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hydroxy polyunsaturated fatty acid

Any polyunsaturated fatty acid carrying one or more hydroxy substituents.

ChEBI ID: 140345

Members (14)

MemberDefinitionRole
12-hydroxy-5,8,10-heptadecatrienoic acidA trienoic fatty acid that consists of heptadeca-5,8,10-trienoic acid bearing an additional 12-hydroxy substituent.12-HHTrE
5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acidAn icosanoid that is (6E,8Z,11Z,13E)-icosatetraenoic acid substituted at positions 5 and 15 by oxo and hydroxy groups respectively.(6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid
5,12-dihydroxy-6,8,14-eicosatrienoic acidA leukotriene obtained by formal dehydrogenation of the 10,11-double bond in leukotriene B4.10,11-dihydroleukotriene B4
5s,12r,18r-trihydroxy-6z,8e,10e,14z,16e-eicosapentaenoic acidA resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer).resolvin E1
ci 940A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.leptomycin B
leukotriene b4A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.leukotriene B4
leukotriene b5A leukotriene composed of (6Z,8E,10E,14Z,17Z)-icosapentaenoic acid carrying (5S)- and (12R)-hydroxy substituents.leukotriene B5
lipoxin a4A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.lipoxin A4
minquartynoic acidA straight-chain, C18 polyunsaturated fatty acid having four conjugated C#C bonds at positions 9, 11, 13 and 15 as well as an (S)-hydroxy group at position 17.minquartynoic acid
resolvin d1A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7, 8, and 17 positions (the 7S,8R,17S-stereoisomer).resolvin D1
resolvin d2A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer).resolvin D2
resolvin d3A member of the class of resolvins that is (5Z,7E,9E,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 11 and 17 (the 4S,11R,17S-stereoisomer).resolvin D3
resolvin D4A member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17S-stereoisomer).resolvin D4
resolvin e2A member of the class of resolvins that is (6E,8Z,11Z,14Z,16E)-icosapentaenoic acid carrying two hydroxy substituents at positions 5 and 18 (the 5S,18R stereoisomer).resolvin E2

Research

Studies (7,122)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19901,905 (26.75)18.7374
1990's2,270 (31.87)18.2507
2000's1,213 (17.03)29.6817
2010's1,328 (18.65)24.3611
2020's406 (5.70)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials284 (3.71%)5.53%
Reviews508 (6.64%)6.00%
Case Studies27 (0.35%)4.05%
Observational6 (0.08%)0.25%
Other6,831 (89.22%)84.16%