Page last updated: 2024-08-05 15:18:42
EC 5.99.1.2 (DNA topoisomerase) inhibitor
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
ChEBI ID: 50276
Members (19)
| Member | Definition | Class |
|---|---|---|
| amarogentin | A secoiridoid glycoside that consists of (4aS,5R,6R)-5-ethenyl-6-hydroxy-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one having a 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-beta-D-glucopyranosyl group attached at position 6 via a glycosidic linkage. | amarogentin |
| camptothecin | A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). | camptothecin |
| diflomotecan | An organic heteropentacyclic compound that is (5R)-8-[(6,7-difluoroquinolin-3-yl)methyl]-5-ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine moiety is joined to position 3 of the difluoroquinoine ring by a single bond. An E-ring modified camptothecin analogue that has greater lactone stability in plasma compared with other topoisomerase I inhibitors. | diflomotecan |
| dihydrobetulinic acid | A pentacyclic triterpenoid that is lupane having a 3beta-hydroxy and 28-carboxy substituents. Isolated from the leaves of Syzygium claviflorum, it exhibits anti-HIV and antileishmanial activity. | dihydrobetulinic acid |
| discretamine | A berberine alkaloid isolated from Corydalis saxicola. | (S)-scoulerine |
| disulfiram | An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. | disulfiram |
| ellagic acid | An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. | ellagic acid |
| homocamptothecin | An organic heteropentacyclic compound that is (5R)-5-ethyl-5-hydroxy-8-(quinolin-3-ylmethyl)-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine group has been joined to position 2 of the quinoline ring by a single bond. A semisynthetic analogue of camptothecin, it is an inhibitor of topoisomerase I. | (R)-homocamptothecin |
| irinotecan | A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. | irinotecan |
| irinotecan hydrochloride | A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. | irinotecan hydrochloride (anhydrous) |
| lucanthone | A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. | lucanthone |
| manoalide | A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2. | manoalide |
| methyl brevifolincarboxylate | An organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from Phyllanthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity. | methyl brevifolincarboxylate |
| morin | A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5. | morin |
| rubitecan | A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. | rubitecan |
| saintopin | A member of the class of tetracenequinones that is tetracene-5,12-dione in which the hydrogens at positions 1, 3, 8, 10, and 11 have been replaced by hydroxy groups. Isolated from Paecilomyces. | saintopin |
| sn 38 | A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. | SN-38 |
| topopyrone c | A naphthochromene that is 4H-naphtho[2,3-h]chromene-4,7,12-trione substituted by hydroxy groups at positions 5, 9 and 11 and a methyl group at position 2. It is isolated from fungal strains Phoma and Penicillium and acts as an inhibitor of the enzyme topoisomerase I. | topopyrone C |
| topotecan | A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. | topotecan |
Research
Studies (21,648)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,650 (12.24) | 18.7374 |
| 1990's | 2,309 (10.67) | 18.2507 |
| 2000's | 6,356 (29.36) | 29.6817 |
| 2010's | 7,651 (35.34) | 24.3611 |
| 2020's | 2,682 (12.39) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,989 (16.50%) | 5.53% |
| Reviews | 3,219 (10.65%) | 6.00% |
| Case Studies | 2,039 (6.74%) | 4.05% |
| Observational | 118 (0.39%) | 0.25% |
| Other | 19,865 (65.71%) | 84.16% |
Protein Targets (509)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 10.7701 | 1 | 15 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 10.2723 | 1 | 6 |
| 67.9K protein | Vaccinia virus | Potency | 15.3026 | 2 | 8 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 41.7205 | 4 | 10 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.6270 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 10.2478 | 1 | 11 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 18.1258 | 3 | 13 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 7.4598 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 2.6413 | 8 | 32 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 39.3252 | 3 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.2386 | 3 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 25.3823 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 14.2998 | 2 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 29.2493 | 2 | 7 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 2.3934 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 5.2119 | 1 | 1 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 0.6513 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 18.5477 | 2 | 7 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 25.4565 | 1 | 2 |
