Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.
| Excerpt | Reference |
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| "The therapy of gout is discussed taking into consideration the concomitant diseases occurring significantly frequently in patients with gout: Hypertension, uric acid-nephrolithiasis, hyperlipoproteinaemia, obesity, premature arteriosclerosis as well as diabetes mellitus." | ( Heidelmann, G; Thiele, P, 1977) |
| "Gout is a painful and potentially crippling disorder." | ( Middlemiss, H; Watt, I, 1975) |
| "The occurence of gout is questionable in this connection, relevant seems to be only the coincidence of psoriasis and gout." | ( Eckes, L, 1975) |
| "Gout is a common disease in the primary health care setting." | ( Feng, PH; Leong, KH, 1992) |
| "Although typical gout is easily recognized and treated, several recent papers have addressed atypical presentations of gout, as well as other causes of podagra that might have been attributed previously to gout." | ( Agudelo, CA; Wise, CM, 1991) |
| "Gout is primarily a disease of middle-aged males and is unusual in females and adolescent males." | ( Calabrese, G; Cameron, JS; Davies, PM; Simmonds, HA, 1990) |
| "Control of gout is one of the premier success stories of modern medicine." | ( McCarty, DJ, 1986) |
| "Gout is largely solved, both from diagnostic and therapeutic standpoints." | ( McCarty, DJ, 1988) |
| "Gout is a clinical syndrome with a limited range of manifestations arising as a result of the deposition of crystals of monosodium urate, the final product of purine metabolism in humans." | ( Becker, MA, 1988) |
| "Gout is a clinical syndrome encompassing a group of metabolic diseases that are all characterized by abnormal uric acid metabolism." | ( German, DC; Holmes, EW, 1986) |
| "Gout is a disease linked to altered uric acid metabolism with increased uric acid concentration in the blood, the deposition of sodium urate crystals in certain tissues and abscesses." | ( Milano, L, 1986) |
| "Acute gout is best treated with colchicine or indomethacin." | ( Sloan, RW, 1982) |
| "Gout is principally a disease of middle-aged men." | ( Cameron, JS; Dillon, MJ; Farebrother, DA; Pincott, JR; Simmons, HA; Warren, DJ, 1981) |
| "Gout is a common disease with a worldwide distribution." | ( Hochberg, MC; Star, VL, 1993) |
| "Gout is an inflammatory joint disease that primarily affects middle-aged men and postmenopausal women." | ( Joseph, J; McGrath, H, 1995) |
| "Gout is increasingly recognized in African populations, especially in urban centres." | ( Darmawan, J; Lutalo, SK, 1995) |
| "Gout is a syndrome caused by an inflammatory response to the formation of monosodium urate monohydrate crystals which develop secondary to hyperuricaemia." | ( Christophidis, N; Rasaratnam, I, 1995) |
| "Gout is a disease caused by deposits of sodium urate crystals in tissues." | ( Bourgeois, P; Rozenberg, S, 1994) |
| "Acute gout is a well known complication of the commencement of allopurinol therapy." | ( Brooks, PM; Day, RO; Kot, TV, 1993) |
| "When gout is suspected, yet the initial examination does not reveal the telltale crystals, reexamination of synovial fluid is warranted." | ( Nuwayhid, N; Saadeh, C; Uy, JP, 1996) |
| "Gout is a common disease." | ( Bourgerois, P; Koeger, AC; Laatar, A; Lang, T; Orcel, P; Rozenberg, S, 1996) |
| "Primary gout is characterized by increased plasma and decreased urinary concentrations of hypoxanthine, xanthine and uric acid." | ( Herrero, E; Mateos, FA; Miranda-Carús, E; Puig, JG; Ramos, T; Sanz, AG, 1997) |
| "Gout is an acute rheumatic disorder that occurs in connection with the deposition of monosodium urate (MSU) crystals in the joints." | ( Duffin, KL; Gregory, SA; Isakson, PC; Margalit, A; Shaffer, AF, 1997) |
| "Gout is common disease with a worldwide distribution." | ( Peichl, P, 1997) |
| "Gout is a condition characterized by the deposition of monosodium urate crystals in the joints or soft tissue." | ( Alloway, JA; Harris, MD; Siegel, LB, 1999) |
| "Gout is a disease resulting from the deposition of urate crystals caused by the overproduction or underexcretion of uric acid." | ( Bross, MH; Pittman, JR, 1999) |
| "Hyperuricemia and gout are known to occur in patients receiving diuretic therapy." | ( Chopra, KF; Grossman, ME; Schneiderman, P, 1999) |
| "Gout is an inflammatory response to deposition of monosodium urate crystals in and around joints." | ( Ryan, PF; van Doornum, S, 2000) |
| "Gout is a common and challenging problem in South Auckland, New Zealand." | ( Gow, P; Raill, B; Sharples, K; Stamp, L, 2000) |
| "Gout is a common form of arthritis, in which many of the risk factors, pathogenetic mechanisms, and clinical features have been recognized for years." | ( Agudelo, CA; Wise, CM, 2001) |
| "Gout is rarely localized to the wrist." | ( Cesari, B; Fouque, PA; Le Bourg, M; Raimbeau, G; Saint-Cast, Y, 2001) |
| "Episodes of gout are common in the setting of renal transplantation." | ( Dittmer, I; Faire, B; Pilmore, HL, 2001) |
| "Gout is a common disease arising due to abnormal purin metabolism and excessive accumulation of uric acid in the blood (hyperuricemia) and manifesting with attacks of acute gouty arthritis." | ( Fedorova, NE; Grigor'eva, VD, 2002) |
| "Gout is a metabolic disorder in which there is either an increase in production or a decrease in excretion of uric acid leading to hyperuricemia." | ( Gentili, A, 2003) |
| "Gout is a common co-morbidity in patients with chronic heart failure and its treatment is complex." | ( Conraads, V; Debie, K; Vrints, C, 2003) |
| "In most cases gout is the clinical manifestation of familial hyperuricemia." | ( Gröbner, W; Zöllner, N, 2004) |
| "Gout is a group of diseases characterized by arthritis and results from a disturbance of urate metabolism with the deposition of monosodium urate crystals in the joints and soft tissues." | ( Monu, JU; Pope, TL, 2004) |
| "In most cases, gout is an easy disease to treat, but we do not have enough information about how to handle those few patients with "difficult" disease, and what we refer colloquially to as difficult gout has not been properly defined yet." | ( Pascual, E; Pedraz, T, 2004) |
| "Tophaceous gout is a recognized cause of carpal tunnel syndrome." | ( Bush, DC; Harrington, TM; Lincoski, CJ; Rich, JT, 2004) |
| "Gout is among the most common causes of acute monoarticular arthritis." | ( Peronato, G, 2005) |
| "Although gout is common in the UK, particularly among older men, the incidence of the disease seems to have remained stable during the 1990s." | ( Bilker, WB; Farrar, JT; Fernandes, S; Mikuls, TR; Saag, KG; Schumacher, HR, 2005) |
| "Gout is the most common crystal-induced arthritis." | ( Chen, CH; Chen, CK; Pan, HB; Yang, CF; Yeh, LR, 2005) |
| "Gout is associated with increased body weight." | ( Antozzi, P; Arias, F; Carrodeguas, L; Ropos, T; Rosenthal, R; Soto, F; Szomstein, S; Zundel, N, 2005) |
| "Gout is a metabolic disorder that results in hyperuricemia and the deposition of positively birefringent monosodium urate crystals in various parts of the body." | ( Ejaz, S; Kim, BS; Lim, CW, 2005) |
| "Gout is usually considered an affliction confined to middle-aged men, but has an increasing prevalence in older populations, with unique and often atypical features." | ( Wise, CM, 2005) |
| "Gout is one of the best understood among the rheumatological disorders and one of the most satisfying to treat." | ( Suresh, E, 2005) |
| "Gout is one of the most readily manageable of the rheumatic diseases." | ( Cannella, AC; Mikuls, TR, 2005) |
| "Gout is the most common inflammatory arthritis in men, affecting approximately 1-2% of adult men in Western countries." | ( Kavanaugh, A; Lee, SJ; Terkeltaub, RA, 2006) |
| "Hyperuricemia and gout are common conditions that have long been known to have a heritable component." | ( Bleyer, AJ; Hart, TC, 2006) |
| "As gout is very often primarily caused by a renal secretion disturbance of uric acid special diagnostics should be done." | ( Grässler, J; Richter, K; Roch, B; Schröder, HE; Tausche, AK; Unger, S; Wunderlich, C, 2006) |
| "The incidence of gout is highest in the elderly population." | ( Katbamna, R; Sutaria, S; Underwood, M, 2006) |
| "Hyperuricemia and gout are common complications in adult renal transplant recipients." | ( Kemper, MJ; Neuhaus, TJ; Spartà, G, 2006) |
| "Gout is a common form of inflammatory arthritis that has been managed primarily in general medical practices for centuries." | ( Nair, R; Saag, KG; Teng, GG, 2006) |
| "Gout is a less commonly diagnosed rheumatic disease in China compared with Western countries, but its prevalence appears to be climbing." | ( Chen, LX; Fang, W; Li, M; Schumacher, HR; Zeng, X; Zhang, F, 2006) |
| "Gout is one of the most common rheumatic diseases worldwide." | ( Catton, M; Maxwell, L; Schlesinger, N; Schumacher, R, 2006) |
| "Gout is a chronic metabolic disease caused by a disorder of the purine metabolism leading to hyperuricaemia." | ( Cantatore, FP; Corrado, A; D'Onofrio, F; Melillo, N; Santoro, N, 2006) |
| "Gout is a disease caused by the deposition of monosodium urate monohydrate crystals." | ( Akahoshi, T; Kitasato, H; Murakami, Y, 2007) |
| "Treatment of gout is usually considered after the first attack of arthritis, typically podagra." | ( Gilliland, WR; Keith, MP, 2007) |
| "Gout is the most frequent cause of man's inflammatory arthritis after forty years of age and its prevalence is increasing." | ( Guerne, PA; Zaninetti-Schaerer, A, 2007) |
| "Gout is the most common inflammatory arthropathy for men." | ( Aringer, M; Grässler, J; Winzer, M, 2007) |
| "Diagnosis of gout is established when typical monosodium urate crystals can be identified." | ( Gerster, JC, 2007) |
| "Gout is known to mimic conditions as diverse as joint and soft tissue infections, skin malignancies, nerve compression syndromes and soft tissue tumours." | ( Chui, CH; Lee, JY, 2007) |
| "Gout is the most commnon acute inflammatory arthropathy and rheumatoid arthritis the most prevalent arthropathy due to chronic inflammation." | ( Meli, J; Muna, WF; Nouédoui, C; Ntsiba, H; Sida, MB; Singwe-Ngandeu, M; Yollo, AV, 2007) |
| "Gout is caused by monosodium urate (MSU) crystal-induced inflammation of the joints and periarticular tissues." | ( Kabelitz, D; Lamprecht, P; Till, A, 2008) |
| "Gout is a common cause of inflammatory arthritis in the United States, and its prevalence has increased in recent decades, especially among older adults." | ( Cahill, KE; Krishnan, E; Mody, RR; Patel, PA; Tang, J; Wu, EQ; Yu, AP, 2008) |
| "Gout is a type of inflammatory arthritis that is triggered by the crystallization of monosodium urate (MSU) within the joints and is often associated with hyperuricemia." | ( Nakamura, T; Takagi, K; Ueda, T, 2008) |
| "Gout is a crystal deposition disease." | ( Fujimori, S, 2008) |
| "Gout is one of the most frequently occurring rheumatic diseases, worldwide." | ( Janssen, M; Janssens, HJ; Lucassen, PL; Van de Laar, FA; Van de Lisdonk, EH, 2008) |
| "Gout is characterized by the deposition of monosodium urate crystals on the surface of the articular cartilage, within periarticular tissues, and within bone and skin." | ( André, V; Berthelot, JM; Guillot, P; Le Goff, B; Maugars, Y, 2008) |
| "Gout is the most common inflammatory arthritis in the United States, with more than three million sufferers." | ( Keenan, RT; Pillinger, MH, 2008) |
| "Gout is currently the most common form of inflammatory arthritis in men." | ( Edwards, NL; Kirby, BS; McTigue, JC, 2008) |
| "Gout is the most common autoinflammatory arthritis characterized by elevated serum urate and recurrent attacks of intra-articular crystal deposition of monosodium urate (MSU)." | ( Li, CG; Meng, DM; Mi, QS; Miao, ZM; Wang, YG; Yan, SL; Zhao, SH; Zhou, L, 2009) |
| "Gout is a true crystal deposition disease caused by formation of monosodium urate crystals in joints and other tissues." | ( Doherty, M, 2009) |
| "Gout is well known to be produced by increased uric acid level in blood." | ( Marickar, YM, 2009) |
| "Gout is an inflammatory arthritis characterized by self-limiting but excruciatingly painful acute attacks." | ( Jordan, KM; Rider, TG, 2010) |
| "Gout is a common rheumatic disease in humans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crystals in the joint." | ( Ralston, SH; Riches, PL; Wright, AF, 2009) |
| "Gout is an acute form of arthritis caused by the deposition of urate crystals, in which phagocytic cells and cytokines play a major pathogenic role." | ( Capsoni, F; Catania, A; Ongari, AM; Reali, E, 2009) |
| "Gout is rare among young women." | ( Rimar, D; Rosner, I; Rozenbaum, M; Shai, A; Wolfovitz, E, 2010) |
| "Although classic gout is still most commonly seen, the disease can manifest as with a wide array of presentations." | ( Keenan, RT; Ning, TC, 2010) |
| "Gout is the most common inflammatory arthritis in an elderly population, and can be diagnosed with absolute certainty by polarization microscopy." | ( Jansen, TL; Reinders, MK, 2010) |
| "Gout is relatively unique among rheumatological diseases in that its effects were common and, at least in history, disproportionately represented in prominent authority figures." | ( Bhattacharjee, S, 2009) |
| "Gout is a common metabolic disorder characterized by elevated uric acid leading to the formation and accumulation of uric acid crystals in synovial fluids." | ( Martinon, F, 2010) |
