Roles > TRPV1 agonist
Page last updated: 2024-08-05 15:44:08

TRPV1 agonist

An agonist at the transient receptor potential vanilloid 1 (TRPV1).

ChEBI ID: 140535

Members (3)

MemberDefinitionClass
capsaicincapsaicin
n-oleoyldopamineA fatty amide resulting from the formal condensation of the carboxy group of oleic acid with the amino group of dopamine. Synthesised in catecholaminergic neurons, it crosses the blood-brain barrier and might be considered as a carrier of dopamine into the brain. It is a transient receptor potential vanilloid type 1 (TRPV1) receptor agonist.N-oleoyldopamine
resiniferatoxinA heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).resiniferatoxin

Research

Studies (11,266)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,144 (10.15)18.7374
1990's2,771 (24.60)18.2507
2000's3,415 (30.31)29.6817
2010's3,052 (27.09)24.3611
2020's884 (7.85)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials683 (5.72%)5.53%
Reviews808 (6.77%)6.00%
Case Studies112 (0.94%)4.05%
Observational15 (0.13%)0.25%
Other10,319 (86.45%)84.16%

Protein Targets (147)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency35.481311
15-lipoxygenase, partialHomo sapiens (human)Potency17.802012
67.9K proteinVaccinia virusPotency39.810711
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency21.645215
Alpha-synucleinHomo sapiens (human)Potency30.357812
Amyloid-beta precursor proteinHomo sapiens (human)Potency20.596211
AR proteinHomo sapiens (human)Potency30.914089
arylsulfatase AHomo sapiens (human)Potency0.952811
ATAD5 protein, partialHomo sapiens (human)Potency21.828022
Ataxin-2Homo sapiens (human)Potency19.952611
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.803022
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency18.492711
Bloom syndrome protein isoform 1Homo sapiens (human)Potency19.952622
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency12.589322
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency19.952611
Chain A, Beta-lactamaseEscherichia coli K-12Potency3.162311
Chain A, CruzipainTrypanosoma cruziPotency14.125411
Chain A, Ferritin light chainEquus caballus (horse)Potency28.183811
Chain A, HADH2 proteinHomo sapiens (human)Potency30.462023
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency35.481311
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency11.896112
Chain B, HADH2 proteinHomo sapiens (human)Potency30.462023
chromobox protein homolog 1Homo sapiens (human)Potency69.905422
cytochrome P450 2C19 precursorHomo sapiens (human)Potency12.589311
cytochrome P450 2C9 precursorHomo sapiens (human)Potency1.584911
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency2.837124
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency21.265612
D(1A) dopamine receptorHomo sapiens (human)Potency4.610611
D(1A) dopamine receptorSus scrofa (pig)Potency5.211911
D(3) dopamine receptor isoform eHomo sapiens (human)Potency3.981111
DNA polymerase betaHomo sapiens (human)Potency25.118911
DNA polymerase eta isoform 1Homo sapiens (human)Potency19.952611
DNA polymerase III, partialBacillus subtilisPotency18.887611
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency42.436313
DNA polymerase kappa isoform 1Homo sapiens (human)Potency36.699112
dopamine D1 receptorHomo sapiens (human)Potency0.651311
endonuclease IVEscherichia coliPotency35.481311
estrogen nuclear receptor alphaHomo sapiens (human)Potency37.035278
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency11.875411
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency42.302777
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency33.976613
eyes absent homolog 2 isoform aHomo sapiens (human)Potency100.000011
flap endonuclease 1Homo sapiens (human)Potency20.029812
GABA theta subunitRattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency2.837112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency2.837112
gemininHomo sapiens (human)Potency8.150233
GLI family zinc finger 3Homo sapiens (human)Potency5.951811
glp-1 receptor, partialHomo sapiens (human)Potency10.000011
GLS proteinHomo sapiens (human)Potency5.712222
glucocerebrosidaseHomo sapiens (human)Potency17.782811
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency59.517811
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency25.118911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency2.102427
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency22.138712
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency31.622822
IDH1Homo sapiens (human)Potency4.610911
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency2.818411
Integrin alpha-IIbHomo sapiens (human)Potency12.589311
Integrin beta-3Homo sapiens (human)Potency12.589311
lamin isoform A-delta10Homo sapiens (human)Potency17.034923
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.589311
M-phase phosphoprotein 8Homo sapiens (human)Potency39.810711
Microtubule-associated protein tauHomo sapiens (human)Potency17.894826
mitogen-activated protein kinase 1Homo sapiens (human)Potency22.136023