| C-terminal-binding protein 1 | Homo sapiens (human) | Potency | 16.9469 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 16.0321 | 1 | 4 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 10.5590 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 16.0321 | 1 | 4 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 10.5590 | 1 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 10.5014 | 2 | 8 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 11.7176 | 2 | 8 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 14.9712 | 1 | 13 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 11.9770 | 2 | 8 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 62.6190 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 13.9422 | 2 | 9 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 19.4862 | 2 | 6 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 9.8294 | 2 | 15 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 40.0704 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 6.1645 | 4 | 10 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.9398 | 2 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0849 | 2 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 9.8294 | 2 | 15 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 27.3792 | 2 | 5 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 0.4492 | 3 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 14.3454 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 13.1802 | 1 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.2762 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 16.2801 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 13.9336 | 2 | 10 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 14.8526 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.8433 | 1 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.6836 | 1 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 0.1040 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 11.8362 | 2 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 11.8685 | 2 | 2 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 1.7292 | 1 | 3 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 32.6209 | 1 | 3 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 18.8876 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 34.7960 | 1 | 7 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 5.0594 | 1 | 7 |
| endonuclease IV | Escherichia coli | Potency | 11.7504 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 10.9360 | 8 | 36 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 0.1904 | 2 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 2.8339 | 10 | 32 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.5622 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 1.0017 | 4 | 21 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 8.4936 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 2.0740 | 2 | 6 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 36.0045 | 2 | 8 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 63.0957 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 9.3290 | 1 | 9 |
| G | Vesicular stomatitis virus | Potency | 12.2762 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 13.9336 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 12.1749 | 4 | 16 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.6237 | 3 | 9 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 15.0049 | 2 | 6 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 14.7193 | 1 | 5 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 17.7399 | 3 | 6 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 4.8802 | 2 | 5 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 0.1814 | 2 | 6 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 3.6683 | 3 | 3 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 10.1828 | 2 | 24 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.4549 | 1 | 7 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 11.1255 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 12.2868 | 2 | 9 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 28.8374 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.2762 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 8.7901 | 1 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 9.9429 | 2 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 0.4062 | 2 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.1026 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 0.9120 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.2762 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.6713 | 2 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5720 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5720 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 12.9539 | 3 | 19 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 1.1617 | 2 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 7.5399 | 1 | 4 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 14.4933 | 3 | 9 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 18.6833 | 2 | 4 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 42.7507 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.8110 | 2 | 19 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 6.3046 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 29.4610 | 1 | 5 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 19.7830 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.1821 | 2 | 6 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.3117 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 8.7992 | 3 | 9 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 10.5379 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.4729 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 2.2032 | 2 | 22 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 1.8583 | 3 | 12 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 2.5261 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 13.4776 | 2 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 6.1174 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 12.9709 | 3 | 10 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 0.3138 | 2 | 5 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 12.4127 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 28.5646 | 1 | 6 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.5280 | 1 | 2 |
| polyprotein | Zika virus | Potency | 9.3290 | 1 | 9 |