| "An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation." | ( Busso, N; So, A, 2010) |
| "Gout is a common, painful, and often debilitating rheumatologic disorder that remains one of the few arthritic conditions that can be diagnosed with certainty and cured with appropriate therapy." | ( Barrons, R; Love, BL; Snider, KM; Veverka, A, 2010) |
| "Gout is commonly associated with obesity, arterial hypertension, diabetes, and dyslipidemia." | ( de Miguel, ME; Fraile, JM; Lundelin, KJ; Martínez, P; Puig, JG; Torres, RJ; Vázquez, JJ, 2010) |
| "Acute gout is intensely painful and can reduce patients' quality of life." | ( , 2010) |
| "Because refractory gout is associated with high oxidative stress in spite of high PUA, and profoundly depleting uric acid did not increase lipid or protein oxidation, we conclude that urate is not a major factor controlling oxidative stress in vivo." | ( Ganson, NJ; Hershfield, MS; Jaggers, D; Kelly, SJ; Roberts, LJ; Santisteban, I; Scarlett, E; Sundy, JS, 2010) |
| "Gout is the most common cause of inflammatory arthritis among men and postmenopausal women." | ( VanItallie, TB, 2010) |
| "Gout is an acute inflammatory arthritis with the potency to fully destroy the integrity of the joint leading to severe disability." | ( Bhansing, KJ; Janssen, M; Radstake, TR; van Bon, L, 2010) |
| "Gout is a common disease and the prevalence is increasing." | ( Quillen, DM, 2010) |
| "Gout is increasingly recognized as a prevalent chronic disease state requiring appropriate long-term management while controlling for risk factors and comorbid conditions." | ( Graser, E; Pope, RS; Zychowicz, ME, 2010) |
| "Gout is not common in childhood compared with adulthood, and careful consideration of inborn errors of metabolism should be considered in these cases." | ( Yamanaka, H, 2011) |
| "Gout is commonly undertreated and can lead to significant disability." | ( Dalbeth, N; Gow, P; Lindsay, K; Logo, P; Vanderpyl, J, 2011) |
| "Gout is a common systemic metabolic disease characterized by deposition of monosodium urate monohydrate crystals with resultant acute intense inflammation of the involved joint." | ( Aronow, WS; Ash, JY; Chilappa, CS; Patel, U; Shapiro, D; Sperber, K, 2010) |
| "Gout is an ancient disease that still plagues us." | ( Ghaemi-Oskouie, F; Shi, Y, 2011) |
| "As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout." | ( Chu, N; Han, L; Jia, Z; Li, C; Liu, S; Ma, X; Meng, D; Wang, B; Wang, J; Zhang, K; Zhoub, S, 2011) |
| "Gout is a common inflammatory arthritis that affects ∼4% of the US population." | ( Davis, MW; Lauterio, TJ; Wertheimer, AI, 2011) |
| "Gout is an inflammatory arthritis that typically presents as acute onset, recurrent, monoarticular pain." | ( Doghramji, PP, 2011) |
| "Gout is common in the elderly and its management is frequently complicated by the presence of co-morbid conditions and medications prescribed for other conditions." | ( Jordan, S; Stamp, LK, 2011) |
| "Hyperuricemia and gout are not a clinical problem in sickle cell disease in our country." | ( Arlet, JB; Chatellier, G; Courbebaisse, M; de Montalembert, M; Pouchot, J; Prié, D; Ribeil, JA, 2012) |
| "Gout is increasing in prevalence throughout the world, particularly in developed countries." | ( Shipley, M, 2011) |
| "Gout is an inflammatory-rheumatic disease characterized by an elevated serum urate concentration and recurrent flares, including painful, hot, red, and swollen joints and surrounding tissue." | ( Mittag, F; Wuenschel, M, 2011) |
| "Gout is a serious medical problem in our centre." | ( Chan, PL; Chan, T; Cheong, YK; Ling, GR; Ling, HN; Teh, CL, 2013) |
| "Gout is an often-overlooked and undertreated inflammatory arthritis that is most frequently managed in the primary care office." | ( Lieberman, JA, 2011) |
| "Gout is a lifestyle disease, which was nicely illustrated in the joint symposium of the Japanese Society of Gout and Nucleic Acid Metabolism and of the Purine and Pyrimidine Society held in February 2011 in Tokyo, Japan." | ( Hosoya, T; Ichida, K; Ohno, I; Peters, GJ, 2011) |
| "Gout is the most common form of microcrystalline arthropathy, and does not usually pose a diagnostic challenge when patients have a typical presentation, appropriate biochemical picture and classical radiographic appearance." | ( Khoo, JN; Tan, SC, 2011) |
| "Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β)." | ( Apostolidou, E; Boumpas, DT; Chrysanthopoulou, A; Drosos, GI; Kambas, K; Kourtzelis, I; Mitroulis, I; Ritis, K; Skendros, P, 2011) |
| "Gout is a common rheumatologic condition of recurrent polyarticular involvement." | ( Avhad, G; Dandale, A; Dhurat, R; Ghate, S, 2011) |
| "Acute and chronic gout are common complications following organ transplantation." | ( Chapman, PT; Stamp, LK, 2012) |
| "Gout is frequently associated with the metabolic syndrome." | ( Conaghan, PG; Rakieh, C, 2011) |
| "However, gout is a historical disease, thanks to the descriptions of Hippocrates, Caelius Aurelianus, Soranus of Ephesus and Araeteus of Cappadocia." | ( Marson, P; Pasero, G, 2012) |
| "Gout is a metabolic disease characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals in the joints and soft tissues, consisting of a self-limited acute phase characterized by recurrent attacks of synovitis and a chronic phase in which inflammatory and structural changes of the joints and periarticular tissues may lead to persistent symptoms." | ( De Angelis, R; Grassi, W, 2012) |
| "Gout is a painful inflammatory arthropathy caused by crystallization of monosodium urate within the joints." | ( Glazebrook, KN; Ida, CM; Kakar, S; Laurini, JA; Leng, S; Moder, KG, 2012) |
| "Gout is a rheumatologic disease due to the deposition of urate (the catabolite of purines) crystals within joints." | ( André, B; Bouquegneau, A; Delanaye, P; Dubois, BE, 2012) |
| "Gout care is suboptimal because of lack of translation of knowledge into real-world practice, despite evidence-based guidelines." | ( Lateef, A; Lau, TC; Lim, AY; Shen, L; Tan, CH; Teng, GG, 2012) |
| "Gout is a chronic, potentially debilitating condition characterized by an inflammatory process in the joints or periarticular tissues that results from the deposition of monosodium urate crystals." | ( Doghramji, PP; Mandell, BF; Pope, RS, 2012) |
| "Gout is a metabolic disorder of excess uric acid accumulation that manifests clinically as inflammatory arthritis, chronic arthropathy and the formation of deposits of uric acid known as tophi." | ( George, RL; Sundy, JS, 2012) |
| "Gout is the most common inflammatory arthritis and one in which pathogenesis and risk factors are best understood." | ( Bardin, T; Doherty, M; Jansen, TL; Nuki, G; Pascual, E; Perez-Ruiz, F; Punzi, L; So, AK, 2012) |
| "Gout is probably one of the oldest diseases affecting men." | ( Oliviero, F; Punzi, L; Ramonda, R; Scanu, A, 2012) |
| "Gout is a chronic, progressive inflammatory disease with intermittent arthritic flares, which should not be regarded as a minor inconvenience or nuisance." | ( Goh, LH; How, CH; Teng, GG; Tong, CY, 2012) |
| "Gout is a common and very painful inflammatory arthritis caused by hyperuricaemia." | ( Choi, HK; Mount, DB; Reginato, AM; Yang, I, 2012) |
| "Gout is a common form of arthritis." | ( Chapman, PT; Stamp, LK, 2013) |
| "The new epidemic of gout is likely secondary in significant part to the rise in fructose consumption, as well as to the increase in obesity, the endurance of other dietary and non-dietary gout risk factors such as consumption of meat and alcohol, the continued use of culprit medications and potentially to the under-recognition of the benefits of certain foods and drinks (such as dairy products and coffee)." | ( Kedar, E; Simkin, PA, 2012) |
| "Gout is a metabolic disorder of purine metabolism with primary manifestations of acute and chronic arthritis and tophus formation." | ( Sundy, JS, 2012) |
| "Gout is a disease caused by deposition of monosodium urate crystals in tissues." | ( Herrero-Beites, AM; Perez-Ruiz, F, 2012) |
| "Gout is an inflammatory arthritis characterized by sudden, painful inflammation." | ( Dave, AJ; Kelly, VM; Krishnan, E, 2012) |
| "Gout is a metabolic disorder of purine metabolism and uric acid elimination." | ( Keenan, RT, 2012) |
| "Gout is the most common inflammatory arthritis in men over 40 years and has an increasing prevalence among postmenopausal women." | ( Lopez-Olivo, MA; Suarez-Almazor, ME; Tayar, JH, 2012) |
| "Women who develop gout are more likely to be over the age of 50, have other comorbidities and be on diuretics." | ( Gupta, R; Kumar, S; Suppiah, R, 2012) |
| "Gout is an ancient disease." | ( Shmerling, RH, 2012) |
| "Acute gout is associated with a decrease in serum uric acid (SUA) that is considered to be in response to acute inflammation but it may be a feature of gout itself." | ( Ashby, HL; Chugh, S; Deshpande, S; Ford, C; Gama, R; Razavi, C; Thomas, OL; Waldron, JL, 2013) |
| "Gout is a painful inflammatory arthritis associated with hyperuricemia, with a prevalence of almost 10 million in the USA." | ( Mount, DB, 2013) |
| "Gout is a prototype crystal-induced inflammatory disorder, characterized by neutrophil infiltration into inflamed joints." | ( Kambas, K; Mitroulis, I; Ritis, K, 2013) |
| "Gout is increasing worldwide." | ( Gibson, TJ, 2013) |
| "Gout is caused by monosodium urate (MSU) crystal-induced inflammation of the joints and periarticular tissues." | ( Chu, N; Han, L; Li, C; Liu, S; Yin, C, 2013) |
| "Gout is the most common arthritis in adults." | ( Bianchi, G; Borghi, C; Bortoluzzi, A; Cimmino, MA; D'Avola, GM; Desideri, G; Di Giacinto, G; Favero, M; Govoni, M; Grassi, W; Lombardi, A; Manara, M; Marangella, M; Matucci Cerinic, M; Medea, G; Minisola, G; Prevete, I; Punzi, L; Ramonda, R; Scirè, CA; Spadaro, A, 2013) |
| "Gout is an abnormality in the body resulting in the accumulation of uric acid mainly in joints." | ( Chandra, MS; Krishnan, UM; Muthukoori, S; Narayanan, N; Sethuraman, S, 2013) |
| "Gout is a common form of inflammatory arthritis with an increasing prevalence in developed countries." | ( Franklin, JM; Kim, SC; Liu, J; Schmidt, BM; Schneeweiss, S; Solomon, DH, 2013) |
| "Gout is a major health problem in Polynesians and allopurinol, the drug of choice for the management gout, appears to be less effective in Polynesian patients." | ( Black, MA; Cadzow, M; Dalbeth, N; Harrison, AA; Jones, PB; Merriman, TR; Roberts, RL; Stamp, LK; Wallace, MC; Wright, DF, 2014) |
| "Gout is a common condition which is mainly treated with the hypo-uricemic agent, allopurinol." | ( Yeo, SI, 2013) |
| "Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels." | ( Chiba, T; Hamajima, N; Hishida, A; Ichida, K; Inoue, K; Kato, Y; Kawai, S; Matsuo, H; Nakamura, T; Nakashima, H; Nakayama, A; Ogata, H; Sakiyama, M; Sakurai, Y; Shimizu, S; Shimizu, T; Shinomiya, N; Takada, T; Takada, Y; Ushiyama, C; Wakai, K, 2013) |
| "Gout is an ancient autoinflammatory disease that affects millions of people worldwide." | ( Qiao, L; Zhai, Y; Zhong, Z, 2013) |
| "Gout is a growing health problem worldwide especially in affluent countries, such as Australia." | ( Merriman, TR; Robinson, PC; Taylor, WJ, 2012) |
| "If tophaceous gout is suspected, alcohol fixation of the biopsy specimen is preferable, as it enables visualization of characteristic needle-shaped urate crystals." | ( Chabra, I; Singh, R, 2013) |
| "Gout is estimated to affect 1." | ( Cottrell, E; Crabtree, V; Edwards, JJ; Roddy, E, 2013) |
| "Chronic tophaceous gout is treated with dietary control and medication." | ( Chang, HJ; Hsu, YC; Huang, SH; Wang, PC, 2013) |
| "Gout is a common disease resulting from hyperuricemia which causes acute arthritis." | ( Chiba, T; Hamajima, N; Ichida, K; Inoue, H; Kanai, Y; Makino, T; Matsuo, H; Morita, E; Naito, M; Nakamura, T; Nakayama, A; Sakiyama, M; Sakurai, Y; Sato, J; Satoh, T; Shimizu, S; Shimizu, T; Shimono, K; Shinomiya, N; Suzuki, H; Takada, T; Takada, Y; Tatsukawa, S; Wakai, K, 2014) |
| "Acute gout is an auto-inflammatory disease characterized by self-limiting inflammation in response to the deposition of monosodium urate (MSU) crystals in the joints or tissues." | ( Harper, JL; Steiger, S, 2014) |
| "Gout is a common crystal-induced arthritis, in which monosodium urate (MSU) crystals precipitate within joints and soft tissues and elicit an inflammatory response." | ( Crittenden, DB; Martillo, MA; Nazzal, L, 2014) |
| "Gout is defined as an arthritic condition resulting from the deposition of monosodium urate (MSU) crystals in and/or around joints, following long-standing hyperuricemia." | ( Bardin, T; Richette, P, 2014) |
| "Gout is an important but certainly not an exclusive cause of arthritis of the first metatarsophalangeal joint." | ( Fransen, J; Janssen, M; Janssens, HJ; Kienhorst, LB; van de Lisdonk, EH, 2014) |
| "Gout is the most common inflammatory arthritis worldwide." | ( Doherty, M; Hui, M; Rees, F, 2014) |
| "Gout is often suboptimally managed." | ( Arroll, B; Reaves, E, 2014) |
| "Acute gout is traditionally treated with NSAIDs, corticosteroids, and colchicine; however, subjects have multiple comorbidities that limit the use of some conventional therapies." | ( Bae, S; Berrocal, V; FitzGerald, JD; Gladue, HS; Gogia, M; Kaldas, M; Khanna, D; Khanna, PP; Prakash, S; Singh, MK; Terkeltaub, R; Townsend, W, 2014) |
