EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor

A DNA polymerase inhibitor that interferes with the action of a DNA-directed DNA polymerase (EC 2.7.7.7).

ChEBI ID: 131699

Members (7)

Member	Definition	Class
aphidicolin	A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.	aphidicolin
daidzein	A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.	daidzein
ellagic acid	An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.	ellagic acid
neobavaisoflavone	A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation.	neobavaisoflavone
phosphonoacetic acid	A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.	phosphonoacetic acid
pyridoxal phosphate	The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.	pyridoxal 5'-phosphate
solanapyrone a		solanapyrone A

Research

Studies (12,456)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	4,435 (35.61)	18.7374
1990's	2,399 (19.26)	18.2507
2000's	2,563 (20.58)	29.6817
2010's	2,299 (18.46)	24.3611
2020's	760 (6.10)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	374 (2.87%)	5.53%
Reviews	604 (4.63%)	6.00%
Case Studies	164 (1.26%)	4.05%
Observational	7 (0.05%)	0.25%
Other	11,897 (91.19%)	84.16%

Protein Targets (317)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	17.4850	1	8
15-lipoxygenase, partial	Homo sapiens (human)	Potency	5.0119	1	1
67.9K protein	Vaccinia virus	Potency	0.9450	2	2
activating transcription factor 6	Homo sapiens (human)	Potency	1.9303	1	1
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	34.5053	1	7
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	0.7943	1	1
AR protein	Homo sapiens (human)	Potency	23.8909	11	14
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	13.6987	3	4
arylsulfatase A	Homo sapiens (human)	Potency	6.7456	1	1
ATAD5 protein, partial	Homo sapiens (human)	Potency	14.8920	2	2
Ataxin-2	Homo sapiens (human)	Potency	18.7030	2	2
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	8.8505	2	2
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	33.5340	2	2
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	10.0295	2	7
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.3972	1	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	8.5018	1	2
caspase-3	Homo sapiens (human)	Potency	8.5018	1	2
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	15.3603	2	5
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	17.9466	1	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	2.1033	2	5
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	56.2341	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	39.8107	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	20.5996	2	8
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	44.9165	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	14.8325	3	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	9.9982	2	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	10.6126	2	6
Chain B, HADH2 protein	Homo sapiens (human)	Potency	20.5996	2	8
chromobox protein homolog 1	Homo sapiens (human)	Potency	1.0000	1	1
core-binding factor subunit beta isoform 2	Homo sapiens (human)	Potency	0.3604	2	2
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	20.8114	1	2
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	23.0602	1	2
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	0.2132	1	1
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	15.8489	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	20.4839	2	4
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	12.2060	1	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	6.0509	1	1
DNA polymerase beta	Homo sapiens (human)	Potency	0.1585	1	1
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	0.7943	1	1
DNA polymerase III, partial	Bacillus subtilis	Potency	21.1923	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	4.6038	1	3
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	0.3905	1	3
endonuclease IV	Escherichia coli	Potency	10.1537	2	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	10.1247	11	18
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	2.7395	3	5
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	19.7528	10	16
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	17.3924	1	6
EWS/FLI fusion protein	Homo sapiens (human)	Potency	17.9701	3	3
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	54.4037	1	1