| polypyrimidine tract-binding protein 1 isoform a | Homo sapiens (human) | Potency | 14.5500 | 2 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 2.9019 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.1855 | 1 | 6 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 2.9904 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 12.5525 | 1 | 10 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 26.1992 | 2 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 1.7073 | 2 | 4 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 15.8489 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 17.9008 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 7.3501 | 2 | 9 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 23.2536 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 23.1531 | 1 | 5 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 1.0709 | 3 | 10 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.3582 | 3 | 8 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 0.4492 | 3 | 4 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.4717 | 4 | 5 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 4.6402 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 6.9570 | 2 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.6012 | 1 | 4 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.9581 | 2 | 25 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.8128 | 4 | 15 |
| Thrombopoietin | Homo sapiens (human) | Potency | 1.2288 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 8.3655 | 3 | 12 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 41.4446 | 5 | 11 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 23.5267 | 2 | 3 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 9.8074 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.5280 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.5280 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 40.9915 | 2 | 7 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 7.3834 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 18.6434 | 5 | 10 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 12.0928 | 1 | 5 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 6.0967 | 1 | 4 |
| Vpr | Human immunodeficiency virus 1 | Potency | 12.5893 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 4.2905 | 2 | 2 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 6.8500 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2.3000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 17.7585 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 11.3005 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 16.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 7.4290 | 1 | 1 |
| 5'-nucleotidase | Homo sapiens (human) | IC50 | 1.8500 | 1 | 1 |
| 5'-nucleotidase | Mus musculus (house mouse) | IC50 | 0.0400 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 6.8500 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| acetyl-CoA acetyltransferase/HMG-CoA reductase | Enterococcus faecalis | IC50 | 1,265.3900 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 132.9200 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 1.8270 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 0.0505 | 1 | 1 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 0.0264 | 1 | 1 |
| Acidic phospholipase A2 2 | Naja naja (Indian cobra) | IC50 | 17.0000 | 1 | 1 |
| Acidic phospholipase A2 beta | Crotalus adamanteus (eastern diamondback rattlesnake) | IC50 | 0.4000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 10.5700 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 7.6150 | 2 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.3560 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 17.1005 | 2 | 2 |
| Aldehyde dehydrogenase, mitochondrial | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
| Aldehyde oxidase 1 | Cavia porcellus (domestic guinea pig) | Ki | 4.5300 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 70.3700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 69.8120 | 1 | 1 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3560 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2010 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.3560 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2010 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 4.9040 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.8390 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 3.2180 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.4690 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 3.1710 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.4610 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 13.7340 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 93.8200 | 5 | 5 |
| Angiopoietin-1 receptor | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| apelin receptor | Homo sapiens (human) | IC50 | 2.6300 | 1 | 1 |
| Apoptotic peptidase activating factor 1 | Homo sapiens (human) | IC50 | 58.1500 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 92.0667 | 1 | 3 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 2.4800 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 3.6050 | 2 | 2 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 8.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 8.1000 | 2 | 2 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 20.7000 | 1 | 1 |
| bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase | Mycobacterium tuberculosis H37Rv | IC50 | 85.0300 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 108.8000 | 3 | 5 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 17.5865 | 3 | 4 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 2.4680 | 1 | 1 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 0.9540 | 1 | 1 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | IC50 | 8.3950 | 1 | 1 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | Ki | 4.3970 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 23.6610 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | Ki | 18.2840 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 6.0130 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 4.2090 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | IC50 | 0.6000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 108.8333 | 1 | 3 |