| "Gout is currently one of the most common causes of inflammatory arthritis in most industrialised countries." | ( Bocale, R; Desideri, G; Ferri, C; Grassi, D; Pontremoli, R, 2014) |
| "Gout is a common disorder with clinical signs and symptoms resulting from inflammatory responses to monosodium urate crystals deposited in tissues from extracellular fluids saturated for urate." | ( Becker, MA; Chaichian, Y; Chohan, S, 2014) |
| "Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals." | ( Bilyy, R; Frey, B; Harrer, T; Herrmann, M; Hoffmann, M; Holmdahl, R; Janko, C; Jeremic, I; Kienhöfer, D; Krenn, V; Lell, M; Manger, B; Munoz, LE; Naschberger, E; Rech, J; Schauer, C; Schett, G; Zhao, Y, 2014) |
| "Gout is a common inflammatory arthritis precipitated by an inflammatory reaction to urate crystals in the joint." | ( Horsburgh, S; Robinson, PC, 2014) |
| "Gout is one of the most common forms of arthritis." | ( Barclay, ML; Dalbeth, N; Merriman, TR; Roberts, RL; Singh, JA; Stamp, LK; Wright, DF, 2014) |
| "Gout is one of the most common rheumatic diseases worldwide." | ( Aletaha, D; Buchbinder, R; Schlesinger, N; van Echteld, I; Wechalekar, MD, 2014) |
| "Gout is increasingly seen in the elderly population, in large part due to physiological decline in renal function with age, and as a result of therapy for comorbidities, in particular the use of diuretic therapies for hypertension and congestive heart failure." | ( Chapman, PT; Stamp, LK, 2014) |
| "Gout is commonly associated with excesses in soluble urate and in nutrition, both of which suppress tissue AMPK activity." | ( Liu-Bryan, R; Terkeltaub, R; Viollet, B; Wang, Y, 2016) |
| "Gout is the most common inflammatory arthritis in the United States." | ( Choi, HK; Jutkowitz, E; Kuntz, KM; Pizzi, LT, 2014) |
| "Gout is a metabolic disorder associated with hyperuricemia resulting in the deposition of monosodium urate (MSU) crystals in joints and tissues." | ( Cao, L; Ding, G; Guo, CR; Huang, WZ; Meng, ZQ; Tang, ZH; Wang, KD; Wang, ZZ; Xiao, W; Yan, YX; Yang, ZL, 2014) |
| "Gout is a common inflammatory arthritis affecting almost 6% of US males and 2% of US females." | ( Dalbeth, N; Robinson, PC, 2015) |
| "Gout is a rheumatologic condition associated with elevated serum uric acid levels and deposition of monosodium urate crystals in joints and soft tissues." | ( Bridgeman, MB; Chavez, B, 2015) |
| "Gout is characterized by painful joint inflammation, most commonly in the first metatarsophalangeal joint, resulting from precipitation of monosodium urate crystals in a joint space." | ( Hainer, BL; Matheson, E; Wilkes, RT, 2014) |
| "Gout is associated with comorbidities such as nephrolithiasis, chronic renal impairment, metabolic syndrome, depression and heart disease." | ( Doherty, M; Rees, F, 2014) |
| "Gout is a chronic inflammatory condition associated with poor urate metabolism." | ( Bottorff, MB; Gandhi, PK; Gentry, WM; Ma, Q, 2015) |
| "Hyperuricemia and gout are associated with an increased risk of cardiovascular disease (CVD)." | ( Choudhry, N; Glynn, RJ; Kim, SC; Liu, J; Schneeweiss, S; Solomon, DH, 2015) |
| "Gout is one of the most common forms of arthritis and the prevalence is increasing." | ( Roberts, RL; Stamp, LK, 2015) |
| "Gout is a metabolic disorder that results in hyperuricemia and the deposition of positively birefringent monosodium urate crystals in various parts of the body." | ( Fayyaz, AF; Kamyabi-Moghaddam, Z; Mokarizadeh, A; Nasoori, A; Pedram, B; Pirasteh, H; Shooshtari, MB, 2015) |
| "Gout is a chronic metabolic disease caused by disturbance of purine metabolism that leads to hyperuricemia." | ( Akdur, A; Ayvazoglu Soy, EH; Haberal, M; Karakaya, E; Karatas Togral, A; Moray, G, 2015) |
| "Gout is not recorded as an adverse event in product information for either medicine." | ( Chan, EW; Choi, NK; Kao Yang, YH; Kimura, M; Kimura, T; Kubota, K; Lai, EC; Man, KK; Ooba, N; Park, BJ; Pratt, N; Roughead, EE; Sato, T; Shin, JY; Wong, IC, 2015) |
| "Gout is a common inflammation disease resulting from an increase in serum uric acid." | ( Dong, Z; He, H; Ji, H; Jin, L; Ma, Y; Pang, Y; Qian, Q; Wang, J; Wang, X; Xu, X; Yang, C; Yang, Y; Zhao, D; Zhou, J; Zou, H, 2015) |
| "Gout is a disorder of purine metabolism that primarily occurs in adult males." | ( Ferrara, LR; Saccomano, SJ, 2015) |
| "Gout is a common clinical problem encountered by both general and specialist clinicians." | ( Graf, SW; Ting, K; Whittle, SL, 2015) |
| "Gout is managed poorly in Australian primary care, with low levels of allopurinol prescribing and serum urate testing." | ( Dalbeth, N; Robinson, PC; Taylor, WJ, 2015) |
| "Gout is an inflammatory arthritis characterised by hyperuricemia, which, if poorly controlled, can lead to the development of tophi." | ( Filanovsky, MG; McNamara, MC; Sukhdeo, K, 2015) |
| "Gout is a consequence of an innate immune reaction to monosodium urate crystals deposited in joints." | ( Cadzow, M; Dalbeth, N; Flynn, TJ; Hindmarsh, JH; Jones, PB; Merriman, TR; Stamp, LK; Todd, AS; Topless, R; Walker, RJ, 2015) |
| "Gout is a potentially destructive inflammatory disorder occurring in the setting of hyperuricaemia and urate crystal deposition in tissue." | ( Jørgensen, SH; Knudsen, ET; Rasmussen, C, 2015) |
| "Gout is an acute inflammatory disease characterised by the presence of uric acid crystals in the joint." | ( Amaral, FA; Galvão, I; Martins, FS; Nicoli, JR; Teixeira, MM; Vieira, AT, 2015) |
| "Although gout is potentially curable with long-term urate lowering therapy, confusion about the details of urate measurement has contributed to suboptimal care." | ( Arroll, B; Boswell, DR; Dalbeth, N; Gow, PJ; Lindsay, K; Stamp, LK; Te Karu, L; Winnard, D, 2015) |
| "Given that gout is common in patients with renal impairment, clinicians need to be aware of the relationships between serum urate and kidney function as well as the effects of allopurinol on kidney function and vice versa." | ( Chapman, PT; Palmer, SC; Stamp, LK, 2016) |
| "Gout is a chronic disease of monosodium urate (MSU) crystal deposition." | ( Chhana, A; Dalbeth, N; Lee, G, 2015) |
| "Gout is a common metabolic disorder characterized by hyperuricemia and chronic inflammation." | ( Chang, PJ; Chang, ST; Chen, MC; Chung, CM; Lin, CL; Lin, JC; Pan, KL, 2015) |
| "Gout is a chronic, extremely painful disease that is potentially curable when treated effectively." | ( Baumgartner, S; Doghramji, PP; Fermer, S; Morlock, R; Wood, R, 2016) |
| "Gout is a common entity; yet it is such a great mimicker in its imaging features that it can confuse clinicians and radiologists alike, sometimes leading to unnecessary investigations and treatment." | ( Eide, SE; Khor, YM; Seet, JE; Sia, DS, 2015) |
| "Patients with gout are more likely to develop most cancers than subjects without gout." | ( Chang, SJ; Hsieh, MC; Kuo, MC, 2015) |
| "The prevalence of gout is increasing, but it is only partially clear that the incidence may be increasing as well." | ( Carmona-Ortells, L; Perez-Ruiz, F; Urionagüena, I, 2016) |
| "Gout is a metabolic disease, which is characterized by acute or chronic arthritis, and deposition of monosodium urate crystals in joint, bones, soft tissues, and kidneys." | ( Abourazzak, FZ; Aradoini, N; Berrada, K; Harzy, T; Talbi, S, 2015) |
| "Hyperuricaemia and gout are well-recognized complications of diuretic use." | ( Dalbeth, N; Franklin, C; Horne, A; Merriman, TR; Mitnala, S; Phipps-Green, A; Stamp, LK, 2016) |
| "Flares of gout are often caused by large meals and high alcohol consumption." | ( Kiss, C; Nickolai, B, 2016) |
| "Gout is a clinical disorder that is characterized by the deposition of monosodium urate crystals (MSU) in joints and tendons, usually in the presence of prolonged hyperuricaemia." | ( Ao, J; Casson, RJ; Goldblatt, F, 2017) |
| "Gout is a true crystal deposition arthropathy caused by the precipitation of monosodium urate into joints and periarticular soft tissues." | ( Fishman, EK; Fritz, J; Fuld, MK; Henes, JC; Horger, MS, 2016) |
| "Gout is the most common type of inflammatory arthritis and is largely managed in primary care." | ( Bevis, M; Marshall, M; Rathod, T; Roddy, E, 2016) |
| "Gout is associated with dyslipidaemia." | ( Dalbeth, N; Harrison, AA; Hill, C; Jansen, TL; Janssen, M; Jones, GT; Joosten, LA; Lester, S; Lioté, F; McCormick, SP; Merriman, TR; Phipps-Green, AJ; Radstake, TR; Rasheed, H; Riches, PL; Rischmueller, M; Smith, MD; So, A; Stamp, LK; Tausche, AK; Topless, R; van Rij, A, 2016) |
| "Gout is the most common inflammatory arthropathy in the western world." | ( Keenan, RT; Schlesinger, N, 2016) |
| "Gout is a common inflammatory arthritis among middle-aged men and postmenopausal women and can be a debilitating disease." | ( Schlesinger, N; Sharon, Y, 2016) |
| "Gout is a common problem that is increasing in prevalence in Australia." | ( Robinson, PC; Stamp, LK, 2016) |
| "Gout is characterized by the monosodium urate monohydrate (MSU)-induced arthritis." | ( Chang, JG; Chen, CL; Chiang, SL; Huang, CM; Ko, AM; Ko, YC; Kuo, TM; Lee, CP; Liu, YF; Lu, CY; Ma, C; Tsai, EM, 2016) |
| "Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression." | ( Feng, T; Geng, TT; He, N; Jin, TB; Kang, LL; Liu, K; Liu, LJ; Shi, XG; Yuan, DY; Zhang, XY, 2016) |
| "Gout is the most common inflammatory arthropathy of metabolic origin and it is characterized by intense inflammation, the underlying mechanisms of which are unknown." | ( Camacho-Galindo, J; Cerna-Cortés, JF; Fernández-Torres, J; Gutierrez, M; Hernández-Díaz, C; Loissell-Baltazar, YA; López-Macay, A; López-Reyes, A; López-Villegas, EO; Martínez-Flores, K; Medina-Luna, D; Oliviero, F; Pineda, C; Santamaría-Olmedo, MG; Scanu, A; Zamudio-Cuevas, Y, 2016) |
| "Gout is a chronic disease characterized by the deposition of urate crystals in the joints and throughout the body, caused by an excess burden of serum uric acid (sUA)." | ( Gahn, JC; Mitri, G; Shiozawa, A; Smolen, LJ, 2016) |
| "The prevalence of gout is rising and is likely attributed to several factors including increased incidence of comorbidities, lifestyle factors, and increased use of causative medications." | ( Saseen, JJ; Wilson, L, 2016) |
| "Gout is a form of crystal arthropathy where monosodium urate (MSU) crystals deposit and elicit inflammation in a joint." | ( Fitzgerald, J; Furst, D; Lee, SY; Ozcan, A; Zhang, Y, 2016) |
| "BACKGROUND Gout is characterized by deposition of uric acid crystals (monosodium urate) in tissues and fluids." | ( Christensen, HD; Hansen, IM; Morillon, MB; Sheta, HM, 2016) |
| "Gout is an inflammatory arthritis caused by deposition of monosodium urate crystals within synovial joints." | ( Beyl, RN; Hughes, L; Morgan, S, 2016) |
| "Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints." | ( Amaral, FA; Galvão, I; Garcia, CC; Macia, LM; Mackay, CR; Martins, FS; Sernaglia, ÉM; Sousa, LP; Tavares, LP; Teixeira, MM; Vieira, AT; Vinolo, MA, 2017) |
| "Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints." | ( Amaral, FA; Galvão, I; Garcia, CC; Macia, LM; Mackay, CR; Martins, FS; Sernaglia, ÉM; Sousa, LP; Tavares, LP; Teixeira, MM; Vieira, AT; Vinolo, MA, 2017) |
| "Gout is a progressive, painful, debilitating form of inflammatory arthritis." | ( Edwards, NL; Ruoff, G, 2016) |
| "Gout is the most common inflammatory arthritis, which, if left untreated or inadequately treated, will lead to joint destruction, bone erosion and disability due to the crystal deposition." | ( Liu, W; Liu, Y; Shang, Q; Tang, L; Wang, J; Wu, J; Xie, Y; Xu, W; Zhang, X; Zhao, G; Zhou, Z, 2017) |
| "Gout is the most common inflammatory arthritis in men over 40 years of age." | ( Christensen, R; Dalbeth, N; Fransen, J; Lassere, M; Morillon, MB; Singh, JA; Stamp, L; Taylor, W, 2016) |
| "Gout is a chronic disease with a high burden of pain and inflammation." | ( Bardin, T; Braun, J; Cohen Solal, A; da Rocha Castelar-Pinheiro, G; Dalbeth, N; Doherty, M; Engel, B; Flader, C; Kay, J; Kiltz, U; Matsuoka, M; Perez-Ruiz, F; Saag, K; Smolen, J; So, A; Vazquez Mellado, J; Weisman, M; Westhoff, TH; Yamanaka, H, 2017) |
| "Gout is a systemic disorder characterized by hyperuricemia and recurrent arthritis, most involvement of ankles, midfoot joint and first metatarsophalangeal joint, with monosodium urate crystals deposition in synovial fluid and other tissues." | ( Chiang, CP; Hung, TL; Wang, WM, 2016) |
| "Although gout is potentially curable, the management of this disease is often suboptimal." | ( Balcı, MA; Balkarlı, A; Çobankara, V; Gök, K; Kaya, A; Kimyon, G; Kısacık, B; Küçük, A; Mercan, R; Onat, AM; Öztürk, MA; Pamuk, Ö; Şahin, Ş; Sayarlıoğlu, M; Şenel, S; Tezcan, ME; Tufan, A; Üreten, K; Yıldırım Çetin, G, 2016) |
| "Gout is caused by the overproduction of uric acid and the inefficient metabolism of dietary purines in humans." | ( Aslan, K; Bonyi, E; Boone-Kukoyi, Z; Kioko, B; Lansiquot, C; Ozturk, B; Shortt, R; Thompson, N; Toker, S, 2016) |
| "Gout is a common type of inflammatory arthritis in patients seen by primary care physicians." | ( FitzGerald, JD; Han, D; Motala, A; Newberry, SJ; O'Hanlon, CE; Okunogbe, A; Shanman, R; Shekelle, PG; Tariq, A, 2017) |
| "Gout is the most common inflammatory arthritis in adults in the Western world." | ( Singh, JA, 2016) |
| "Arthritic gout is caused by joint inflammation triggered by the damaging effects of monosodium uric acid (MSU) crystal accumulation in the synovial space." | ( Rada, B; Sil, P; Surell, C; Wicklum, H, 2017) |
