A substance capable of undergoing rapid and highly exothermic decomposition.
| Member | Definition | Class |
|---|
| 2-amino-4,6-dinitrotoluene | An amino-nitrotoluene that is 4,6-dinitrotoluene substituted at position 2 by an amino group. | 2-amino-4,6-dinitrotoluene |
| 2,3-dinitrotoluene | A dinitrotoluene that is toluene in which the hydrogens at positions 2 and 3 have been replaced by nitro groups. | 2,3-dinitrotoluene |
| 2,4-dinitroanisole | A member of the class of dinitroanisoles that is 2-nitroanisole in which the hydrogen para to the methoxy group is replaced by a second nitro group. | 2,4-dinitroanisole |
| 4-amino-2,6-dinitrotoluene | An amino-nitrotoluene that is 2,6-dinitrotoluene substituted at position 4 by an amino group. | 4-amino-2,6-dinitrotoluene |
| ammonium nitrate | The ammonium salt of nitric acid. | ammonium nitrate |
| cyclonite | An N-nitro compound that is 1,3,5-triazinane in which all three of the hydrogens attached to the nitrogens have been replaced by nitro groups. It is widely used in both industrial and military explosives. | 1,3,5-trinitro-1,3,5-triazinane |
| dicyandiamido | A guanidine in which one of the amino hydrogens of guanidine itself is substituted by a cyano group. It is used in the manufacture of fertilizers, pharmaceuticals, explosives, oil well drilling muds, and dyestuffs. | cyanoguanidine |
| erythrityl tetranitrate | Erythritol in which each of the hydroxy groups has been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to nitroglycerin. It is usually used diluted with lactose or other suitable inert excipients, in order to minimise the risk of explosion; undiluted erythrityl tetranitrate can be exploded by percussion or excessive heat. | erythrityl tetranitrate |
| hexanitrohexaazaisowurzitane | A polycyclic cage that is hexaazaisowurtzitane in which all six amino hydrogens are replaced by nitro groups. | CL-20 |
| musk xylene | A C-nitro compound that is m-xylene bearing three nitro substituents at positions 2, 4 and 6 as well as a tert-butyl group at position 5. | musk xylene |
| nitramine | A nitramine that is methylamine in which one of the hydrogens attached to the nitrogen is substituted by a nitro group while the other is substituted by a 2,4,6-trinitrophenyl group. A yellow crystalline powder, it is a high explosive, capable of being detonated by friction, shock, or a spark. | N-methyl-N-picrylnitramine |
| nitroglycerin | A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain. | nitroglycerin |
| nitromethane | A primary nitroalkane that is methane in which one of the hydrogens is replace by a nitro group. A polar solvent (b.p. 101 degreeC), it is an important starting material in organic synthesis. It is also used as a fuel for rockets and radio-controlled models. | nitromethane |
| octogen | A tetrazocane that is 1,3,5,7-tetrazocane in which the hydrogen atom attached to each of the nitrogens is replaced by a nitro group. | octogen |
| pentaerythritol tetranitrate | A pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex. | pentaerythritol tetranitrate |
| picric acid | A C-nitro compound comprising phenol having three nitro substtituents at the 2-, 4- and 6-positions. | picric acid |
| picryl chloride | The C-nitro compound that is chlorobenzene with three nitro substituents in the 2-, 4- and 6-positions. | 1-chloro-2,4,6-trinitrobenzene |
| sodium azide | The sodium salt of hydrogen azide (hydrazoic acid). | sodium azide |
| sym-trinitrobenzene | A trinitrobenzene in which each of the nitro groups is meta- to the other two. | 1,3,5-trinitrobenzene |
| trinitrobenzenesulfonic acid | The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions. | 2,4,6-trinitrobenzenesulfonic acid |
| trinitrotoluene | A trinitrotoluene having the nitro groups at positions 2, 4 and 6. | 2,4,6-trinitrotoluene |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 40.2804 | 2 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 9.6839 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 26.6763 | 9 | 12 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 43.7588 | 2 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 35.6844 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 15.0113 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 16.8430 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 23.1749 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 44.5955 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.2995 | 8 | 18 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 30.2457 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 46.8205 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 25.5806 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 15.0113 | 1 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 30.5129 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 19.3908 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 6.9589 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 58.2036 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 18.2516 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 15.0113 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 15.0113 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 15.0113 | 1 | 2 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 36.1415 | 4 | 12 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.0033 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 21.1082 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.4778 | 3 | 11 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 29.2124 | 3 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 57.5190 | 2 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 13.1922 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 51.8103 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 23.7452 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 11.3856 | 2 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 46.6259 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 29.5525 | 5 | 7 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0164 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 6.9589 | 1 | 2 |