| Carbamate kinase | Giardia intestinalis | IC50 | 0.6000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 59.7150 | 4 | 8 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.1250 | 2 | 2 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.2400 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 10.3000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 8.9100 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 63.6725 | 4 | 8 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 13.5500 | 1 | 4 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 12.6560 | 2 | 5 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7.5900 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 12.7000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 7.0600 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 7.5550 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 44.5850 | 2 | 2 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 4.0240 | 5 | 5 |
| Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Casein kinase II subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 5.0200 | 4 | 4 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 5.0200 | 4 | 4 |
| Casein kinase II subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| caspase-9 isoform alpha precursor | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Cationic trypsin | Bos taurus (cattle) | IC50 | 110.8000 | 1 | 1 |
| Chain A, Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 0.0264 | 1 | 1 |
| Chain A, Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Class A sortase SrtA | Staphylococcus aureus | IC50 | 31.2600 | 3 | 3 |
| Cruzipain | Trypanosoma cruzi | IC50 | 142.0000 | 2 | 2 |
| Cyclin-A1 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-A2 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | IC50 | 1.0900 | 1 | 1 |
| Cysteine protease ATG4B | Homo sapiens (human) | IC50 | 4.2500 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 4.7700 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 1.5211 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 25.0000 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 2.1580 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.5505 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 23.0180 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 3.9435 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 1.0840 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.3680 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 3.1500 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 1.1050 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 6.3000 | 2 | 2 |
| Deoxyribonuclease-1 | Bos taurus (cattle) | IC50 | 300.0000 | 1 | 1 |
| Deoxyribonuclease-2-alpha | Sus scrofa (pig) | IC50 | 300.0000 | 1 | 1 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 85.0000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 0.4500 | 1 | 1 |
| DNA ligase | Tequatrovirus T4 | IC50 | 300.0000 | 1 | 1 |
| DNA polymerase eta | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| DNA polymerase iota | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| DNA polymerase kappa | Homo sapiens (human) | IC50 | 4.5000 | 2 | 2 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 100.0000 | 1 | 1 |
| DNA topoisomerase | Bos taurus (cattle) | IC50 | 17.0000 | 1 | 1 |
| DNA topoisomerase 1 | Chlorocebus aethiops (grivet) | IC50 | 27.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 23.2678 | 24 | 33 |
| DNA topoisomerase 1 | Mus musculus (house mouse) | IC50 | 19.0000 | 2 | 4 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 161.8683 | 5 | 6 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | IC50 | 0.6050 | 2 | 2 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | IC50 | 5.0000 | 2 | 2 |
| DNA-3-methyladenine glycosylase | Homo sapiens (human) | IC50 | 2.6000 | 1 | 1 |
| dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 1.1050 | 2 | 2 |
| dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 39.5000 | 1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Mus musculus (house mouse) | IC50 | 0.5000 | 1 | 1 |
| ELAV-like protein 3 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.0000 | 1 | 1 |
| Ephrin type-B receptor 4 | Homo sapiens (human) | IC50 | 1.8300 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 0.6900 | 1 | 1 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 2.9272 | 1 | 2 |
| eukaryotic translation initiation factor 4 gamma 1 isoform 4 | Homo sapiens (human) | IC50 | 47.6714 | 1 | 1 |
| eukaryotic translation initiation factor 4E isoform 1 | Mus musculus (house mouse) | IC50 | 47.6714 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 363.0780 | 1 | 1 |
| Focal adhesion kinase 1 | Homo sapiens (human) | IC50 | 3.1100 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 101.2380 | 10 | 10 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 0.8500 | 1 | 2 |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | IC50 | 1.0900 | 1 | 1 |
| Gasdermin-D | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Gasdermin-D | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 56.7000 | 3 | 3 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 22.8000 | 1 | 1 |
| Glutathione S-transferase | Plasmodium falciparum 3D7 | IC50 | 74.4000 | 1 | 1 |