| "Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals." | ( Liang, M; Liu, L; Wang, J; Xuan, D; Xue, Y; Yang, X; Zhang, J; Zhu, X; Zhu, Y; Zou, H, 2016) |
| "Gout is associated with cardiovascular diseases, and systemic inflammation has a role in this." | ( Jacobs, J; Janssen, M; Janssens, H; Kienhorst, L; Radstake, T; van Koolwijk, E; van Lochem, E; van Riel, P, 2017) |
| "Although gout is one of the most common forms of inflammatory arthritis, it has been relatively neglected until recently." | ( Stamp, LK, 2017) |
| "Gout is the most common inflammatory arthritis in men and is increasingly prevalent." | ( Carland, JE; Day, RO; Graham, GG; Kannangara, DR; Stocker, SL; Williams, KM, 2017) |
| "Gout is a common debilitating form of arthritis and despite our extensive knowledge on the pathogenesis its prevalence is still rising quickly." | ( Cleophas, MC; Crişan, TO; Joosten, LA, 2017) |
| "Gout is a self-limited inflammatory disease caused by deposition of monosodium urate (MSU) crystals in the joints." | ( Amaral, FA; Barroso, LC; Carneiro, FS; Costa, VV; Ferreira, TP; Galvão, I; Queiroz-Junior, CM; Silva, PM; Sousa, LP; Tavares, LP; Teixeira, MM; Vago, JP, 2017) |
| "Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available." | ( Aviña-Zubieta, JA; Choi, HK; De Vera, MA; McCormick, N; Rai, SK; Sayre, EC; Shojania, K, 2017) |
| "Gout is a painful disorder which does not have an efficient delivery system for its treatment." | ( Kaithwas, G; Kanoujia, J; Parashar, P; Saraf, SA; Singh, N; Tripathi, CB, 2017) |
| "Gout is often poorly managed for several reasons, including a lack of adherence to treatment guidelines by health care providers, patients' poor adherence to therapy, and differences between a provider's and patient's perspectives regarding treatment." | ( Keenan, RT, 2017) |
| "Gout is the most common inflammatory arthritis in humans." | ( Schlesinger, N, 2017) |
| "Gout is closely associated with the metabolic syndrome and is an independent risk factor for cardiovascular mortality." | ( Bertsch, T; Bollheimer, LC; Härle, P; Schlee, S; Sieber, CC, 2018) |
| "The treatment of gout is based on several principles." | ( Bertsch, T; Bollheimer, LC; Härle, P; Schlee, S; Sieber, CC, 2018) |
| "Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout." | ( Dong, Z; He, H; Ji, H; Jiang, S; Jin, L; Li, Y; Ma, Y; Pang, Y; Wang, J; Wang, X; Wang, Y; Xu, X; Yang, C; Yang, Y; Zhao, D; Zhou, J; Zou, H, 2017) |
| "Both diabetes and gout are risk factors for cardiovascular disease." | ( Curtis, JR; Ramachandaran, R; Singh, JA; Yu, S, 2017) |
| "Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain." | ( Fan, YX; Gui, X; Han, Y; Hu, L; Jiang, CY; Liu, BQ; Liu, HJ; Liu, WT; Pan, XX; Tang, YL, 2017) |
| "Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1." | ( Gunic, E; Liu, S; Miner, JN; Tan, PK, 2017) |
| "Gout is one of the few rheumatological diseases that can be cured." | ( Bleckwenn, M; Engel, B; Just, J; Weckbecker, K, 2017) |
| "The prevalence of gout is rising around the world." | ( Bleckwenn, M; Engel, B; Just, J; Weckbecker, K, 2017) |
| "Gout is one of the most painful types of arthritis that arises when the body mounts an acute inflammatory reaction against a crystallized form of uric acid known as monosodium urate crystals (MSUs)." | ( Fernandes, M; Lachhab, A; Marceau, F; Naccache, PH; Paré, G; Pelletier, M; Rousseau, LS; Tessier, P, 2017) |
| "Tophaceous gout is painful and impairs quality of life." | ( Crittenden, DB; Gyftopoulos, S; Karis, E; Keenan, RT; Krasnokutsky, S; Lee, K; Modjinou, DV; Pike, VC; Pillinger, MH; Samuels, J, 2017) |
| "Gout is an inflammatory arthritis characterized by red, tender, hot and tumid joints." | ( Chen, J; Li, X; Qiao, Y; Wang, J; Wu, M; Yang, J, 2017) |
| "Gout is a chronic disease resulting from elevated serum urate (SU)." | ( Chen, J; Cheng, X; Cui, L; Han, L; Hou, X; Ji, J; Jia, Z; Li, C; Li, X; Li, Z; Liu, T; Liu, Z; Lu, D; Lu, J; Ma, L; Mi, QS; Ren, W; Shi, Y; Wang, C; Wang, X; Xin, Y; Yu, Q; Yuan, X; Zhang, K; Zhou, Z, 2017) |
| "Gout is a rheumatologic condition associated with elevated serum uric acid levels and deposition of monosodium urate crystals in joints and soft tissues." | ( Abazia, DT; Bridgeman, MB; Soskind, R, 2017) |
| "Gout is the most common form of inflammatory arthropathy and is caused by an excess of uric acid in the blood (hyperuricemia)." | ( Punzi, L, 2017) |
| "Gout is a common disease responsible for recurrent flares triggered by the deposition of monosodium urate crystals secondary to longstanding hyperuricaemia." | ( Pascart, T; Richette, P, 2017) |
| "Management of gout is frequently suboptimal." | ( Chapman, PT; Frampton, C; O'Donnell, JL; Raja, R; Stamp, LK; Wright, S, 2017) |
| "Gout is linked to monosodium urate crystals." | ( Badr, S; Cotten, A; Jacques, T; Larkman, N; Lefebvre, G; Michelin, P; Nasuto, M, 2017) |
| "Gout is the most common form of inflammatory arthritis in the United States." | ( Aslam, F; Michet, C, 2017) |
| "Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient." | ( Brusco, I; Camponogara, C; de Carvalho, LM; Faccin, H; Fischer, SPM; Gobo, LA; Oliveira, SM; Piana, M, 2018) |
| "Gout is both an inflammatory and a metabolic disease." | ( Krasnokutsky, S; Pillinger, MH; Thottam, GE, 2017) |
| "Gout is increasing despite effective therapies to lower serum urate concentrations to 0." | ( Aung, E; Baysari, MT; Braithwaite, J; Buchbinder, R; Clay-Williams, R; Coiera, E; Day, RO; Frensham, LJ; Hunter, DJ; Laba, T; Lau, AYS; Li, L; McLachlan, A; McNeil, HP; Nguyen, AD; Pile, KD; Portek, I; Reath, J; Runciman, WB; Westbrook, JI; WIlliams, KM; Zwar, N, 2017) |
| "Gout is the most common type of inflammatory arthritis in adults with rising incidence and prevalence." | ( Denisova, K; Lazzaro, DR; Mechel, E; Rizzuti, AE; Yazdanyar, A, 2018) |
| "Gout is a multifactorial disease characterized by acute inflammatory arthritis, and it is caused as a consequence of hyperuricemia." | ( Higashino, T; Hishida, A; Imaki, J; Kawaguchi, M; Komatsu, M; Matsuo, H; Nakashima, H; Nakatochi, M; Nakayama, A; Okada, Y; Ooyama, H; Sakiyama, M; Shimizu, S; Shinomiya, N; Tadokoro, S, 2018) |
| "Gout is a common form of inflammatory arthritis caused by deposition of monosodium urate crystals." | ( Dalbeth, N; Robinson, PC, 2017) |
| "Spinal column gout is unknown, but seems to occur with some regularity." | ( Masteling-Slaats, MG; Schipper, LG; Snijders, GF; van Leuven, SI, 2017) |
| "Relapse of gout is common although delayed after discontinuation of ULT." | ( Beslon, V; Fournier, JP; Giraudeau, B; Maisonneuve, H; Maruani, A; Moreau, P, 2018) |
| "Gout is common in the elderly, affecting an estimated 4." | ( Abhishek, A, 2017) |
| "The aetiology of gout is closely linked to the deposition of monosodium uric acid (MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome." | ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Yang, G; Yeon, SH, 2018) |
| "Gout is an inflammatory disease manifested by the deposition of monosodium urate (MSU) crystals in joints, cartilage, synovial bursa, tendons or soft tissues." | ( Chen, DY; Chen, JH; Chen, SM; Chen, SY; Cheng, TT; Hsieh, SC; Hsieh, TY; Hsu, PF; Kuo, CF; Kuo, MC; Lam, HC; Lee, IT; Liang, TH; Lin, HY; Lin, SC; Tsai, WC; Tsai, WP; Tsay, GJ; Wei, JC; Yang, CH; Yu, KH, 2018) |
| "Patients with gout are at an increased risk of cardiovascular (CV) disease including myocardial infarction (MI), stroke, and heart failure (HF)." | ( Desai, RJ; Kang, EH; Kim, SC; Liu, J; Neogi, T; Solomon, DH; Zhang, M, 2018) |
| "Gout is a painful disorder and is common in type 2 diabetes." | ( Ansquer, JC; Best, JD; Buizen, L; d'Emden, MC; Davis, TME; Feher, MD; Flack, J; Foucher, C; Gebski, V; Hedley, J; Jenkins, AJ; Keech, AC; Kesaniemi, YA; Li, L; McGill, N; Scott, RS; Sullivan, DR; Waldman, B, 2018) |
| "Gout is the most common inflammatory arthritis affecting men." | ( Ashimbayeva, E; Astin, JW; Britto, D; Crosier, KE; Crosier, PS; Dalbeth, N; Hall, CJ; Harper, JL; Lawrence, LM; Lieschke, GJ; Pool, B; Sanderson, LE; van der Kroef, M, 2018) |
| "Gout is a disabling and common arthritis with increasing prevalence." | ( Gudbjornsson, B; Johannsdottir, GA; Jonsson, H; Palsson, O, 2018) |
| "Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint." | ( Hu, Q; Li, S; Liu, W; Song, L; Zhou, M, 2018) |
| "Gout is the most common inflammatory arthritis and is increasing in relevance due to its rising prevalence and incidence." | ( Garner, HW; Wessell, DE, 2018) |
| "Gout is a common inflammatory arthritis caused by the deposition of urate crystals within joints." | ( Li, Y; Liu, X; Peng, J; Zhang, L; Zhou, Y; Zuo, Z, 2018) |
| "Gout is associated with higher cardiovascular risk that increases with disease severity." | ( Budzik, JF; Capon, B; Ducoulombier, V; Godart, C; Grandjean, A; Houvenagel, E; Legrand, J; Luraschi, H; Motte, M; Namane, N; Norberciak, L; Pascart, T; Vandecandelaere, M, 2018) |
| "To assess whether gout is associated with a higher or lower risk of a new diagnosis of giant cell arteritis (GCA) in older adults, adjusting for known risk factors of GCA." | ( Cleveland, JD; Singh, JA, 2019) |
| "Hyperuricemia and gout are associated with an increased risk of cardiovascular disease." | ( Desai, RJ; Kang, EH; Kim, SC; Liu, J; Neogi, T; Solomon, DH; Zhang, M, 2018) |
| "Gout is a systemic disease, characterized by the formation and deposition of crystals in tissues (mainly in and around the joints) of individuals with elevated serum uric acid levels." | ( Angelidis, C; Deftereos, S; Giannopoulos, G, 2019) |
| "Gout is one of the most common inflammatory arthropathies, and the pathogenesis is well understood." | ( Arnold, MH; Rogenmoser, S, 2018) |
| "To examine whether gout is an independent risk factor for total joint replacement (TJR) and whether urate-lowering treatment (ULT) reduces this risk." | ( Chen, JS; Chou, IJ; Doherty, M; Hsieh, AH; Kuo, CF; Luo, SF; See, LC; Yu, KH; Zhang, W, 2018) |
| "Providers of gout care need to be cognizant of these goals." | ( Singh, JA, 2018) |
| "Gout is an inflammatory disease affecting multiple joints." | ( Chu, C; Lin, C; Song, P; Wu, Y; Xu, Q; Yang, Y, 2018) |
| "Gout is the most common arthritic disease in human but was long neglected and therapeutic options are not satisfying." | ( Gellrich, L; Goebel, T; Heering, J; Heitel, P; Kahnt, A; Merk, D; Proschak, E; Schubert-Zsilavecz, M, 2018) |
| "Nurse-led gout care is efficacious and cost-effective compared with usual care." | ( Abhishek, A; Ashton, D; Barclay, C; Doherty, M; Doherty, S; Duley, L; Hatton, R; Jenkins, W; Rees, F; Richardson, H; Sarmanova, A; Stevenson, M; Zhang, W, 2018) |
| "Gout is one of the most common inflammatory arthritis in Malaysia." | ( Amanda Jane, PG; Mahfudzah, A; Nazihah, MY; Tan, HL; Tony Richard, M; Wan Rohani, WT; Wan Syamimee, WG, 2018) |
| "Gout is an increasingly common chronic disorder of urate crystal deposition that manifests as flares of acute inflammatory arthritis." | ( Robinson, PC, 2018) |
| "Gout is a chronic disease associated with deposition of monosodium urate crystals and accompanied by diabetes, hypertension, and dyslipidemia." | ( Choi, Y; Jung, JY; Kim, HA; Suh, CH; Yoon, D, 2018) |
| "Gout is experienced by approximately one in four adults treated with dialysis and two-thirds are prescribed allopurinol." | ( Chapman, PT; Frampton, C; Palmer, SC; Stamp, LK; Yeo, E, 2019) |
| "Gout is the most common inflammatory arthritis in the Dutch general practice population and is often managed with long-term uric acid lowering treatment." | ( Bierma-Zeinstra, SMA; Bindels, PJE; Bohnen, AM; Jacobs, ML; Janssens, HJEM; Koffeman, AR; van Der Lei, J; van Leeuwen, KDB, 2018) |
| "Gout is a chronic disease, characterised by deposition of monosodium urate crystals in joints and tissues." | ( Hondebrink, LLC; Opstelten, W, 2018) |
| "Gout is the most common form of inflammatory arthritis." | ( Burns, RB; Shmerling, RH; Smith, CC; Tess, A, 2018) |
| "Gout is a common disease in clinical practice,usually combined with metabolic syndrome,chronic renal failure and specific drugs using (diuretic and calcineurin inhibitors)." | ( Hao, YJ; Ji, LL; Zhang, ZL, 2018) |
| "Gout is associated with the risk of cardiovascular morbidity and mortality, but the biological relationship between the two remains uncertain." | ( Abeles, AM; Pillinger, MH, 2019) |
| "Gout is independently associated with increased risk of type 2 diabetes mellitus (T2DM)." | ( Chang, HW; Lan, YC; Lin, MH; Lin, YW; Wang, RY, 2019) |
| "Gout is a monosodium urate deposition disease which is prevalent worldwide." | ( Cheong, YK; Chin, WV; Jobli, AT; Tan, BB; Teh, CL; Wan, SA, 2019) |
| "Gout is a crystal-related arthropathy resulting from the deposition of monosodium urate." | ( Wang, X; Wang, YG, 2020) |
| "Gout is a common inflammatory arthritis associated with adverse clinical outcomes." | ( Adeeb, F; Browne, LD; Fraser, AD; Kumar A U, A; Mohammed, E; Stack, AG, 2019) |
| "Gout is common in CKD and increases with worsening kidney function in the Irish health system." | ( Adeeb, F; Browne, LD; Fraser, AD; Kumar A U, A; Mohammed, E; Stack, AG, 2019) |
