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EC 2.2.1.6 (acetolactate synthase) inhibitor

An EC 2.2.1.* (transketolase/transaldolase) inhibitor that interferes with the action of acetolactate synthase (EC 2.2.1.6).

ChEBI ID: 22180

Members (9)

MemberDefinitionClass
5-methyl-2-furfural5-methyl-2-furaldehyde
a 8947An N-sulfonylurea that is urea in which a nitrogen attached to one of the nitrogens has been replaced by a 4,6-dipyrimidin-2-yl group while a hydrogen attached to the other urea nitrogen has been replaced by a [1-methyl-4-(2-methyl-2H-tetrazol-5-yl)-1H-pyrazol-5-yl]sulfonyl group. An acetolactate synthase inhibitor, it is used as a herbicide for the control of a variety of broad-leaved and sedge weeds in paddy fields and other aquatic situations.azimsulfuron
chlorimuron ethylAn ethyl ester resulting from the formal condensation of the carboxy group of chlorimuron with ethanol. A proherbicide for chloimuron, it is used as herbicide for the control of broad-leaved weeds in peanuts, soya beans, and other crops.chlorimuron-ethyl
chlorsulfuronAn N-sulfonylurea that is N-carbamoyl-2-chlorobenzenesulfonamide in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used for the control of broadleaf weeds in wheat, barley and oats.chlorsulfuron
cloransulam-methylThe methyl ester of cloransulam. An inhibitor of acetohydroxyacid synthase (AHAS), it prevents the synthesis of amino acids in plants and is used as a herbicide for the control of post-emergence control of broad-leaved weeds in soybeans. It is not approved for use within the European Area.cloransulam-methyl
methyl 2-(((((4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoateA methyl ester resulting from the formal condensation of the carboxy group of ethametsulfuron with methanol. A herbicide used for the control of broad-leaved weeds in oil seed rape and fodder rape.ethametsulfuron-methyl
methyl bensulfuronThe methyl ester of bensulfuron. An acetolactate synthase inhibitor, it is used as a herbicide for the control of a variety of both annual and perennial weeds in crops, particularly wheat and rice. It is not licensed for use within the UK.bensulfuron-methyl
sulfometuron methylA benzoate ester that is the methyl ester of 2-{[(4,6-dimethylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoic acid.sulfometuron methyl
triflusulfuron-methylA methyl ester resulting from the formal condensation of the carboxy group of triflusulfuron with methanol. A proherbicide for triflusulfuron.triflusulfuron-methyl

Research

Studies (334)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199028 (8.38)18.7374
1990's31 (9.28)18.2507
2000's113 (33.83)29.6817
2010's115 (34.43)24.3611
2020's47 (14.07)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (0.83%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other359 (99.17%)84.16%

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency3.170611
AR proteinHomo sapiens (human)Potency0.001611
Cellular tumor antigen p53Homo sapiens (human)Potency25.118911
estrogen nuclear receptor alphaHomo sapiens (human)Potency27.353212
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency15.825823
GLI family zinc finger 3Homo sapiens (human)Potency68.659411
LuciferasePhotinus pyralis (common eastern firefly)Potency89.358411
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.003011
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency0.242111
pregnane X nuclear receptorHomo sapiens (human)Potency23.500222
progesterone receptorHomo sapiens (human)Potency13.461322
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency52.185422
thioredoxin reductaseRattus norvegicus (Norway rat)Potency89.125111
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency8.912511
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency50.118711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Acetolactate synthase Raphanus raphanistrumIC5033.338033
Acetolactate synthase catalytic subunit, mitochondrialSaccharomyces cerevisiae S288CKi0.106315
Acetolactate synthase, chloroplasticArabidopsis thaliana (thale cress)Ki0.009422

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7Homo sapiens (human)AC5050.000011