Page last updated: 2024-08-05 12:31:38
meroterpenoid
Meroterpenoids are complex organooxygen natural products produced from polyketide and terpenoid precursors.
ChEBI ID: 64419
Members (11)
| Member | Definition | Role |
|---|---|---|
| 11-hydroxysugiol | An abietane diterpenoid that is sugiol in which the hydrogen ortho to the phenolic hydroxy group has been replaced by a hydroxy group. | 11-hydroxysugiol |
| ascochlorin | A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (1E,3E)-3-methyl-1-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-1,3-dien-5-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by several fungi including Ascochyta viciae . It exhibits anticancer, antifungal and antiprotozoal activities. | ascochlorin |
| ascofuranone | A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. | ascofuranone |
| austinol | A meroterpenoid produced by Aspergillus nidulans. It has a pentacyclic structure which incorporates three lactone functionalities and a spiro union. | austinol |
| berkeleydione | A meroterpenoid found in Penicillium rubrum. It has been shown to exhibit inhibitory activity against caspase-1. | berkeleydione |
| berkeleytrione | A meroterpenoid found in Penicillium rubrum and has been shown to exhibit inhibitory activity against caspase-1. | berkeleytrione |
| ferruginol | An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12. | ferruginol |
| fumagillin | A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. | fumagillin |
| liphagal | A meroterpenoid isolated from the marine sponge Aka coralliphaga and has been shown to exhibit inhibitory activity against phosphatidylinositol-3-OH kinase. | liphagal |
| novofumigatonin | novofumigatonin | |
| sugiol | An abietane diterpenoid that is ferruginol in which the methylene group para to the phenolic hydroxy group has been substituted by an oxo group. | sugiol |
Research
Studies (507)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 66 (13.02) | 18.7374 |
| 1990's | 49 (9.66) | 18.2507 |
| 2000's | 174 (34.32) | 29.6817 |
| 2010's | 180 (35.50) | 24.3611 |
| 2020's | 38 (7.50) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 5 (0.89%) | 5.53% |
| Reviews | 51 (9.06%) | 6.00% |
| Case Studies | 21 (3.73%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 486 (86.32%) | 84.16% |