Any fatty acid having at least one of the chain methylene groups replaced by sulfur. Members of this group are believed to have important pharmacological (antioxidant and antiatherosclerosis) properties.
ChEBI ID: 59643
| Member | Definition | Role |
|---|---|---|
| 3-methylthiopropionate | A thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position; an intermediate in mammalian methionine metabolism in vitro. The simplest known phytotoxin, it is a blight-inducing toxin produced by the cassava pathogen Xanthomonas campestris manihotis. | 3-(methylthio)propionic acid |
| alpha-hydroxy-gamma-methylmercaptobutyric acid | 2-hydroxy-4-(methylthio)butanoic acid | |
| berlition | The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. | (R)-lipoic acid |
| thioctic acid | A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position. | lipoic acid |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 899 (19.55) | 18.7374 |
| 1990's | 443 (9.63) | 18.2507 |
| 2000's | 1,091 (23.73) | 29.6817 |
| 2010's | 1,638 (35.62) | 24.3611 |
| 2020's | 527 (11.46) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 338 (6.92%) | 5.53% |
| Reviews | 338 (6.92%) | 6.00% |
| Case Studies | 68 (1.39%) | 4.05% |
| Observational | 11 (0.23%) | 0.25% |
| Other | 4,129 (84.54%) | 84.16% |