| "Gout is a disease characterized by abnormal metabolism of the uric acid, leading to undesired buildup of monosodium urate crystals affecting mainly the first metatarsal-phalangeal joint of the foot and less commonly other joints or the soft tissues of the body." | ( IIliev, G; Ivanova, PP; Nedev, P; Popov, H, 2019) |
| "Gout is a disease driven solely by IL-1β secretion in response to monosodium urate (MSU) crystals which form during periods of hyperuricemia and thus presents an opportunity to study factors contributing to IL-1β secretion." | ( Alberts, BM; Basnayake, K; Bruce, C; Davies, KA; Ghezzi, P; Mullen, LM, 2019) |
| "Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases." | ( Broen, JCA; Jansen, M; Merriman, T; Ottria, A; Phipps-Green, A; Radstake, TRDJ; Schuiveling, M; van der Linden, M; van Lochem, E; Vazirpanah, N; Wichers, CGK; Zimmermann, M, 2019) |
| "However, gout is associated with an increased risk of fractures (RR, 1." | ( Hu, Y; Huang, J; Wang, T; Zhang, Q; Zhang, X; Zong, Q, 2019) |
| "Gout is associated with a higher risk of atrial fibrillation (AF)." | ( Cleveland, JD; Singh, JA, 2019) |
| "To assess if gout is associated with a higher risk of incident chronic pain." | ( Cleveland, JD; Singh, JA, 2019) |
| "Gout is one of the most common metabolic disorders in human." | ( Chen, J; Duan, L; Rao, X; Razavi, M; Tao, Y; Wei, Y; Zhong, J, 2019) |
| "Spinal gout is rarely encountered in clinical practice, is easily misdiagnosed, and often remains undiagnosed." | ( An, Q; Gu, R; Jiang, R; Ma, S; Zhao, J, 2019) |
| "Acute gout is an inflammatory response to MSU crystals." | ( Liu, L; Xue, Y; Yu, Y; Zhao, T; Zhu, X; Zou, H, 2019) |
| "People with gout are at an increased risk of readmission for heart failure and have longer hospital stays." | ( Doughty, RN; Drake, J; Frampton, C; Richards, AM; Stamp, LK; Troughton, RW, 2019) |
| "Gout is a common inflammatory disease, and the prevalence of gout in men is significantly higher than in women." | ( Chen, Y; Duan, S; Ying, X; Zheng, Z, 2019) |
| "Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed." | ( Bardin, T; Barskova, V; Becce, F; Castaneda, J; Coyfish, M; Doherty, M; Guillo, S; Jansen, T; Janssens, H; Lioté, F; Mallen, CD; Nuki, G; Pascual, E; Perez-Ruiz, F; Pimentao, J; Punzi, L; Pywell, A; Richette, P; So, AK; Tausche, AK; Tubach, F; Uhlig, T; Zavada, J; Zhang, W, 2020) |
| "Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues." | ( Cho, YY; Kang, HC; Lee, HE; Lee, HS; Lee, JY; Park, YB; Yang, G, 2019) |
| "Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation." | ( He, YL; Mi, QS; Yang, QB; Zhang, QB; Zhou, JG, 2019) |
| "Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout." | ( Belcher, J; Evans, PL; Hay, CA; Mallen, CD; Prior, JA; Roddy, E, 2019) |
| "Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals." | ( Chen, H; Chen, S; Liu, F; Lu, J; Ma, Y; Zhang, M, 2019) |
| "Acute gout is among the most painful inflammatory arthritides and a frequent cause of emergency department (ED) visits." | ( Dalal, DS; Hilliard, R; Mbuyi, N; Reginato, A; Reinert, S; Shah, I, 2020) |
| "Gout is a common metabolic disease in humans, and it is due to persistently elevated levels of uric acid in the blood." | ( Chen, J; Duan, L; Fu, Q; Li, Y; Luo, J; Shang, K; Wang, Y; Wei, Y, 2019) |
| "Gout is common crystal arthritis that is often managed sub-optimally." | ( Bavanendrakumar, M; Robinson, PC, 2020) |
| "Gout is associated with elevated risk of CKD progression." | ( Blak, B; Carpenter, L; Johnson, ME; Klein, A; Maguire, AR; Morlock, R; Parsons, VL; Stack, AG, 2019) |
| "Gout is characterized by high serum uric acid (SUA) levels and arthritis." | ( Kaushal, S; Koura, A; Lim, B; Oo, AM; Rao, J; Syn, N; Yeo, C; Yeo, D, 2019) |
| "Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition." | ( Choi, HK; Dalbeth, N; Joosten, LAB; Khanna, PP; Matsuo, H; Perez-Ruiz, F; Stamp, LK, 2019) |
| "Gout is a type of inflammatory arthritis that can be complicated with bone erosion through several inflammatory factors." | ( Chen, Y; Gao, K; Ke, J; Li, Z; Ma, L; Xie, Y; Zhang, Q; Zhang, Y; Zhou, J, 2019) |
| "Gout is caused by deposition of monosodium urate crystals in joints when plasma uric acid levels are chronically elevated beyond the saturation threshold, mostly due to renal underexcretion of uric acid." | ( Birk, OS; Drabkin, M; Gurevich, E; Halperin, D; Kadir, R; Landau, D; Perez, Y; Wormser, O; Yogev, Y; Zalk, R; Zarivach, R; Zeller, L, 2019) |
| "Gout is a chronic inflammatory disease caused by precipitation of urate crystals in the joints, kidneys, and urinary tract." | ( Kuriyama, S, 2020) |
| "Gout is one of the most prevalent inflammatory rheumatic disease." | ( de Vries, R; Gerritsen, M; Heslinga, M; Nurmohamed, M; van Schaardenburg, D; Vedder, D; Walrabenstein, W, 2019) |
| "Gout is a crystalline-related arthropathy caused by the deposition of monosodium urate (MSU)." | ( Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M, 2020) |
| "Gout is a common complication of blood pressure management and a frequently cited cause of medication nonadherence." | ( Beach, JL; Davis, BR; Ishak, A; Juraschek, SP; Mukamal, KJ; Shmerling, RH; Simpson, LM, 2020) |
| "Gout is a common arthritis caused by monosodium urate crystals." | ( Anzai, N; Hasegawa, T; Jutabha, P; Kawai, Y; Kojima, K; Matsuo, M; Misawa, K; Mishima, E; Nagasaki, M; Ouchi, M, 2020) |
| "Gout is a prevalent and incapacitating disease triggered by the deposition of monosodium urate (MSU) crystals in joints, which are also massively infiltrated by neutrophils." | ( de Carvalho Oliveira, V; Dubois, CM; Isabel, M; Mayer, TZ; McDonald, PP; Sylvain-Prévost, S; Tatsiy, O, 2019) |
| "Gout is increasing in prevalence despite effective pharmacotherapies." | ( Aung, E; Coleshill, M; Day, R; Graham, G; Nguyen, A; Stocker, S, 2020) |
| "Gout is a metabolic disorder and one of the most common arthritic conditions." | ( Prom-Wormley, E; Roman, Y; Tiirikainen, M, 2020) |
| "Gout is characterised by severe interleukin (IL)-1-mediated joint inflammation induced by monosodium urate crystals." | ( Arts, P; Cavalli, G; Cleophas, MC; Crișan, TO; Dagna, L; Dalbeth, N; Dinarello, CA; Eisenmesser, EZ; Gilissen, C; Hindmarsh, JH; Hoischen, A; Jansen, TLTA; Janssen, M; Joosten, LA; Kim, S; Klück, V; Lelieveld, S; Merriman, TR; Netea, MG; Riches, P; Shaukat, A; Stamp, LK; Steehouwer, M; Tausche, AK; Van de Veerdonk, FL; van de Vorst, M; van Deuren, RC, 2020) |
| "Gout is the most common inflammatory arthritis and the worldwide incidence is increasing." | ( Cao, S; Chen, Z; Gu, J; Huang, Y; Jiang, Y; Lv, Q; Ou, J; Qi, J; Qiu, M; Tu, L; Wei, Q; Wu, J; Xiao, M; Zhang, X, 2020) |
| "Gout is an inflammatory arthropathy caused by the deposition of monosodium urate (MSU)." | ( Asano, T; Fujita, Y; Furuya, MY; Kawakami, A; Kozuru, H; Matsumoto, H; Matsuoka, N; Migita, K; Sato, S; Temmoku, J; Urano, T; Watanabe, H; Yatsuhashi, H, 2021) |
| "Gout is an inflammatory arthropathy caused by the deposition of monosodium urate (MSU)." | ( Asano, T; Fujita, Y; Furuya, MY; Kawakami, A; Kozuru, H; Matsumoto, H; Matsuoka, N; Migita, K; Sato, S; Temmoku, J; Urano, T; Watanabe, H; Yatsuhashi, H, 2021) |
| "Gout is a painful form of inflammatory arthritis associated with several comorbidities, particularly cardiovascular disease." | ( Barker, ME; Lamb, KL; Lynn, A; Russell, J, 2020) |
| "Gout is a chronic disease due to the deposition of monosodium urate microcrystals in joints and tissues." | ( Bernard, A; Oehler, E; Pascart, T; Scuiller, A, 2020) |
| "Gout is a common comorbidity among solid organ transplantation patients and is usually attributed to the use of cyclosporine." | ( Brigham, MD; Francis, K; Hadker, N; Johnson, RJ; Kent, JD; LaMoreaux, B; Lenco, MO; Li, JW; Mandell, BF; Milgroom, A; Miyasato, G; Radeck, LP; Sanchez, H; Wang, Z, 2020) |
| "Gout is the typical feature of GAstrV infection in goslings." | ( Bao, E; Lv, Y; Wu, W; Xu, R, 2020) |
| "Gout is the most common type of arthritis and is evoked by arousal of the inflammasome in the presence of urate crystals superponed on a dysmetabolism with urate accumulation." | ( Jansen, TL; Janssen, M, 2020) |
| "Gout is the most common form of inflammatory arthritis worldwide and its prevalence is rising." | ( di Gangi, S; Meier, R; Rosemann, T; Valeri, F; Zechmann, S, 2020) |
| "Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites." | ( Guo, C; Tian, Y; Wang, Q; Wu, M, 2020) |
| "Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes." | ( Andersson, K; Bjursell, M; Carnicelli, AP; Chiswell, K; Clare, R; Hedman, K; Lytle, B; Mentz, RJ; Pagidipati, N; Perl, S; Roe, MT; Vemulapalli, S, 2020) |
| "Gout is the most common inflammatory arthritis affecting 1." | ( Bai, XS; Cui, LL; He, YW; Li, CG; Li, XD; Qu, XJ; Sun, MS; Wang, C; Wang, M; Zhao, XD, 2021) |
| "Patients with gout are at increased risk of MI, and colchicine is associated with a reduced risk of MI." | ( Crittenden, DB; Fisher, MC; Jeurling, S; Katz, SD; Krasnokutsky, S; Pike, VC; Pillinger, MH; Shah, B; Slobodnick, A; Tenner, CT; Toprover, M; Xia, Y, 2020) |
| "Gout is an inflammatory disease caused by monosodium urate (MSU) crystals." | ( Björkman, L; Buck, A; Bylund, J; Christenson, K; Dahlstrand Rudin, A; Davidsson, L; Sanchez Klose, FP, 2020) |
| "Gout is a crystal associated arthritis caused by monosodium urate (MSU) accumulating in joint, and it belongs to metabolic rheumatic disease." | ( Gu, JR; Xu, D; Zeng, XF; Zeng, XJ; Zhao, Y; Zhou, JG; Zhu, XX; Zou, HJ, 2020) |
| "Gout is the most common inflammatory arthritis and occurs when hyperuricaemia, sustained elevation of serum urate levels resulting in supersaturation of body tissues with urate, leads to the formation and deposition of monosodium urate crystals in and around the joints." | ( Dehlin, M; Jacobsson, L; Roddy, E, 2020) |
| "Gout is a form of inflammatory arthritis which is characterized by an increase in the serum uric acid deposits in and around the joints of the extremities, the so called tophi." | ( Doria, A; Moroni, G; Ponticelli, C, 2021) |
| "Gout is a common chronic disease with a high recurrence rate." | ( Li, Q; Tang, Y; Wang, D; Wang, M; Zhang, X, 2021) |
| "• ULT in acute gout is not associated with the risk of gout flares (RR, 0." | ( Li, Q; Tang, Y; Wang, D; Wang, M; Zhang, X, 2021) |
| "Gout is now the commonest type of inflammatory arthritis despite availability of safe, effective and potentially 'curative' urate-lowering drugs." | ( Nuki, G; Riches, P, 2020) |
| "Gout is an inflammatory arthritis caused by the phagocytosis of monosodium urate (MSU) crystal deposition in joints." | ( Chuang, JP; Kao, CY; Lee, JC; Leu, TH; Ling, P; Maa, MC, 2020) |
| "Gout is a heterogeneous inflammatory disease with numerous clinical manifestations." | ( Edwards, NL; Lipsky, PE; Schlesinger, N; Yeo, AE, 2020) |
| "Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system." | ( Mandell, BF; Pillinger, MH, 2020) |
| "Gout is a multisystem disease that may present in different ways." | ( Azevedo, F; Baudrier, T; Cerejeira, A; Gomes, N; Lopes, JM; Moura, CS, 2020) |
| "Gout is the most common form of inflammatory arthritis in men, yet both patients and the public often do not recognise gout as a form of arthritis." | ( Aung, E; Carland, JE; Coleshill, MJ; Day, RO; Faasse, K; Stocker, S, 2021) |
| "Gout is an important cause of disability among Filipinos, despite measures for effective management." | ( Penserga, EG; Quilisadio, JEC; Salido, EO, 2021) |
| "Gout is the most prevalent inflammatory arthritis in adults." | ( Chung, YL; Fang, YJ; Lim, YP; Lin, CL, 2020) |
| "Gout is a complex inflammatory arthritis affecting ~20% of people with an elevated serum urate level (hyperuricemia)." | ( Bixley, M; Cadzow, M; Choi, HK; Dalbeth, N; Guo, H; He, M; Hu, H; Li, C; Li, Z; Major, TJ; Markie, D; Merriman, TR; Phipps-Green, A; Shi, Y; Stamp, LK; Takei, R; Wei, WH, 2021) |
| "Gout is an inflammatory disease characterized by the deposition of monosodium urate (MSU) in synovial fluid and other tissues." | ( Chen, S; Huang, Q; Huang, X; Huang, Y; Li, T; Zhao, W; Zheng, S, 2020) |
| "Gout is a serious medical, social and economic problem of today." | ( Andreychyn, S; Hanberher, I; Korylchuk, N; Mudra, U, 2020) |
| "Nevertheless, gout is a "curable disease" by ULT, a treatment which in adequate doses may also have positive effect on several associated co-morbidities." | ( Bengtsson Boström, K; Dehlin, M; Forsblad d'Elia, H; Jacobsson, L; Kapetanovic, M; Sigurdardottir, V; Svärd, A; Wändell, P, 2020) |
| "Although gout is rare in children, chronic sustained hyperuricemia can lead to monosodium urate deposits progressing to gout, just as in adults." | ( Honda, M; Horiuchi, H; Iijima, T; Ito, S; Murano, H; Nakajima, A; Torii, T; Yamanaka, H, 2020) |
| "Gout is caused by monosodium urate crystal deposition in joints and tissues." | ( Clebak, KT; Croad, JR; Morrison, A, 2020) |
| "Gout is an increasingly common metabolic disorder worldwide." | ( McClelland, L; Richards, E; Watts, E, 2020) |
| "Gout is characterized by inflammatory arthritis with hyperuricaemia and deposition of monosodium urate (MSU) crystals in the joints." | ( He, Z; Lin, X; Shao, T; Wang, M; Wen, C; Wen, X, 2020) |
| "Gout is a painful arthritic inflammatory disease caused by buildup of monosodium urate (MSU) crystals in the joints." | ( Dimitriou, I; Fine, N; Glogauer, M; Gracey, E; La Rose, J; Rottapel, R, 2020) |