| Glutathione S-transferase Mu 1 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 63.5500 | 2 | 2 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| heat shock 70kDa protein 1A | Homo sapiens (human) | IC50 | 66.9200 | 3 | 3 |
| heat shock cognate 71 kDa protein isoform 1 | Homo sapiens (human) | IC50 | 99.6000 | 2 | 2 |
| heat shock cognate 71 kDa protein isoform 2 | Homo sapiens (human) | IC50 | 99.6000 | 2 | 2 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 0.5800 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT1 | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Histone-lysine N-methyltransferase SETD7 | Homo sapiens (human) | IC50 | 6.0200 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 1.5300 | 2 | 2 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | IC50 | 1.9800 | 1 | 1 |
| Insulin receptor | Homo sapiens (human) | IC50 | 0.3400 | 1 | 1 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 43.6800 | 5 | 5 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 5.4550 | 2 | 2 |
| Islet amyloid polypeptide | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 6.1030 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 2.4410 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 30.1995 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 10.7300 | 1 | 1 |
| likely tRNA 2'-phosphotransferase | Candida albicans SC5314 | IC50 | 0.2913 | 2 | 2 |
| Low molecular weight phosphotyrosine protein phosphatase | Bos taurus (cattle) | IC50 | 10.0000 | 1 | 1 |
| Lysine-specific demethylase 5A | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Lysyl oxidase homolog 2 | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| Lysyl oxidase homolog 3 | Homo sapiens (human) | IC50 | 0.0930 | 1 | 1 |
| Lysyl oxidase homolog 4 | Homo sapiens (human) | IC50 | 0.0590 | 1 | 1 |
| M17 leucyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 138.0800 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 4.7700 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 19.1861 | 2 | 3 |
| microphthalmia-associated transcription factor isoform 9 | Homo sapiens (human) | IC50 | 6.3810 | 3 | 3 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 19.1000 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 19.1000 | 1 | 2 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 1.5100 | 1 | 1 |
| Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (human) | IC50 | 2.3700 | 1 | 1 |
| Monoglyceride lipase | Homo sapiens (human) | IC50 | 0.8095 | 2 | 2 |
| mothers against decapentaplegic homolog 3 isoform 1 | Homo sapiens (human) | IC50 | 0.1420 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 3.5110 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 1.4250 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 3.9000 | 3 | 4 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 31.7000 | 2 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 48.5000 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.5560 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2170 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 3.0000 | 1 | 1 |
| NUAK family SNF1-like kinase 1 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Nucleophosmin | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 6.9590 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 1.6220 | 1 | 1 |
| Phosphatidylcholine 2-acylhydrolase | Apis mellifera (honey bee) | IC50 | 0.0400 | 1 | 1 |
| Phospholipase A2 | Apis mellifera (honey bee) | IC50 | 13.3571 | 7 | 7 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Phospholipase A2, membrane associated | Homo sapiens (human) | IC50 | 320.9800 | 5 | 5 |
| Phospholipase A2, membrane associated | Rattus norvegicus (Norway rat) | IC50 | 1,019.2000 | 2 | 2 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Polypeptide N-acetylgalactosaminyltransferase 2 | Homo sapiens (human) | IC50 | 1.7200 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 16.0660 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| Protein E6 | Human papillomavirus 16 | IC50 | 4.0000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 0.4667 | 3 | 3 |
| putative polyprotein | IC50 | 30.5737 | 3 | 3 | |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 3.3400 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 3.5400 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase S | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Renin | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 18.0750 | 2 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 9.3500 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.9171 | 9 | 9 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 3.7100 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 3.7100 | 1 | 1 |
| Retinal dehydrogenase 1 | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| Ribonuclease pancreatic | Bos taurus (cattle) | IC50 | 300.0000 | 1 | 1 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 1.7600 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 2.7000 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 7.9700 | 2 | 2 |
| Serine/threonine-protein kinase PLK4 | Homo sapiens (human) | IC50 | 2.9700 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 4.6370 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 3.6840 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 70.3700 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 69.8120 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 20.8000 | 1 | 1 |
| Solute carrier family 22 member 12 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Solute carrier family 22 member 12 | Rattus norvegicus (Norway rat) | IC50 | 18.0000 | 1 | 1 |
