Page last updated: 2024-08-05 11:23:39
butenolide
A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.
ChEBI ID: 50523
Members (26)
| Member | Definition | Role |
|---|---|---|
| (Z)-6,6',7,3'a-Diligustilide | (Z)-6,6',7,3'a-Diligustilide | |
| 2,3-dimethylmaleic anhydride | 2,3-Dimethylmaleic anhydride | |
| 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone | 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone | |
| 3-o-ethylascorbic acid | 3-O-Ethylascorbic acid | |
| 4,5-dimethyl-3-hydroxy-2(5h)-furanone | sotolone | |
| 5-hydroxy-4-methoxy-5-(1-methylethenyl)-2-furanone | 5-hydroxy-4-methoxy-5-(1-methylethenyl)-2-furanone | |
| ajugarin i | Ajugarin I | |
| angelica lactone | beta-angelica lactone | |
| ascladiol | A butenolide that is furan-2(5H)-one which is substituted by a hydroxymethyl group at position 4 and a 2-hydroxyethylidene group at position 5 (the 5E isomer). A direct precursor of patulin in cell-free preparations of Penicillium urticae patulin-minus mutants J1 and S11, but not S15. | (E)-ascladiol |
| ascorbic acid 2-sulfate | L-ascorbic acid 2-sulfate | |
| butenolide | but-2-en-4-olide | |
| butyrolactone i | butyrolactone I | |
| firocoxib | An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs. | firocoxib |
| flupyradifurone | A tertiary amino compound that is ammonia in which the nitrogens have been replaced by (6-chloropyridin-3-yl)methyl, 2,2-difluoroethyl, and 5-oxo-2,5-dihydrofuran-3-yl groups, respectively. A nicotinic acetylcholine receptor (AChR) agonist, it is used as an insecticide to control sucking pests in a variety of crops. | flupyradifurone |
| ligustilide | (Z)-ligustilide | |
| linderalactone | linderalactone | |
| manoalide | A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2. | manoalide |
| N-butan-2-yl-3,8-dimethyl-2-oxo-1-oxaspiro[4.5]dec-3-ene-4-carboxamide | N-butan-2-yl-3,8-dimethyl-2-oxo-1-oxaspiro[4.5]dec-3-ene-4-carboxamide | |
| protoanemonin | protoanemonin | |
| pulvinic acid | Pulvinic acid | |
| rofecoxib | A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. | rofecoxib |
| spiromesifen | A butenolide that is but-2-en-4-olide bearing a 2,4,6-trimethylphenyl group at position 3, a 3,3-dimethylbutyryloxy group at position 4 and a spiro-fused cyclopentyl ring at position 5. | spiromesifen |
| trilobacin | A polyketide isolated from the bark of Asimina triloba. It has been shown to exhibit cytotoxicity in the NCI human tumor cell line screen. | trilobacin |
| triptonide | A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. | triptonide |
| vulpinic acid | Vulpinic acid | |
| wf 3681 | 3-(4-Hydroxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoic acid |
Research
Studies (3,244)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 122 (3.76) | 18.7374 |
| 1990's | 258 (7.95) | 18.2507 |
| 2000's | 1,901 (58.60) | 29.6817 |
| 2010's | 705 (21.73) | 24.3611 |
| 2020's | 258 (7.95) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 350 (10.10%) | 5.53% |
| Reviews | 278 (8.02%) | 6.00% |
| Case Studies | 141 (4.07%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,696 (77.81%) | 84.16% |