| "Gout is the most common inflammatory arthritis in the USA, affecting about 4% of all adults." | ( Cohen, RE; Pillinger, MH; Toprover, M, 2020) |
| "Patients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia." | ( Chung, YL; Fang, YJ; Li, JR; Lim, YP; Lin, CL; Su, CY; Tien, N; Wu, TY, 2020) |
| "Gout is highly prevalent in Australia compared to global comparisons and continues to increase over time." | ( Hill, CL; Keen, HI; Pathmanathan, K; Robinson, PC, 2021) |
| "Gout is the most common inflammatory arthritis in adults." | ( Abrahim, M, 2021) |
| "Gout is present in one third of subjects with CKD but is usually an exclusion criterion in clinical trials investigating the role of uric acid in kidney disease." | ( Johnson, RJ; Piani, F, 2021) |
| "Hyperuricaemia and gout are strongly related with traditional cardiovascular risk factors and vascular damage." | ( Borghi, C; Desideri, G; Gerritsen, M; Giannattasio, C; Nurmohamed, MT; Rajzer, M; Tausche, AK, 2022) |
| "Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals." | ( Gao, W; Huang, Q; Liu, J; Long, F; Mu, H; Qin, T; Ren, L; Tang, H; Zeng, M, 2020) |
| "Gout is a common metabolic disease with growing burden, caused by monosodium urate (MSU) microcrystal deposition." | ( Ao, J; Chen, J; Hua, Y; Ji, M; Xu, H; Xue, Y; Yang, Y; Zhang, B; Zhu, X, 2021) |
| "Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues." | ( Cho, YY; Choi, N; Jang, JH; Kang, HC; Lee, HS; Lee, JY; Yang, G, 2021) |
| "Gout is the most common inflammatory arthritis in men with a rising incidence worldwide." | ( Tausche, AK, 2021) |
| "Gout is often not adequately treated, and we aimed to apply urate lowering treatment (ULT) combined with individual information to achieve target serum urate (sUA) in clinical practice, and to identify predictors of achievement of this sUA target." | ( Borgen, T; Haavardsholm, EA; Hammer, HB; Karoliussen, LF; Kvien, TK; Sexton, J; Uhlig, T, 2021) |
| "Gout is an autoinflammatory disease driven by interleukin-1 (IL-1) induction in response to uric acid crystals." | ( Asano, T; Fujita, Y; Kawakami, A; Matsumoto, H; Matsuoka, N; Migita, K; Sato, S; Suzuki, E; Temmoku, J; Watanabe, H; Yago, T; Yashiro-Furuya, M, 2021) |
| "The treatment of gout is subject to different national and international guidelines." | ( de Jong, ICA; Rongen, GA; van der Pol, KH; van Herwaarden, N, 2021) |
| "Gout is an inflammatory disease triggered by deposition of urate crystals secondary to longstanding hyperuricemia, and its management implies both the treatment of flares and management of hyperuricemia." | ( Hosoya, T; Ishikawa, T; Takahashi, T; Taniguchi, T, 2021) |
| "Gout is a multifaceted inflammatory disease involving vascular impairments induced by hyperuricemia." | ( He, M; Li, X; Shi, W; Shyy, JY; Wang, L; Zhang, Y; Zhao, Y; Zhao, Z, 2021) |
| "Gout is an inflammatory disease triggered by deposition of monosodium urate (MSU) crystals in the joints, resulting in high neutrophil influx and pain." | ( Galvão, I; Levi-Schaffer, F; Queiroz-Junior, CM; Teixeira, MM; Valiate, BVS, 2021) |
| "Gout is a metabolically-related joint disease, characterized by recurrent episodic arthritis." | ( Líška, D, 2021) |
| "Gout is the most common form of inflammatory arthritis, and its incidence is highest in middle-aged and older patients." | ( Kumar, M; Manley, N; Mikuls, TR, 2021) |
| "Gout is one of the most common rheumatic diseases worldwide." | ( Buchbinder, R; Johnston, RV; McKenzie, BJ; Schlesinger, N; Wechalekar, MD, 2021) |
| "Gout is a recurrent and chronic form of arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints." | ( Ahn, H; Lee, G; Lee, GS, 2021) |
| "Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue." | ( Andrejewski, J; Birnbacher, L; Braig, EM; Busse, M; Herzen, J; Kimm, MA; Korbel, R; Petrich, C; Pfeiffer, D; Roiser, N; Sauter, A; Scholz, J, 2021) |
| "Gout is an auto-inflammatory disease driven by urate deposits with a second co-stimulatory factor evoking an (peri)arthritic fulminant inflammation often with a debute at night; inflammatory signals are enhanced via a NLRP3 pathway." | ( Jansen, TL; Matthijs, J; Tanja, G, 2022) |
| "While gout is a well-known entity, little research has been conducted on its pathophysiology." | ( Engel, B; Freitag, MH; Hoffmann, F; Jacobs, H, 2021) |
| "Gout is the most common inflammatory arthritis, but was not considered in most COVID-19 and rheumatic diseases reports." | ( Burgos-Vargas, R; García-Maturano, JS; Gómez-Ruiz, C; Mosqueda-Gutiérrez, M; Peláez-Ballestas, I; Tafoya-Amado, A; Torres-Ordaz, DE; Vázquez-Mellado, A; Vázquez-Mellado, J, 2022) |
| "BACKGROUND Gout is a chronic disease characterized by deposition of monosodium urate crystals, typically manifesting as arthritis." | ( Cardoso Nóbrega, V; Curcelli, EC; Junior, LAJ; Luiz da Silva, D; Martins, D; Matchil, NL; Okoshi, MP; Pacca, RL; Padovani de Toledo Moraes, M; Padovese, V; Pereira, FWL; Queiroz, DS; Silva, AM; Tonon, CR, 2021) |
| "Gout is an inflammatory arthritis resulting from the deposition of monosodium urate crystals in and around joints." | ( Buchbinder, R; Cyril, S; Landewé, RB; Pardo Pardo, J; van der Heijde, D; van Durme, CM; Wechalekar, MD, 2021) |
| "Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions, including hypertension, myocardial infarction, stroke, obesity, hyperlipidaemia, type 2 diabetes mellitus and chronic kidney disease." | ( Choi, HK; McCormick, N; Yokose, C, 2022) |
| "Gout is the most common form of inflammatory arthritis affecting millions of persons around the world." | ( Blake, KEG; Saag, JL; Saag, KG, 2022) |
| "Gout is a painful chronic disease which disrupts work and family life and can lead to chronic joint damage." | ( Dalbeth, N; Goodyear-Smith, F; Grey, C; Heather, M; Lutui, H; Ofanoa, M; Ofanoa, SM; Tu'akoi, S; van der Werf, B, 2021) |
| "Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue." | ( Altinoz, E; Ballur, AFH; Bicer, Y; Demir, M; Elbe, H; Karayakali, M; Onal, MO; Yigitturk, G, 2022) |
| "Gout is a common form of inflammatory arthritis where urate crystals deposit in joints and surrounding tissues." | ( Cao, H; Li, S; Liang, J; Lin, J; Wan, L; Xu, G, 2021) |
| "Gout is a local inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in joints or adjacent tissues." | ( Chen, LL; Kong, W; Liao, Y; Min, J; Peng, M; Qiu, K; Zeng, T; Zhang, N, 2021) |
| "Gout is characterized by acute arthritis due to the deposition of urate crystals in joints in a state of hyperuricemia." | ( Flendrie, M; Jansen, TLTA; Janssen, M; Moses, A; Oude Voshaar, AMH; Peeters, IR; van Herwaarden, N, 2022) |
| "Gout is a systemic disease from which some patients develop numerous painful tophi that adversely affect quality of life and functionality." | ( Abdellatif, A; Albert, J; Amin, M; Baraf, HSB; Botson, JK; Edwards, NL; Freyne, B; Keenan, RT; Masri, KR; Peterson, J; Soloman, N; Strand, V; Yung, C, 2022) |
| "Gout is associated with several comorbidities linked to poor outcomes in COVID-19, and gout flares can be triggered by some vaccinations." | ( Dalbeth, N; He, Y; Hu, S; Li, C; Li, X; Lu, J; Ran, Z; Shi, Y; Sun, M; Terkeltaub, R; Wang, C; Xu, X; Xue, X; Yan, F; Yin, H; Zhang, H, 2022) |
| "Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints." | ( Chen, J; Liu, N; Yin, H, 2022) |
| "Gout is the most common form of inflammatory arthritis in adults." | ( Chen, HC; Chen, YC; Chou, YC; Chu, CC; Lin, MH; Liu, FC; Sun, CA; Wu, WT, 2022) |
| "Gout is usually found in patients with atrial fibrillation (AF)." | ( Higaki, K; Hisatome, I; Kurata, Y; Kuwabara, M; Lanaspa, MA; Li, P; Ninomiya, H; Shirayoshi, Y; Taufiq, F; Tsuneto, M, 2022) |
| "Gout is the most common inflammatory arthritis in the United States." | ( Keller, SF; Mandell, BF, 2022) |
| "Gout is an inflammatory disease characterized by the accumulation of monosodium urate crystals (MSU) in the joints, leading to severe pain and inflammation." | ( Barbosa, MF; Borges Linhares, CR; da Silva Brum, E; de Melo Rodrigues Ávila, V; Dechichi, P; Espíndola, FS; Franco, RR; Gontijo Couto, AC; Justino, AB; Lopes Saraiva, AL; Mesquita Luiz, JP; Oliveira, SM; Pivatto, M; Santos, PD; Silva, CR; Vieira, TN, 2022) |
| "Gout is a disease that manifests itself after decades of following a high-purine diet, with excessive alcohol consumption assumed to be one of the main contributors to the development of the disease." | ( Chen, H; Chen, J; Fahira, A; Li, Z; Shi, Y; Syed, AAS; Yang, Q, 2022) |
| "Gout is a common comorbidity in heart failure (HF) patients and is frequently associated with acute exacerbations during treatment for decompensated HF." | ( Bilchick, KC; Chinn, ME; Dunn, SP; Mazimba, S; Roth, ME, 2022) |
| "Gout is a chronic and degenerative disease that affects the joints and soft tissues because of the crystalline deposit of monosodium urate." | ( Fernández-Torres, J; Gimeno, M; Luján-Juárez, IA; Martínez-Flores, K; Martínez-López, V; Montaño-Armendariz, N; Sánchez-Sánchez, R; Zamudio-Cuevas, Y, 2022) |
| "Gout is the most common form of inflammatory arthritis and is caused by deposition of monosodium urate crystals resulting from a high burden of uric acid (UA)." | ( Alkilany, R; Antonelli, M; Einstadter, D, 2022) |
| "Gout is the most common inflammatory arthritis in men with a rising incidence worldwide." | ( Tausche, AK, 2022) |
| "Gout is a common and potentially debilitating disease characterized by a painful inflammatory arthritis ("gout flare"), caused by the deposition of monosodium urate crystals in joints and surrounding tissues." | ( Gaffo, AL; Huddleston, EM, 2022) |
| "Gout is caused by deposition of monosodium urate (MSU) crystals." | ( Nam, VT; Quoc, TAH; Tam, V, 2022) |
| "Gout is a common disease caused by hyperglycemia." | ( Liu, ZB; Liu, ZQ; Sun, X; Wu, CJ; Zhang, LL; Zhang, T, 2022) |
| "Gout is a common arthritis caused by deposition of monosodium urate crystals." | ( Cao, L; Liu, J; Wan, W; Xu, R; Xuan, D; Xue, Y; Yu, Y; Zhao, L; Zhao, T; Zou, H, 2022) |
| "Gout is a common chronic inflammatory disorder due to monosodium urate deposition, which results in severe inflammatory arthritis." | ( Cai, K; Han, J; Lam, C; Manolios, N; Mitchell, J; Ng, BCK; Spencer, D; Wong, PKK, 2023) |
| "Gout is the most common form of inflammatory arthritis in men." | ( Aung, E; Caillet, V; Coleshill, MJ; Cronin, P; Day, RO; Kannangara, DRW; Kouhkamari, M; Rodgers, A; Stocker, SL; Tam, K, 2022) |
| "Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues." | ( Jiang, YJ; Lian, LH; Nan, JX; Piao, MH; Wang, H; Wu, YL, 2022) |
| "Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in individuals with hyperuricemia." | ( Agrawal, M; Bick, AG; Cunin, P; Ebert, BL; Gibson, CJ; Griffin, GK; Jaiswal, S; Kim, PG; Lin, AE; McConkey, M; Miller, PG; Natarajan, P; Neuberg, D; Nigrovic, PA; Niroula, A; Rao, DA; Schaefer, IM; Sekar, A; Shkolnik, V; Stone, RM; Uddin, MM; Weeks, LD; Wong, WJ, 2022) |
| "Gout is the most common cause of inflammatory arthritis in adults." | ( Becce, F; Fields, T; Mechlin, M; Oh, C; Pillinger, MH; Toprover, M, 2022) |
| "Gout is of unknown reason associated with cardiovascular disease." | ( Haavardsholm, EA; Hammer, HB; Jensen, G; Karoliussen, LF; Kvien, TK; Rollefstad, S; Semb, AG; Terslev, L; Uhlig, T, 2022) |
| "Gout is a common type of inflammatory arthritis characterized by the presence of monosodium urate crystals (MSU) in the joints." | ( Liu, L; Liu, M; Shan, L; Xue, Y; Yu, Y; Zhao, L; Zhu, L, 2022) |
| "Gout is a self-limiting inflammatory arthritis mediated by the precipitation of monosodium urate (MSU) crystals that further activate the NLRP3 inflammasome and initiate a cascade of inflammatory events." | ( Chen, C; Fu, D; Ge, D; Guo, Y; Li, M; Liang, Z; Liu, Y; Sun, B; Wang, J; Yang, X; Zhang, L, 2022) |
| "Gout is an inflammatory joint disease caused by urate crystal deposition, which is associated with hyperuricemia." | ( Cao, X; Chen, J; Cheng, Y; Liu, J; Pan, X; Wang, Y, 2022) |
| "Gout is a chronic metabolic disease that seriously affects human health." | ( Nian, YL; You, CG, 2022) |
| "Gout is a common crystal induced disease of high personal and social burden, characterised by severe arthritis and comorbidity if untreated." | ( Juhász, P; Kulin, A; Mózner, O; Nagy, K; Pálinkás, M; Poór, G; Rásonyi, R; Sarkadi, B; Szabó, E; Várady, G; Vörös, D; Zámbó, B, 2023) |
| "Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid." | ( Chen, S; Xu, H; Xu, Y; Yuan, M; Zhang, Y, 2022) |
| "Gout is a metabolic disorder, and one of the most common inflammatory arthritic conditions, caused by elevated serum urate (SU)." | ( Roman, YM, 2022) |
| "Gout is a chronic disease caused by monosodium urate crystal deposition, typically affecting the big toe, midfoot, and ankle." | ( Chen, SH; Guo, QH; Li, T; Lu, JG; Zheng, BL, 2023) |
| "Gout is triggered by high urate levels and causes inflammation, pain, and an impaired quality of life." | ( Chou, KR; Karwur, FF; Kurniasari, MD; Miao, NF; Rayanti, RE; Shen, CJ; Shih, YW; Tsai, HT; Yuliana, S, 2023) |
| "Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status." | ( Chang, JG; Chang, SJ; Chang, YS; Chen, YC; Chung, CC; Huang, CM; Lin, CY; Liu, TY; Tsai, FJ, 2022) |
| "Gout is one of the most common inflammatory arthritis, where identification of MSU crystals in synovial fluid is a widely used diagnostic measure." | ( El Attar, EA; El-Mallah, R; Ibrahim, RA, 2022) |
