Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
| Member | Definition | Class |
|---|
| 10-hydroxy-2-decenoic acid | An omega-hydroxy amino acid that is 2-decenoic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group and in which the C=C double bond has E configuration. It is a component of royal jelly. | (E)-10-hydroxydec-2-enoic acid |
| 12-epi-scalarin | The 12-epimer of scalarin, a metabolite of marine sponges of the genus Spongia. | 12-epi-scalarin |
| 2-acetamido-2-deoxy-d-glucono-(1,5)-lactone | A deoxygluconolactone that results from the cyclisation and formal condensation of the carboxy group of 2-amino-2-deoxy-D-gluconic acid with its 5-hydroxy group. It is a sex pheromone found in the urine of female blue crabs, Callinectes sapidus. | N-acetyl-D-glucosamino-1,5-lactone |
| 2-undecanol | A secondary alcohol that is undecane substituted by a hydroxy group at position 2. | undecan-2-ol |
| 2,3,5-trimethylpyrazine | A member of the class of pyrazines that is pyrazine in which three hydrogens at positions 2, 3 and 5 have been replaced by methyl groups. | trimethylpyrazine |
| 2,5-xylenol | A member of the class of phenols that phenol substituted by methyl groups at positions 2 and 5. | 2,5-xylenol |
| 3-hydroxy-3-methylbutene | A tertiary alcohol that is 3-methylbut-1-ene carrying a hydroxy substituent at position 3. | 3-hydroxy-3-methylbut-1-ene |
| acetophenone | A methyl ketone that is acetone in which one of the methyl groups has been replaced by a phenyl group. | acetophenone |
| adonixanthin | A carotenone that consists of beta,beta-caroten-4-one bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'R diastereomer). | adonixanthin |
| alpha-methylhistamine | An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position. | alpha-methylhistamine |
| anserine | A dipeptide comprising of beta-alanine and 3-methyl-L-histidine units. | anserine zwitterion; anserine |
| anserine | Zwitterionic form of anserine. | anserine zwitterion; anserine |
| astaxanthine | A carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein. | astaxanthin |
| benzyl cyanide | A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a phenyl group. | phenylacetonitrile |
| beta-glucono-1,5-lactone | An aldono-1,5-lactone obtained from D-gluconic acid. | D-glucono-1,5-lactone |
| brassicasterol | An 3beta-sterol that is (22E)-ergosta-5,22-diene substituted by a hydroxy group at position 3beta. It is a phytosterol found in marine algae, fish, and rapeseed oil. | brassicasterol |
| bufalin | A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo. | bufalin |
| carmine | A tetrahydroxyanthraquinone that is that is 1,3,4,6-tetrahydroxy-9,10-anthraquinone substituted by a methyl group at position 8, a carboxy group at position 7 and a 1,5-anhydro-D-glucitol moiety at position 2 via a C-glycosidic linkage. It is a natural dye isolated from several insects such as Dactylopius coccus. | carminic acid |
| cembrene a | A fourteen-membered macrocyclic diterpene consisting of 1,5,9-trimethyl-12-(prop-1-en-2-yl)cyclotetradecane having three endocyclic double bonds located at positions 1, 5 and 9. | (R)-cembrene A |
| civetone | A macrocycle that is cycloheptadecanone with an unsaturation at position 9 (the 9Z-stereoisomer). It has been found in African Civets. | civetone |
| coniferyl alcohol | A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring. | coniferol |
| cysteic acid | An amino sulfonic acid that is the sulfonic acid analogue of cysteine. | cysteic acid |
| dehydroluciferin | A member of the class of 1,3-thiazolemonocarboxylic acids that is 1,3-thiazole-4-carboxylic acid in which the hydrogen at position 2 has been replaced by a 6-hydroxy-1,3-benzothiazol-2-yl group. | dehydroluciferin |
| dibromophakellin | An alkaloid isolated from the marine sponge Phakellia flabellata and Acanthella costata. It acts as an alpha2B adrenoceptor agonist. | (-)-dibromophakellin |
| diethyl ketone | A pentanone that is pentane carrying an oxo group at position 3. It has been isolated from Triatoma brasiliensis and Triatoma infestans. | pentan-3-one |
| dinophysistoxin 1 | A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models. | dinophysistoxin 1 |
| dolastatin 10 | A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization. | dolastatin 10 |
| dolichodial | A dialdehyde that is cyclopentanecarbaldehyde substituted by a methyl group at position 2 and a 3-oxo-prop-1-en-2yl group at position 5. It has been found to occur in pheromones of insects such as aphids. | dolichodial |
| dysidenin | A secondary carboxamide resulting from the formal condensation of the carboxy group of (4S)-5,5,5-trichloro-N-methyl-N-[(3S)-4,4,4-trichloro-3-methylbutanoyl]-L-leucine with the amino group of (1S)-1-(1,3-thiazol-2-yl)ethanamine. It is a marine metabolite initially isolated from the sponge dysidea herbacea. | dysidenin |
| dysiherbaine | A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and methylamino groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6S,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea that has high affinity for kainate ionotropic glutamate receptors. | dysiherbaine |
| ecdysterone | An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20. | 20-hydroxyecdysone |
| echinenone | A carotenone that is beta-carotene in which the 4 position has undergone formal oxidation to afford the corresponding ketone. Isolated as orange-red crystals, it is widely distributed in marine invertebrates. | echinenone |