neuropeptide S receptor isoform AHomo sapiens (human)Potency1.584911
NFKB1 protein, partialHomo sapiens (human)Potency19.952622
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency91.999711
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency35.645045
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency29.092911
Nuclear receptor ROR-gammaHomo sapiens (human)Potency33.491511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency21.835524
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency39.983833
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency100.000012
ParkinHomo sapiens (human)Potency15.121722
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency31.622811
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency9.074311
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency16.944111
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency55.065222
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency15.074311
phosphopantetheinyl transferaseBacillus subtilisPotency89.125111
PINK1Homo sapiens (human)Potency28.183811
plasminogen precursorMus musculus (house mouse)Potency3.162311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency2.490612
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency35.481311
pregnane X nuclear receptorHomo sapiens (human)Potency32.799623
progesterone receptorHomo sapiens (human)Potency53.045311
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency45.373622
RAR-related orphan receptor gammaMus musculus (house mouse)Potency59.517811
ras-related protein Rab-9AHomo sapiens (human)Potency25.866212
regulator of G-protein signaling 4Homo sapiens (human)Potency42.898812
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency3.412422
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency6.080444
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency23.778111
Smad3Homo sapiens (human)Potency35.481311
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency44.668411
survival motor neuron protein isoform dHomo sapiens (human)Potency25.285512
TAR DNA-binding protein 43Homo sapiens (human)Potency22.387211
TDP1 proteinHomo sapiens (human)Potency17.841728
thioredoxin reductaseRattus norvegicus (Norway rat)Potency49.427747
ThrombopoietinHomo sapiens (human)Potency0.501222
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency32.671524
transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Potency0.043333
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency13.131122
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.162311
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.162311
USP1 protein, partialHomo sapiens (human)Potency19.952611
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency60.011811
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency44.668411
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency59.517811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)IC50200.000011
Bile salt export pumpHomo sapiens (human)IC5010.000011
Cannabinoid receptor 1Homo sapiens (human)Ki8.900034
Cannabinoid receptor 2 Homo sapiens (human)Ki10.000023
Corticotropin-releasing factor receptor 2Homo sapiens (human)Ki10.000011
Cytochrome P450 1A2Homo sapiens (human)IC503.000011
Lethal factorBacillus anthracisIC5015.000011
Lethal factorBacillus anthracisKi3.000011
Lysine-specific histone demethylase 1AHomo sapiens (human)IC500.600033
NADH-ubiquinone oxidoreductase chain 1Bos taurus (cattle)IC5052.480811
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC5056.000011
Potassium voltage-gated channel subfamily A member 1Homo sapiens (human)IC5029.000011
Prostaglandin G/H synthase 1Homo sapiens (human)IC502.675522
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)IC500.008022
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)IC500.019011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Ki1.186544
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)Ki1.779544

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2AMus musculus (house mouse)EC500.957011
bcl-2-like protein 11 isoform 1Homo sapiens (human)EC508.057011
Chain A, BCL-2-RELATED PROTEIN A1Homo sapiens (human)EC508.057011
D(2) dopamine receptorRattus norvegicus (Norway rat)EC500.300011
insulin-degrading enzyme isoform 1Homo sapiens (human)EC5031.824022
mu-type opioid receptor isoform MOR-1Homo sapiens (human)EC5092.342011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)EC501.84631718
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)EC500.409489
Transient receptor potential cation channel subfamily V member 2Rattus norvegicus (Norway rat)EC500.246045
Transient receptor potential cation channel subfamily V member 4Rattus norvegicus (Norway rat)EC500.246045

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bcl-2-like protein 11Homo sapiens (human)AC5011.550011
Chain A, BCL-2-RELATED PROTEIN A1Homo sapiens (human)AC5035.253333
NAD-dependent protein deacylase sirtuin-5, mitochondrialHomo sapiens (human)AC5018.110011
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Activity0.010011