1,3,6-tri-o-galloyl-beta-d-glucose

Description

1,3,6-tri-O-galloyl-beta-D-glucose, also known as **1,3,6-trigalloylglucose (1,3,6-TGG)**, is a naturally occurring polyphenol found in plants, particularly in the leaves of oak trees. It's a complex molecule with a glucose core and three galloyl groups attached to it.

Here's why 1,3,6-TGG is important for research:

**1. Biological Activities:**

* **Antioxidant:** 1,3,6-TGG exhibits strong antioxidant properties, which means it can neutralize harmful free radicals in the body. This makes it potentially relevant in fighting oxidative stress and related diseases.
* **Anti-inflammatory:** Studies suggest that 1,3,6-TGG has anti-inflammatory effects, potentially making it beneficial in treating inflammatory conditions.
* **Anti-cancer:** 1,3,6-TGG has shown promising anti-cancer activity in vitro and in some animal studies. It can inhibit tumor growth and induce apoptosis (programmed cell death) in cancer cells.
* **Neuroprotective:** Some research suggests that 1,3,6-TGG may have neuroprotective effects, protecting brain cells from damage and potentially benefiting cognitive function.

**2. Potential Therapeutic Applications:**

* **Dietary Supplement:** The antioxidant and other beneficial properties of 1,3,6-TGG have sparked interest in its potential use as a dietary supplement for promoting overall health.
* **Pharmaceutical Development:** Due to its various biological activities, 1,3,6-TGG is being investigated as a potential drug candidate for treating various conditions, including cancer, inflammatory diseases, and neurodegenerative disorders.

**3. Research Tool:**

* **Understanding Plant Metabolism:** 1,3,6-TGG is a valuable tool for studying plant metabolism and the biosynthesis of polyphenols.
* **Exploring Drug Delivery:** Research is exploring the use of 1,3,6-TGG as a carrier molecule for targeted drug delivery.

**4. Food Chemistry:**

* **Food Preservation:** 1,3,6-TGG's antioxidant properties make it potentially useful as a natural food preservative to extend the shelf life of food products.
* **Sensory Properties:** 1,3,6-TGG contributes to the astringent taste and color of certain foods and beverages.

**It's important to note that while 1,3,6-TGG shows promising potential, more research is needed to understand its full effects and safety in humans before it can be widely used as a therapeutic agent or supplement.**

**Current Research:**

Ongoing research on 1,3,6-TGG focuses on:

* **Mechanism of action:** Understanding how 1,3,6-TGG exerts its biological effects at a molecular level.
* **Optimization and delivery:** Finding efficient ways to extract, synthesize, and deliver 1,3,6-TGG to the body.
* **Clinical trials:** Evaluating the safety and efficacy of 1,3,6-TGG in humans for various conditions.

1,3,6-tri-O-galloyl-beta-D-glucose represents a promising area of research with potential benefits for human health and wellness.

1,3,6-tri-O-galloylglucose: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]