| "Tophaceous gout is a common arthritis caused by the deposition of urate crystals and is related to limited joint function." | ( Chen, YC; Hsu, CC; Hsu, CM; Huang, CC; Wu, RW, 2023) |
| "Gout is an autoinflammatory disease caused by the deposition of urate crystals." | ( Chen, R; Chi, X; Jiang, Z; Liu, Z; Shi, C; Xiu, S; Yi, C; Zhang, L; Zhou, Z, 2023) |
| "Gout is the most common inflammatory arthritis worldwide and starts with the crystallization of uric acid within the joints and soft tissues." | ( Acikalin, MF; Kasifoglu, T; Yilmaz, F, 2023) |
| "Gout is characterized by the deposition of monosodium urate crystals in patients with chronically elevated blood levels of uric acid." | ( Cohen-Rosenblum, AR; Guevara, ME; Hynes, KK; Somogyi, JR, 2022) |
| "Gout is a painful form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints." | ( Aganetti, M; Amaral, FA; Braga, AD; de Faria, AMC; de Oliveira, VLS; Galvão, I; Georgel, P; Martins, VD; Mastrippolito, D; Mendes, V; Muller, S; Rocha, V; Talamini, L; Verdot, C; Vieira, AT, 2022) |
| "Gout is a painful form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints." | ( Aganetti, M; Amaral, FA; Braga, AD; de Faria, AMC; de Oliveira, VLS; Galvão, I; Georgel, P; Martins, VD; Mastrippolito, D; Mendes, V; Muller, S; Rocha, V; Talamini, L; Verdot, C; Vieira, AT, 2022) |
| "Gout is caused by elevated serum urate leading to the deposition of monosodium urate (MSU) crystals that can trigger episodes of acute inflammation." | ( Astin, JW; Dalbeth, N; Hall, CJ; Linnerz, T; Rolland, L; Sung, YJ, 2022) |
| "Gout is a progressive metabolic disease closely related to hyperuricemia and urate deposition, with an increasing prevalence and incidence across the globe." | ( Huang, J; Li, Y; Lin, Z; Ren, Z; Wang, Y; Wu, H; Zhang, B, 2022) |
| "Gout is a common inflammatory disease." | ( Chen, Y; Guo, X; Xia, H; Xu, L; You, CG; Zhao, M; Zhong, X; Zhou, Y, 2022) |
| "Gout is a metabolic disease affected by monosodium urate (MSU) deposition, which is directly related to hyperuricemia." | ( Huang, J; Li, Y; Lin, Z; Wang, Y; Wu, H; Zhang, B, 2023) |
| "Hyperuricemia and gout are a group of disorders of purine metabolism." | ( Wu, X; You, C, 2023) |
| "Gout is the most common inflammatory arthritis with an increasing prevalence and incidence across the globe." | ( Han, Y; Li, W; Lin, Z; Wang, Y; Wu, H; Zhang, B, 2023) |
| "Gout is a chronic disease caused by monosodium urate crystal deposition." | ( Chen, W; Chen, X; Gao, K; Huang, H; Huang, R; Mei, L; Wang, M; Wu, X; Yang, Z; Zhang, X, 2023) |
| "Gout is a chronic self-limiting inflammatory arthritis." | ( Chen, X; Cong, J; Dai, H; Huang, X; Huang, Z; Ma, Y; Wu, D; Ye, Z; Yin, Z; Zou, L, 2023) |
| "Gout is common in patients with heart failure (HF), and sodium-glucose cotransporter 2 inhibitors, a foundational treatment for HF, reduce uric acid levels." | ( Butt, JH; Claggett, BL; de Boer, RA; Desai, AS; Docherty, KF; Hernandez, AF; Inzucchi, SE; Jhund, PS; Kosiborod, MN; Køber, L; Lam, CSP; Langkilde, AM; Martinez, FA; McMurray, JJV; Petersson, M; Ponikowski, P; Sabatine, MS; Shah, SJ; Solomon, SD; Vaduganathan, M, 2023) |
| "Gout is considered uncommon among Black Africans." | ( Adamu, AA; Sulaiman, MM; Yerima, A, 2023) |
| "Gout is associated with a higher risk of fracture; however, findings on the associations of hyperuricemia and urate-lowering therapy (ULT) with the risk of fracture have been inconsistent." | ( Choi, HK; Dalbeth, N; Lane, NE; Lei, G; Lyu, H; Wei, J; Wu, J; Zeng, C; Zhang, Y, 2023) |
| "Gout is the most common inflammatory rheumatic disease and elevated levels of serum urate (SU) are the main cause for its development." | ( Fernández-Torres, J; Martínez-Flores, K; Martínez-Nava, GA; Ruíz-Dávila, X; Sánchez-Sánchez, R; Zamudio-Cuevas, Y, 2023) |
| "BACKGROUND Spinal gout is not so uncommon." | ( Gebreselassie, KZ; Kligora, C; Ranic, LM; Valancius, D, 2023) |
| "Gout is a crystal related arthropathy caused by monosodium urate deposition." | ( Chen, J; Gong, S; Hu, J; Li, X; Ma, L; Yu, H; Zheng, Y; Zheng, Z, 2023) |
| "Gout is a metabolic disease caused by the deposition of monosodium urate (MSU) crystals inside joints, which leads to inflammation and tissue damage." | ( Liu, W; Mo, Y; Tao, H; Wang, H, 2023) |
| "Gout is one of the most common noncommunicable diseases in Hong Kong." | ( Chan, JP; Cheung, TT; Ho, CT; So, H; Tsang, HH; Wong, PC; Yip, RM; Yu, CK, 2023) |
| "Gout is a high incidence and high-risk disease, and the current treatments are not satisfactory." | ( Huang, G; Zhou, S, 2023) |
| "Gout is a form of inflammatory arthritis that results from elevated serum uric acid levels and the deposition of urate crystals in multiple joints." | ( Fu, N; Li, Q; Quan, J; Zhang, Z, 2023) |
| "Gout is an inflammatory arthritis initiated by the deposition of monosodium urate crystals (MSU) around the joints and surrounding tissues." | ( Chanjitwiriya, K; Charoenwutthikun, S; Kunthalert, D; Roytrakul, S, 2023) |
| "Gout is caused by monosodium urate (MSU) crystal deposition within joints." | ( Alhilali, M; Dalbeth, N; Jain, L; Popov, D; Poulsen, RC, 2023) |
| "Gout is an autoimmune disease characterized by acute or chronic inflammation and damage to bone joints induced due to the precipitation of monosodium urate (MSU) crystals." | ( Li, H; Liu, W; Peng, J; Wu, R; Wu, Y; Ye, Z; Zong, Z, 2023) |
| "Gout is a common metabolic rheumatic disease, and there have been no reports on the serum levels of interleukin (IL)-41 in gout patients." | ( Li, M; Li, Y; Meng, S; Shi, S; Wu, X; Zhao, H; Zhou, Y, 2023) |
| "Gout is a common inflammatory arthritis caused by increased serum uric acid levels." | ( Hua, Q; Lin, Y; Liu, X; Luo, Y; Xia, A; Yang, Q; Zheng, K, 2023) |
| "Gout is a common metabolic disorder characterized by deposits of monosodium urate monohydrate crystals (tophi) in soft tissue, triggering intense and acute arthritis with intolerable pain as well as articular and periarticular inflammation." | ( Chang, CC; Chang, CK; Lee, HY; Lin, KH; Lin, TM; Peng, SJ; Wu, BF, 2023) |
| "Gout is a metabolic disease resulting from the accumulation of monosodium urate (MSU) in joints, leading to crystal-induced arthritis." | ( Lin, H; Xu, D; Zhao, Y; Zhu, XX; Zou, HJ, 2023) |
| "Gout is a common inflammatory arthritis caused by persistently elevated uric acid levels." | ( Boucetta, H; Chen, Z; He, W; Lai, Y; Li, X; Peng, X; Sosnik, A; Xie, B, 2023) |
| "Gout is the most common form of rheumatic disease in which monosodium urate crystals are deposited in the joints followed by acute inflammatory reactions." | ( Böhm, S; Bülow, R; Chenot, JF; Dörr, M; Engeli, S; Freyer Martins Pereira, J; Gágyor, I; Greser, A; Hummers, E; Kamin, P; Richter, A; Schuster, F; Stracke, S; Truthmann, J; Witte, A, 2023) |
| "Gout is the most common inflammatory arthritis and closely related to metabolic syndrome, leading to excruciating pain and the decline in quality of patients' life." | ( Liu, S; Liu, Y; Liu, Z; Wu, X, 2023) |
| "Gout is a multifactorial metabolic and inflammatory disease that occurs when increased uric acid (UA) induce HU resulting in monosodium urate (MSU) crystal deposition in joints." | ( Zhang, WZ, 2023) |
| "Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity." | ( Abe, K; Akashi, N; Aoki, Y; Fukuuchi, T; Hisatome, I; Ichida, K; Kurajoh, M; Kuwabara, M; Maruhashi, T; Miyata, H; Mizuta, E; Morikawa, N; Morita, M; Nishimiya, K; Ogino, K; Otani, N; Ouchi, M; Takada, T; Tanaka, A; Tanaka, Y; Tsutani, H, 2023) |
| "Gout is characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals around joints." | ( Fan, Y; Liu, Y; Meng, Y; Qin, M; Wu, D; Zeng, X, 2023) |
| "Gout is the most common inflammatory arthritis and is almost exclusively managed in primary care, however the course and severity of the condition is variable and poorly characterised." | ( Finnikin, S; Mallen, CD; Roddy, E, 2023) |
| "Gout is associated with lifestyle, body mass index (BMI) and comorbidities, including dyslipidaemia." | ( Haavardsholm, EA; Hammer, HB; Karoliussen, LF; Kvien, TK; Sexton, J; Uhlig, T, 2023) |
| Excerpt | Reference |
|---|
| "Eight of 36 untreated gouty men excreted acid at a rate more than three standard deviations above normal." | ( Hoover, PL; Paxson, CS; Simkin, PA; Wilson, WF, 1979) |
| "In the treatment of acute gout, the NSAIDs are the most important, and simple analgesics are relatively unimportant, but in the treatment of rheumatoid and osteoarthritis and other arthropathies, analgesics taken as and if required to cover the more painful periods of a day do have a role, usually in conjunction with NSAIDs and other agents." | ( Hart, FD, 1987) |
| "Accordingly, one must treat the patient's gout as well as his various stages of the associated medical conditions, and each patient must be individualized." | ( Smith, H; Yu, TF, 1986) |
| "As in the younger population, treatment of gout in the elderly is dependent on renal function." | ( Brooks, PM; Buchanan, WW; Kassam, Y; Kean, WF, 1984) |
| "With the exception of the treatment of gout and bacterial infections of joints, therapy in the rheumatic diseases remains inadequate." | ( Buchanan, WW; Craig, GL, 1980) |
| "The most widely prescribed treatments in acute gout attack were colchicine alone (63%), colchicine with a nonsteroidal antiinflammatory drug (NSAID) (31." | ( Bourgerois, P; Koeger, AC; Laatar, A; Lang, T; Orcel, P; Rozenberg, S, 1996) |
| "Cardiac transplant recipients, when treated for gout, are at high risk of therapeutic complications." | ( Bergin, PJ; Esmore, DS; Miller, AM; Page, JL; Richardson, M; Ryan, PF; Wluka, AE, 2000) |
| "First choice treatment of acute gout consists of NSAIDs." | ( Gorter, KJ; Romeijnders, AC, 2002) |
| "Colchicine is widely employed for the treatment of gout in renal transplant patients where NSAIDs are contra-indicated and allopurinol prophylaxis is often avoided due to concomitant azathioprine immunosuppression." | ( Dupont, P; Goldberg, L; Hunt, I; Warrens, A, 2002) |
| "The pathophysiology and treatment of gout in these special circumstances are discussed." | ( Clermont, D; Pasteels, JL; Remmelink, M; Schuind, FA; Stallenberg, B, 2003) |
| "Because untreated gouty arthritis can lead to serious adverse outcomes (such as recurrent gouty arthritis, chronic gouty arthropathy, tophi, and urolithiasis) that are usually avoidable with antihyperuricemic therapy, efforts to achieve better compliance are warranted." | ( Becker, M; Joseph-Ridge, N; MacDonald, P; Nelson, M; Riedel, AA; Wallace, K, 2004) |
| "Drugs available for the treatment of acute gouty arthritis, such as non-steroidal anti-inflammatory drugs, selective cyclo-oxygenase 2 inhibitors, systemic corticosteroids, or colchicine, are effective." | ( Li, EK, 2004) |
| "Drugs used for the treatment of gout remained constant in prevalent cases with the exception of a significant decline in non-steroidal anti-inflammatory drug use over the 10 year follow up." | ( Bilker, WB; Farrar, JT; Fernandes, S; Mikuls, TR; Saag, KG; Schumacher, HR, 2005) |
| "Future directions in the treatment of gout, in part guided by a better understanding of pathophysiology, are discussed." | ( Agudelo, C; Liu-Bryan, R; Masseoud, D; Rott, K, 2005) |
| "All of the drugs used to treat gout can have serious side effects." | ( Katbamna, R; Sutaria, S; Underwood, M, 2006) |
| "When treating acute gout in otherwise healthy patients, most physicians (77%) prefer oral colchicine, and in patients with renal impairment, about half of them (48%) choose corticosteroids or corticotropin as their first treatment." | ( Chen, LX; Fang, W; Li, M; Schumacher, HR; Zeng, X; Zhang, F, 2006) |
| "Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory diseases such as familial Mediterranean fever (FMF)." | ( Niel, E; Scherrmann, JM, 2006) |
| "To record practice patterns of treatment of acute gout in hospitalized patients." | ( Petersel, D; Schlesinger, N, 2007) |
| "There has been renewed interest in the treatment of gout with recent reported intervention studies of new agents such as etoricoxib, febuxostat and pegylated-uricase." | ( Dalbeth, N; Grainger, R; Schumacher, HR; Singh, JA; Taylor, WJ, 2007) |
| "Forty-eight (96%) patients treated for acute gout received colchicine at doses < or =2." | ( Dalbeth, N; Gow, P; Ly, J, 2007) |
| "There are no formal guidelines for the treatment of acute gout and only a few randomized controlled trials have been conducted to evaluate the efficacy of the various treatments for acute gout." | ( Schlesinger, N, 2008) |
| "When treating gout patients, we have incidentally found elevated serum levels of adiponectin in some after administration of benzbromarone." | ( Inokuchi, T; Ka, T; Masuzaki, H; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamamoto, A; Yamamoto, T, 2009) |
| "It is the first drug marketed for treatment of gout in 40 years." | ( , 2009) |
| "When treating gout one needs to treat acute attacks, and lower excess stores of uric acid to achieve dissolution of monosodium urate crystals through a long-term reduction of SU concentrations far beyond the threshold for saturation of urate and provide prophylaxis to prevent acute flares." | ( Dalbeth, N; Perez-Ruiz, F; Schlesinger, N, 2009) |
| "Published guidelines for the treatment of gout aim to improve the evidenced-based management of this disorder." | ( Bottenberg, MM; Hegge, KA; Koenigsfeld, CF; Wall, GC, 2010) |