| epietiocholanolone | A 3beta-hydroxy steroid that is 5beta-androstane substituted by a hydroxy group at position 3beta and an oxo group at position 17. It is a metabolite of testosterone. | epietiocholanolone |
| farnesoic acid | A farnesoic acid in which the double bonds at positions 2 and 6 both have E-configuration. | (2E,6E)-farnesoic acid |
| fluoren-9-ol | A member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon). | fluoren-9-ol |
| forapin | A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom. | melittin |
| isomaltulose | A glycosylfructose that is D-fructofuranose attached to a alpha-D-glucopyranosyl unit at position 6 via a glycosidic linkage. It is found in honey and sugarcane. | 6-O-alpha-D-glucopyranosyl-D-fructofuranose |
| isovanillin | A member of the class of benzaldehydes that is 4-methoxybenzaldehyde substituted by a hydroxy group at position 3. It is an inhibitor of aldehyde oxidase. | isovanillin |
| jaspamide b | A cyclodepsipeptide isolated from Jaspis splendens. A derivative of jaspamide, it exhibits anti-tumour activity. | jaspamide B |
| jasplakinolide | A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer. | jaspamide |
| laulimalide | A macrolide with formula C30H42O7 that is isolated from the marine sponges, Cacospongia mycofijiensis and Hyattella sp. | laulimalide |
| manzamine a | An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). | manzamine A |
| massadine | An alkaloid isolated from Stylissa massa. | massadine |
| melezitose | A trisaccharide produced by insects such as aphids. | melezitose |
| methionine sulfone | An L-methionine derivative in which the sulfur has been oxidised to the corresponding sulfone. | L-methionine sulfone; methionine sulfone zwitterion |
| methyl n-methylanthranilate | A methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol. | methyl N-methylanthranilate |
| n-acetylhistidine | A histidine derivative that is L-histidine having an acetyl substituent on the alpha-nitrogen. | N-acetyl-L-histidine |
| n-acetyltyramine | A member of the class of tyramines that is tyramine in which one of the hydrogens of the amino group is replaced by an acetyl group. | N-acetyltyramine |
| neodysiherbaine a | A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and hydroxy groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6R,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea. | neodysiherbaine A |
| norsalsolinol | An isoquinolinol that is 1,2,3,4-tetrahydroisoquinoline substituted by hydroxy groups at positions 6 and 7. It is present in the dopamine-rich areas of the human brain, including the substantia nigra. | norsalsolinol |
| octopine | The (1R)-1-carboxyethyl derivative of L-arginine. It is a metabolite released by plant tumours. | D-octopine dizwitterion; D-octopine |
| pentadecane | A straight-chain alkane with 15 carbon atoms. It is a component of volatile oils isolated from plants species like Scandix balansae. | pentadecane |
| phospho-l-arginine | An arginine derivative that is L-arginine substituted by a phosphono group at N(omega)-position. | N(omega)-phospho-L-arginine |
| scalaradial | A scalarane sesterterpenoid with formula C27H40O4. It is a natural product found in the marine sponges Spongia officinalis and Cacospongia mollior, and exhibits anti-inflammatory activity. | scalaradial |
| tetrodotoxin | A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels. | tetrodotoxin |
| trimethylsulfonium | A sulfonium compound in which the substituents on sulfur are three methyl groups. It is found in the midgut gland of the sea hare, Aplysia brasiliana, and exhibits probable ability to inhibit cholinergic responses. | trimethylsulfonium |
| validoxylamine a | An amino cyclitol that is (1R,2S,3S,4S,6R)-4-amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol in which one of the hydrogens attached to the nitrogen is replaced by a (1R,4R,5R,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl group. | validoxylamine A |
| xanthurenic acid | A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by hydroxy groups at C-4 and C-8. | xanthurenic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 10.0000 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 46.4343 | 1 | 1 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 37.5759 | 6 | 11 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.0920 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 15.9112 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 22.4952 | 1 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 26.6514 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 19.5064 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.0341 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 13.3574 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 80.1870 | 1 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 21.8761 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 28.9502 | 1 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 62.9025 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 55.8092 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 46.2014 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 29.1399 | 8 | 18 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 89.3256 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 33.0855 | 6 | 17 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 280.0596 | 2 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 70.5778 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 21.8761 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 10.3620 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.2491 | 1 | 1 