| Solute carrier family 22 member 12 | Homo sapiens (human) | Ki | 5.7400 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 31.8500 | 1 | 2 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 74.6000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| Somatostatin receptor type 1 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 2 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 3 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 4 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Somatostatin receptor type 5 | Homo sapiens (human) | IC50 | 0.0022 | 1 | 1 |
| Sortase A | Streptococcus mutans | IC50 | 27.2000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 9.3500 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Tat | Human immunodeficiency virus 1 | IC50 | 1.6690 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 57.0000 | 1 | 1 |
| Translin-associated protein X | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| Triosephosphate isomerase | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Triosephosphate isomerase, glycosomal | Trypanosoma cruzi | IC50 | 6.5000 | 1 | 1 |
| type-1 angiotensin II receptor | Homo sapiens (human) | IC50 | 6.6370 | 1 | 1 |
| Type-2 restriction enzyme BamHI | Bacillus amyloliquefaciens | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme EcoRI | Escherichia coli | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme HindIII | Haemophilus influenzae Rd KW20 | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme PstI | Providencia stuartii | IC50 | 300.0000 | 1 | 1 |
| Type-2 restriction enzyme ScaI | Streptomyces caespitosus | IC50 | 300.0000 | 1 | 1 |
| Tyrosine-protein kinase Fgr | Rattus norvegicus (Norway rat) | IC50 | 3.5000 | 1 | 1 |
| Tyrosine-protein kinase Lyn | Rattus norvegicus (Norway rat) | IC50 | 7.5000 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | Ki | 7.9000 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 111.0000 | 1 | 1 |
| tyrosyl-DNA phosphodiesterase 2 | Homo sapiens (human) | IC50 | 119.6660 | 2 | 2 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 360.0000 | 1 | 1 |
| unnamed protein product | Aspergillus oryzae RIB40 | IC50 | 52.7195 | 2 | 2 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.7900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 1.5400 | 1 | 1 |
| Vif | Human immunodeficiency virus 1 | IC50 | 0.4500 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 10.1000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | EC50 | 1.6000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | EC50 | 0.1731 | 3 | 5 |
| DNA topoisomerase 1 | Homo sapiens (human) | Kd | 0.0265 | 1 | 1 |
| DNA topoisomerase type IB small subunit | Leishmania major | EC50 | 0.6700 | 1 | 1 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | Kd | 0.0890 | 1 | 1 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | EC50 | 0.0713 | 1 | 1 |
| eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor | Homo sapiens (human) | EC50 | 55.7000 | 2 | 2 |
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 3.9000 | 2 | 4 |
| Heterogeneous nuclear ribonucleoprotein A1 | Homo sapiens (human) | Kd | 0.0827 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | EC50 | 0.0713 | 1 | 1 |
| LacZ protein (plasmid) | Escherichia coli | EC50 | 40.0000 | 1 | 1 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 0.7690 | 1 | 2 |
| Polypeptide N-acetylgalactosaminyltransferase 2 | Homo sapiens (human) | Kd | 0.3710 | 1 | 1 |
| Serine/threonine-protein kinase Chk1 | Homo sapiens (human) | EC50 | 0.0021 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 3.0000 | 1 | 1 |
| Triosephosphate isomerase, glycosomal | Trypanosoma cruzi | Kd | 10.4000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-1 chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-2A chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-2B chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-3 chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-4A chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-4B chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-6 chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tubulin beta-8 chain | Homo sapiens (human) | Kd | 149.7630 | 1 | 2 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| Wee1-like protein kinase | Homo sapiens (human) | Kd | 0.0014 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | EC24 | 250.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Km | 4.0000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | EC16 | 250.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | CC50 | 21.1240 | 2 | 5 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC10 | 0.0002 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | Inhibition | 100.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | MIC | 0.0100 | 1 | 1 |
| DNA topoisomerase 1 | Mus musculus (house mouse) | MIC | 0.0860 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | MIC | 100.0000 | 1 | 1 |
| H3 histone acetyltransferase | Candida albicans SC5314 | AC50 | 3.2600 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 4.5540 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 5.1780 | 1 | 1 |
| hypothetical protein CAALFM_CR05890CA | Candida albicans SC5314 | AC50 | 3.2600 | 1 | 1 |
| interferon gamma precursor | Homo sapiens (human) | AC50 | 22.8550 | 2 | 2 |
| Lactoperoxidase | Bos taurus (cattle) | Km | 0.3000 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Km | 1,453.0000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | MIC | 100.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | Km | 97.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Km | 24.5000 | 2 | 2 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 147.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A7 | Homo sapiens (human) | Km | 5.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Km | 13.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B15 | Homo sapiens (human) | Km | 186.0000 | 1 | 1 |