flap endonuclease 1	Homo sapiens (human)	Potency	36.1898	1	2
fructose-bisphosphate aldolase A	Oryctolagus cuniculus (rabbit)	Potency	63.0957	1	1
G	Vesicular stomatitis virus	Potency	0.2132	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
geminin	Homo sapiens (human)	Potency	7.4581	2	5
GLI family zinc finger 3	Homo sapiens (human)	Potency	14.1229	2	4
GLS protein	Homo sapiens (human)	Potency	6.4092	2	2
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	31.9463	3	3
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Potency	0.0141	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	2.2986	2	3
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Potency	0.0141	1	1
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Potency	0.0141	1	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	Homo sapiens (human)	Potency	79.4328	1	1
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	0.7308	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	8.6437	2	3
hemoglobin subunit beta	Homo sapiens (human)	Potency	10.0000	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	15.3498	2	10
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	25.1189	1	1
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	5.5679	2	4
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	19.0843	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	11.2202	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	0.2132	1	1
huntingtin isoform 2	Homo sapiens (human)	Potency	0.6310	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	1.9953	2	2
IDH1	Homo sapiens (human)	Potency	0.1300	1	1
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	8.2898	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	0.2132	1	2
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	8.1750	2	2
Integrin alpha-IIb	Homo sapiens (human)	Potency	10.0000	1	1
Integrin beta-3	Homo sapiens (human)	Potency	10.0000	1	1
Interferon beta	Homo sapiens (human)	Potency	0.2132	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	1.0359	1	5
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	1.0000	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	19.5008	4	6
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	4.4668	1	1
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	89.1251	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	25.3634	2	8
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	19.9526	1	1
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	79.4328	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	4.4668	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	0.2818	1	1
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	9.2000	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	16.4561	4	8
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	1.1883	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	35.4813	1	1
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	13.3321	3	6
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	25.1189	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	50.1187	1	1
Parkin	Homo sapiens (human)	Potency	7.3078	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	1.2589	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	9.0743	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	47.7548	1	1
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	14.1254	1	1
phosphoglycerate kinase	Trypanosoma brucei brucei TREU927	Potency	0.8913	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	79.4328	1	2
plasminogen precursor	Mus musculus (house mouse)	Potency	5.6234	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	3.7842	1	2
pregnane X nuclear receptor	Homo sapiens (human)	Potency	24.6701	2	4
progesterone receptor	Homo sapiens (human)	Potency	38.5708	1	1
pyruvate kinase	Leishmania mexicana mexicana	Potency	12.5893	2	2
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	25.1189	2	2
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	10.0000	1	1
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	19.9526	1	1
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	16.0678	2	7
ras-related protein Rab-9A	Homo sapiens (human)	Potency	10.0000	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	40.1892	1	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	15.2246	3	6
runt-related transcription factor 1 isoform AML1b	Homo sapiens (human)	Potency	0.3604	2	2