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 24.0353 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 1.5804 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 35.2316 | 1 | 3 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 23.2748 | 2 | 4 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 46.3194 | 2 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 50.5209 | 2 | 6 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 21.8761 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 53.1764 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 21.8761 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 5.4746 | 2 | 4 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 29.2267 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 10.4289 | 2 | 8 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.9152 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 45.9148 | 2 | 4 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 22.3872 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 57.0494 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.0074 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 76.9588 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 51.9181 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.5155 | 2 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 31.1037 | 2 | 7 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 53.1764 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 1.9953 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 26.5811 | 2 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 51.5165 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 45.2427 | 5 | 10 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 29.0896 | 1 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.2316 | 1 | 3 |
| Vpr | Human immunodeficiency virus 1 | Potency | 39.8107 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 20-hydroxy-ecdysone receptor | Leptinotarsa decemlineata (Colorado potato beetle) | IC50 | 0.4365 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Nezara viridula (southern green stink bug) | IC50 | 2.8490 | 3 | 3 |
| 20-hydroxy-ecdysone receptor | Spodoptera frugiperda (fall armyworm) | IC50 | 0.1660 | 1 | 1 |
| 20-hydroxy-ecdysone receptor | Nezara viridula (southern green stink bug) | Ki | 2.7500 | 2 | 2 |
| Aldehyde oxidase | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 160.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2,089,300,000,000.0000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2,089,300,000,000.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2,089,300,000,000.0000 | 1 | 1 |
| Bile acid receptor | Homo sapiens (human) | IC50 | 60.4000 | 1 | 1 |
| Chain A, Hyaluronoglucosaminidase | Oceanicola granulosus HTCC2516 | IC50 | 11.0000 | 1 | 1 |
| Class A sortase SrtA | Staphylococcus aureus | IC50 | 150.0000 | 1 | 1 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 5.8800 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 11.0150 | 2 | 2 |
| Cytochrome P450 3A5 | Homo sapiens (human) | IC50 | 2.7600 | 1 | 1 |
| Cytochrome P450 3A7 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 9.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 10.2000 | 1 | 1 |
| Ecdysone receptor | Drosophila melanogaster (fruit fly) | IC50 | 0.0457 | 2 | 2 |
| Ecdysone receptor | Lucilia cuprina (Australian sheep blowfly) | IC50 | 5.5000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 1 | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 23.0429 | 7 | 7 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | Ki | 30.0000 | 1 | 1 |
| matrix metalloproteinase-14 preproprotein | Homo sapiens (human) | IC50 | 19.5000 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 9.0000 | 1 | 1 |
| N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase | Homo sapiens (human) | Ki | 1,400.0000 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 128,520,000,002.8500 | 2 | 2 |
| Phosphatidylcholine 2-acylhydrolase | Apis mellifera (honey bee) | IC50 | 0.0700 | 1 | 1 |
| Phospholipase A2 | Apis mellifera (honey bee) | IC50 | 0.0700 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 675.0000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 8.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| Protein ultraspiracle | Drosophila melanogaster (fruit fly) | IC50 | 0.0457 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 2.2000 | 1 | 2 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 0.0186 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 6.3000 | 2 | 2 |
| Sterol O-acyltransferase 2 | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 2 | Homo sapiens (human) | IC50 | 0.2100 | 2 | 2 |
| Transient receptor potential cation channel subfamily M member 2 | Rattus norvegicus (Norway rat) | IC50 | 0.3300 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 7 | Mus musculus (house mouse) | IC50 | 0.7600 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 2.2000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 2.2000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 0.3012 | 4 | 4 |
| Ultraspiracle | Nezara viridula (southern green stink bug) | IC50 | 2.8490 | 3 | 3 |
| Ultraspiracle | Nezara viridula (southern green stink bug) | Ki | 2.7500 | 2 | 2 |
| Ultraspiracle | Leptinotarsa decemlineata (Colorado potato beetle) | IC50 | 0.4365 | 1 | 1 |
| Ultraspiracle protein | Spodoptera frugiperda (fall armyworm) | IC50 | 0.1660 | 1 | 1 |
| Vesicular glutamate transporter 3 | Rattus norvegicus (Norway rat) | Ki | 190.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |