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benzoic acids

Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.

ChEBI ID: 22723

Members (113)

MemberDefinitionRole
(3-amino-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone(3-amino-1,2,4-triazol-4-yl)-(2,5-dimethylphenyl)methanone
[3-(2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenylmethanone[3-(2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenylmethanone
[4-[(4-bromo-3,5-dimethyl-1-pyrazolyl)methyl]phenyl]-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]methanone[4-[(4-bromo-3,5-dimethyl-1-pyrazolyl)methyl]phenyl]-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]methanone
1-[[[2-(difluoromethoxy)phenyl]-oxomethyl]amino]-3-(3-methylphenyl)thiourea1-[[[2-(difluoromethoxy)phenyl]-oxomethyl]amino]-3-(3-methylphenyl)thiourea
1-[[[2-(difluoromethoxy)phenyl]-oxomethyl]amino]-3-(4-fluorophenyl)thiourea1-[[[2-(difluoromethoxy)phenyl]-oxomethyl]amino]-3-(4-fluorophenyl)thiourea
1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-oneA member of the class of benzoic acids that is benzoic acid in which the hydrogens at positions 3 and 4 have been replaced by pentan-2-ylamino and 2,2-bis(hydroxymethyl)-5-oxopyrrolidin-1-yl groups, respectively.1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one
1-benzoyl-5-hydroxy-5-(4-methylphenyl)-4H-pyrazole-3-carboxylic acid ethyl ester1-benzoyl-5-hydroxy-5-(4-methylphenyl)-4H-pyrazole-3-carboxylic acid ethyl ester
1-salicylate glucuronideA beta-D-glucosiduronic acid that is the glucuronide conjugate of salicyclic acid.1-salicylate glucuronide
2-({[2-acetyl-5-(tert-butyl)-3-thienyl]amino}carbonyl)benzoic acid2-({[2-acetyl-5-(tert-butyl)-3-thienyl]amino}carbonyl)benzoic acid
2-(2-cyclohexylidenehydrazinyl)benzoic acid2-(2-cyclohexylidenehydrazinyl)benzoic acid
2-(6-amino-5-cyano-3-thiophen-2-yl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)benzoic acid2-(6-amino-5-cyano-3-thiophen-2-yl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)benzoic acid
2-[(2-bromophenyl)methoxy]benzoic acid2-[(2-bromophenyl)methoxy]benzoic acid
2-[(2-chlorophenoxy)methyl]benzoic acid2-[(2-chlorophenoxy)methyl]benzoic acid
2-[(2-chlorophenyl)methoxy]-N-(4,5-dihydrothiazol-2-yl)benzamide2-[(2-chlorophenyl)methoxy]-N-(4,5-dihydrothiazol-2-yl)benzamide
2-[(3-methoxyphenyl)-oxomethyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester2-[(3-methoxyphenyl)-oxomethyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester
2-[2-[[benzamido(sulfanylidene)methyl]amino]-4-thiazolyl]acetic acid ethyl ester2-[2-[[benzamido(sulfanylidene)methyl]amino]-4-thiazolyl]acetic acid ethyl ester
2-iodosobenzoic acidA benzoic acid compound having an iodosyl substituent at the ortho-position.ortho-iodosylbenzoic acid
2-methyl-N-(4-oxo-2-sulfanylidene-3-thiazolidinyl)benzamide2-methyl-N-(4-oxo-2-sulfanylidene-3-thiazolidinyl)benzamide
2-methyl-N-[[[oxo-(3,4,5-trimethoxyphenyl)methyl]hydrazo]-sulfanylidenemethyl]benzamide2-methyl-N-[[[oxo-(3,4,5-trimethoxyphenyl)methyl]hydrazo]-sulfanylidenemethyl]benzamide
2-trifluoromethylbenzoic acidA benzoic acid carrying a trifluoromethyl substituent at the 2-position.2-(trifluoromethyl)benzoic acid
2,3,5-triiodobenzoic acidA member of the class of benzoic acids that is benzoic acid in which the hydrogens at positions 2, 3 and 5 are replaced by iodine atoms. It is an auxin polar transport inhibitor.2,3,5-triiodobenzoic acid
3-(1-azepanylazo)benzoic acid3-(1-azepanylazo)benzoic acid
3-(4-carboxybenzoyl)-2-quinolinecarboxaldehydeCBQCA reagent
3-(difluoromethoxy)-N-(4,5-dihydrothiazol-2-yl)benzamide3-(difluoromethoxy)-N-(4,5-dihydrothiazol-2-yl)benzamide
3-[(4-bromophenoxy)methyl]benzohydrazide3-[(4-bromophenoxy)methyl]benzohydrazide
3-[(4-methoxyphenoxy)methyl]-N-(4-nitro-1-pyrazolyl)benzamide3-[(4-methoxyphenoxy)methyl]-N-(4-nitro-1-pyrazolyl)benzamide
3-[[[5-(phenylmethyl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acid3-[[[5-(phenylmethyl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acid
3-benzamido-3-oxopropanethioic acid S-methyl ester3-benzamido-3-oxopropanethioic acid S-methyl ester
3-ethoxy-N-[(3-pyridinylamino)-sulfanylidenemethyl]benzamide3-ethoxy-N-[(3-pyridinylamino)-sulfanylidenemethyl]benzamide
3-methyl-N-[oxo-[(2,4,6-trimethyl-3-pyridinyl)amino]methyl]benzamide3-methyl-N-[oxo-[(2,4,6-trimethyl-3-pyridinyl)amino]methyl]benzamide
3-o-methylgallic acidA member of the class of benzoic acids that is gallic acid in which the phenolic hydroxy group at position 3 is converted into the corresponding methyl ether.3-O-methylgallic acid
3,4-dihydroxybenzohydroxamic acidN-3,4-tridhydroxybenzamide
3,4,5-trimethoxy-N-[[[oxo-[(1S,2S)-2-phenylcyclopropyl]methyl]hydrazo]-sulfanylidenemethyl]benzamide3,4,5-trimethoxy-N-[[[oxo-[(1S,2S)-2-phenylcyclopropyl]methyl]hydrazo]-sulfanylidenemethyl]benzamide
3,4,5-trimethoxybenzoic acidA benzoic acid derivative carrying 3-, 4- and 5-methoxy substituents.3,4,5-trimethoxybenzoic acid
3,5-dinitrobenzoic acidA member of the class of benzoic acids that is benzoic acid in which the hydrogens at positions 3 and 5 are replaced by nitro groups.3,5-dinitrobenzoic acid
4-(1,1,2,3,3,3-hexafluoropropoxy)benzoic acid4-(1,1,2,3,3,3-hexafluoropropoxy)benzoic acid
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidA retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).arotinoid acid
4-(octyloxy)benzoic acid4-(octyloxy)benzoic acid
4-(trifluoromethyl)benzoic acidA benzoic acid carrying a 4-trifluoromethyl substituent.4-trifluoromethylbenzoic acid
4-[(2,4,6-triamino-5-pyrimidinyl)azo]benzoic acid4-[(2,4,6-triamino-5-pyrimidinyl)azo]benzoic acid
4-[[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid4-[[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid
4-[[(4-tert-butylphenyl)-oxomethyl]hydrazo]-N-(5-methyl-3-isoxazolyl)-4-oxobutanamide4-[[(4-tert-butylphenyl)-oxomethyl]hydrazo]-N-(5-methyl-3-isoxazolyl)-4-oxobutanamide
4-[[[(2S,3S)-10-[[cyclopropyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl-methylamino]methyl]benzoic acid4-[[[(2S,3S)-10-[[cyclopropyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl-methylamino]methyl]benzoic acid
4-[[dimethoxyphosphoryl(phenyl)methyl]amino]benzoic acid4-[[dimethoxyphosphoryl(phenyl)methyl]amino]benzoic acid
4-[4-(2,4-dichlorophenyl)-2-thiazolyl]benzoic acid4-[4-(2,4-dichlorophenyl)-2-thiazolyl]benzoic acid
4-[5-(carboxymethyl)-4-phenyl-2-thiazolyl]benzoic acid4-[5-(carboxymethyl)-4-phenyl-2-thiazolyl]benzoic acid
4-aminomethylbenzoic acidaminomethylbenzoic acid
4-benzyloxybenzoic acid4-(Benzyloxy)benzoic acid
4-carboxybenzaladehydeA member of the class of benzoic acids that is benzoic acid substituted by a formyl group at position 4.4-formylbenzoic acid
4-ethylbenzoic acid4-Ethylbenzoic acid
4-guanidinobenzoateBenzoic acid substituted at the para position by a guanidino group.4-guanidinobenzoic acid
4-methoxy-N-(3-methyl-2-thiazolylidene)benzamide4-methoxy-N-(3-methyl-2-thiazolylidene)benzamide
4-methoxy-N-[[(1-oxo-2-phenoxyethyl)hydrazo]-sulfanylidenemethyl]benzamide4-methoxy-N-[[(1-oxo-2-phenoxyethyl)hydrazo]-sulfanylidenemethyl]benzamide
4-methoxy-N-[[(phenylmethyl)amino]-sulfanylidenemethyl]benzamide4-methoxy-N-[[(phenylmethyl)amino]-sulfanylidenemethyl]benzamide
4-methyl-N-[(1-oxopentylhydrazo)-sulfanylidenemethyl]benzamide4-methyl-N-[(1-oxopentylhydrazo)-sulfanylidenemethyl]benzamide
4-methyl-N-[sulfanylidene-(1,2,4-triazol-4-ylamino)methyl]benzamide4-methyl-N-[sulfanylidene-(1,2,4-triazol-4-ylamino)methyl]benzamide
acifluorfenA member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds.acifluorfen
aspirinA member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.acetylsalicylic acid
bay 58-2667A benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure.cinaciguat
bay u9773A dicarboxylic acid that is that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 4S and a (4-carboxyphenyl)sulfanediyl group at 5R. It is a dual cysteinyl leukotriene receptor antagonist that acts at the CysLT1 and CysLT2 receptors (IC50 = 0.44 and 0.30 muM, respectively).BAYu9773
benzoic acidA compound comprising a benzene ring core carrying a carboxylic acid substituent.benzoic acid
bexarotenebexarotene
bispyribacA member of the class of benzoic acids that is benzoic acid substituted by (4,6-dimethoxypyrimidin-2-yl)oxy groups at positions 2 and 6. Its sodium salt is used as a broad spectrum post emergent herbicide for the control of grasses, sedges and broadleaf weeds in rice crops.bispyribac
bms 195614A carboxamide resulting from the formal condensation of the carboxy group of 5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxylic acid with the amino group of p-aminobenzoic acid. It is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. It antagonizes agonist-induced coactivator (CoA) recruitment.BMS 195614
bms 204493A member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenylethynyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer).BMS-493
bms453A member of the class of dihydronaphthalenes that is 1,2-dihydronaphthalene which is substituted at positions 1, 1, 4, and 6 by methyl, methyl, phenyl, and 2-(p-carboxyphenyl)vinyl groups, respectively (the E isomer). It is a potent retinoic acid receptor gamma (RARbeta) agonist that acts as an antagonist against RARalpha and RARgamma.BMS-453
bumetanideA member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.bumetanide
deferasiroxA member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.deferasirox
diatrizoic acidA member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.amidotrizoic acid
fluoresciteA xanthene dye that is highly fluorescent and commonly used as a fluorescent tracer.fluorescein (acid form)
gsk2879552A member of the class of piperidines that is piperidine substituted by (4-carboxyphenyl)methyl and {[(1R,2S)-2-phenylcyclopropyl]amino}methyl groups at positions 1 and 4, respectively. It is a potent and irreversible inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A). It was under clinical investigation for the treatment of acute myeloid leukaemia and small cell lung carcinoma.GSK2879552
iodamideA benzoic acid compound having iodo substituents at the 2-, 4- and 6-positions, an acetamido substituent at the 3-position and an acetamidomethyl substituent at the 5-position.iodamide
iodipamideAn organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.adipiodone
ioxaglateA benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an acetyl(methyl)amino group at the 5-position.ioxaglic acid
ioxitalamic acidAn organoiodine compound that is 2,4,6-triiodobenzoic acid substituted by an acetylamino group at position 3 and a (2-hydroxyethyl)carbamoyl group at position 5. It is used as a contrast medium.iooxitalamic acid
lumacaftorAn aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fibrosis.lumacaftor
ly382884LY382884
N-(3,4-dimethyl-2-thiazolylidene)benzamideN-(3,4-dimethyl-2-thiazolylidene)benzamide
N-[(2-phenylethylamino)-sulfanylidenemethyl]benzamideN-[(2-phenylethylamino)-sulfanylidenemethyl]benzamide
N-[(4-methoxyphenyl)-oxomethyl]-1-piperidinecarboxamideN-[(4-methoxyphenyl)-oxomethyl]-1-piperidinecarboxamide
N-[[(3-cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)amino]-sulfanylidenemethyl]-2-methylbenzamideN-[[(3-cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)amino]-sulfanylidenemethyl]-2-methylbenzamide
N-[[(4,6-dimethyl-2-pyrimidinyl)amino]-sulfanylidenemethyl]benzamideN-[[(4,6-dimethyl-2-pyrimidinyl)amino]-sulfanylidenemethyl]benzamide
N-[[(5-methyl-1H-pyrazol-3-yl)amino]-oxomethyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamideN-[[(5-methyl-1H-pyrazol-3-yl)amino]-oxomethyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamide
N-[[(6-methyl-2-pyridinyl)amino]-oxomethyl]benzamideN-[[(6-methyl-2-pyridinyl)amino]-oxomethyl]benzamide
N-[[[(2-methylphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]benzamideN-[[[(2-methylphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]benzamide
N-[[[(4-methoxyphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamideN-[[[(4-methoxyphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]-2-furancarboxamide
N-[[[oxo(thiophen-2-yl)methyl]hydrazo]-sulfanylidenemethyl]benzamideN-[[[oxo(thiophen-2-yl)methyl]hydrazo]-sulfanylidenemethyl]benzamide
N-[3-(2-chlorophenyl)-4-oxo-2-thiazolidinylidene]benzamideN-[3-(2-chlorophenyl)-4-oxo-2-thiazolidinylidene]benzamide
N-[bis(methylthio)methylideneamino]-4-hydroxybenzamideN-[bis(methylthio)methylideneamino]-4-hydroxybenzamide
n-benzamidothioureabenzamidothiourea
N'-[(2-methoxyphenyl)-oxomethyl]-2-(4-morpholinyl)-4-thiazolecarbohydrazideN'-[(2-methoxyphenyl)-oxomethyl]-2-(4-morpholinyl)-4-thiazolecarbohydrazide
N'-[2-[(4,5-dimethyl-1,2,4-triazol-3-yl)thio]-1-oxoethyl]-4-methoxybenzohydrazideN'-[2-[(4,5-dimethyl-1,2,4-triazol-3-yl)thio]-1-oxoethyl]-4-methoxybenzohydrazide
N'-[2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]-4-methoxybenzohydrazideN'-[2-[[4-ethyl-5-(2-furanyl)-1,2,4-triazol-3-yl]thio]-1-oxoethyl]-4-methoxybenzohydrazide
N'-benzoyl-2-(3-pyridinyl)-4-thiazolecarbohydrazideN'-benzoyl-2-(3-pyridinyl)-4-thiazolecarbohydrazide
nafamostatnafamostat
nifuroxazidenifuroxazide
nigerloxinA member of the class of benzoic acids that is benzoic acid which is substituted at positions 2, 3, 4, 5, and 6 by carbamoyl, hydroxy, E)-prop-1-en-1-yl, methyl, and methoxy groups, respectively. Obtained from solid-state fermentation of Aspergillus niger CFR-W-105, it inhibits soy bean lipoxygenase-1 (LOX-1) and rat lens aldose reductase (RLAR). It also shows free radical scavenging activity.nigerloxin
olivetolic acidA member of the class of benzoic acids that is salicylic acid in which the hydrogens ortho- and para- to the carboxy group are replaced by a pentyl and a hydroxy group, respectively.olivetolic acid
phenolphthaleinPhenolphthalin
primisulfuronPrimisulfuron
probenecidA sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.probenecid
pyromellitic acidA tetracarboxylic acid that is benzene substituted by four carboxy groups at positions 1, 2, 4 and 5 respectively.pyromellitic acid
ro 41-5253A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, while the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.Ro 41-5253
salicylic acid glucosideA monosaccharide derivative that is salicylic acid in which the phenolic hydrogen is replaced by a D-glucosyl residue.2-(D-glucosyloxy)benzoic acid
salicylsalicylic acidA dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.salsalate
sulfosalicylic acidAn arenesulfonic acid that is benzoic acid substituted by a hydroxy at position C-2 and a sulfo group at C-5.5-sulfosalicylic acid
syringic acidA dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.syringic acid
taprosteneTaprostene
tosiben2,3-diacetyloxybenzoic acid
triflusal2-acetyloxy-4-(trifluoromethyl)benzoic acid
trimesic acidA tricarboxylic acid that consists of benzene substituted by carboxy groups at positions 1, 3 and 5.benzene-1,3,5-tricarboxylic acid
valerylsalicylateA valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.valerylsalicylic acid
veratric acidA member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3.3,4-dimethoxybenzoic acid

Research

Studies (61,847)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199020,550 (33.23)18.7374
1990's9,619 (15.55)18.2507
2000's12,679 (20.50)29.6817
2010's14,234 (23.01)24.3611
2020's4,765 (7.70)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials8,158 (12.12%)5.53%
Reviews7,744 (11.51%)6.00%
Case Studies4,399 (6.54%)4.05%
Observational483 (0.72%)0.25%
Other46,524 (69.12%)84.16%