
| lamivudine | A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B. | lamivudine |
| robustaflavone | A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-6 of the chromene ring. Isolated from Thuja orientalis and Rhus succedanea it exhibits antioxidant, cytotoxic and anti-hepatitis B activity. | robustaflavone |
| salutaridine | A morphinane alkaloid from the opium poppy, in which the 5,6,8,14-tetradehydromorphinan-7-one skeleton is substituted at position 4 by a hydroxyl group, positions 3 and 6 by methoxy groups and position N17 by a methyl group. An intermediate in the biosynthesis of narcotic analgesics such as morphine and codeine. | salutaridine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (0.06) | 18.7374 |
| 1990's | 797 (11.94) | 18.2507 |
| 2000's | 3,373 (50.52) | 29.6817 |
| 2010's | 2,070 (31.00) | 24.3611 |
| 2020's | 433 (6.48) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,425 (20.08%) | 5.53% |
| Reviews | 760 (10.71%) | 6.00% |
| Case Studies | 753 (10.61%) | 4.05% |
| Observational | 77 (1.09%) | 0.25% |
| Other | 4,080 (57.51%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 10.2200 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Capsid protein | Hepatitis B virus | IC50 | 50.0500 | 2 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 335.0000 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 11.8500 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 34.6000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 1.3300 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 65.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 6.2000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 6.8000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 54.2000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 54.2000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 54.2000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 54.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Homo sapiens (human) | Kd | 44.0000 | 1 | 1 |
| Capsid protein | Hepatitis B virus | EC50 | 5.1850 | 2 | 2 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 0.2870 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 32.5000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | EC50 | 25.0210 | 2 | 2 |