serine-protein kinase ATM isoform a	Homo sapiens (human)	Potency	19.9526	1	1
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	8.4368	1	1
Smad3	Homo sapiens (human)	Potency	1.2589	1	1
snurportin-1	Homo sapiens (human)	Potency	8.2898	2	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	19.9526	1	1
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	12.6619	1	7
TDP1 protein	Homo sapiens (human)	Potency	9.7760	2	3
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	11.9204	3	3
Thrombopoietin	Homo sapiens (human)	Potency	2.5119	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	36.1963	1	2
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	29.1056	2	3
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	12.1882	2	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	1.1220	1	1
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	5.6234	1	1
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	5.6234	1	1
USP1 protein, partial	Homo sapiens (human)	Potency	50.4512	2	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	33.4889	1	1
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	39.8107	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	3.4408	1	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5'-nucleotidase	Homo sapiens (human)	IC50	1.8500	1	1
5'-nucleotidase	Mus musculus (house mouse)	IC50	0.0400	1	1
acetyl-CoA acetyltransferase/HMG-CoA reductase	Enterococcus faecalis	IC50	1,265.3900	1	1
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	132.9200	1	1
Adenosine receptor A1	Rattus norvegicus (Norway rat)	Ki	10.5700	3	3
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Ki	7.6150	2	2
Aldehyde dehydrogenase, mitochondrial	Homo sapiens (human)	IC50	9.0000	2	2
Aldehyde oxidase 1	Cavia porcellus (domestic guinea pig)	Ki	4.5300	1	1
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	IC50	81.0000	2	2
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	IC50	32.2000	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	IC50	40.0000	1	1
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	14.0000	2	2
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	14.0000	2	2
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	200.0000	2	2
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	0.2600	1	1
Angiotensin-converting enzyme	Homo sapiens (human)	IC50	5,000.0000	1	1
Aromatase	Homo sapiens (human)	Ki	100.0000	1	1
Aurora kinase A	Homo sapiens (human)	IC50	2.4800	1	1
Aurora kinase B	Homo sapiens (human)	IC50	2.5000	1	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	30.0000	1	1
Beta-secretase 1	Homo sapiens (human)	IC50	3.9000	1	1
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	IC50	20.7000	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Bos taurus (cattle)	IC50	0.6000	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	IC50	2.0500	2	2
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	IC50	2.0500	2	2
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	IC50	2.0500	2	2
Carbonic anhydrase 1	Homo sapiens (human)	Ki	86.7040	4	5
Carbonic anhydrase 12	Homo sapiens (human)	Ki	6.1021	3	3
Carbonic anhydrase 13	Homo sapiens (human)	Ki	4.2400	1	1
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	10.3000	1	1
Carbonic anhydrase 14	Homo sapiens (human)	Ki	8.9100	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	93.0360	4	5
Carbonic anhydrase 3	Homo sapiens (human)	Ki	10.5000	1	1
Carbonic anhydrase 4	Homo sapiens (human)	Ki	4.8994	2	2
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	7.5900	1	1
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	12.7000	1	1
Carbonic anhydrase 6	Homo sapiens (human)	Ki	7.0600	1	1
Carbonic anhydrase 7	Homo sapiens (human)	Ki	5.0381	3	3
Carbonic anhydrase 9	Homo sapiens (human)	Ki	44.5850	2	2
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	0.0400	3	3
Casein kinase II subunit alpha	Homo sapiens (human)	Ki	0.0200	1	1
Casein kinase II subunit alpha	Rattus norvegicus (Norway rat)	IC50	0.0400	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	0.0400	2	2
Casein kinase II subunit beta	Homo sapiens (human)	IC50	0.0400	2	2
Casein kinase II subunit beta	Rattus norvegicus (Norway rat)	IC50	0.0400	1	1
Chain A, ALKALINE PHOSPHATASE	Escherichia coli	Ki	5,500.0000	1	2
Chain A, Casein kinase II subunit alpha	Homo sapiens (human)	Ki	0.0200	1	1