| "In the treatment of acute gout, 68." | ( Goh, EM; Gun, SC; Yeap, SS, 2009) |
| "Over time, untreated or insufficiently treated gout may progress, with more frequent flares and formation of urate crystal deposits (tophi) and associated chronic, deforming arthritis (gouty arthropathy)." | ( Becker, MA; Ruoff, GE, 2010) |
| "Effective treatment of acute gout is nonsteroidal anti-inflammatory drugs with intra-articular or systematic corticosteroids." | ( Julkunen, H; Konttinen, YT, 2010) |
| "At the recommended dosage for the treatment of acute gout flares, Colcrys was as well tolerated as placebo in patients with gout." | ( Yang, LP, 2010) |
| "The goals when treating gout are no different in these patients, but the choice and dosage of drugs may need to be modified." | ( El-Zawawy, H; Mandell, BF, 2010) |
| "These experiences may lead to undertreatment of gout because of lack of disclosure of symptom severity and lack of expectation of treatment effectiveness, which in turn could contribute to the development of progressive gout." | ( Dalbeth, N; Gow, P; Lindsay, K; Logo, P; Vanderpyl, J, 2011) |
| "Participants with untreated gout had an adjusted hazard ratio ranging from 1." | ( Dabbous, O; Hariri, A; Krishnan, E; Lingala, B; Pandya, BJ, 2012) |
| "sUA and untreated gout may be independent prognostic markers for poor all-cause and CHD mortality in patients with recent acute MI." | ( Dabbous, O; Hariri, A; Krishnan, E; Lingala, B; Pandya, BJ, 2012) |
| "Corticosteroids are commonly used to treat acute gout due to the adverse profile and drug interactions with NSAIDs and colchicine." | ( Chapman, PT; Stamp, LK, 2012) |
| "One of the limitations for successful treatment of gout is to consider it as an intermittent disease rather than a chronic inflammatory disease which, if improperly treated, leads to chronic clinical manifestations." | ( Herrero-Beites, AM; Perez-Ruiz, F, 2012) |
| "The concept of 'treatment-failure gout' describes a unique population that has been either unable to tolerate allopurinol or who have not experienced normalization of serum urate levels on allopurinol." | ( Dave, AJ; Kelly, VM; Krishnan, E, 2012) |
| "Using colchicine to treat an acute gout crisis in an organ transplant recipient (TR) on cyclosporine (CsA) may result in life-threatening intoxication." | ( Enache, I; Garrouste, C; Heng, AE; Kaysi, S; Philipponnet, C; Tiple, A, 2012) |
| "A progressive disorder, untreated gout can be debilitating and result in tophi, chronic arthropathy, and recurrent kidney stones." | ( Bakris, GL; Doghramji, PP; Keenan, RT; Silber, SH, 2014) |
| "In general, treatments for gout are well tolerated, although clinicians must keep in mind the potential for drug interactions and the contribution of comorbidities to the potential for adverse effects with gout therapies." | ( Stamp, LK, 2014) |
| "Sustained treatment for gouty arthritis is essential in the prevention of serious adverse outcomes." | ( Bennett, K; McGowan, B; Silke, C; Whelan, B, 2016) |
| "Twelve patients indicated that treatment of gout only encompasses treatment of the acute attack." | ( Boonen, A; de Vries, H; Hinsenveld, E; van Onna, M, 2015) |
| "The salient points include the need to treat gout to a serum urate target, the ability to start allopurinol during acute attacks, the need to treat with prophylactic anti-inflammatory drugs for adequate time periods, and the availability of a new urate-lowering drug on the Pharmaceutical Benefits Scheme (PBS)." | ( Robinson, PC; Stamp, LK, 2016) |
| "Expanded use of febuxostat in the treatment of all gout patients, independent of renal impairment status, should be considered based on improved clinical outcomes and longer-term medical cost savings associated with these improved outcomes." | ( Gahn, JC; Mitri, G; Shiozawa, A; Smolen, LJ, 2016) |
| "INTRODUCTION Treatment of gout, specifically with colchicine, varies globally." | ( Bassett-Clarke, D; Martini, N; Rebello, C; Thomson, M, 2016) |
| "Untreated or improperly treated gout can lead to chronic manifestation of the disease, including persistent inflammation, increased number of flares, development of tophi, and structural joint damage." | ( Edwards, NL; Ruoff, G, 2016) |
| "In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties." | ( Balcı, MA; Balkarlı, A; Çobankara, V; Gök, K; Kaya, A; Kimyon, G; Kısacık, B; Küçük, A; Mercan, R; Onat, AM; Öztürk, MA; Pamuk, Ö; Şahin, Ş; Sayarlıoğlu, M; Şenel, S; Tezcan, ME; Tufan, A; Üreten, K; Yıldırım Çetin, G, 2016) |
| "Current treatments of gout, which include anti-inflammatory drugs, cyclooxygenase-2 inhibitors, and systemic glucocorticoids, have harmful side-effects." | ( Aslan, K; Bonyi, E; Boone-Kukoyi, Z; Kioko, B; Lansiquot, C; Ozturk, B; Shortt, R; Thompson, N; Toker, S, 2016) |
| "To review evidence about treatment of acute gout attacks, management of hyperuricemia to prevent attacks, and discontinuation of medications for chronic gout in adults." | ( FitzGerald, JD; Han, D; Motala, A; Newberry, SJ; O'Hanlon, CE; Okunogbe, A; Shanman, R; Shekelle, PG; Tariq, A, 2017) |
| "To determine if urate-lowering treatment (ULT) in gout can reduce cardiovascular (CV) outcomes." | ( Pope, JE; Zhang, T, 2017) |
| "Among treated gout patients, 76% were receiving allopurinol at a mean dose lower than 200mg/d, most without any further change of dose regimen over one year." | ( Flipo, RM; Hincapie, N; Lioté, F; Maravic, M; Pilet, S, 2018) |
| "Colchicine is a treatment for gout that has been used for more than a millennium." | ( Brownell, I; Dasgeb, B; Kornreich, D; McGuinn, K; Okon, L; Sackett, DL, 2018) |
| "Benzbromarone (BBR) is effective in the treatment of gout; however, clinical findings have shown it can also cause fatal hepatic failure." | ( Lan, Q; Pang, J; Peng, Y; Wang, H; Wang, S; Wang, W; Wang, X; Zhang, T; Zhao, H; Zhao, Y; Zheng, J, 2017) |
| "Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups." | ( Lee, EB; Lee, EY; Lee, GH; Lee, JH; Lee, WW; Park, JK; Shin, K; Song, YW; Yang, JA, 2017) |
| "Though efficacious and affordable treatments for gout are widely available, gout is still not well controlled in many countries of the world including China." | ( Fang, W; Sha, Y; Sheng, F; Zeng, X; Zhang, B, 2017) |
| "It may be particularly relevant in the treatment of gout in the elderly as they are unable to tolerate long-term colchicine for flare prophylaxis and frequently have contraindications to corticosteroids and NSAIDs." | ( Abhishek, A, 2017) |
| "Furthermore, the possibility of treating gout and hyperuricemia by upregulating intestinal ABCG2 expression is examined." | ( Fujita, K; Ichida, K, 2018) |
| "Evidence suggests that not treating gout to target in the long term is overall associated with worsening outcomes, such as flares, tophi and structural damage, which is associated to loss of quality of life and mortality." | ( Dickson, AJ; Moreno-Lledó, A; Perez-Ruiz, F; Urionagüena, I, 2018) |
| "Efficacy of colchicine for the treatment of gout flares has been demonstrated only recently by a randomized- controlled trial, but it still has not been compared to other drugs." | ( Pascart, T; Richette, P, 2018) |
| "This is a cross-sectional study of untreated gout subjects (n = 34) and non-gout healthy controls (n = 64)." | ( Bang, D; Dektiarev, I; Guo, Y; Igel, TF; Katz, SD; Krasnokutsky, S; Pike, VC; Pillinger, MH; Romero, AG; Shah, B; Zhong, J, 2018) |
| "Difficult-to-treat gout encompasses polyarticular flares, and mostly patients with comorbidities, renal or heart failure, leading to contraindications or side effects of standard-of-care drugs (colchicine, NSAIDs, oral steroids) for flares; and tophaceous and/or destructive arthropathies, leading to switching between XOIs (febuxostat) or to combining XOI and uricosurics." | ( Lioté, F; Pascart, T, 2019) |
| "Despite being regarded as an easily-treatable disease, gout diagnosis and management can be challenging." | ( Borghi, C; Genderini, A; Grassi, W; Punzi, L; Rossi, C; Scirè, CA, 2018) |
| "Examining therapies aimed at treating gout flares [anti-inflammatory action], bucillamine has some potential, but more data and Phase III studies are needed, to better understand its efficacy and safety." | ( Merriman, TR; Singh, JA; Stamp, LK, 2018) |
| "Despite many effective treatments for gout, its management remains a challenge internationally." | ( Fields, TR, 2019) |
| "The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year)." | ( Burns, RB; Shmerling, RH; Smith, CC; Tess, A, 2018) |
| "(Colchicaceae) is used in the treatment of gout and rheumatism as a traditional medicine dates back to 1810." | ( Agrawal, PK; Barik, SK; Kumar, M; Kumar, S; Misra, A; Shukla, PK; Srivastava, S, 2020) |
| "Currently, the treatment of gout mainly includes two basic methods: reducing uric acid and alleviating inflammation." | ( Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M, 2020) |
| "Staged operation for the treatment of giant gout stone on the first metatarsophalangeal joint of foot could correct joint deformity, restore shape of the first metatarsophalangeal joint, relieve pain of the affected foot, and beneficial for control content of serum uric acid, and has less complications." | ( Li, P; Wang, Y; Xu, SQ; Zhang, WJ; Zhang, Y, 2020) |
| "Thirty-eight untreated gout patients meeting American College of Rheumatology (ACR)/European League Against Rheumatism classification criteria for gout and ACR guidelines for initiating urate-lowering therapy (ULT) received colchicine (0." | ( Bang, D; Curovic, F; Igel, TF; Katz, SD; Krasnokutsky, S; Lazaro, D; Oh, C; Pike, VC; Pillinger, MH; Romero, AG; Shah, B; Toprover, M, 2020) |
| "UR-1102, a novel uricosuric agent for treating gout, has been confirmed to exhibit a pharmacological effect in patients." | ( Igarashi, F; Nakagawa, T; Yamane, M; Yamauchi, T, 2021) |
| "Pegloticase is used for the treatment of severe gout, but its use is limited by immunogenicity." | ( Biggers, S; Cutter, G; Danila, MI; Feese, M; Foster, J; Jaafar, S; Kent, J; Khanna, D; Khanna, PP; King, C; Kivitz, A; Kuo, HC; Melnick, J; Peloso, PM; Rahman, AKMF; Saag, KG; Shergy, W, 2021) |
| "This review provides an overview of the treatment of gout flares and lowering serum urate." | ( Blake, KEG; Saag, JL; Saag, KG, 2022) |
| "Pharmacological treatment of gout consists of treating acute flares with anti-inflammatory drugs and, if indicated, of urate lowering therapies (ULT)." | ( Flendrie, M; Jansen, TLTA; Janssen, M; Moses, A; Oude Voshaar, AMH; Peeters, IR; van Herwaarden, N, 2022) |
| "Our findings reinforce the need to treat gout early, before destruction of bone scaffold by extensive tophi, as MSU crystal dissolution by ULT may further weaken these areas and induce their collapse." | ( Bardin, T; Bousson, V; Dalbeth, N; Do, MD; Ea, HK; Hieu, NL; Nguyen, QD; Resche-Rigon, M; Richette, P; Tran, KM, 2022) |
| "Phytochemicals in TCM treatment of gout mainly includes two aspects, anti-inflammatory and reducing uric acid content." | ( Liu, ZB; Liu, ZQ; Sun, X; Wu, CJ; Zhang, LL; Zhang, T, 2022) |
| "In addition to traditional treatments for gout, novel therapies have been introduced in recent years." | ( Choi, ST; Park, EH; Song, JS, 2022) |
| "Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration." | ( Ding, Y; Ding, Z; Huang, Z; Ji, S; Liu, Y; Zang, Y; Zhang, J; Zhu, X, 2022) |
| "The core targets of Ermiao san for treating HUA and gout are AT1 (namely Protein Kinase Bα), interleukin-1 beta, prostaglandin-endoperoxide synthase 2, JUN, etc." | ( Chen, Z; Duan, FY; Geng, YH; Han, L; Liu, YF; Song, CD; Tu, SH; Yan, JH; Zhang, LQ, 2022) |
| "Surgical treatment of gout stone in hand and foot under the guidance of three-dimensional CT reconstruction image can effectively alleviate the local symptoms of gout stone and improve the function of hand and foot." | ( Du, X; Jin, S; Qiu, X; Zhao, B; Zhao, W, 2022) |
| "The main treatment for gout is medical management of acute inflammation and chronic uric acid levels, but surgical treatment may be indicated in cases of damage to the surrounding soft tissue, concomitant septic arthritis, symptomatic cartilage loss, or neurologic deficits." | ( Cohen-Rosenblum, AR; Guevara, ME; Hynes, KK; Somogyi, JR, 2022) |
| "Rutin treatment improves gout and reduces inflammatory expression in quail." | ( Huang, J; Li, Y; Lin, Z; Wang, Y; Wu, H; Zhang, B, 2023) |
| "If untreated, acute gout may eventually develop into chronic tophaceous gout characterized by tophi, chronic gouty synovitis, and structural joint damage, leading the crushing burden of treatment." | ( Liu, W; Mo, Y; Tao, H; Wang, H, 2023) |
| "Colchicine has been widely used in the treatment of acute gout over the years, but it has a narrow therapeutic index, and overdose can be life threatening." | ( Deng, H; Liu, W; Wu, H; Xiang, P; Yan, H; Zhang, S, 2023) |
| "Untreated or insufficiently treated gout can lead to deposition of monosodium urate crystals in joints, cartilage, and kidneys." | ( Hua, Q; Lin, Y; Liu, X; Luo, Y; Xia, A; Yang, Q; Zheng, K, 2023) |
| "Uricases are being used to treat uncontrolled gout, and can achieve rapid reduction of hyperuricaemia, dramatic resolution of tophi, decreased chronic joint pain and improved quality of life." | ( Lioté, F; Pérez-Ruiz, F; Schlesinger, N, 2023) |
| "Undertreated, gout can progress to palpable tophi and joint damage." | ( Terkeltaub, R, 2023) |