Cruzipain	Trypanosoma cruzi	IC50	142.0000	2	2
Cyclin-A1	Homo sapiens (human)	IC50	3.3900	1	1
Cyclin-A2	Homo sapiens (human)	IC50	3.3900	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	3.3900	1	1
Cyclin-dependent kinase 4	Homo sapiens (human)	IC50	1.0900	1	1
Cysteine protease ATG4B	Homo sapiens (human)	IC50	4.2500	2	2
Cytochrome P450 2D6	Homo sapiens (human)	IC50	4.7700	1	1
Cytochrome P450 2D6	Homo sapiens (human)	Ki	1.9500	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	IC50	0.4500	1	1
DNA polymerase alpha catalytic subunit	Homo sapiens (human)	IC50	5.1500	6	6
DNA polymerase beta	Homo sapiens (human)	IC50	100.0000	1	1
DNA polymerase beta	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1
DNA polymerase catalytic subunit	Human alphaherpesvirus 1 strain 17	IC50	0.5000	1	1
DNA polymerase catalytic subunit	Human alphaherpesvirus 1 strain KOS	IC50	0.4380	1	1
DNA polymerase catalytic subunit	Human herpesvirus 3 strain Dumas	IC50	1.6000	1	2
DNA polymerase catalytic subunit	Human herpesvirus 5 strain AD169	IC50	0.4435	2	2
DNA polymerase catalytic subunit	Human herpesvirus 6 (strain Uganda-1102)	IC50	0.4000	1	1
DNA polymerase delta catalytic subunit	Homo sapiens (human)	IC50	40.0000	1	1
DNA polymerase eta	Homo sapiens (human)	IC50	0.0620	1	1
DNA polymerase iota	Homo sapiens (human)	IC50	0.0620	1	1
DNA polymerase lambda	Homo sapiens (human)	IC50	200.0000	1	1
DNA polymerase subunit gamma-1	Homo sapiens (human)	IC50	100.0000	1	1
DNA primase	Mycobacterium tuberculosis CDC1551	IC50	100.0000	1	1
dual specificity protein phosphatase 3	Homo sapiens (human)	IC50	1.1050	2	2
dual specificity protein phosphatase 6	Rattus norvegicus (Norway rat)	IC50	39.5000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	IC50	40.0000	1	1
Ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus (house mouse)	IC50	0.5000	1	1
ELAV-like protein 3	Homo sapiens (human)	IC50	0.6000	1	1
Ephrin type-B receptor 4	Homo sapiens (human)	IC50	1.8300	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	0.6900	1	1
Estrogen receptor	Homo sapiens (human)	IC50	175.4267	6	6
Estrogen receptor	Homo sapiens (human)	Ki	1.8000	1	1
Estrogen receptor beta	Homo sapiens (human)	IC50	1.6568	5	6
Estrogen receptor beta	Homo sapiens (human)	Ki	0.3000	1	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	Homo sapiens (human)	IC50	47.6714	1	1
eukaryotic translation initiation factor 4E isoform 1	Mus musculus (house mouse)	IC50	47.6714	1	1
Fe(3+)-Zn(2+) purple acid phosphatase	Phaseolus vulgaris	Ki	590.0000	1	1
Focal adhesion kinase 1	Homo sapiens (human)	IC50	3.1100	1	1
G-protein coupled receptor 35	Homo sapiens (human)	IC50	0.1000	1	1
G1/S-specific cyclin-D1	Homo sapiens (human)	IC50	1.0900	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	IC50	22.8000	1	1
Glutathione S-transferase	Plasmodium falciparum 3D7	IC50	74.4000	1	1
Glutathione S-transferase Mu 1	Mus musculus (house mouse)	IC50	100.0000	1	1
Glutathione S-transferase P	Homo sapiens (human)	IC50	63.5500	2	2
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	7.5000	1	1
heat shock 70kDa protein 1A	Homo sapiens (human)	IC50	66.9200	3	3
heat shock cognate 71 kDa protein isoform 1	Homo sapiens (human)	IC50	99.6000	2	2
heat shock cognate 71 kDa protein isoform 2	Homo sapiens (human)	IC50	99.6000	2	2
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50	0.5800	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	IC50	1.9800	1	1
Insulin receptor	Homo sapiens (human)	IC50	0.3400	1	1
Insulin-like growth factor 1 receptor	Homo sapiens (human)	IC50	0.2500	1	1
Integrase	Human immunodeficiency virus 1	IC50	5.1000	2	2
likely tRNA 2'-phosphotransferase	Candida albicans SC5314	IC50	0.2913	2	2
Low molecular weight phosphotyrosine protein phosphatase	Homo sapiens (human)	Ki	13.0000	1	1
M17 leucyl aminopeptidase	Plasmodium falciparum 3D7	IC50	138.0800	1	1
Macrophage migration inhibitory factor	Homo sapiens (human)	IC50	4.7700	1	1
Macrophage migration inhibitory factor	Homo sapiens (human)	Ki	1.9500	1	1
Mcl-1	Homo sapiens (human)	IC50	27.2850	2	2
Mitogen-activated protein kinase kinase kinase 8	Homo sapiens (human)	IC50	2.3700	1	1
mothers against decapentaplegic homolog 3 isoform 1	Homo sapiens (human)	IC50	0.1420	1	1
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	IC50	0.5700	1	4
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	IC50	0.5700	1	3
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	IC50	0.5700	1	3
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	IC50	0.5700	1	3
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	IC50	0.5700	1	3
Neuraminidase	Influenza A virus (A/Wilson-Smith/1933(H1N1))	IC50	36.8333	3	3
NUAK family SNF1-like kinase 1	Homo sapiens (human)	IC50	0.5100	1	1
Nucleophosmin	Homo sapiens (human)	IC50	40.0000	1	1
P2X purinoceptor 1	Homo sapiens (human)	IC50	10.0000	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	1.3000	1	1
Polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens (human)	IC50	1.7200	2	2
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	IC50	100.0000	1	2
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (human)	IC50	100.0000	1	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	IC50	100.0000	1	2
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	100.0000	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	40.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	0.4667	3	3
rac GTPase-activating protein 1 isoform a	Homo sapiens (human)	IC50	91.2600	1	1
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	IC50	3.3400	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	3.5400	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	40.0000	1	1
Renin	Homo sapiens (human)	IC50	0.9800	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	105.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	1.7600	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	3.3400	1	1
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	IC50	2.9700	1	1
Solute carrier family 22 member 6	Homo sapiens (human)	IC50	0.2700	1	1
Squalene monooxygenase	Rattus norvegicus (Norway rat)	IC50	2.0000	1	1
Substance-K receptor	Cavia porcellus (domestic guinea pig)	IC50	37.1000	1	1
Substance-P receptor	Cavia porcellus (domestic guinea pig)	IC50	37.1000	1	1
Tat	Human immunodeficiency virus 1	IC50	1.6690	1	1
Thioredoxin reductase 1, cytoplasmic	Homo sapiens (human)	IC50	176.8000	2	2
Thioredoxin reductase 2, mitochondrial	Homo sapiens (human)	IC50	176.8000	2	2
Thioredoxin reductase 3	Homo sapiens (human)	IC50	176.8000	2	2
Trans-sialidase	Trypanosoma cruzi	Ki	7,300.0000	2	2
Translin-associated protein X	Homo sapiens (human)	IC50	3.5000	1	1
Transporter	Rattus norvegicus (Norway rat)	IC50	0.4500	1	1
Transthyretin	Homo sapiens (human)	IC50	16.0000	1	1
Tyrosinase	Mus musculus (house mouse)	IC50	500.0000	1	1
Tyrosine-protein kinase Fgr	Rattus norvegicus (Norway rat)	IC50	3.5000	1	1
Tyrosine-protein kinase Lyn	Rattus norvegicus (Norway rat)	IC50	7.5000	1	1
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)	IC50	63.6500	2	2
unnamed protein product	Aspergillus oryzae RIB40	IC50	52.7195	2	2
Urease subunit alpha	Helicobacter pylori 26695	IC50	556.0000	1	1
Urease subunit beta	Helicobacter pylori 26695	IC50	556.0000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	0.7900	1	1
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	1.5400	1	1
Vif	Human immunodeficiency virus 1	IC50	0.4500	1	1
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	IC50	714.9000	2	2

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Amine oxidase [flavin-containing] A	Homo sapiens (human)	EC50	1.6000	1	1
DNA polymerase alpha catalytic subunit	Homo sapiens (human)	EC50	2.0000	1	1
Estrogen receptor	Ovis aries (sheep)	Kd	5.9000	1	1
Estrogen receptor beta	Ovis aries (sheep)	Kd	5.9000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	1.5350	2	2
P2X purinoceptor 1	Rattus norvegicus (Norway rat)	EC50	3.0000	1	1
P2X purinoceptor 2	Homo sapiens (human)	EC50	39.5000	1	1
P2X purinoceptor 4	Rattus norvegicus (Norway rat)	EC50	219.0000	1	1
Polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens (human)	Kd	0.3710	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Acetylcholinesterase	Electrophorus electricus (electric eel)	EC24	250.0000	1	1
Androgen receptor	Homo sapiens (human)	EC150	10.1000	1	1
Cholinesterase	Equus caballus (horse)	EC16	250.0000	1	1
Glucocorticoid receptor	Homo sapiens (human)	EC150	10.1000	1	1
Lactoperoxidase	Bos taurus (cattle)	Km	0.3000	1	1
Prenyltransferase homolog	Streptomyces coelicolor A3(2)	Km	290.0000	1	1
Receptor-type tyrosine-protein phosphatase beta	Homo sapiens (human)	Kis	5.6650	2	2
UDP-glucuronosyltransferase 1A4	Homo sapiens (human)	Km	400.0000	1	1